Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Whole Food Zinc 20 mg Ingredients & Drug Interactions

by VitaScript

Whole Food Zinc 20 mg label
See full label image
Tablet Or Pill Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Whole Food Zinc 20 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Whole Food Zinc 20 mg is a dietary supplement by VitaScript with 6 active ingredients. Its ingredients are commonly taken for zinc deficiency, immune support, cold symptoms.Based on those ingredients, 158 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Blueberry, Spinach, Zinc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Whole Food Zinc 20 mg by VitaScript

Ask about any prescription or over-the-counter medication and we check it for interactions with Whole Food Zinc 20 mg by VitaScript — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Whole Food Zinc 20 mg by VitaScript

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 6 active ingredients.
  • “Organic Whole Food Blend” is a proprietary blend — the label gives one combined amount (72 mg) without saying how much of each component you get.

This tablet or pill contains 6 ingredients, of which 5 are active: zinc (the primary ingredient at 20 mg), plus blueberry, spinach, carrot, and pumpkin — all whole-food sources intended to complement the zinc. Rice husk appears in the blend but has no documented active role.

The product also contains inactive ingredients (excipients such as cellulose, calcium stearate, and silica) that give the tablet its form and stability.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Essential mineral for immune and tissue health.
  • We looked for evidence on: Acne, Acrodermatitis enteropathica, Atopic dermatitis (eczema), Canker sores, Child growth, Cystic fibrosis — and 4 related terms.
  • The strongest evidence on file: Zinc is rated "Possibly Effective" for Acne (Natural Medicines).
  • Also on file: Zinc is rated "Possibly Effective" for Acrodermatitis enteropathica, Diaper rash, Gingivitis, Herpes labialis (cold sores), and more.
  • Also on file: Zinc is rated "Possibly Ineffective" for Cystic fibrosis.

Zinc itself is rated Effective for zinc deficiency and Likely Effective for Wilson disease. It's Possibly Effective for acne, acrodermatitis enteropathica, age-related macular degeneration, and diabetes.

The blueberry component is rated Possibly Ineffective for high blood pressure and has Insufficient evidence for cognitive decline, anxiety, athletic performance, high cholesterol, and heart disease. Spinach has Insufficient evidence for fatty liver disease, cognitive function, muscle strength, obesity, and PCOS.

Carrot is Possibly Effective for vitamin A deficiency but has Insufficient evidence for various cancers and fibromyalgia. Pumpkin is Possibly Effective for benign prostatic hyperplasia but has Insufficient evidence for hair loss, bladder inflammation, parasites, and UTIs.

The evidence, ingredient by ingredient Zinc Blueberry Spinach Carrot Pumpkin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Zinc is generally well tolerated in doses below 40 mg daily (the tolerable upper limit for adults). This product contains 20 mg, which is within that range.

The most common side effects from oral zinc are abdominal cramps, diarrhea, metallic taste, and nausea — these are dose-related and typically mild. At high doses above the limit, there's concern that zinc may increase the risk of copper deficiency over time.

Blueberry is generally safe as food; freeze-dried blueberry supplements can cause constipation, diarrhea, nausea, and vomiting — in one trial, 26% of participants taking 50 grams daily dropped out in the first week due to stomach upset. Spinach, carrot, and pumpkin are all well tolerated as foods.

There isn't enough safety data for concentrated supplements of carrot or pumpkin during pregnancy and breastfeeding, though the foods themselves are considered fine. Blueberry is rated Likely Safe in pregnancy and lactation.

Side effects, ingredient by ingredient Zinc Blueberry Spinach Carrot Pumpkin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Spinach, Pumpkin, Zinc, Blueberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 158 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check if you take quinolone or tetracycline antibiotics, cephalexin, penicillamine, ritonavir, or any integrase inhibitor (these are Moderate interactions with zinc). Also check for warfarin or other blood thinners, antidiabetes drugs, lithium, flurbiprofen, buspirone, or cisplatin.

Your pharmacist can help you space doses so the drugs and supplement don't interfere with each other.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take antibiotics (especially quinolones or tetracyclines), blood thinners like warfarin, HIV medications, diabetes drugs, lithium, or cisplatin, you need to check your exact medications before using this product — spacing matters. The 20 mg dose is within the safe daily limit for zinc in otherwise healthy adults.

Talk to your pharmacist about timing if you're on any prescription medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Whole Food Zinc 20 mg, straight from the product label.

Brand VitaScript
Net contents 60 Vegan Tablet(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 319249
Product type Botanical With Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Whole Food Zinc 20 mg by VitaScript, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegan Tablet(s)
Maximum serving Sizes:
1 Vegan Tablet(s)
Servings per container
60
IngredientAmount% DV
Zinc20 mg182%
Blueberry0 NP--
Rice Husk0 NP--
Spinach0 NP--
Carrot0 NP--
Pumpkin0 NP--
Organic Whole Food Blend72 mg--

Other ingredients: Saccharomyces boulardii, Cellulose, Calcium Stearate, Silica, Guar Gum, Acacia, Agave Fiber, Rice Bran Extract, Agave Syrup, Sunflower Oil, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take one tablet daily.

Formula

Whole food source of Zinc Zinc is an essential mineral found in every cell in the body. It is required for the proper functioning of the body's natural defenses and for protein synthesis, tissue health and growth hormones. Zinc also helps maintain normal taste and smell acuity, and promotes healthy skin. Adequate daily intake of zinc is essential for good health. This formulation utilizes whole food based zinc from the fermented probiotic nutritional yeast for bioavailability along with an orgaic blend of supporting botanicals.

Whole food Zinc 20 mg from fermented probiotic complex

Formulation

Contains no artificial colors, flavors, or preservatives; no wheat, gluten, milk, eggs, peanuts, sesame, tree nuts, soy, crustacean shellfish or fish.

We guarantee our supplements for potency and purity

Supports immune and skin health

No GMO ingredients SGS verified the process for manufacturing this product with no GMO ingredients. www.sgs.com/no-gmo Double Verified GF Gluten Free

Storage

Store in a cool, dry place.

Precautions

To report a serious adverse event, call 1-888-710-0006

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

No GMO ingredients Double Verified GF Gluten Free

FDA Statement of Identity

Whole Food Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Whole Food Zinc 20 mg by VitaScript label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Whole Food Zinc 20 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Whole Food Zinc 20 mg by VitaScript

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegan Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Zinc

Interacts with
67 drugs
20 mg per serving

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Organic Whole Food Blend

72 mg per serving

Other (inactive) ingredients: Saccharomyces boulardii, Cellulose, Calcium Stearate, Silica, Guar Gum, Acacia, Agave Fiber, Rice Bran Extract, Agave Syrup, Sunflower Oil, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Whole Food Zinc 20 mg by VitaScript Drug Interactions

Want to check YOUR meds against Whole Food Zinc 20 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
158Drugs
152 Moderate 6 Minor

Ingredients driving the most interactions

Blueberry 88
Spinach 88
Zinc 67
Pumpkin 1

Individual Drug Interactions

The ingredients in Whole Food Zinc 20 mg interact with 158 drugs. Click any drug to see the details.

4 of the 6 ingredients in Whole Food Zinc 20 mg interact with drugs. Each result below shows which ingredient is responsible. Blueberry Spinach Zinc Pumpkin

Each ingredient & the kinds of drugs it affects

For each ingredient in Whole Food Zinc 20 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Blueberry3 drug types · 88 drugs

Antidiabetes Drugs

Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggests that blueberry and/or blueberry leaf extracts can lower blood glucose levels.

Likelihood Unlikely Evidence D
Buspirone (Buspar)

Theoretically, blueberry juice might increase blood levels of buspirone.
In vitro research shows that blueberry juice can inhibit the metabolism of buspirone, possibly by inhibiting cytochrome P450 3A (CYP3A) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking buspirone hydrochloride 10 mg does not significantly affect the concentration or clearance of buspirone.

Likelihood Unlikely Evidence B
Flurbiprofen (Ansaid, Others)

Theoretically, blueberry juice might increase blood levels of flurbiprofen.
In vitro research shows that blueberry juice can inhibit the metabolism of flurbiprofen, possibly by inhibiting cytochrome P450 2C9 (CYP2C9) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking flurbiprofen 100 mg does not significantly affect the concentration or clearance of flurbiprofen.

Likelihood Unlikely Evidence B
Blueberry full monograph & interactions

Spinach2 drug types · 88 drugs

Antidiabetes Drugs

There are claims that spinach leaves have hypoglycemic effects. Evidence from clinical research suggests that consumption of a spinach-rich meal reduces post-meal blood glucose levels. Theoretically, spinach might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia. Monitor blood glucose levels closely. Dose adjustments might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Spinach contains vitamin K, which can interfere with the activity of warfarin.
In human research, although eating spinach with one meal does not result in coagulation test results outside the therapeutic range, daily consumption for one week necessitates dose adjustment of warfarin. Individuals using anticoagulants should consume a consistent daily amount of spinach to maintain the effect of anticoagulant therapy.

Likelihood Possible Evidence D
Spinach full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions

Pumpkin1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Whole Food Zinc 20 mg, from the product label.

VitaScript

See all VitaScript products
Name
E-NutritionStore.com
City
Elkridge
State
MD
ZipCode
21075
Phone Number
443-483-3340
Web Address
E-NutritionStore.com
Pharmacist Counseling Corner

Whole Food Zinc 20 mg by VitaScript: Common Questions

Does Whole Food Zinc 20 mg by VitaScript interact with any medications?
Yes. Based on its ingredients, Whole Food Zinc 20 mg has a known interaction with 158 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Whole Food Zinc 20 mg contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on an antibiotic?
It depends on which antibiotic. If it's a quinolone (like ciprofloxacin), tetracycline, cephalexin, or penicillamine, you'll need to space the zinc at least 2–4 hours away from it — the timing matters because zinc can block the antibiotic's absorption. Ask your pharmacist about the specific antibiotic you're taking.
Does this product have 'no fillers'?
No. This tablet contains inactive ingredients like cellulose, calcium stearate, silica, and guar gum, which help hold the tablet together and keep it stable. These are standard in supplements — they're not harmful, just not the active part of the product.
Will it upset my stomach?
Zinc can cause nausea, diarrhea, and a metallic taste in some people, especially at higher doses. The 20 mg in this product is a moderate amount. Blueberry supplements may also cause stomach upset — in trials, some people experienced nausea and diarrhea. If you have a sensitive stomach, take it with food and watch how you respond.
Is this safe to take long-term?
At 20 mg daily, this is below the safe upper limit of 40 mg for adults, so it's generally safe for everyday use. However, if you take zinc long-term at high doses, there's a concern about copper deficiency over time. For this dose, that's less of a worry — just don't exceed the upper limit and mention it to your doctor if you're on any long-term supplements.
Can I take this while pregnant or breastfeeding?
The blueberry in this product is rated Likely Safe during pregnancy and lactation. However, the safety data for concentrated carrot and pumpkin supplements during these times isn't well studied, so we don't have a clear answer. Talk to your doctor or pharmacist about whether this specific product is right for you during pregnancy or breastfeeding.
What is zinc actually used for?
Zinc is effective for treating zinc deficiency and is likely effective for Wilson disease. It's possibly effective for acne, certain types of age-related vision loss, and diabetes. The other ingredients — blueberry, spinach, carrot, and pumpkin — add antioxidants and nutrients, but the main active ingredient is the zinc.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Whole Food Zinc 20 mg label
Go deeper

The Full Monographs Behind Whole Food Zinc 20 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Blueberry

Interacts with 88 drugs

Blueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most people. Concentrated supplements are mark...

Read the full Blueberry monograph → Herb & supplement monograph

Spinach

Interacts with 88 drugs

Spinach is a nutrient-dense leafy green that is a healthy part of a balanced diet, providing vitamins, minerals, fiber, and antioxidants. While it is very safe as a food, concentrated supple...

Read the full Spinach monograph → Herb & supplement monograph

Carrot

Carrot is a common food vegetable that is a rich source of beta-carotene (which the body turns into vitamin A) and other nutrients. Eating carrots is safe and nutritious for most people, but...

Read the full Carrot monograph → Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph →
Sources

Sources & How We Checked

Whole Food Zinc 20 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 120 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zinc 88 references
  1. Barceloux DG. Zinc. J Toxicol Clin Toxicol 1999;37:279-92.
  2. Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother 1984;25:20-4. DOI
  3. Smith DS, Helzner EC, Nuttall CE Jr, et al. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. Antimicrob Agents Chemother 1989;33:646-8. PubMed
  4. Blondeau JM. Expanded activity and utility of the new fluoroquinolones: a review. Clin Ther 1999;21:3-40. PubMed
  5. Reyes AJ, Olhaberry JV, Leary WP, et al. Urinary zinc excretion, diuretics, zinc deficiency and some side-effects of diuretics. S Afr Med J 1983;64:936-41.
  6. Kugelmas M. Preliminary observation: oral zinc sulfate replacement is effective in treating muscle cramps in cirrhotic patients. J Am Coll Nutr 2000;19:13-5. PubMed
  7. Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
  8. Chan S, Gerson B, Subramaniam S. The role of copper, molybdenum, selenium, and zinc in nutrition and health. Clin Lab Med 1998;18:673-85. DOI
  9. Brewer GJ, Yuzbasiyan-Gurkan V, Johnson V, et al. Treatment of Wilson's disease with zinc: XI. Interaction with other anticopper agents. J Am Coll Nutr 1993;12:26-30. PubMed
  10. Fosmire GJ. Zinc toxicity. Am J Clin Nutr 1990;51:225-7.
  11. Lomaestro BM, Bailie GR. Absorption interactions with fluoroquinolones. 1995 update. Drug Saf 1995;12:314-33. PubMed
  12. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  13. Seelig MS. Auto-immune complications of D-penicillamine - A possible result of zinc and magnesium depletion and of pyridoxine inactivation. J Am Coll Nutr 1982;1:207-14. PubMed
  14. Neuvonen PJ. Interactions with the absorption of tetracyclines. Drugs 1976;11:45-54.. PubMed
  15. Hirt M, Nobel S, Barron E. Zinc nasal gel for the treatment of common cold symptoms: A double-blind, placebo-controlled trial. Ear Nose Throat J 2000;79:778-82.. DOI
  16. Simkin PA. Oral zinc sulphate in rheumatoid arthritis. Lancet 1976;2:539-42. PubMed
  17. Wray D. A double-blind trial of systemic zinc sulfate in recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol 1982;53:469-72. PubMed
  18. Douglas RM, Miles HB, Moore BW, et al. Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults. Antimicrob Agents Chemother 1987;31:1263-5. PubMed
  19. Lagiou P, Wuu J, Trichopoulou A, et al. Diet and benign prostatic hyperplasia: a study in Greece. Urology 1999;54:284-90. PubMed
  20. Ewing CI, Gibbs AC, Ashcroft C, David TJ. Failure of oral zinc supplementation in atopic eczema. Eur J Clin Nutr 1991;45:507-10.
  21. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  22. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. AREDS report no. 8. Arch Oph
  23. Greenberg JE, Lynn M, Kirsner RS, et al. Mucocutaneous pigmented macule as a result of zinc deposition. J Cutan Pathol 2002;29:613-5. PubMed
  24. Godfrey HR, Godfrey NJ, Godfrey JC, Riley D. A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine. Altern Ther Health Med 2001;7:49-56.
  25. Turner RB. Ineffectiveness of intranasal zinc gluconate for prevention of experimental rhinovirus colds. Clin Infect Dis 2001;33:1865-70. PubMed
  26. Belongia EA, Berg R, Liu K. A randomized trial of zinc nasal spray for the treatment of upper respiratory illness in adults. Am J Med 2001;111:103-8. PubMed
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Blueberry 7 references
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Spinach 6 references
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Carrot 14 references
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Pumpkin 5 references
  1. Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
  2. Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
  3. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
  4. Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
  5. Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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