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Dietary supplement

Wild Lettuce and California Poppy Ingredients & Drug Interactions

by Hawaii Pharm

Wild Lettuce and California Poppy label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Lettuce and California Poppy against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Lettuce and California Poppy is a dietary supplement by Hawaii Pharm with 2 active ingredients. Its ingredients are commonly taken for anxiety and stress, trouble sleeping (insomnia), mild aches and pains.Based on those ingredients, 393 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Lettuce Herb Extract, Dry, California Poppy. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wild Lettuce and California Poppy by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Lettuce and California Poppy by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Wild Lettuce and California Poppy by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (983 mg) without saying how much of each component you get.

This liquid contains 2 active ingredients: a proprietary extract blend, California poppy, and wild lettuce herb extract (dry form). You'll also find alcohol, water, and glycerin as inactive ingredients that help deliver and preserve the liquid.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Anxiety, sleep, and nervous tension support.
  • We looked for evidence on: Anxiety, Insomnia, Restlessness, Nervous tension.
  • The closest evidence on file: California Poppy is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: California Poppy is rated "Insufficient Reliable Evidence To Rate" for Insomnia.

The evidence we hold doesn't establish how well this product works for its intended uses. California poppy has been studied for anxiety and insomnia, but the data is insufficient to rate it.

Wild lettuce has no effectiveness ratings in our data. Neither ingredient has reliable evidence backing its use for these conditions.

The evidence, ingredient by ingredient California Poppy Wild Lettuce

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

California poppy is generally well tolerated for short-term use, but human safety data are limited. In combination with hawthorn and magnesium, it's been reported to cause muscular stiffness, morning fatigue, and nausea — though it's unclear whether these come from California poppy alone or the combination.

Wild lettuce has limited safety data overall; large doses have been linked to sweating, increased breathing, dizziness, ringing in the ears, vision changes, and in rare cases, serious effects like respiratory depression. California poppy should be avoided during pregnancy and breastfeeding due to insufficient safety data.

Wild lettuce should also be avoided during pregnancy and breastfeeding for the same reason — there isn't enough data to know if it's safe.

Side effects, ingredient by ingredient California Poppy Wild Lettuce

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — California Poppy, Wild Lettuce.
  • The most serious interaction on file is rated Moderate.
  • For scale: 393 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you use any CNS depressants — that includes sleep aids, anti-anxiety medications, opioid painkillers, antihistamines, or muscle relaxants — since both ingredients may intensify sedation. Also flag any anticholinergic drugs (often used for overactive bladder or certain neurological conditions), as wild lettuce may add to their side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with relaxation or sleep, but we don't have strong evidence for how well it works. If you take any sedating medication or drugs that affect nerve signals, you'll want to check with your doctor or pharmacist before adding this to your routine — the combination could amplify drowsiness or other side effects.

Pregnancy and breastfeeding are reasons to talk it over with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Lettuce and California Poppy, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253664211
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 301981
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Lettuce and California Poppy by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253664211
IngredientAmount% DV
Proprietary Extract Blend983 mg--
California Poppy0 NP--
Wild Lettuce Herb Extract, Dry0 NP--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Keep out of the reach of children!

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Organic Alcohol Based USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Made in USA, Hawaii

Only natural ingredients Purity is laboratory tested and verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Not tested on animals

Organic Alcohol Based

FDA Statement of Identity

Herbal Supplement

Formula

Organic Alcohol Based

General Statements

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Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Lettuce and California Poppy by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Lettuce and California Poppy label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Lettuce and California Poppy by Hawaii Pharm

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Extract Blend

983 mg per serving

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wild Lettuce and California Poppy by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Wild Lettuce and California Poppy?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
393Drugs
393 Moderate

Ingredients driving the most interactions

Wild Lettuce Herb Extract, Dry 393
California Poppy 248

Individual Drug Interactions

The ingredients in Wild Lettuce and California Poppy interact with 393 drugs. Click any drug to see the details.

2 of the 2 ingredients in Wild Lettuce and California Poppy interact with drugs. Each result below shows which ingredient is responsible. Wild Lettuce Herb Extract, Dry California Poppy

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Lettuce and California Poppy with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Lettuce Herb Extract, Dry2 drug types · 393 drugs

Anticholinergic Drugs

Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Likelihood Possible Evidence D
Wild Lettuce Herb Extract, Dry full monograph & interactions

California Poppy1 drug type · 248 drugs

Cns Depressants

Theoretically, taking California poppy with drugs with sedative effects may increase the risk of sedative effects.
Laboratory research shows that California poppy has sedative effects.

Likelihood Possible Evidence D
California Poppy full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Lettuce and California Poppy, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St. Ste. 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-854-2924
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Wild Lettuce and California Poppy by Hawaii Pharm: Common Questions

Does Wild Lettuce and California Poppy by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Wild Lettuce and California Poppy has a known interaction with 393 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Lettuce and California Poppy contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
The safety data aren't there for either ingredient during pregnancy or breastfeeding, so both should be avoided in these situations. Talk with your doctor or pharmacist about what's right for you during pregnancy or while nursing.
What are the side effects?
Human data are limited for both ingredients. When California poppy was used with hawthorn and magnesium, some people reported muscular stiffness, morning fatigue, and nausea — though it's not clear if those came from California poppy itself. Large amounts of wild lettuce can cause dizziness, headache, sweating, increased breathing, and vision changes; very high doses have caused rare, serious effects.
Will this help me sleep or calm my anxiety?
We don't have reliable evidence that either ingredient works well enough for insomnia or anxiety to rate them. You'd want to talk with your doctor about whether this is the right choice for you.
Is this safe to use long-term?
California poppy is considered generally well tolerated for short-term use, but long-term human safety data are limited. Wild lettuce has even less safety information overall, and high doses have been tied to side effects, so neither is well established for ongoing use. Check with your pharmacist or doctor about duration.
What's in this liquid besides the active ingredients?
The liquid also contains alcohol, water, and glycerin — these are inactive ingredients that help preserve and deliver the herbal extracts.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Lettuce and California Poppy is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Lettuce and California Poppy label
Go deeper

The Full Monographs Behind Wild Lettuce and California Poppy’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

California Poppy

Interacts with 248 drugs

California poppy is a traditional herbal remedy used mainly for anxiety and sleep problems, often combined with other calming herbs. Human research is very limited, so its true benefits are...

Read the full California Poppy monograph → Herb & supplement monograph

Wild Lettuce

Interacts with 393 drugs

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because its safety is not well studied, it should...

Read the full Wild Lettuce monograph →
Sources

Sources & How We Checked

Wild Lettuce and California Poppy's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

California Poppy 3 references
  1. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate
  2. Paul LD, Springer D, Staack RF, et al. Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine. Eur J Pharmacol 2004;485:69-79. PubMed
  3. Paul LD, Maurer HH. Studies on the metabolism and toxicological detection of the Eschscholtzia californica alkaloids californine and protopine in urine using gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2003;789:43-5

See these in context on the California Poppy monograph →

Wild Lettuce 5 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Besharat S, Besharat M, Jabbari A. Wild lettuce (Lactuca virosa) toxicity. BMJ Case Rep. 2009;2009. pii: bcr06.2008.0134.
  5. Mullins ME, Horowitz BZ. The case of the salad shooters: intravenous injection of wild lettuce extract. Vet Hum Toxicol. 1998;40(5):290-1.

See these in context on the Wild Lettuce monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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