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Dietary supplement

Wild Yam Root 2,000 mg Ingredients & Drug Interactions

by Nature's Answer

Wild Yam Root 2,000 mg label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Yam Root 2,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Yam Root 2,000 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for menopausal symptoms, menstrual cramps, hormone balance (popular belief).Based on those ingredients, 41 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Yam Root Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wild Yam Root 2,000 mg by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Yam Root 2,000 mg by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Wild Yam Root 2,000 mg by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: wild yam root extract at 2,000 mg per serving. Wild yam has been used traditionally to support hormonal balance, though the evidence for most of its claimed uses remains limited.

The liquid formulation also includes water, glycerin, and alcohol as inactive ingredients to deliver the extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Wild Yam product and its label doesn't state a use — see Wild Yam's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for wild yam root is patchy. For menopausal symptoms — probably the most common reason people try it — it's rated possibly ineffective, meaning the research doesn't back up the claim.

For gallbladder disease, sexual dysfunction, dysmenorrhea (painful periods), and infertility, we don't have enough reliable evidence to rate whether it works or doesn't. If you're considering it for one of those uses, talk with your pharmacist about what the research actually shows.

The evidence, ingredient by ingredient Wild Yam

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Wild yam is generally well tolerated by mouth in the short term for healthy adults, but we don't know much about long-term safety. The most common side effects are fever, headache, upset stomach, and vomiting — especially at higher doses.

Anaphylaxis (a severe allergic reaction) is rare but possible. Because there isn't enough safety data, avoid this product during pregnancy and while breastfeeding.

Side effects, ingredient by ingredient Wild Yam

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Yam.
  • The most serious interaction on file is rated Moderate.
  • For scale: 41 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before starting if you take any estrogen-based medication, including birth control pills, hormone replacement therapy, or other estrogen products — wild yam may increase or decrease their effect, and we can't predict which way it'll swing for you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Wild yam root may appeal to you if you're looking for traditional hormonal support, but the evidence for most uses is weak or absent. The key concern is its interaction with estrogens and hormone therapy — if you take any form of estrogen or birth control, check with us first.

Even if you don't take hormones, stick to short-term use and talk to your pharmacist about whether it makes sense for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Yam Root 2,000 mg, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000005541
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 295465
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Yam Root 2,000 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
2 mL
Servings per container
30
UPC/BARCODE
083000005541
IngredientAmount% DV
Wild Yam Root Extract2000 mg--

Other ingredients: Water, Purified, Glycerin, Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Gluten free

Lowest 12-15% Organic Alcohol

Our alcohol extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.

Formula

K Parve (Kosher)

Fluid Extract Wild Yam Root Dioscorea vilosa L. 2,000mg per serving

12-15% By Volume Certified Organic Alcohol.

Seals/Symbols

K Parve (Kosher) Bio-Chelated Cold Extraction Process

FDA Statement of Identity

Herbal Supplement

Brand IP Statement(s)

Nature's Answer Since 1972 Discover Nature's Answer

Copyright 2020 Nature's Answer

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 1-2 mL (41-81 drops) three (3) times a day in a small amount of water.

Shake well.

Precautions

Keep out of reach of children.

Warning: Do not use if pregnant or nursing.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

General Statements

For product information, call (800)439-2324

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Yam Root 2,000 mg by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Yam Root 2,000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Yam Root 2,000 mg by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Wild Yam Root Extract

Interacts with
41 drugs
2000 mg per serving Form: Dioscorea villosa Root Extract

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...

Wild Yam Root Extract monograph & interactions

Other (inactive) ingredients: Water, Purified, Glycerin, Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wild Yam Root 2,000 mg by Nature's Answer Drug Interactions

Want to check YOUR meds against Wild Yam Root 2,000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
41Drugs
41 Moderate

Ingredients driving the most interactions

Wild Yam Root Extract 41

Individual Drug Interactions

The ingredients in Wild Yam Root 2,000 mg interact with 41 drugs. Click any drug to see the details.

1 of the 1 ingredient in Wild Yam Root 2,000 mg interact with drugs. Each result below shows which ingredient is responsible. Wild Yam Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Yam Root 2,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Yam Root Extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Yam Root 2,000 mg, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
Street Address
85 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Wild Yam Root 2,000 mg by Nature's Answer: Common Questions

Does Wild Yam Root 2,000 mg by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Wild Yam Root 2,000 mg has a known interaction with 41 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Yam Root 2,000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on birth control?
Not without checking first. Wild yam root can theoretically interfere with how estrogen works in your body, and that includes estrogen in birth control pills. Call us or your doctor before starting — your contraceptive effectiveness could be at risk.
Will wild yam help with my hot flashes?
The evidence says probably not. For menopausal symptoms like hot flashes, wild yam is rated possibly ineffective, meaning studies haven't shown it actually works. If you're looking for relief, your pharmacist can discuss what the research does support.
What side effects should I watch for?
Most people tolerate it fine, but headache, fever, upset stomach, and vomiting can happen — they're more likely at higher doses. Rarely, anaphylaxis (severe allergic reaction) has occurred. If you develop any of these, stop and reach out right away.
Is this safe to use long-term?
We don't have good data on long-term safety. It's considered likely fine for short-term use in healthy adults, but if you're thinking about taking it for months, talk with your pharmacist first.
Can I take this while pregnant or nursing?
No — there isn't enough safety data. Both pregnancy and breastfeeding are times to avoid wild yam root. If you're planning to conceive or are nursing, check with your doctor or pharmacist about alternatives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Yam Root 2,000 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Yam Root 2,000 mg label
Go deeper

The Full Monographs Behind Wild Yam Root 2,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph →
Sources

Sources & How We Checked

Wild Yam Root 2,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Yam 7 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

See these in context on the Wild Yam monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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