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Dietary supplement

Wobenzyme PS Professional Strength Ingredients & Drug Interactions

by Wobenzyme PS

Wobenzyme PS Professional Strength label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wobenzyme PS Professional Strength against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wobenzyme PS Professional Strength is a dietary supplement by Wobenzyme PS with 3 active ingredients. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 227 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain, Rutoside trihydrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wobenzyme PS Professional Strength by Wobenzyme PS

Ask about any prescription or over-the-counter medication and we check it for interactions with Wobenzyme PS Professional Strength by Wobenzyme PS — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Wobenzyme PS Professional Strength by Wobenzyme PS

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Wobenzyme PS has three active ingredients: bromelain (a protein-digesting enzyme from pineapple), trypsin (another digestive enzyme), and rutoside trihydrate (a bioflavonoid also called rutin). The product also contains several inactive ingredients—cellulose, calcium phosphate, hydroxypropyl cellulose, vegetable stearate, and others—that serve as binders and tablet structure; the enteric coating is designed to let the tablet dissolve in your small intestine rather than your stomach.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: supports the immune system.
  • We looked for evidence on: Allergic rhinitis (hay fever), Exercise-induced respiratory infections, Inflammatory bowel disease (IBD), Periodontitis, Rhinosinusitis.
  • The closest evidence on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD) (Natural Medicines).
  • Also on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced respiratory infections.
  • Also on file: Trypsin is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced respiratory infections.

The evidence we hold does not establish that any of the three active ingredients work for their intended uses. Bromelain is listed for allergic rhinitis (hay fever), burns, cancer, chemotherapy-related nerve damage, chronic venous insufficiency, and diabetes—all rated insufficient evidence to rate.

Trypsin is listed for sprains, osteoarthritis, radiation skin damage, wound healing, exercise-induced muscle soreness, and multiple sclerosis—also all insufficient evidence. Rutoside is listed for aging skin, autism spectrum disorder, inflammatory bowel disease, diabetes, respiratory infections, and hemorrhoids—again, all insufficient evidence.

That means we don't have reliable data showing these ingredients work for those purposes.

The evidence, ingredient by ingredient Bromelain Trypsin Rutin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bromelain is generally well tolerated short-term, but long-term safety data are limited. The most common side effects when taken by mouth are diarrhea, flatulence, stomach upset, and headache.

Some people may have allergic reactions, especially if they inhale bromelain dust (occupational exposure can cause asthma-like symptoms, throat itching, and eye irritation). Trypsin, taken with other enzymes in a product like this, may cause mild-to-moderate stomach symptoms—nausea, heartburn, stomach pain—though it's unclear if trypsin alone is responsible.

Rutoside is generally well tolerated in food and short-term supplement use, but can cause headache, flushing, or rashes in some people. Long-term safety data for supplement doses are limited.

None of these ingredients have established safety in pregnancy; the safety data advises against bromelain and trypsin in pregnancy, and for rutoside there isn't enough data for supplement doses. For breastfeeding, safety is either unknown (bromelain and trypsin) or best avoided (rutoside).

Side effects, ingredient by ingredient Bromelain Trypsin Rutin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Rutin, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 227 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Wobenzyme PS, check with your pharmacist if you're on blood thinners or antiplatelet drugs like warfarin or clopidogrel—bromelain may increase your bleeding risk (Moderate). Also check if you take diabetes medications, since rutin may lower your blood sugar (Moderate).

If you're on tetracycline antibiotics like doxycycline, bromelain might change how much your body absorbs (Minor).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Wobenzyme PS might appeal to someone looking for a multi-enzyme product, but the evidence we hold doesn't show it works for any of its listed purposes. If you take blood thinners, antiplatelet drugs, or diabetes medications, talk to your pharmacist before you start—these interactions are Moderate severity.

Pregnant or breastfeeding? Discuss this product with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wobenzyme PS Professional Strength, straight from the product label.

Brand Wobenzyme PS
Barcode (UPC) 310539033401
Net contents 180 Enteric-Coated Tablet(s)
Market status On market
Date entered into DSLD Jul 25, 2012
DSLD ID 10586
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wobenzyme PS Professional Strength by Wobenzyme PS, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
60
UPC/BARCODE
310539033401
IngredientAmount% DV
Bromelain270 mg--
Trypsin144 mg--
Rutoside trihydrate300 mg--

Other ingredients: Microcrystalline Cellulose, Calcium Phosphate, Hydroxypropyl Cellulose, Vegetable Stearate, pH resistant enteric coating, Triethyl Citrate, Magnesium Silicate, natural Vanilla flavor, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

General Statements

Supports the Immune System

All Natural Active Ingredients

Highly Active Enzyme Formula

Made in Berlin, Germany.

Seals/Symbols

MUCOS

Formulation

This product does not contain yeast, gluten, soy, sodium, sugar, artificial coloring or preservatives.

Suggested/Recommended/Usage/Directions

Suggested Usage: Take three (3) tablets, two (2) times daily, at least 45 minutes before meals or as recommended by your healthcare professional.

FDA Disclaimer Statement

This statement has not bee evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: If you are pregnant or breast feeding, suffer from bleeding disorders or liver damage, or if you are taking anticoagulant drugs (such as warfarin), consult a healthcare professional before using this product.

KEEP OUT OF REACH OF CHILDREN.

Storage

Store in a cool dry place.

General

Component #WOB-PS-BOX

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wobenzyme PS Professional Strength by Wobenzyme PS label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wobenzyme PS Professional Strength label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wobenzyme PS Professional Strength by Wobenzyme PS

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bromelain

Interacts with
141 drugs
270 mg per serving Form: Ananas comosus

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early st...

Bromelain monograph & interactions

Trypsin

No known
interactions
144 mg per serving Form: Pancreas

Trypsin is a protein-digesting enzyme usually taken from the pancreas of animals and used either by mouth (often combined with other enzymes like chym...

Trypsin monograph & interactions

Rutoside trihydrate

Interacts with
86 drugs
300 mg per serving Form: Rutin

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...

Rutoside trihydrate monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Calcium Phosphate, Hydroxypropyl Cellulose, Vegetable Stearate, PH resistant enteric coating, Triethyl Citrate, Magnesium Silicate, Natural Vanilla flavor, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wobenzyme PS Professional Strength by Wobenzyme PS Drug Interactions

Want to check YOUR meds against Wobenzyme PS Professional Strength?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
227Drugs
208 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141
Rutoside trihydrate 86

Individual Drug Interactions

The ingredients in Wobenzyme PS Professional Strength interact with 227 drugs. Click any drug to see the details.

2 of the 3 ingredients in Wobenzyme PS Professional Strength interact with drugs. Each result below shows which ingredient is responsible. Bromelain Rutoside trihydrate

Each ingredient & the kinds of drugs it affects

For each ingredient in Wobenzyme PS Professional Strength with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Rutoside trihydrate1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.

Likelihood Possible Evidence D
Rutoside trihydrate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wobenzyme PS Professional Strength, from the product label.

Wobenzyme PS

See all Wobenzyme PS products
Name
MUCOS Pharma GmbH & Co. KG
State
Berlin
Pharmacist Counseling Corner

Wobenzyme PS Professional Strength by Wobenzyme PS: Common Questions

Does Wobenzyme PS Professional Strength by Wobenzyme PS interact with any medications?
Yes. Based on its ingredients, Wobenzyme PS Professional Strength has a known interaction with 227 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wobenzyme PS Professional Strength contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's in Wobenzyme PS, and what is it supposed to do?
It contains three active enzymes: bromelain from pineapple, trypsin, and rutoside (a bioflavonoid). Manufacturers market it for various conditions like sprains, arthritis, and wound healing, but the evidence we hold doesn't show it works for those purposes.
Can I take Wobenzyme PS if I'm on blood thinners?
Bromelain in this product may thin your blood further and raise your bleeding risk. This is a Moderate-severity interaction. Talk to your pharmacist about your specific blood thinner before you start.
What side effects might I get from Wobenzyme PS?
The most common are stomach-related: diarrhea, flatulence, nausea, heartburn, and stomach pain. Bromelain may also cause headache. Some people may have allergic reactions. If you have a pineapple allergy, be extra cautious.
Is it safe to take Wobenzyme PS if I'm pregnant or breastfeeding?
The safety data advise against bromelain and trypsin in pregnancy. For rutoside, there isn't enough data on supplement doses to know either way. For breastfeeding, safety is either unknown or best avoided for all three ingredients. Talk with your doctor or pharmacist for personalized advice.
Can I take Wobenzyme PS with my diabetes medication?
Rutoside in this product may lower your blood sugar, which could raise your risk of low blood sugar if combined with antidiabetes drugs. This is a Moderate-severity interaction. Check with your pharmacist before you start.
Does Wobenzyme PS have any fillers?
Yes. Alongside the three active enzymes, the product contains microcrystalline cellulose, calcium phosphate, hydroxypropyl cellulose, vegetable stearate, and other inactive ingredients that help form and stabilize the tablet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wobenzyme PS Professional Strength is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wobenzyme PS Professional Strength label
Go deeper

The Full Monographs Behind Wobenzyme PS Professional Strength’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Trypsin

Trypsin is a protein-digesting enzyme usually taken from the pancreas of animals and used either by mouth (often combined with other enzymes like chymotrypsin and bromelain) for swelling and...

Read the full Trypsin monograph → Herb & supplement monograph

Rutin

Interacts with 86 drugs

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limite...

Read the full Rutin monograph →
Sources

Sources & How We Checked

Wobenzyme PS Professional Strength's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 38 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Trypsin 17 references
  1. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  2. Latha B, Ramakrishnan M, Jayaraman V, Babu M. The efficacy of trypsin: chymotrypsin preparation in the reduction of oxidative damage during burn injury. Burns 1998;24:532-8. PubMed
  3. Latha B, Ramakrishnan M, Jayaraman V, Babu M. Serum enzymatic changes modulated using trypsin: chymotrypsin preparation during burn wounds in humans. Burns 1997;23:560-4. PubMed
  4. Klein, G., Kullich, W., Schnitker, J., and Schwann, H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp
  5. Dale, P. S., Tamhankar, C. P., George, D., and Daftary, G. V. Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects. Cancer Chemother.Pharmacol 2001;47 Suppl:S29-S34. PubMed
  6. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  7. Miller, P. C., Bailey, S. P., Barnes, M. E., Derr, S. J., and Hall, E. E. The effects of protease supplementation on skeletal muscle function and DOMS following downhill running. J Sports Sci 2004;22(4):365-372. PubMed
  8. Bolten WW, Glade MJ, Raum S, Ritz BW. The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: a randomized, double-blind, placebo-controlled trial. Arthritis 2015;2015:251521. PubMed
  9. US Department of Justice. U.S. Files Complaint Against Texas-Based Healthpoint Ltd. Under the False Claims Act. https://www.justice.gov/opa/pr/us-files-complaint-against-texas-based-healthpoint-ltd-under-false-claims-act. (Accessed June 19, 2019).
  10. Grabs V, Kersten A, Haller B, et al. Rutoside and hydrolytic enzymes do not attenuate marathon-induced inflammation. Med Sci Sports Exerc. 2017;49(3):387-395. PubMed
  11. Baumhackl U, Kappos L, Radue EW, et al. A randomized, double-blind, placebo-controlled study of oral hydrolytic enzymes in relapsing multiple sclerosis. Mult Scler. 2005;11(2):166-8. PubMed
  12. Gujral MS, Patnaik PM, Kaul R, et al. Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers. Cancer Chemother Pharmacol. 2001;47 Suppl:S23-8. PubMed
  13. Kempf K, Manzo G, Hanifi-Moghaddam P, et al. Effect of combined oral proteases and flavonoid treatment in subjects at risk of Type 1 diabetes. Diabet Med. 2009;26(12):1309-10. PubMed
  14. Kerkhoffs GM, Struijs PA, de Wit C, Rahlfs VW, Zwipp H, van Dijk CN. A double blind, randomised, parallel group study on the efficacy and safety of treating acute lateral ankle sprain with oral hydrolytic enzymes. Br J Sports Med. 2004;38(4):431-5. PubMed
  15. Popiela T, Kulig J, Klek S, Wachol D, Bock PR, Hanisch J. Double-blind pilot-study on the efficacy of enzyme therapy in advanced colorectal cancer. Przegl Lek. 2000;57 Suppl 5:142.
  16. Shetty V, Mohan A. A prospective, randomized, double-blind, placebo-controlled clinical trial comparing the efficacy of systemic enzyme therapy for edema control in orthognathic surgery using ultrasound scan to measure facial swelling. J Oral Maxillofac S PubMed
  17. Comparison of Chronic Wound Care Products. Pharmacist's Letter/Prescriber's Letter 2008;12(3):1203.

See these in context on the Trypsin monograph →

Rutin 2 references
  1. Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
  2. Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.

See these in context on the Rutin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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