Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

XFit Power Ingredients & Drug Interactions

by MHP Maximum Human Performance

XFit Power label
See full label image
Tablet Or Pill Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking XFit Power against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

XFit Power is a dietary supplement by MHP Maximum Human Performance with 5 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 230 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against XFit Power by MHP Maximum Human Performance

Ask about any prescription or over-the-counter medication and we check it for interactions with XFit Power by MHP Maximum Human Performance — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of XFit Power by MHP Maximum Human Performance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “POWER 24 Hour Muscle Building & Repair System” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

XFit Power contains 5 active ingredients. Two are B vitamins: Vitamin B6 and Vitamin B12, both play roles in energy, nerve function, and metabolism.

The product also includes D-aspartic acid, folate, and a proprietary blend labeled POWER 24 Hour Muscle Building & Repair System. The inactive ingredients are standard tablet components — microcrystalline cellulose, calcium carbonate, stearic acid, and several processing aids — that help form and stabilize the tablet.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: xtreme fitness intensity training performance.
  • We looked for evidence on: Physical performance, Fatigue, Athletic endurance, Muscle performance.
  • The closest evidence on file: Vitamin B12 is rated "Possibly Ineffective" for Physical performance (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Fatigue.

The evidence we hold covers only the B vitamins in this product. Vitamin B6 is effective for sideroblastic anemia and B6 deficiency itself, likely effective for high homocysteine (hyperhomocysteinemia), and possibly effective for pregnancy-related nausea and vomiting.

Vitamin B12 is effective for B12 deficiency and Imerslund-Grasbeck disease, likely effective for cyanide poisoning, and possibly effective for canker sores and nerve pain after shingles (postherpetic neuralgia). We hold no effectiveness data for the other ingredients in this product.

The evidence, ingredient by ingredient Vitamin B6 Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at doses under 100 mg daily, but high doses over time can damage nerves (a condition called sensory neuropathy). Doses above 1,000 mg daily or lifetime totals of 1,000 grams or more carry the highest risk, though nerve damage can occur at lower amounts too.

Common side effects at any dose include headache, nausea, abdominal pain, and loss of appetite. Vitamin B12 is very safe overall — your body excretes excess B12 in urine, so there's no established upper limit.

The most common side effect is injection site soreness if given by needle. Allergic reactions (rash, itching) are rare.

No pregnancy or breastfeeding safety data is on file for either B vitamin in this product; talk with your doctor or pharmacist for guidance if you're pregnant or nursing.

Side effects, ingredient by ingredient Vitamin B6 Vitamin B12

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Vitamin B12, Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 230 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product if you take seizure medications (phenobarbital or phenytoin), blood pressure pills, the heart drug amiodarone (Cordarone), levodopa for Parkinson's disease without carbidopa, or metformin for diabetes. The first two seizure drugs and blood pressure medications carry Moderate-severity concerns; the others are Minor.

No interactions are documented for the other ingredients we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

XFit Power may work for you if you're looking to support energy and muscle recovery with B vitamins, but it comes with real drug interactions you need to check first — especially if you take seizure medications, blood pressure drugs, or heart medications. If you take metformin for diabetes, be aware that this product's B12 won't offset metformin's effect on B12 levels.

Run your medications through the checker on this page, and talk with your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about XFit Power, straight from the product label.

Brand MHP Maximum Human Performance
Barcode (UPC) 666222091488
Net contents 168 Tablet(s)
Market status On market
Date entered into DSLD May 23, 2014
DSLD ID 33148
Product type Amino Acid/protein
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for XFit Power by MHP Maximum Human Performance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
84
UPC/BARCODE
666222091488
IngredientAmount% DV
Vitamin B62 mg100%
Vitamin B126 mcg100%
D-Aspartic Acid1000 mg--
Folate400 mcg100%
POWER 24 Hour Muscle Building & Repair System0 NP--
DL-a-hydroxyisocaproic acid567.9 mg--

Other ingredients: Microcrystalline Cellulose, Calcium Carbonate, Stearic Acid, Croscarmellose Sodium, Crospovidone, Magnesium Stearate, Silica, Film Coat ingredients

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

XTREME FITNESS INTENSITY TRAINING

Clinically Dosed BANNED SUBSTANCE FREE**

MUSCLE - STRENGTH - RECOVERY 24 Hour Muscle Building & Repair Formula*

The POWER to Build and Repair!* High Intensity Cross-Training (HICT) is a new breed of training used to achieve peak physical fitness and lean muscle development. However, these fast-paced extreme workouts may also lead to muscle damage, soreness and runaway muscle catabolism, all of which can hinder your results. Now, you have the POWER to "turn off" muscle soreness and muscle wasting (catabolism) and "turn on" recovery and muscle building (anabolism) with Clinically Dosed, Patent Pending X-FIT POWER to achieve even better results from your workouts!* The POWER to RECOVER!* Full Clinical Dose of HICA - Reduces DOMS and Builds Lean Muscle: Recover faster from today's workout for a better and stronger workout tomorrow! In clinical studies, athletes taking DL-a-hydroxyisocaproic acid (HICA) in the same dose as provided by POWER reported a dramatic reduction in delayed onset muscle soreness (DOMS) and a measureable increase in lean body mass. HICA is a naturally occurring amino acid derivative that demonstrates powerful recovery and anti-catabolic activity.* The Muscle Building POWER of More TESTOSTERONE!* Full Clinical Dose of DAA - Increase Testosterone up to 42% in Just 12 Days: When it comes to muscle building, the anabolic power of elevated testosterone is king! In a clinical study, subjects taking the same dose of D-aspartic acid (DAA) provided by POWER increased their testosterone level by an average of 42% after just 12 days. DAA is a safe natural testosterone optimizer with powerful anabolic and androgenic activity.*

Precautions

Do not use if you are currently unaware of your health status, if you have pre-existing medical conditions or if you are taking any medication.

KEEP OUT OF REACH OF CHILDREN.

-Do not purchase if seal is broken.

-Keep out of reach of children.

WARNING: POWER is strictly intended for healthy males 18 years of age and over.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

-Protect from heat, light and moisture. -Store at 15(0)-30(0)C (59(0)-86(0)F).

General

E4251601

Formulation

BANNED SUBSTANCE FREE** **Does not contain any substances banned by World Anti-Doping Agency (WADA).

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

DIRECTIONS: To support 24 hour muscle building and repair, take 2 tablets of POWER 3 times daily with meals (6 tablets daily).*

Brand IP Statement(s)

U.S. Patent Pending: POWER's unique composition of clinically dosed HICA and DAA is patent pending.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

XFit Power by MHP Maximum Human Performance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

XFit Power label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in XFit Power by MHP Maximum Human Performance

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container84 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
2 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Vitamin B12

Interacts with
20 drugs
6 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Folate

400 mcg per serving Form: Folic Acid

POWER 24 Hour Muscle Building & Repair System

0 NP per serving
  • › D-Aspartic Acid
  • › DL-a-hydroxyisocaproic acid

Other (inactive) ingredients: Microcrystalline Cellulose, Calcium Carbonate, Stearic Acid, Croscarmellose Sodium, Crospovidone, Magnesium Stearate, Silica, Film Coat ingredients. These complete the product’s ingredient list but are not active constituents.

Interaction report

XFit Power by MHP Maximum Human Performance Drug Interactions

Want to check YOUR meds against XFit Power?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
230Drugs
205 Moderate 25 Minor

Ingredients driving the most interactions

Vitamin B6 210
Vitamin B12 20

Individual Drug Interactions

The ingredients in XFit Power interact with 230 drugs. Click any drug to see the details.

2 of the 5 ingredients in XFit Power interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in XFit Power with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for XFit Power, from the product label.

MHP Maximum Human Performance

See all MHP Maximum Human Performance products
Name
MHP, LLC
Street Address
21 Dwight Place
City
Fairfield
State
NJ
ZipCode
07004
Phone Number
1.888.783.8844
Web Address
www.MHPXFIT.com
Pharmacist Counseling Corner

XFit Power by MHP Maximum Human Performance: Common Questions

Does XFit Power by MHP Maximum Human Performance interact with any medications?
Yes. Based on its ingredients, XFit Power has a known interaction with 230 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
XFit Power contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Vitamin B6 safe at the doses in this product?
Vitamin B6 is well tolerated below 100 mg daily. We don't have the exact dose in XFit Power from the label provided, so check your tablet's strength. High doses over time can harm nerves; the biggest risk is above 1,000 mg daily or lifetime totals over 1,000 grams.
Can I take this if I'm pregnant or breastfeeding?
We don't have pregnancy or breastfeeding safety data on file for the B vitamins in this product. Talk with your doctor or pharmacist — they can give you personalized advice based on your situation.
What's D-aspartic acid in here for?
D-aspartic acid is listed as an active ingredient in XFit Power, likely included to support muscle building and repair, but we hold no published effectiveness data for it. The product label or manufacturer info may explain its role more fully.
What are the most common side effects?
Vitamin B6 can cause headache, nausea, abdominal pain, and loss of appetite. Vitamin B12 is generally very well tolerated; injection site soreness is the main side effect if given by needle rather than taken by mouth.
Is this product gluten-free or free of common allergens?
We hold ingredient and interaction data only — not allergen or dietary restriction info. Check the product label or contact the manufacturer (MHP) for allergen details.
Can I take this with metformin?
Metformin can lower your B12 levels over time and interfere with your body's ability to absorb it. You can take XFit Power with metformin, but your doctor should monitor your B12 levels if you use both long-term.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if XFit Power is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

XFit Power label
Go deeper

The Full Monographs Behind XFit Power’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

XFit Power's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 62 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
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See these in context on the Vitamin B12 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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