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Dietary supplement

White Mulberry Leaf Extract 500 mg Ingredients & Drug Interactions

by Tru Body Wellness

White Mulberry Leaf Extract 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking White Mulberry Leaf Extract 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

White Mulberry Leaf Extract 500 mg is a dietary supplement by Tru Body Wellness with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, high cholesterol, weight management.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mulberry Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against White Mulberry Leaf Extract 500 mg by Tru Body Wellness

Ask about any prescription or over-the-counter medication and we check it for interactions with White Mulberry Leaf Extract 500 mg by Tru Body Wellness — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of White Mulberry Leaf Extract 500 mg by Tru Body Wellness

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: white mulberry leaf extract at 500 mg per capsule. The extract is enclosed in a vegetable capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see White Mulberry's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support blood sugar and inhibit fat digestion.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Hyperlipidemia, Obesity, glycemic control, postprandial glucose — and 1 related terms.
  • The closest evidence on file: White Mulberry is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: White Mulberry is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia, Obesity, Impaired glucose tolerance (prediabetes).

The evidence we hold doesn't establish that white mulberry leaf works for any condition. We rate it insufficient reliable evidence for androgenic alopecia (male-pattern hair loss), osteoporosis, common cold, diabetes, and high cholesterol (hyperlipidemia).

That doesn't mean it's ineffective — it means the research so far isn't strong enough to confirm a benefit.

The evidence, ingredient by ingredient White Mulberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

White mulberry leaf is generally well tolerated as a food, but concentrated supplements are less studied and may lower blood sugar. In clinical trials, a small number of people reported transient bloating, constipation, flatulence, and loose stools.

In one 4-week study using 4.6 grams three times daily, about half of participants experienced bloating and flatulence, a quarter had loose stools, and one in five had constipation — though these effects decreased over the 12-week trial period, suggesting they may ease with time. During pregnancy and breastfeeding, there isn't enough safety data for medicinal amounts of white mulberry leaf.

Talk with your doctor or pharmacist before using this supplement if you're pregnant or nursing.

Side effects, ingredient by ingredient White Mulberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — White Mulberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 87 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications with us if you take antidiabetes drugs (insulin, metformin, sulfonylureas, or others) — white mulberry leaf may lower blood sugar and slow how your body clears some of these. Also flag any medications that use the OCT2 kidney transporter, especially metformin.

If you're unsure whether any of your drugs fall into these categories, use the interaction checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

White mulberry leaf extract is worth considering if you're looking for a supplement that's fairly well tolerated. If you take diabetes medications or any drug that uses the OCT2 kidney transporter, though, you'll need to check with your pharmacist first — the blood-sugar effect is real and needs monitoring.

Run your exact medications through our tool before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about White Mulberry Leaf Extract 500 mg, straight from the product label.

Brand Tru Body Wellness
Barcode (UPC) 700604323832
Net contents 60 Capsule(s); 500 mg
Market status On market
Date entered into DSLD Jun 25, 2014
DSLD ID 34655
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for White Mulberry Leaf Extract 500 mg by Tru Body Wellness, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
700604323832
IngredientAmount% DV
Mulberry Leaf Extract500 mg--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Allergy Information: Manufactured in a facility that processes Milk, Egg, Fish, Tree Nuts,

Warning: Do not exceed recommended dose.

Pregnant or nursing women, children under 18 and individuals with known medical conditions should consult their physician prior to taking.

Storage

Store in a cool, dry place.

Seals/Symbols

Made in USA

GOOD MANUFACTURING PRACTICE GMP CONSISTENT QUALITY

General Statements

SUPPORT BLOOD SUGAR INHIBIT FAT*

Inhibit Sugar Digestion and Fat* Support Blood Sugar Levels*

Supports Healthy Blood Sugar Levels, Weight Loss*

Less sugar may mean less fat and other benefits. White Mulberry has been used for centuries in Traditional Chinese Medicine tonics for blood sugar support and cardiovascular nourishment.*

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one capsule per day with food and water. For weight loss take one capsule twice daily with food and water.

Take 1 capsule daily with food

Formulation

NO BINDERS, FILLERS OR OTHER INGREDIENTS.

Formula

White Mulberry Leaves contain a compound called 1-deoxynojirimycin (DNJ) that is thought to inhibit sugar digestion so that most sugar is not absorbed into the bloodstream and is instead excreted.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

White Mulberry Leaf Extract 500 mg by Tru Body Wellness label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

White Mulberry Leaf Extract 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in White Mulberry Leaf Extract 500 mg by Tru Body Wellness

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Mulberry Leaf Extract

Interacts with
87 drugs
500 mg per serving Form: Alkaloids, Flavonoids

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is gen...

Mulberry Leaf Extract monograph & interactions

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

White Mulberry Leaf Extract 500 mg by Tru Body Wellness Drug Interactions

Want to check YOUR meds against White Mulberry Leaf Extract 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

Mulberry Leaf Extract 87

Individual Drug Interactions

The ingredients in White Mulberry Leaf Extract 500 mg interact with 87 drugs. Click any drug to see the details.

1 of the 1 ingredient in White Mulberry Leaf Extract 500 mg interact with drugs. Each result below shows which ingredient is responsible. Mulberry Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in White Mulberry Leaf Extract 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Mulberry Leaf Extract2 drug types · 87 drugs

Antidiabetes Drugs

Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that white mulberry leaf can lower blood glucose levels. Advise patients to monitor glucose levels closely.

Likelihood Possible Evidence D
Organic Cation Transporter 2 (Oct2) Substrates

Theoretically, white mulberry leaf might slow the elimination and increase the adverse effects of drugs which are OCT2 substrates.
Animal research shows that coadministration of white mulberry leaf extract with metformin, an OCT2 substrate, slows the renal elimination of metformin via inhibition of OCT2 activity. OCT2 is expressed in the kidneys and is responsible for transporting cationic drugs into tubular epithelial cells in order to be excreted in the urine.

Likelihood Possible Evidence D
Mulberry Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for White Mulberry Leaf Extract 500 mg, from the product label.

Tru Body Wellness

See all Tru Body Wellness products
Name
Healthy Body, LLLP
Street Address
#3-17th Avenue South
City
Nampa
State
ID
ZipCode
83651
Pharmacist Counseling Corner

White Mulberry Leaf Extract 500 mg by Tru Body Wellness: Common Questions

Does White Mulberry Leaf Extract 500 mg by Tru Body Wellness interact with any medications?
Yes. Based on its ingredients, White Mulberry Leaf Extract 500 mg has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
White Mulberry Leaf Extract 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on metformin for diabetes?
Not without talking to your doctor first. White mulberry leaf lowers blood sugar and may also slow how your body clears metformin, which could cause your blood sugar to drop too low. You'd need close monitoring and possibly a dose adjustment.
What side effects should I expect?
Most people tolerate it well. Some experience bloating, gas, loose stools, or constipation — but these tend to be temporary and often improve after a few weeks. Drink plenty of water and start with a lower dose if your stomach is sensitive.
Is there evidence it actually works for blood sugar?
White mulberry leaf can lower blood glucose in clinical research, but we don't have enough reliable evidence to say it effectively treats diabetes. If you're interested in it for that reason, talk with your doctor about whether it fits your overall plan.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data for medicinal amounts during pregnancy or breastfeeding. Talk with your doctor or pharmacist for personalized advice.
How long does it take to work?
We don't have information in our data about how quickly white mulberry leaf exerts an effect. Ask your pharmacist what a reasonable timeframe is for the condition you're treating.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if White Mulberry Leaf Extract 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

White Mulberry Leaf Extract 500 mg label
Go deeper

The Full Monographs Behind White Mulberry Leaf Extract 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

White Mulberry

Interacts with 87 drugs

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is generally well tolerated as a food and tea,...

Read the full White Mulberry monograph →
Sources

Sources & How We Checked

White Mulberry Leaf Extract 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

White Mulberry 6 references
  1. Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53. PubMed
  2. Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4. PubMed
  3. Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74. PubMed
  4. Huh HW, Na YG, Bang KH, et al. Extended intake of mulberry leaf extract delayed metformin elimination via inhibiting the organic cation transporter 2. Pharmaceutics. 2020;12(1):49. PubMed
  5. Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. 2020;49:102292. PubMed
  6. Thondre PS, Lightowler H, Ahlstrom L, Gallagher A. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) 2021;18(1):41. PubMed

See these in context on the White Mulberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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