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Dietary supplement

Yerba Santa Combination Ingredients & Drug Interactions

by Pure Herbs

Yerba Santa Combination label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Yerba Santa Combination against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Yerba Santa Combination is a dietary supplement by Pure Herbs with 3 active ingredients. Its ingredients are commonly taken for cough and chest congestion, sore throat, bronchitis and respiratory irritation.Based on those ingredients, 123 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mullein Leaf Extract, Lobelia Aerial Parts Extract, Yerba Santa leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Yerba Santa Combination by Pure Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Yerba Santa Combination by Pure Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Yerba Santa Combination by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,890 mg) without saying how much of each component you get.

This liquid contains three active herbal extracts. Mullein leaf extract, lobelia aerial parts extract, and yerba santa leaf extract make up a proprietary blend — that means the exact amount of each is not listed separately on the label.

There are no inactive ingredients (fillers or binders) listed for this product.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support healthy respiratory tract.
  • We looked for evidence on: Asthma, Bronchitis, Cough, chest congestion, respiratory irritation, sore throat.
  • The closest evidence on file: Mullein is rated "Insufficient Reliable Evidence To Rate" for Bronchitis (Natural Medicines).
  • Also on file: Mullein is rated "Insufficient Reliable Evidence To Rate" for Asthma, Cough.

The evidence for what these ingredients do is thin across the board. Mullein leaf extract is rated as having insufficient reliable evidence for bronchitis, asthma, cough, migraine headache, and diarrhea — basically, we don't have solid data proving it works for any of those.

Lobelia aerial parts extract is rated possibly ineffective for smoking cessation. Yerba santa leaf extract is rated as having insufficient reliable evidence for obesity.

If you're considering this product for a specific health goal, the data we hold doesn't establish that it works.

The evidence, ingredient by ingredient Mullein Lobelia Yerba Santa

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Mullein leaf extract is generally well tolerated for short-term use, though human safety data are limited. It's been reported to cause dermatitis (a skin rash) in a small number of cases, typically from skin contact or inhaled dust.

Lobelia aerial parts extract is the main safety flag here — it can be toxic at higher doses, causing nausea, vomiting, diarrhea, cough, dizziness, tremors, throat irritation, and at 600 mg or above, serious effects like rapid heart rate, low blood pressure, and potentially death. Effects have been reported even at doses as low as 50 mg.

Yerba santa leaf extract has limited human safety data available. During pregnancy, mullein leaf extract is best avoided due to insufficient safety information.

Lobelia aerial parts extract is likely unsafe in pregnancy because of toxicity concerns and lack of safety data. Yerba santa leaf extract also lacks enough safety data — medicinal amounts are best avoided during pregnancy.

None of these ingredients have adequate safety data for breastfeeding, so talk with your doctor or pharmacist before use if you're nursing.

Side effects, ingredient by ingredient Mullein Lobelia Yerba Santa

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Lobelia, Yerba Santa, Mullein.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 123 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against this product if you take lithium (mood stabilizer) — both lobelia and yerba santa may raise its levels. Also flag any blood thinners or antiplatelet drugs like warfarin or aspirin, since mullein leaf extract can increase bleeding time.

Run your full medication list through the search tool below before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to someone looking for respiratory or herbal support, but the evidence that it works isn't established in our data. The bigger concern is safety and drug interactions — especially if you take lithium or blood thinners.

Lobelia's toxicity potential at higher doses is real and worth taking seriously. Talk with your pharmacist before you start, particularly if you're on any prescription medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Yerba Santa Combination, straight from the product label.

Brand Pure Herbs
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 279998
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Yerba Santa Combination by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
15
IngredientAmount% DV
Proprietary Blend1890 mg--
Mullein Leaf Extract0 NP--
Lobelia Aerial Parts Extract0 NP--
Yerba Santa leaf extract0 NP--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Helps to support a healthy respiratory tract.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Yerba Santa Combination by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Yerba Santa Combination label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Yerba Santa Combination by Pure Herbs

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1890 mg per serving

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Yerba Santa Combination by Pure Herbs Drug Interactions

Want to check YOUR meds against Yerba Santa Combination?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
123Drugs
1 Moderate 122 Minor

Ingredients driving the most interactions

Mullein Leaf Extract 122
Lobelia Aerial Parts Extract 1
Yerba Santa leaf extract 1

Individual Drug Interactions

The ingredients in Yerba Santa Combination interact with 123 drugs. Click any drug to see the details.

3 of the 3 ingredients in Yerba Santa Combination interact with drugs. Each result below shows which ingredient is responsible. Mullein Leaf Extract Lobelia Aerial Parts Extract Yerba Santa leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Yerba Santa Combination with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Mullein Leaf Extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot. This is likely due to at least one of the known constituents of muellein, triterpenoid saponins. However, the effects appear to be mild and results have been inconsistent. Extracts from different plant parts have been show to have varying anticoagulant strengths, with water-based ones being more potent than alcohol-based extracts.

Likelihood Unlikely Evidence A
Mullein Leaf Extract full monograph & interactions

Lobelia Aerial Parts Extract1 drug type · 1 drug

Lithium

Lobelia is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, lobelia might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Lobelia Aerial Parts Extract full monograph & interactions

Yerba Santa leaf extract1 drug type · 1 drug

Lithium

Yerba santa is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, yerba santa might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Yerba Santa leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Yerba Santa Combination, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

Yerba Santa Combination by Pure Herbs: Common Questions

Does Yerba Santa Combination by Pure Herbs interact with any medications?
Yes. Based on its ingredients, Yerba Santa Combination has a known interaction with 123 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Yerba Santa Combination contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe during pregnancy?
No — none of the three ingredients have enough safety data for pregnancy. Mullein leaf extract is best avoided, and lobelia aerial parts extract is considered likely unsafe due to toxicity concerns. Talk with your doctor or pharmacist about whether this product is right for you while pregnant.
Can I breastfeed while taking this?
The safety data we hold don't support breastfeeding use of any of these ingredients. Before you use this product while nursing, speak with your doctor or pharmacist.
What does each ingredient in this product do?
This is a proprietary blend, so the label doesn't tell you how much of each ingredient you're getting. Mullein leaf extract is traditionally used for respiratory support, lobelia for smoking cessation, and yerba santa for various purposes — but evidence that any of them work for specific conditions is insufficient in our data.
Could this product cause side effects?
Mullein leaf extract is generally well tolerated but can rarely cause dermatitis from skin contact or inhaled dust. Lobelia is the main concern — it can cause nausea, vomiting, diarrhea, cough, dizziness, tremors, and throat irritation, even at low doses. At 600 mg or higher, it can cause serious toxicity including rapid heart rate, low blood pressure, and potentially life-threatening effects. Yerba santa's side effects aren't documented in our data.
Will this help with bronchitis or cough?
We don't have reliable evidence that mullein leaf extract works for bronchitis or cough. The safety data and potential interactions with your medications are the main things to consider before taking this product.
Is this product safe to use long-term?
Mullein leaf extract is generally well tolerated for short-term use, but long-term human safety data are limited. Lobelia's toxicity potential means it should be dosed carefully. We'd recommend talking with your pharmacist about how long to use this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Yerba Santa Combination label
Go deeper

The Full Monographs Behind Yerba Santa Combination’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Mullein

Interacts with 122 drugs

Mullein is a traditional herbal remedy most often used as a tea or syrup to soothe coughs, sore throats, and respiratory irritation. High-quality human studies are lacking, so its benefits a...

Read the full Mullein monograph → Herb & supplement monograph

Lobelia

Interacts with 1 drug

Lobelia is a traditional herb once used for breathing problems and to help people quit smoking, but reliable evidence supporting these uses is lacking. It can be toxic in higher amounts, cau...

Read the full Lobelia monograph → Herb & supplement monograph

Yerba Santa

Interacts with 1 drug

Yerba Santa is an aromatic shrub from the western United States and Mexico that has long been used in folk medicine for coughs, congestion, and other respiratory complaints. Modern scientifi...

Read the full Yerba Santa monograph →
Sources

Sources & How We Checked

Yerba Santa Combination's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Mullein 2 references
  1. Castro AI, Carmona JB, Gonzales FG, Nestar OB. Occupational airborne dermatitis from gordolobo (Verbascum densiflorum). Contact Dermatitis 2006;55(5):301.
  2. Flores Echaiz C, Al Ali A, Cao AQ, Sasseville D. Simultaneous contact dermatitis caused by Asteraceae and Verbascum thapsus. Contact Dermatitis 2017;76(5):316-8.

See these in context on the Mullein monograph →

Lobelia 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. McChargue DE, Collins FL Jr, Cohen LM. Effect of non-nicotinic moist snuff replacement and lobeline on withdrawal symptoms during 48-h smokeless tobacco deprivation. Nicotine Tob Res 2002;4:195-200. PubMed
  5. Stead LF, Hughes JR. Lobeline for smoking cessation. Cochrane Database Syst Rev 2000;2:CD000124. PubMed
  6. Plakun, A. L., Ambrus, J., Bross, I., Graham, S., Levin, M. L., and Ross, C. A. Clinical factors in smoking withdrawal: preliminary report. Am J Public Health Nations.Health 1966;56(3):434-441. PubMed

See these in context on the Lobelia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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