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Dietary supplement

Yerba Santa Combination Ingredients & Drug Interactions

by Pure Herbs

Yerba Santa Combination label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Yerba Santa Combination against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Yerba Santa Combination is a dietary supplement by Pure Herbs with 3 active ingredients. Its ingredients are commonly taken for cough and chest congestion, sore throat, bronchitis and respiratory irritation.Based on those ingredients, 123 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Mullein Leaf Extract, Lobelia Aerial Parts Extract, Yerba Santa leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Yerba Santa Combination by Pure Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Yerba Santa Combination by Pure Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Yerba Santa Combination by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,890 mg) without saying how much of each component you get.

Yerba Santa Combination contains 3 active ingredients in a proprietary blend: mullein leaf extract, lobelia aerial parts extract, and yerba santa leaf extract. There are no inactive ingredients listed for this liquid product.

Mullein has been used traditionally to support respiratory health, though the evidence for conditions like cough and bronchitis is not yet established. Lobelia and yerba santa are included for their traditional properties, but similar to mullein, we don't have strong evidence yet for their specific uses.

The product is a liquid, which typically means faster absorption than tablets or capsules.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support healthy respiratory tract.
  • We looked for evidence on: Asthma, Bronchitis, Cough, Influenza, Pneumonia, chest congestion — and 1 related terms.
  • The closest evidence on file: Mullein is rated "Insufficient Reliable Evidence To Rate" for Bronchitis (Natural Medicines).
  • Also on file: Mullein is rated "Insufficient Reliable Evidence To Rate" for Asthma, Cough, Influenza, Pneumonia.

The evidence we hold doesn't establish how well these ingredients work. Mullein leaf extract is listed for bronchitis, asthma, cough, migraine headache, and diarrhea, but we have insufficient reliable evidence to rate its effectiveness for any of these.

Lobelia is rated possibly ineffective for smoking cessation. Yerba santa is listed for obesity, but again we have insufficient reliable evidence.

If you're considering this product for a specific health goal, talk with your doctor or pharmacist about whether the evidence supports its use for that purpose.

The evidence, ingredient by ingredient Mullein Lobelia Yerba Santa

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Mullein and yerba santa are generally well tolerated for short-term use, though human safety data are limited for both. Lobelia, however, carries a strong caution: it can be toxic, and even modest doses (50 mg or higher) have caused nausea, vomiting, diarrhea, dizziness, tremors, and throat irritation.

At 600 mg or higher, lobelia can trigger serious toxicity — rapid heart rate, dangerously low blood pressure, sweating, convulsions, low body temperature, and potentially fatal outcomes. Mullein may rarely cause skin rashes or dermatitis with topical or inhaled exposure.

During pregnancy, mullein and yerba santa lack enough safety data and are best avoided at medicinal doses. Lobelia is rated likely unsafe in pregnancy due to toxicity concerns.

For breastfeeding, mullein and yerba santa have not been adequately studied, so medicinal use is not recommended; lobelia should be avoided due to potential toxicity risks.

Side effects, ingredient by ingredient Mullein Lobelia Yerba Santa

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Lobelia, Yerba Santa, Mullein.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 123 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist if you take lithium — both lobelia and yerba santa may raise lithium levels and could need a dose adjustment. If you're on blood thinners or antiplatelet drugs (like warfarin or aspirin), mullein leaf extract may have a mild additive effect.

No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is geared toward respiratory or wellness support, but the evidence for how well it works isn't established in the data we hold. The main safety flag is lobelia — it can cause serious effects at higher doses, and it may interact with lithium.

If you take lithium or blood thinners, you'll want to check with your doctor or pharmacist before starting this product. Anyone pregnant or breastfeeding should talk it over with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Yerba Santa Combination, straight from the product label.

Brand Pure Herbs
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 279998
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Yerba Santa Combination by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
15
IngredientAmount% DV
Proprietary Blend1890 mg--
Mullein Leaf Extract0 NP--
Lobelia Aerial Parts Extract0 NP--
Yerba Santa leaf extract0 NP--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Helps to support a healthy respiratory tract.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Yerba Santa Combination by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Yerba Santa Combination label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Yerba Santa Combination by Pure Herbs

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1890 mg per serving

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Yerba Santa Combination by Pure Herbs Drug Interactions

Want to check YOUR meds against Yerba Santa Combination?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
123Drugs
1 Moderate 122 Minor

Ingredients driving the most interactions

Mullein Leaf Extract 122
Lobelia Aerial Parts Extract 1
Yerba Santa leaf extract 1

Individual Drug Interactions

The ingredients in Yerba Santa Combination interact with 123 drugs. Click any drug to see the details.

3 of the 3 ingredients in Yerba Santa Combination interact with drugs. Each result below shows which ingredient is responsible. Mullein Leaf Extract Lobelia Aerial Parts Extract Yerba Santa leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Yerba Santa Combination with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Mullein Leaf Extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot. This is likely due to at least one of the known constituents of muellein, triterpenoid saponins. However, the effects appear to be mild and results have been inconsistent. Extracts from different plant parts have been show to have varying anticoagulant strengths, with water-based ones being more potent than alcohol-based extracts.

Likelihood Unlikely Evidence A
Mullein Leaf Extract full monograph & interactions

Lobelia Aerial Parts Extract1 drug type · 1 drug

Lithium

Lobelia is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, lobelia might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Lobelia Aerial Parts Extract full monograph & interactions

Yerba Santa leaf extract1 drug type · 1 drug

Lithium

Yerba santa is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, yerba santa might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Yerba Santa leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Yerba Santa Combination, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

Yerba Santa Combination by Pure Herbs: Common Questions

Does Yerba Santa Combination by Pure Herbs interact with any medications?
Yes. Based on its ingredients, Yerba Santa Combination has a known interaction with 123 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Yerba Santa Combination contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
No — mullein and yerba santa lack enough safety data for pregnancy at medicinal doses and are best avoided, and lobelia is rated likely unsafe in pregnancy due to toxicity concerns. For breastfeeding, neither mullein nor yerba santa has been well studied, and lobelia should be avoided because of potential toxicity. Talk with your doctor or pharmacist before using this product if you're pregnant or nursing.
What does mullein do?
Mullein has been used traditionally to support respiratory health — for cough, bronchitis, and asthma — but we don't yet have strong evidence that it works for these conditions. It is generally well tolerated for short-term use, though human safety data are still limited.
Why is lobelia in this product if it can be toxic?
Lobelia has traditional uses, but yes, it does carry real toxicity concerns, especially at higher doses. Even modest amounts (50 mg or more) can cause nausea, vomiting, diarrhea, dizziness, and tremors. At 600 mg or higher, it can cause serious effects including rapid heart rate, dangerously low blood pressure, and potentially life-threatening symptoms. This is why strong caution is advised with this product.
Can I take this with blood thinners like warfarin?
Mullein leaf extract does have mild blood-thinning effects shown in lab tests, so there may be a minor additive effect with warfarin or other antiplatelet drugs. Check with your doctor or pharmacist before combining them, since even a mild effect could matter depending on your dose and your INR levels.
Can I take this with lithium?
Both lobelia and yerba santa are thought to have diuretic properties that could theoretically reduce how your body clears lithium, raising its levels — possibly high enough to need a dose adjustment. You should check with your doctor or pharmacist before starting this product if you take lithium.
What side effects might I experience?
Lobelia can cause nausea, vomiting, diarrhea, coughing, dizziness, tremors, and throat irritation at doses as low as 50 mg. Higher doses (600 mg or more) can bring on serious toxicity symptoms like rapid heart rate, dangerously low blood pressure, sweating, and seizures. Mullein and yerba santa are generally well tolerated, though mullein may rarely cause skin rashes or dermatitis.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Yerba Santa Combination label
Go deeper

The Full Monographs Behind Yerba Santa Combination’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Mullein

Interacts with 122 drugs

Mullein is a traditional herbal remedy most often used as a tea or syrup to soothe coughs, sore throats, and respiratory irritation. High-quality human studies are lacking, so its benefits a...

Read the full Mullein monograph → Herb & supplement monograph

Lobelia

Interacts with 1 drug

Lobelia is a traditional herb once used for breathing problems and to help people quit smoking, but reliable evidence supporting these uses is lacking. It can be toxic in higher amounts, cau...

Read the full Lobelia monograph → Herb & supplement monograph

Yerba Santa

Interacts with 1 drug

Yerba Santa is an aromatic shrub from the western United States and Mexico that has long been used in folk medicine for coughs, congestion, and other respiratory complaints. Modern scientifi...

Read the full Yerba Santa monograph →
Sources

Sources & How We Checked

Yerba Santa Combination's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Mullein 2 references
  1. Castro AI, Carmona JB, Gonzales FG, Nestar OB. Occupational airborne dermatitis from gordolobo (Verbascum densiflorum). Contact Dermatitis 2006;55(5):301.
  2. Flores Echaiz C, Al Ali A, Cao AQ, Sasseville D. Simultaneous contact dermatitis caused by Asteraceae and Verbascum thapsus. Contact Dermatitis 2017;76(5):316-8.

See these in context on the Mullein monograph →

Lobelia 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. McChargue DE, Collins FL Jr, Cohen LM. Effect of non-nicotinic moist snuff replacement and lobeline on withdrawal symptoms during 48-h smokeless tobacco deprivation. Nicotine Tob Res 2002;4:195-200. PubMed
  5. Stead LF, Hughes JR. Lobeline for smoking cessation. Cochrane Database Syst Rev 2000;2:CD000124. PubMed
  6. Plakun, A. L., Ambrus, J., Bross, I., Graham, S., Levin, M. L., and Ross, C. A. Clinical factors in smoking withdrawal: preliminary report. Am J Public Health Nations.Health 1966;56(3):434-441. PubMed

See these in context on the Lobelia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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