Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

YTHE-I Ingredients & Drug Interactions

by Pure Herbs

YTHE-I label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking YTHE-I against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

YTHE-I is a dietary supplement by Pure Herbs with 10 active ingredients. Its ingredients are commonly taken for source of iodine and minerals, thyroid support, respiratory issues and cough.Based on those ingredients, 1,482 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Peppermint Leaf Extract, Alfalfa, Spearmint leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against YTHE-I by Pure Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with YTHE-I by Pure Herbs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of YTHE-I by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 10 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,990 mg) without saying how much of each component you get.

This liquid supplement contains 10 active ingredients: peppermint leaf extract, Irish moss extract, Mojave yucca root extract, bilberry fruit extract, papaya fruit extract, royal jelly extract, wild yam root extract, spearmint leaf extract, spirulina algae extract, and alfalfa. Peppermint is used for digestive discomfort and possibly for nausea.

Bilberry, royal jelly, and spirulina are included for general wellness; bilberry has been studied for eye health, spirulina for blood pressure support, and royal jelly for menopausal symptoms. Papaya fruit is a traditional digestive aid.

Yucca, wild yam, and spearmint are included for joint and hormonal support, though evidence for these uses is limited. The product also contains inactive ingredients (excipients) to preserve and deliver the formula.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: overall good health.
  • We looked for evidence on: Dyslipidemia, Hypercholesterolemia, Hyperlipidemia, Hypertension, Cardiovascular disease (CVD), Atherosclerosis — and 4 related terms.
  • The strongest evidence on file: Blue-green Algae is rated "Possibly Effective" for Hypertension (Natural Medicines).
  • Also on file: Royal Jelly is rated "Possibly Ineffective" for Diabetes.
  • Also on file: Alfalfa is rated "Insufficient Reliable Evidence To Rate" for Diabetes, Hypercholesterolemia.

The evidence for this product's individual ingredients is mixed. Peppermint leaf is likely effective for irritable bowel syndrome and possibly effective for indigestion and chemotherapy-related nausea.

Spirulina has possibly effective evidence for high blood pressure. Royal jelly is possibly effective for menopausal symptoms.

For the other ingredients in this product — bilberry, papaya, wild yam, yucca, spearmint, and alfalfa — the data we hold shows insufficient reliable evidence to rate their effectiveness for the conditions they're traditionally used for. No overall effectiveness rating exists for the product as a whole.

The evidence, ingredient by ingredient Sea Moss Peppermint Yucca Bilberry Papaya Royal Jelly Wild Yam Spearmint

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 10 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 10 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Peppermint, bilberry, papaya, and spirulina are generally well tolerated when taken by mouth; common side effects are mild and gastrointestinal (belching, diarrhea, abdominal discomfort, dark stools). Peppermint is rated likely safe in pregnancy and lactation.

Bilberry is likely safe in pregnancy and lactation. Papaya fruit in food amounts is well tolerated; however, unripe papaya, papaya latex, and seeds should be avoided, and large amounts are cautioned against in pregnancy.

Royal jelly is generally well tolerated but can cause serious allergic reactions (anaphylaxis, severe asthma) in people with a history of asthma or atopy; there is insufficient data for pregnancy and breastfeeding, so the product advises avoiding it. Alfalfa is well tolerated in small food amounts but carries a rare risk of a lupus-like syndrome with long-term use; it is possibly unsafe in pregnancy due to its estrogen-like activity.

Wild yam and spearmint have insufficient safety data for pregnancy and breastfeeding; spearmint is generally well tolerated but can cause allergic skin reactions. Yucca has very limited safety data and is best avoided; safety during breastfeeding is unknown.

Irish moss extract's safety profile is not on file. Always inform your pharmacist of all the medications and supplements you take.

Side effects, ingredient by ingredient Sea Moss Peppermint Yucca Bilberry Papaya Royal Jelly Wild Yam Spearmint

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 9 of the 10 matched ingredients can interact with medications — Alfalfa, Bilberry, Papaya, Royal Jelly, Peppermint, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,483 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you use warfarin or other blood thinners (anticoagulants or antiplatelet drugs) — the alfalfa in this product may reduce warfarin's effectiveness. Also ask about diabetes medications, blood pressure drugs, immunosuppressants, estrogen-containing hormonal contraceptives or hormone therapy, and any medications that are processed by your liver.

No interactions are documented for the Irish moss extract we could not check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is best considered if you're exploring herbal digestive and wellness support and you have no major medical conditions or take no prescription drugs — especially no blood thinners, diabetes medications, hormonal contraceptives, or hormone therapy. Anyone on warfarin (or any blood thinner), diabetes drugs, blood pressure medication, or immunosuppressants should check with their pharmacist first.

People with asthma or a history of allergies, those pregnant or breastfeeding, and anyone with lupus should avoid it. Talk to your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about YTHE-I, straight from the product label.

Brand Pure Herbs
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 281413
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for YTHE-I by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
60
IngredientAmount% DV
Proprietary Blend1990 mg--
Irish Moss Extract0 NP--
Peppermint Leaf Extract0 NP--
Mojave Yucca Root Extract0 NP--
Bilberry Fruit Extract0 NP--
Papaya fruit extract0 NP--
Royal Jelly extract0 NP--
Wild Yam Root Extract0 NP--
Spearmint leaf extract0 NP--
Spirulina algae extract0 NP--
Alfalfa0 NP--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Beneficial for overall good health.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, LTD. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

YTHE-I by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

YTHE-I label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in YTHE-I by Pure Herbs

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

YTHE-I by Pure Herbs Drug Interactions

Want to check YOUR meds against YTHE-I?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,482Drugs
2 Major 1,468 Moderate 12 Minor

Ingredients driving the most interactions

Peppermint Leaf Extract 796
Alfalfa 583
Spearmint leaf extract 579
Spirulina algae extract 327
Bilberry Fruit Extract 275

Individual Drug Interactions

The ingredients in YTHE-I interact with 1,482 drugs. Click any drug to see the details.

9 of the 10 ingredients in YTHE-I interact with drugs. Each result below shows which ingredient is responsible. Peppermint Leaf Extract Alfalfa Spearmint leaf extract Spirulina algae extract Bilberry Fruit Extract Royal Jelly extract Papaya fruit extract Wild Yam Root Extract Irish Moss Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in YTHE-I with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Peppermint Leaf Extract5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
Peppermint Leaf Extract full monograph & interactions

Alfalfa6 drug types · 583 drugs

Warfarin (Coumadin)

Theoretically, alfalfa might reduce the anticoagulant activity of warfarin.
Alfalfa contains a large amount of vitamin K. This could theoretically interfere with the activity of warfarin.

Likelihood Probable Evidence D
Antidiabetes Drugs

Theoretically, alfalfa might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that alfalfa decreases blood sugar in diabetic mice. Also, in one case report, a diabetic patient experienced hypoglycemia after consuming alfalfa extract. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, alfalfa might interfere with the activity of contraceptive drugs.
Alfalfa contains coumestrol, a phytoestrogen, and isoflavonoids, which have estrogenic effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, alfalfa might interfere with hormone therapy.
Alfalfa contains coumestrol, a phytoestrogen, and isoflavonoids, which have estrogenic effects.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.
In vitro research and human case reports suggest that alfalfa may have immunostimulant effects.

Likelihood Possible Evidence D
Photosensitizing Drugs

Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Animal research suggests that excessive doses of alfalfa may increase photosensitivity, possibly due to its chlorophyll content. It is unclear if this effect would be clinically relevant in humans.

Likelihood Possible Evidence D
Alfalfa full monograph & interactions

Spearmint leaf extract2 drug types · 579 drugs

Cns Depressants

Theoretically, spearmint might alter the sedative effects of CNS depressants.
Animal research suggests that (-)-carvone, a major constituent of spearmint, has sedative effects. However, in humans, chewing spearmint-flavored gum induced arousal effects.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.
Animal research suggests that drinking spearmint tea for 30 days can increase markers of liver damage, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and cause liver degeneration and necrosis, in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Spearmint leaf extract full monograph & interactions

Spirulina algae extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs. However, this is unlikely.
Spirulina blue-green algae have shown antiplatelet and anticoagulant effects in vitro. However, one preliminary study in 24 patients receiving spirulina blue-green algae 2.3 grams daily for 2 weeks showed no effect on platelet activation or measures of clotting time.

Likelihood Unlikely Evidence D
Antidiabetes Drugs

Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Human research shows that spirulina blue-green algae can have hypoglycemic effects in patients with diabetes, at least some of whom were using antidiabetes drugs. However, blue-green algae does not seem to improve glycated hemoglobin (HbA1c) levels in patients with diabetes. A meta-analysis of animal studies also suggests that spirulina blue-green algae have hypoglycemic effects.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Blue-green algae have been shown to stimulate the immune system.

Likelihood Possible Evidence D
Spirulina algae extract full monograph & interactions

Bilberry Fruit Extract4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Bilberry Fruit Extract full monograph & interactions

Royal Jelly extract2 drug types · 174 drugs

Antihypertensive Drugs

Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that royal jelly might lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Royal jelly might increase the risk of bleeding when taken with warfarin.
In one case, an 87-year-old male who was previously stabilized on warfarin developed hematuria and was found to have an INR of 7.29 after taking a royal jelly supplement for one week.

Likelihood Possible Evidence D
Royal Jelly extract full monograph & interactions

Papaya fruit extract4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papaya fruit extract full monograph & interactions

Wild Yam Root Extract1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam Root Extract full monograph & interactions

Irish Moss Extract3 drug types · 22 drugs

Amiodarone (Cordarone)

Theoretically, combining sea moss with amiodarone might cause excessively high iodine levels.
Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use with sea moss, which contains approximately 4-7 mcg of iodine per gram, might increase the risk of adverse effects from iodine, including altered thyroid function.

Likelihood Possible Evidence D
Antithyroid Drugs

Due to its iodine content, sea moss might alter the effects of antithyroid drugs.
Sea moss contains approximately 4-7 mcg of iodine per gram. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking sea moss could theoretically alter the effects of antithyroid drugs.

Likelihood Possible Evidence D
Thyroid Hormone

Due to its iodine content, sea moss might alter the effects of thyroid hormone.
Sea moss contains approximately 4-7 mcg of iodine per gram. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking sea moss could theoretically alter the effects of thyroid hormone.

Likelihood Possible Evidence D
Irish Moss Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for YTHE-I, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

YTHE-I by Pure Herbs: Common Questions

Does YTHE-I by Pure Herbs interact with any medications?
Yes. Based on its ingredients, YTHE-I has a known interaction with 1,482 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
YTHE-I contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is peppermint in this product safe during pregnancy?
Yes — peppermint leaf extract is rated likely safe in pregnancy and lactation according to our data. But as always, check with your doctor or pharmacist for advice tailored to your situation.
What is spirulina used for in this product?
Spirulina blue-green algae is included for general wellness. Our data shows it is possibly effective for high blood pressure. It may also provide protein and other nutrients, though evidence is limited.
Can I use this if I have asthma or allergies?
Royal jelly in this product can trigger serious allergic reactions — including anaphylaxis and severe asthma — in people with a history of asthma or atopy (allergic tendency). Talk to your doctor before using this product if you have either condition.
What are the most common side effects?
The ingredients that are well studied show mostly mild, gastrointestinal side effects: belching, diarrhea, abdominal discomfort, nausea, flatulence, and dark-colored stools. These are generally temporary and stop when you discontinue the product.
Does this product work for joint pain?
The yucca and wild yam in this product are traditional joint-support ingredients, but our data shows insufficient reliable evidence to rate their effectiveness for joint pain. The evidence for these uses is not established.
Is this safe to use while breastfeeding?
Most ingredients either have insufficient data or are cautioned against during breastfeeding — yucca should be avoided, and wild yam, royal jelly, spearmint, and spirulina all have limited safety information. Talk to your doctor or pharmacist before taking this product while nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

YTHE-I label
Go deeper

The Full Monographs Behind YTHE-I’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sea Moss

Interacts with 22 drugs

Sea moss is a type of red seaweed that is naturally rich in iodine and several minerals, and it is popular as a 'whole-food' supplement. Strong human evidence for most of its health claims i...

Read the full Sea Moss monograph → Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph → Herb & supplement monograph

Yucca

Yucca is a desert plant traditionally used for joint pain, arthritis, and digestion, and it contains compounds called saponins thought to have anti-inflammatory effects. Human evidence for t...

Read the full Yucca monograph → Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph → Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph → Herb & supplement monograph

Royal Jelly

Interacts with 174 drugs

Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune support, but solid human evidence is limit...

Read the full Royal Jelly monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph → Herb & supplement monograph

Spearmint

Interacts with 579 drugs

Spearmint is a common culinary mint that is generally safe in food and tea amounts. Early research suggests possible benefits for digestion, mild hormone-related issues (such as excess facia...

Read the full Spearmint monograph → Herb & supplement monograph

Blue-green Algae

Interacts with 327 drugs

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and general wellness. Evidence for most heal...

Read the full Blue-green Algae monograph → Herb & supplement monograph

Alfalfa

Interacts with 583 drugs

Alfalfa is a nutrient-rich legume that people use for high cholesterol, menopause symptoms, and general wellness, but solid human evidence for most of these uses is limited. It is best avoid...

Read the full Alfalfa monograph →
Sources

Sources & How We Checked

YTHE-I's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 170 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sea Moss 3 references
  1. Darias-Rosales J, Rubio C, Gutiérrez ÁJ, Paz S, Hardisson A. Risk assessment of iodine intake from the consumption of red seaweeds (Palmaria palmata and Chondrus crispus). Environ Sci Pollut Res Int 2020;27(36):45737-45741. PubMed
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Peppermint 41 references
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Bilberry 14 references
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Papaya 14 references
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Royal Jelly 14 references
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Wild Yam 7 references
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Spearmint 20 references
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See these in context on the Blue-green Algae monograph →

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See these in context on the Alfalfa monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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