Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Z-Binder Ingredients & Drug Interactions

by Ortho Molecular Products

Z-Binder label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Z-Binder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Z-Binder is a dietary supplement by Ortho Molecular Products with 4 active ingredients. Its ingredients are commonly taken for iron-deficiency anemia, low iron stores during pregnancy, fatigue from iron deficiency.Based on those ingredients, 2,159 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Activated Charcoal, PrimaVie, Iron. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Z-Binder by Ortho Molecular Products

Ask about any prescription or over-the-counter medication and we check it for interactions with Z-Binder by Ortho Molecular Products — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Z-Binder by Ortho Molecular Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “PrimaVie” is listed as a grouped ingredient — the label gives one combined amount (100 mg) without saying how much of each component you get.

Z-Binder has 5 ingredients, of which iron, activated charcoal, humic acid, fulvic acid, and something called G-PUR are the active components. Iron is a mineral your body uses to carry oxygen in the blood and prevent anemia.

Activated Charcoal is a porous form of carbon traditionally used to bind substances in the gut — here likely included for its binding properties. Humic and fulvic acids are natural compounds derived from decomposed organic matter; fulvic acid is marketed for general wellness, though solid evidence for its benefits is limited.

G-PUR isn't detailed in our data. The rest of what you're swallowing — microcrystalline cellulose, hypromellose, stearic acid, silicon dioxide, and magnesium stearate — are inactive ingredients that give the capsule its form and stability.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Anemia of chronic disease — rated "Effective" (Iron) (Natural Medicines).
  • On file: Iron deficiency anemia — rated "Effective" (Iron) (Natural Medicines).
  • On file: Pregnancy-related iron deficiency — rated "Effective" (Iron) (Natural Medicines).
  • On file: Poisoning — rated "Possibly Effective" (Activated Charcoal) (Natural Medicines).
  • On file: Cognitive function — rated "Possibly Effective" (Iron) (Natural Medicines).

Iron is effective for iron-deficiency anemia and anemia of chronic disease, and it's effective for pregnancy-related iron deficiency when dosed under medical guidance. It's also possibly effective for heart failure, though the evidence isn't as strong.

For the other active ingredients, the picture is much less clear. Activated charcoal is possibly effective for poisoning, but evidence for hyperphosphatemia, wound healing, dyspepsia, hangover, and high cholesterol is insufficient to rate.

Fulvic acid's effectiveness for respiratory infections, lead toxicity, eczema, fatigue, and hay fever is also insufficient — we don't have reliable evidence to say it works for any of these. Humic acid has no effectiveness data in our files.

The evidence, ingredient by ingredient Iron Activated Charcoal Shilajit Humic Acid Fulvic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Iron is generally well tolerated at recommended doses, though the product information flags that excess iron can be toxic and should only be used when there's a real need. The most common side effects from iron are gastrointestinal — abdominal pain, constipation, diarrhea, nausea, and vomiting.

Activated charcoal is low-risk for short-term use but commonly causes constipation and can reduce absorption of other things you take. Fulvic acid appears well tolerated in short-term use, with occasional headache, diarrhea, or sore throat reported.

Humic acid has limited safety data. Iron is considered likely safe in pregnancy when dosed by your prenatal provider, and likely safe while breastfeeding at appropriate doses — but check with your doctor.

Activated charcoal is possibly safe in pregnancy only under medical guidance. Humic acid should be avoided in pregnancy and breastfeeding due to insufficient safety data.

Fulvic acid should also be avoided in pregnancy and breastfeeding.

Side effects, ingredient by ingredient Iron Activated Charcoal Shilajit Humic Acid Fulvic Acid

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Activated Charcoal, Iron, Fulvic Acid.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; Parkinson's medications.
  • For scale: 2,132 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check these medication types before taking Z-Binder: oral medications in general (activated charcoal can bind many of them), blood thinners or antiplatelet drugs (fulvic acid may weaken their effect), quinolone and tetracycline antibiotics, bisphosphonates, levothyroxine, methyldopa, levodopa, mycophenolate, and penicillamine — all reduced by iron. Also check oral contraceptives and immunosuppressants.

If you use thyroid hormone, fulvic acid may interfere with dose adjustment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Z-Binder is centered on iron for anemia — a well-established use — but the activated charcoal and fulvic acid add complexity and risk. If you take any prescription medications, especially antibiotics, blood thinners, thyroid hormone, or bisphosphonates, you need to check before starting this product.

Talk to your pharmacist or doctor about whether the timing and spacing required makes it practical for you, or whether a simpler iron supplement might be better.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Z-Binder, straight from the product label.

Brand Ortho Molecular Products
Barcode (UPC) 615033004828
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 269576
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Z-Binder by Ortho Molecular Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
615033004828
IngredientAmount% DV
Iron2 mg11%
Activated Charcoal100 mg--
Humic Acid5 mg--
Fulvic Acid50 mg--
G-PUR400 mg--
PrimaVie100 mg--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Stearic Acid, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: 2 capsules between meals or as recommended by your health care professional.

Formulation

Formulated to be free of allergens derived from: Gluten, corn, yeast, artificial colors and flavors.

Professional Strength: Not for sale through Amazon.com

Vcaps

Gastrointestinal health

Precautions

If you are pregnant or nursing, consult your physician before taking this product.

As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredient panel carefully prior to ingestion. Cease taking this product and consult your physician if you have negative reactions upon ingestion.

Keep out of reach of children.

This product was sealed for your protection. Do not use if outer logoed neck seal or inner-seal is missing or damaged. Do not accept if label shows signs of tampering

Storage

Keep container tightly closed. Store at room temperature.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Vcaps

Formula

PrimaVie Purified Shilajit G-Pur Purified Clinoptilolite

General Statements

Learn more VitaSecure

Learn more about us at OrthoMolecularProducts.com

Brand IP Statement(s)

Ortho Molecular Products Because Efficacy Matters

PrimaVie is a registered trademark of Natreon, Inc. G-PUR is a registered trademark of G-Science, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Z-Binder by Ortho Molecular Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Z-Binder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Z-Binder by Ortho Molecular Products

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Iron

Interacts with
80 drugs
2 mg per serving

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventin...

Iron monograph & interactions

Activated Charcoal

Interacts with
2,027 drugs
100 mg per serving

Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some poisonings...

Activated Charcoal monograph & interactions

G-PUR

400 mg per serving Form: Zeolite Clay

PrimaVie

Interacts with
86 drugs
100 mg per serving Form: Shilajit

Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and v...

PrimaVie monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Stearic Acid, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Z-Binder by Ortho Molecular Products Drug Interactions

Want to check YOUR meds against Z-Binder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,159Drugs
2,022 Major 136 Moderate 1 Minor

Ingredients driving the most interactions

Activated Charcoal 2,027
PrimaVie 86
Iron 80

Individual Drug Interactions

The ingredients in Z-Binder interact with 2,159 drugs. Click any drug to see the details.

3 of the 4 ingredients in Z-Binder interact with drugs. Each result below shows which ingredient is responsible. Activated Charcoal PrimaVie Iron

Each ingredient & the kinds of drugs it affects

For each ingredient in Z-Binder with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Activated Charcoal3 drug types · 2,027 drugs

Oral Drugs

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.
Activated charcoal adsorbs various drugs and may reduce their absorption and/or half-life. Examples of affected drugs include acetaminophen, aminophylline, amiodarone, atenolol, carbamazepine, dapsone, digoxin, disopyramide, fluoxetine, indomethacin, moxifloxacin, nadolol, phenytoin, phenobarbital, piroxicam, quinine, sotalol, theophylline, tricyclic antidepressants, valproate, and verapamil. Avoid co-administration, except after drug overdose.

Likelihood Probable Evidence B
Alcohol (Ethanol)

The binding action of activated charcoal may be reduced by alcohol.
Alcohol may lower the adsorptive capacity of activated charcoal.

Likelihood Probable Evidence D
Contraceptive Drugs

Activated charcoal may reduce the clinical effects of oral contraceptives.
Activated charcoal, taken in a dose of 5 grams four times daily for 3 days, may bind to, and reduce the absorption of, oral contraceptives, thereby limiting their effectiveness and increasing the risk of contraceptive failure. However, some clinical research shows that the risk for this interaction is minimal when activated charcoal is taken either 3 hours after or at least 12 hours before oral contraceptives.

Likelihood Possible Evidence B
Activated Charcoal full monograph & interactions

PrimaVie1 drug type · 86 drugs

Antidiabetes Drugs

Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Most human and animal research shows that shilajit can decrease fasting plasma glucose levels. In an animal model, shilajit 100 mg per kg daily enhanced the glucose-lowering ability of both glibenclamide and metformin when given in combination over a 4 week period. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
PrimaVie full monograph & interactions

Iron13 drug types · 80 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and iron can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, iron containing products.

Likelihood Probable Evidence D
Bisphosphonates

Iron reduces the absorption of bisphosphonates.
Advise patients that doses of bisphosphonates should be separated by at least two hours from doses of all other medications, including supplements such as iron. Divalent cations, including iron, can decrease absorption of bisphosphonates by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D
Denosumab (Prolia, Others)

Administration of intravenous iron within one month of denosumab administration might increase the risk of severe hypophosphatemia and hypocalcemia.
A case of severe hypocalcemia (albumin corrected calcium 6.88 mg/dL, ionized calcium 3.68 mg/dL) and hypophosphatemia (<0.5 mg/dL) with respiratory acidosis, QT interval prolongation, and nonsustained ventricular tachycardia was reported in a 76-year-old male who had received an iron polymaltose infusion within 2 weeks of a subcutaneous injection of denosumab. Serum parathyroid hormone was also elevated (348 pg/mL). Subsequent iron infusions with iron polymaltose and ferric carboxymaltose were followed by transient hypophosphatemia, but without hypocalcemia. Additionally, a literature review describes 6 additional cases of hypophosphatemia and hypocalcemia in patients 52-92 years of age who had been administered intravenous iron as either ferric carboxymaltose or iron polymaltose and subcutaneous denosumab within 1-4 weeks of each other.

Likelihood Possible Evidence D
Dolutegravir (Tivicay)

Iron might decrease dolutegravir levels by reducing its absorption.
Advise patients to take dolutegravir at least 2 hours before or 6 hours after taking iron. Pharmacokinetic research shows that iron can decrease the absorption of dolutegravir from the gastrointestinal tract through chelation. When taken under fasting conditions, a single dose of ferrous fumarate 324 mg orally along with dolutegravir 50 mg reduces overall exposure to dolutegravir by 54%.

Likelihood Probable Evidence B
Integrase Inhibitors

Theoretically, taking iron along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Iron is a divalent cation. There is concern that iron may decrease the absorption of integrase inhibitors from the gastrointestinal tract through chelation. One pharmacokinetic study shows that iron can decrease blood levels of the specific integrase inhibitor dolutegravir through chelation. Also, other pharmacokinetic research shows that other divalent cations such as calcium can decrease the absorption and levels of some integrase inhibitors through chelation.

Likelihood Possible Evidence D
Levodopa

Iron might decrease levodopa levels by reducing its absorption.
Advise patients to separate doses of levodopa and iron as much as possible. There is some evidence in healthy people that iron forms chelates with levodopa, reducing the amount of levodopa absorbed by around 50%. The clinical significance of this hasn't been determined.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Iron might decrease levothyroxine levels by reducing its absorption.
Advise patients to separate levothyroxine and iron doses by at least 2 hours. Iron can decrease the absorption and efficacy of levothyroxine by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence B
Methyldopa (Aldomet)

Iron might decrease methyldopa levels by reducing its absorption.
Advise patients to separate methyldopa and iron doses by at least 2 hours. Iron can decrease the absorption of methyldopa from the gastrointestinal tract through chelation, resulting in increases in blood pressure.

Likelihood Probable Evidence B
Mycophenolate Mofetil (Cellcept)

Theoretically, iron might decrease mycophenolate mofetil levels by reducing its absorption.
Advise patients to take iron 4-6 hours before, or 2 hours after, mycophenolate mofetil. It has been suggested that a decrease of absorption is possible, probably by forming nonabsorbable chelates. However, mycophenolate pharmacokinetics are not affected by iron supplementation in available clinical research.

Likelihood Unlikely Evidence D
Penicillamine (Cuprimine, Depen)

Iron might decrease penicillamine levels by reducing its absorption.
Advise patients to separate penicillamine and iron doses by at least 2 hours. Oral iron supplements can reduce absorption of penicillamine by 30% to 70%, probably due to chelate formation. In people with Wilson's disease, this interaction has led to reduced efficacy of penicillamine.

Likelihood Probable Evidence D
Quinolone Antibiotics

Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Advise patients to separate quinolone antibiotics and iron doses by at least 2 hours. Iron decreases the absorption of quinolones due to formation of insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Advise patients to take iron at least 2 hours before or 4 hours after tetracycline antibiotics. Concomitant use can decrease absorption of tetracycline antibiotics from the gastrointestinal tract by 50% to 90%.

Likelihood Probable Evidence D
Chloramphenicol

Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.
Chloramphenicol interferes with erythrocyte maturation. However, since chloramphenicol isn't usually taken for prolonged periods, this isn't likely to be clinically significant.

Likelihood Unlikely Evidence D
Iron full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Z-Binder, from the product label.

Ortho Molecular Products

See all Ortho Molecular Products products
Name
Ortho Molecular Products, Inc.
Street Address
3017 Business Park Drive
City
Stevens Point
State
WI
ZipCode
54482
Web Address
OrthoMolecularProducts.com
Pharmacist Counseling Corner

Z-Binder by Ortho Molecular Products: Common Questions

Does Z-Binder by Ortho Molecular Products interact with any medications?
Yes. Based on its ingredients, Z-Binder has a known interaction with 2,159 medications, including 2022 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Z-Binder contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Z-Binder help with iron deficiency?
Yes — iron is effective for iron-deficiency anemia and for anemia of chronic disease. It's also effective for pregnancy-related iron deficiency, though your prenatal provider should guide the dose.
Will this work for fatigue or wound healing?
Fulvic acid is marketed for those uses, but we don't have reliable evidence that it works for either one. Iron itself is proven for anemia-related fatigue if low iron is the cause, but that's separate.
What side effects does iron cause?
Gastrointestinal effects are most common — abdominal pain, constipation, diarrhea, nausea, and vomiting. Black stools are normal and harmless. Serious side effects are rare but can include stomach ulcers, and very high long-term iron without oversight can lead to a condition called hemochromatosis where iron builds up in the body.
Is it safe to take Z-Binder while pregnant?
Iron itself is likely safe in pregnancy — it's often recommended — but your prenatal provider should guide the dose. Activated charcoal and fulvic acid should be avoided in pregnancy because safety data is limited. Talk to your doctor before starting this product.
Can I take Z-Binder while breastfeeding?
Iron is likely safe while breastfeeding at appropriate doses, but check with your provider first. Activated charcoal has limited safety data for breastfeeding; fulvic acid and humic acid should be avoided due to insufficient safety information.
Why does Z-Binder have activated charcoal in it?
Activated charcoal binds substances in the gut. In this product it may be intended to help absorb or bind certain compounds, but the interaction with your medications — and with iron itself — is a real concern.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Z-Binder is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Z-Binder label
Go deeper

The Full Monographs Behind Z-Binder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Iron

Interacts with 80 drugs

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventing iron deficiency and iron-deficiency an...

Read the full Iron monograph → Herb & supplement monograph

Activated Charcoal

Interacts with 2,027 drugs

Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some poisonings and overdoses. For everyday uses like g...

Read the full Activated Charcoal monograph → Herb & supplement monograph

Shilajit

Interacts with 86 drugs

Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and vitality. Human evidence is limited and m...

Read the full Shilajit monograph → Herb & supplement monograph

Humic Acid

Humic acid is a natural substance formed when plant and animal matter break down in soil, peat, and coal-like deposits, and it is sold as a supplement marketed for immune, gut, and 'detox' s...

Read the full Humic Acid monograph → Herb & supplement monograph

Fulvic Acid

Interacts with 257 drugs

Fulvic acid is a natural compound formed when plants and microbes break down in soil, and it is sold as a supplement for energy, gut, and overall wellness. Human research is very limited, so...

Read the full Fulvic Acid monograph →
Sources

Sources & How We Checked

Z-Binder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 100 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Iron 72 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Bruner AB, Joffe A, Duggan AK, et al. Randomized study of cognitive effects of iron supplementation in non- anaemic iron-deficient adolescent girls. Lancet 1996;348:992-6.
  3. Ullen H, Augustsson K, Gustavsson C, Steineck G. Supplementary iron intake and risk of cancer: reversed causality? Cancer Lett 1997;114:215-6.
  4. Reunanen A, Takkunen H, Knekt P, et al. Body iron stores, dietary iron intake and coronary heart disease mortality. J Intern Med 1995;238:223-30. PubMed
  5. Lund EK, Wharf SG, Fairweather-Tait SJ, Johnson IT. Oral ferrous sulfate supplements increase the free radical-generating capacity of feces from healthy volunteers. Am J Clin Nutr 1999;69:250-5.
  6. Rehman A, Collis CS, Yang M, et al. The effects of iron and vitamin C co-supplementation on oxidative damage to DNA in healthy volunteers. Biochem Biophys Res Comm 1998;246:293-8. PubMed
  7. Klipstein-Grobusch K, Grobbee DE, den Breeijen JH, et al. Dietary iron and risk of myocardial infarction in the Rotterdam Study. Am J Epidemiol 1999;149:421-8. PubMed
  8. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  9. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  10. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  11. Campbell N, Paddock V, Sundaram R. Alteration of methyldopa absorption, metabolism, and blood pressure control by ferrous sulfate and ferrous gluconate. Clin Pharmacol Ther 1988;43:381-6..
  12. Schumann K, Borch-Iohnsen B, Hentze MW, Marx JJ. Tolerable upper intakes for dietary iron set by the US Food and Nutrition Board (commentary). Am J Clin Nutr 2002;76:499-500. PubMed
  13. Tuomainen TP, Punnonen K, Nyyssonen K, Salonen JT. Association between body iron stores and the risk of acute myocardial infarction in men. Circulation 1998;97:1461-6.. PubMed
  14. Salonen JT, Nyyssonen K, Korpela H, et al. High stored iron levels are associated with excess risk of myocardial infarction in Eastern Finnish men. Circulation 1992;86:803-11.. PubMed
  15. Campbell NRC, Hasinoff B. Ferrous sulfate reduces levodopa bioavailability: Chelation as a possible mechanism. Clin Pharmacol Ther 1989;45:220-5.. PubMed
  16. Campbell NRC, Hasinoff BB, Stalts H, et al. Ferrous sulfate reduces thyroxine efficacy in patients with hypothyroidism. Ann Int Med 1992;117:1010-3.. PubMed
  17. Kiechl S, Willeit J, Egger G, et al. Body iron stores and the risk of carotid atherosclerosis: prospective results from the Bruneck study. Circulation 1997;96:3300-07. PubMed
  18. Comparison of oral iron supplements. Pharmacist's Letter / Prescriber's Letter 2008;24(8):240811.
  19. Tran T., Wax J. R., Philput C., Steinfeld J. D., Ingardia C. J. Intentional iron overdose in pregnancy--management and outcome. J Emerg Med 2000;18(2):225-228. PubMed
  20. Toblli J. E., Brignoli, R. Iron(III)-hydroxide polymaltose complex in iron deficiency anemia / review and meta-analysis. Arzneimittelforschung 2007;57(6A):431-438. PubMed
  21. Köpcke W., Sauerland M. C. Meta-analysis of efficacy and tolerability data on iron proteinsuccinylate in patients with iron deficiency anemia of different severity. Arzneimittelforschung 1995;45(11):1211-1216.
  22. Campbell N. R., Campbell R. R., Hasinoff B. B. Ferrous sulfate reduces methyldopa absorption: methyldopa: iron complex formation as a likely mechanism. Clin Invest Med 1990;13(6):329-332.
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Humic Acid 3 references
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Shilajit 8 references
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See these in context on the Shilajit monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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