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Dietary supplement

Zeaxanthin 4 mg Ingredients & Drug Interactions

by Puritan's Pride

Zeaxanthin 4 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Zeaxanthin 4 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Zeaxanthin 4 mg is a dietary supplement by Puritan's Pride with 1 active ingredient. Its ingredients are commonly taken for eye and macular health, age-related macular degeneration (amd), protection from blue light.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Zeaxanthin 4 mg by Puritan's Pride

Ask about any prescription or over-the-counter medication and we check it for interactions with Zeaxanthin 4 mg by Puritan's Pride — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Zeaxanthin 4 mg by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains one active ingredient: zeaxanthin, a plant pigment and carotenoid found naturally in leafy greens and other vegetables. It also holds several inactive ingredients (corn oil, gelatin, glycerin, beeswax, and caramel color) that make up the capsule and help deliver the zeaxanthin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Zeaxanthin's overall clinical evidence instead.

Moderate

Some clinical evidence supports Zeaxanthin for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Age-related macular degeneration (AMD) — rated "Possibly Effective" (Natural Medicines).

The evidence strongest for zeaxanthin is in age-related macular degeneration (AMD) — the most common cause of vision loss in older adults — where it's rated possibly effective. For age-related cognitive decline, Alzheimer disease, asthma, breast cancer, and bronchopulmonary dysplasia, the evidence isn't established enough in our data to rate it either way.

The evidence, ingredient by ingredient Zeaxanthin

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Zeaxanthin is generally well tolerated at the amounts you'll find in supplements. For pregnancy, the safety data on concentrated supplements isn't robust enough to be certain, so use caution — but dietary amounts from food are fine.

The same goes for breastfeeding: food sources are okay, but we don't have enough data on supplements, so talk it over with your doctor or pharmacist if you're nursing.

Side effects, ingredient by ingredient Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take an antidiabetes drug (insulin, metformin, sulfonylureas, or others), check your exact medications before starting zeaxanthin. There's a moderate-severity risk that it could lower your blood sugar further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and some safety-information gaps remain.

Zeaxanthin may be worth considering if you're concerned about age-related vision loss, though the strongest evidence is for AMD specifically. If you take an antidiabetes medication, check with your doctor or pharmacist before starting — there's a theoretical risk of low blood sugar.

Pregnant or breastfeeding? Same advice: talk it through with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Zeaxanthin 4 mg, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 025077522804
Net contents 60 Easy to Swallow Rapid Release Softgel(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 285459
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Zeaxanthin 4 mg by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
025077522804
IngredientAmount% DV
Zeaxanthin4 mg--

Other ingredients: Corn Oil, Gelatin, Glycerin, yellow Beeswax, Caramel color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Puritan’s Pride supplements are produced from the finest raw materials under stringent quality control standards. State-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health...choose the best.

To reorder item # 52280 www.puritan.com 1-800-645-1030

Precautions

Warning: Not intended for use by pregnant or nursing women. If you are taking any medications or have any medical condition, consult your doctor before use.

Avoid this product if you are allergic to ragweed or daisy-like flowers.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Contains bioengineered food ingredients.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Copyright 2020 Puritan's Pride, Inc.

Healthy Eyes

Formula

Natural Carotenoid

Eye Care with Lutigold

Formulation

Supports Healthy Eyes & Vision

No artificial flavor or sweetener, no sugar, no starch, no milk, no lactose, no soy, no gluten, no wheat, no yeast, no fish. Sodium free.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) softgel two times daily, preferably with meals.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Zeaxanthin 4 mg by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Zeaxanthin 4 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Zeaxanthin 4 mg by Puritan's Pride

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Zeaxanthin

Interacts with
86 drugs
4 mg per serving Form: Marigold

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Other (inactive) ingredients: Corn Oil, Gelatin, Glycerin, Yellow Beeswax, Caramel color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Zeaxanthin 4 mg by Puritan's Pride Drug Interactions

Want to check YOUR meds against Zeaxanthin 4 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Zeaxanthin 4 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Zeaxanthin 4 mg interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Zeaxanthin 4 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Zeaxanthin 4 mg, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Zeaxanthin 4 mg by Puritan's Pride: Common Questions

Does Zeaxanthin 4 mg by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, Zeaxanthin 4 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Zeaxanthin 4 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does zeaxanthin really help with vision problems?
The evidence is clearest for age-related macular degeneration (AMD), where it's rated possibly effective. For other eye or brain conditions in our data, we don't have enough evidence yet to say whether it works.
Is this safe to take if I'm pregnant or breastfeeding?
The safety data on concentrated supplements during pregnancy and breastfeeding isn't well studied enough to be sure. Zeaxanthin from food is fine, but if you're pregnant or nursing, talk with your doctor or pharmacist about whether this supplement is right for you.
What is zeaxanthin, and where does it come from?
Zeaxanthin is a plant pigment (a carotenoid) that you get naturally from leafy greens and other vegetables. This supplement provides it in a concentrated form.
Are there any side effects I should know about?
No adverse effects are documented in our data for zeaxanthin at typical supplement doses — it's generally well tolerated.
Can I take this if I have diabetes?
If you take diabetes medication, check your exact drugs with the search tool on this page and talk with your doctor or pharmacist first. Animal studies suggest zeaxanthin might lower blood sugar, so there's a moderate-severity risk of your levels dropping too far.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Zeaxanthin 4 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Zeaxanthin 4 mg label
Go deeper

The Full Monographs Behind Zeaxanthin 4 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Zeaxanthin 4 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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