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Dietary supplement

Zeaxanthin 4 mg Ingredients & Drug Interactions

by Vitamin World

Zeaxanthin 4 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Zeaxanthin 4 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Zeaxanthin 4 mg is a dietary supplement by Vitamin World with 1 active ingredient. Its ingredients are commonly taken for eye and macular health, age-related macular degeneration (amd), protection from blue light.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Zeaxanthin 4 mg by Vitamin World

Ask about any prescription or over-the-counter medication and we check it for interactions with Zeaxanthin 4 mg by Vitamin World — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Zeaxanthin 4 mg by Vitamin World

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: zeaxanthin, a carotenoid (a plant pigment) that your body can use. It's delivered in a softgel capsule with inactive ingredients including corn oil, gelatin, vegetable glycerin, beeswax, and caramel color.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Eye and macular health support.
  • We looked for evidence on: Age-related macular degeneration (AMD), Cataracts, Asthenopia (eye strain), Glaucoma, Macular telangiectasia type 2, Retinopathy of prematurity — and 3 related terms.
  • The strongest evidence on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Zeaxanthin is rated "Insufficient Reliable Evidence To Rate" for Cataracts, Glaucoma, Retinopathy of prematurity, Asthenopia (eye strain), and more.

Zeaxanthin is possibly effective for age-related macular degeneration (AMD), an eye condition that causes vision loss as you get older. For age-related cognitive decline, Alzheimer disease, asthma, breast cancer, and bronchopulmonary dysplasia, the evidence we hold is insufficient to rate how well it works.

The evidence, ingredient by ingredient Zeaxanthin

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Zeaxanthin is generally well tolerated at typical supplement doses. In pregnancy, dietary amounts from food are fine, but the safety of concentrated supplements hasn't been well studied — talk with your doctor or pharmacist for personalized advice.

The same applies to breastfeeding: food sources are okay, but data on concentrated supplements is limited.

Side effects, ingredient by ingredient Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs, double-check them against this product before you start — zeaxanthin may increase the risk of low blood sugar. This is a Moderate-severity interaction.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

If you're concerned about age-related macular degeneration, this supplement has some evidence behind it — worth a conversation with your eye doctor. If you take antidiabetes medication, check with your pharmacist first: the blood-sugar risk is moderate but real.

Otherwise, it's generally safe and well tolerated.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Zeaxanthin 4 mg, straight from the product label.

Brand Vitamin World
Barcode (UPC) 766443522805
Net contents 60 Easy To Swallow Softgel(s)
Market status On market
Date entered into DSLD Apr 25, 2013
DSLD ID 20973
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Zeaxanthin 4 mg by Vitamin World, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
766443522805
IngredientAmount% DV
Zeaxanthin4 mg--

Other ingredients: Corn Oil, Gelatin, Vegetable Glycerin, yellow Beeswax, natural Caramel color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

QA QUALITY ASSURED

V VITAMIN WORLD(R) get healthy.

EYE CARE with Lutigold(TM)

Formulation

No Artificial Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Precautions

Do not use if seal under cap is broken or missing.

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

This product has been developed, manufactured and packaged by Vitamin World. Our world-class facilities allow us to control exactly what goes into each product. It is your assurance that you are getting the highest quality and freshest products. You have our guarantee!

NATURAL CAROTENOID Supports Healthy Eyes & Vision*

Lutein and zeaxanthin are the predominant carotenoids naturally present in the macula of the eye, and zeaxanthin is selectively placed in the macula’s center. Most lutein supplements usually contain small amounts of zeaxanthin. Our Zeaxanthin softgels offer a higher dosage to support eye health.*

Get healthy.

Storage

Store at room temperature.

Brand IP Statement(s)

(C) 2012 Vitamin World, Inc.

HEALTHY EYES(R)

General

PROD. #52280 B52280 00A

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: For adults, take one (1) softgel two times daily, preferably with meals.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Zeaxanthin 4 mg by Vitamin World label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Zeaxanthin 4 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Zeaxanthin 4 mg by Vitamin World

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Zeaxanthin

Interacts with
86 drugs
4 mg per serving Form: Marigold

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Other (inactive) ingredients: Corn Oil, Gelatin, Vegetable Glycerin, Yellow Beeswax, Natural Caramel color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Zeaxanthin 4 mg by Vitamin World Drug Interactions

Want to check YOUR meds against Zeaxanthin 4 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Zeaxanthin 4 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Zeaxanthin 4 mg interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Zeaxanthin 4 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Zeaxanthin 4 mg, from the product label.

Vitamin World

See all Vitamin World products
Name
Vitamin World, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Pharmacist Counseling Corner

Zeaxanthin 4 mg by Vitamin World: Common Questions

Does Zeaxanthin 4 mg by Vitamin World interact with any medications?
Yes. Based on its ingredients, Zeaxanthin 4 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Zeaxanthin 4 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does zeaxanthin actually help with age-related macular degeneration?
It's rated possibly effective for AMD. That means there's some evidence it can help, but more research would strengthen that claim. Talk with your eye doctor about whether it's right for your situation.
Is it safe to take while I'm pregnant?
Dietary amounts from food are fine. With concentrated supplements, there isn't enough safety data to know for sure — the safety profile is rated likely safe, but talk with your doctor or pharmacist for personalized advice before starting.
Can I breastfeed while taking this?
Food sources of zeaxanthin are okay. For concentrated supplements, there isn't enough data to be certain. Check with your doctor or pharmacist to decide what's best for you and your baby.
What are the side effects I should expect?
No adverse effects are documented in our data at typical supplement doses. It's generally well tolerated.
Can I take this if I'm diabetic and on medication?
You can, but check with your pharmacist or doctor first. Zeaxanthin may theoretically increase your risk of low blood sugar when combined with antidiabetes drugs, so they may want to monitor you more closely or adjust your dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Zeaxanthin 4 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Zeaxanthin 4 mg label
Go deeper

The Full Monographs Behind Zeaxanthin 4 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Zeaxanthin 4 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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