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Dietary supplement

Zeaxanthin 4 mg with Lutein 20 mg Ingredients & Drug Interactions

by Nutricost

Zeaxanthin 4 mg with Lutein 20 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Zeaxanthin 4 mg with Lutein 20 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Zeaxanthin 4 mg with Lutein 20 mg is a dietary supplement by Nutricost with 2 active ingredients. Its ingredients are commonly taken for eye and macular health, age-related macular degeneration (amd), protection from blue light.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Zeaxanthin 4 mg with Lutein 20 mg by Nutricost

Ask about any prescription or over-the-counter medication and we check it for interactions with Zeaxanthin 4 mg with Lutein 20 mg by Nutricost — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Zeaxanthin 4 mg with Lutein 20 mg by Nutricost

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients: zeaxanthin (4 mg) and lutein (20 mg). Both are carotenoids — plant pigments your eye uses to filter light and protect the retina.

The softgel also contains safflower seed oil, gelatin, glycerin, beeswax, purified water, and added color as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Eye health and macular support.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein is possibly effective for age-related macular degeneration (AMD) and cataracts. Zeaxanthin is possibly effective for AMD.

For other conditions listed — cognitive decline, Alzheimer's disease, asthma, breast cancer, and several eye and lung conditions in newborns — the evidence isn't established in the data we hold, or the ingredient has tested ineffective.

The evidence, ingredient by ingredient Zeaxanthin Lutein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both zeaxanthin and lutein are generally well tolerated at typical supplement doses. Lutein studies have shown no adverse effects at doses up to 20 mg daily.

During pregnancy and lactation, both ingredients are rated likely safe, though the data on concentrated supplements (rather than food sources) is limited. If you're pregnant or breastfeeding, talk with your doctor or pharmacist before starting a supplement.

Side effects, ingredient by ingredient Zeaxanthin Lutein

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (Moderate interaction with zeaxanthin, risk of low blood sugar), check your specific medications with the tool below before starting. No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a straightforward two-ingredient supplement aimed at eye health, particularly AMD. If you take antidiabetes medication, check with us or your pharmacist first — zeaxanthin may lower blood sugar further.

Otherwise, it's well tolerated and doesn't interact with most medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Zeaxanthin 4 mg with Lutein 20 mg, straight from the product label.

Brand Nutricost
Barcode (UPC) 810014670300
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 311941
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Zeaxanthin 4 mg with Lutein 20 mg by Nutricost, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
120
UPC/BARCODE
810014670300
IngredientAmount% DV
Calories10 Calorie(s)--
Zeaxanthin4 mg--
Lutein20 mg--

Other ingredients: Safflower seed Oil, Gelatin, Glycerin, Beeswax, Water, Purified, added Color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 1 softgel daily with 8-12 oz of water or as directed by your healthcare professional.

Formulation

Gluten free

Non GMO Gluten Free Product

Packaged and quality tested in the USA with globally sourced ingredients.

Third party tested

Precautions

Consult a healthcare professional prior to use if you are pregnant or nursing, taking medication, or have a medical condition.

Warning: for healthy individuals 18 years and older. Keep out of reach of children.

Do not use if safety seal is broken or missing.

Storage

Notice: Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

4 mg of Zeaxanthin per serving 20 mg of Lutein per serving

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Nutricost Quality Guaranteed Third Party Tested GMP compliant Facility GMP

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Zeaxanthin 4 mg with Lutein 20 mg by Nutricost label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Zeaxanthin 4 mg with Lutein 20 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Zeaxanthin 4 mg with Lutein 20 mg by Nutricost

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Zeaxanthin

Interacts with
86 drugs
4 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Lutein

No known
interactions
20 mg per serving

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Other (inactive) ingredients: Safflower seed Oil, Gelatin, Glycerin, Beeswax, Water, Purified, Added Color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Zeaxanthin 4 mg with Lutein 20 mg by Nutricost Drug Interactions

Want to check YOUR meds against Zeaxanthin 4 mg with Lutein 20 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Zeaxanthin 4 mg with Lutein 20 mg interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Zeaxanthin 4 mg with Lutein 20 mg interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Zeaxanthin 4 mg with Lutein 20 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Zeaxanthin 4 mg with Lutein 20 mg, from the product label.

Nutricost

See all Nutricost products
Name
Nutricost
Street Address
351 E 1750 N
City
Vineyard
State
UT
ZipCode
84059
Phone Number
(866) 438-3694
Web Address
www.nutricost.com
Pharmacist Counseling Corner

Zeaxanthin 4 mg with Lutein 20 mg by Nutricost: Common Questions

Does Zeaxanthin 4 mg with Lutein 20 mg by Nutricost interact with any medications?
Yes. Based on its ingredients, Zeaxanthin 4 mg with Lutein 20 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Zeaxanthin 4 mg with Lutein 20 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this supplement actually help with macular degeneration?
Both lutein and zeaxanthin are possibly effective for AMD, so there's evidence to support their use for that. The data's not as strong for other eye or brain conditions on the label — those lack reliable evidence or have tested ineffective.
Can I take this while I'm pregnant?
Both ingredients are rated likely safe in pregnancy, but the safety data on concentrated supplements — versus getting them from food — is limited. Talk with your doctor or pharmacist to decide what's right for you and your pregnancy.
What are zeaxanthin and lutein, and why are they together?
They're both carotenoids — plant pigments that concentrate in your retina to protect it from light damage. They work alongside each other in that role, so combining them makes sense for eye health.
Are there any side effects I should worry about?
Neither ingredient causes adverse effects at typical supplement doses. Lutein has been studied at up to 20 mg daily with no problems reported, and zeaxanthin is generally well tolerated too.
Can I take this if I'm breastfeeding?
Both ingredients are rated likely safe, and lutein naturally appears in breast milk. That said, safety data on higher supplement doses while breastfeeding isn't as robust — check with your doctor or pharmacist before starting.
Does this product have any fillers or extra stuff?
Yes, it has inactive ingredients: safflower seed oil, gelatin, glycerin, beeswax, purified water, and added color. Those are standard softgel capsule materials and don't add activity — just the two carotenoids do that.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Zeaxanthin 4 mg with Lutein 20 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Zeaxanthin 4 mg with Lutein 20 mg label
Go deeper

The Full Monographs Behind Zeaxanthin 4 mg with Lutein 20 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph →
Sources

Sources & How We Checked

Zeaxanthin 4 mg with Lutein 20 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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