Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

ZemBright MoodPlus Ingredients & Drug Interactions

by Dr. David Williams

ZemBright MoodPlus label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ZemBright MoodPlus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ZemBright MoodPlus is a dietary supplement by Dr. David Williams with 5 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 1,377 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are KSM-66 Ashwagandha extract, Zembrin extract, Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against ZemBright MoodPlus by Dr. David Williams

Ask about any prescription or over-the-counter medication and we check it for interactions with ZemBright MoodPlus by Dr. David Williams — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ZemBright MoodPlus by Dr. David Williams

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

ZemBright MoodPlus has 5 active ingredients: vitamin B12, folate, vitamin B6, KSM-66 ashwagandha extract, and Zembrin (sceletium extract). B vitamins support nerve function and energy metabolism.

Ashwagandha and sceletium are plant extracts traditionally used for stress and mood support. The capsule also contains inactive ingredients: gelatin, dicalcium phosphate, magnesium stearate, and silicon dioxide — standard binders and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: mood support and relaxation.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Depression, Fatigue, stress, emotional well-being — and 1 related terms.
  • The strongest evidence on file: Ashwagandha is rated "Possibly Effective" for Anxiety (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Generalized anxiety disorder (GAD), Stress.
  • Also on file: Vitamin B12 is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Depression, Fatigue.

The evidence is mixed and limited for most of what this product aims to do. Vitamin B12 is effective for B12 deficiency itself, and vitamin B6 is effective for B6 deficiency and a specific type of anemia.

For mood and stress, ashwagandha has possibly effective evidence for anxiety, stress, insomnia, and generalized anxiety disorder — but the data are preliminary. Sceletium (Zembrin) shows insufficient evidence to rate for anxiety, depression, stress, or other conditions the product targets.

Folate's effectiveness isn't documented in the data we hold.

The evidence, ingredient by ingredient Vitamin B12 Vitamin B6 Ashwagandha Sceletium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Overall, these ingredients are generally well tolerated at typical doses. Vitamin B12 is very safe and excess is cleared in the urine.

Vitamin B6 is safe at normal amounts but high doses over time can damage nerves — the product doesn't state its dose, so check the label. Ashwagandha is generally well tolerated short-term but long-term safety is not well established; rare cases of serious liver injury have been reported.

Sceletium has limited safety data. Common side effects across the ingredients include headache, nausea, gastrointestinal upset, and drowsiness.

Side effects, ingredient by ingredient Vitamin B12 Vitamin B6 Ashwagandha Sceletium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Vitamin B12, Vitamin B6, Ashwagandha, Sceletium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications; Parkinson's medications.
  • For scale: 1,378 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check if you take CNS depressants or sedatives (including benzodiazepines) — ashwagandha and sceletium may increase their effect. Antihypertensive drugs (blood pressure medications) may have their effect increased by ashwagandha or vitamin B6.

Antidiabetes drugs may have their effect increased by ashwagandha, raising the risk of low blood sugar. High doses of vitamin B6 may reduce the effect of seizure medications (phenobarbital, phenytoin).

Thyroid hormone, immunosuppressants, and hepatotoxic drugs each have documented interactions as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a mood and stress support blend, but the evidence for its main ingredients is preliminary at best, and several ingredients interact with common medications. If you take blood pressure drugs, seizure medications, diabetes medications, sedatives, benzodiazepines, or thyroid hormone, check your exact medications with the tool on this page first.

Talk to your pharmacist about whether it's right for your health situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ZemBright MoodPlus, straight from the product label.

Brand Dr. David Williams
Barcode (UPC) 678829241371
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 202121
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ZemBright MoodPlus by Dr. David Williams, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
678829241371
IngredientAmount% DV
Vitamin B12200 mcg3333%
Folate100 mg25%
Vitamin B615 mg750%
KSM-66 Ashwagandha extract600 mg--
Zembrin extract25 mg--

Other ingredients: Gelatin, Dicalcium Phosphate, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Almost out? Call 1-800-888-1415 or visit drdavidwilliams.com Choose autodelivery, get free shipping forever

Unconditionally guaranteed for purity and labeled potency.

Improves mood and reduces stress naturally

Storage

Store bottle in a cool, dry place.

Brand IP Statement(s)

Quatrefolic is a registered trademark of Gnosis S.p.A. and protected by US Patent No. 7,947,662. KSM-66 is a registered trademark of Ixoreal Biomed Pvt. Ltd. Zembrin is a registered trademark of HG&H Pharmaceuticals Pty Ltd., exclusively distributed in the USA by PLT Health Solutions, Inc. U.S. Patents #6,288,104 and #8,552,051.

Searching the world for better health

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

GF Gluten Free

Formulation

GF Gluten free

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Doctor's Suggested Use: Take 1 capsule daily with a meal.

Formula

Contains: Milk (KSM-66 Ashwagandha is prepared in accordance with Ayurvedic tradition resulting in trace quantities of milk remaining in the product).

Precautions

Contains: Milk (KSM-66 Ashwagandha is prepared in accordance with Ayurvedic tradition resulting in trace quantities of milk remaining in the product).

Note: Pregnant or lactating women should consult a health care professional before taking this product.

Keep out of reach of children.

General

SKU: ZMP 02 C12000, 2016 R-1

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ZemBright MoodPlus by Dr. David Williams label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ZemBright MoodPlus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ZemBright MoodPlus by Dr. David Williams

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
200 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Folate

100 mg per serving Form: Quatrefolic

Vitamin B6

Interacts with
210 drugs
15 mg per serving Form: Pyridoxine 5-Phosphate, Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

KSM-66 Ashwagandha extract

Interacts with
1,372 drugs
600 mg per serving

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

KSM-66 Ashwagandha extract monograph & interactions

Zembrin extract

Interacts with
248 drugs
25 mg per serving

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, s...

Zembrin extract monograph & interactions

Other (inactive) ingredients: Gelatin, Dicalcium Phosphate, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

ZemBright MoodPlus by Dr. David Williams Drug Interactions

Want to check YOUR meds against ZemBright MoodPlus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,377Drugs
916 Moderate 461 Minor

Ingredients driving the most interactions

KSM-66 Ashwagandha extract 1,372
Zembrin extract 248
Vitamin B6 210
Vitamin B12 20

Individual Drug Interactions

The ingredients in ZemBright MoodPlus interact with 1,377 drugs. Click any drug to see the details.

4 of the 5 ingredients in ZemBright MoodPlus interact with drugs. Each result below shows which ingredient is responsible. KSM-66 Ashwagandha extract Zembrin extract Vitamin B6 Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in ZemBright MoodPlus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

KSM-66 Ashwagandha extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
KSM-66 Ashwagandha extract full monograph & interactions

Zembrin extract1 drug type · 248 drugs

Cns Depressants

Theoretically, concomitant use of sceletium and CNS depressants might result in additive sedative effects.
Some evidence suggests that sceletium has sedative properties.

Likelihood Possible Evidence D
Zembrin extract full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ZemBright MoodPlus, from the product label.

Dr. David Williams

See all Dr. David Williams products
Name
Healthy Directions
City
Bethesda
State
MD
ZipCode
20817
Web Address
healthydirections.com
Pharmacist Counseling Corner

ZemBright MoodPlus by Dr. David Williams: Common Questions

Does ZemBright MoodPlus by Dr. David Williams interact with any medications?
Yes. Based on its ingredients, ZemBright MoodPlus has a known interaction with 1,377 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ZemBright MoodPlus contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Ashwagandha and sceletium should be avoided in pregnancy and breastfeeding — the safety data advise against it. Vitamin B12 and B6 are considered safe at recommended amounts during pregnancy and breastfeeding per your healthcare provider's guidance. Since this product contains ashwagandha and sceletium, talk with your doctor or pharmacist before use if you're pregnant or nursing.
Does this actually work for anxiety and stress?
Ashwagandha has possibly effective evidence for anxiety, stress, and insomnia — meaning the research is preliminary but suggestive. Sceletium, the other main ingredient for mood, has insufficient evidence to rate. The B vitamins support overall nerve function but aren't targeted for anxiety or stress specifically.
What are the most common side effects?
The most common reported side effects are headache, nausea, gastrointestinal upset, and drowsiness. Ashwagandha and sceletium can cause diarrhea and digestive upset at typical doses, though it's not common. Rare but serious liver problems have been reported with ashwagandha, so stop and contact your doctor if you develop yellowing of the skin or eyes, dark urine, or unexplained abdominal pain.
What's in this that makes it a 'mood' supplement?
The main ingredients are ashwagandha and Zembrin (sceletium extract), both plant extracts used traditionally for stress and mood support. The B vitamins — B12, B6, and folate — support nerve and brain function as well. The product doesn't contain antidepressant medications.
Can I take high doses if I want faster results?
No — high doses of vitamin B6 especially can damage nerves over time. The product label will tell you the doses; stick to those. If you're not seeing results after a reasonable time, talk to your pharmacist rather than increasing on your own.
Is sceletium (Zembrin) the same as khat?
Our data don't cover that comparison. Zembrin is an extract from sceletium; ask your pharmacist if you want to know more about how it differs from other plants in its family.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ZemBright MoodPlus label
Go deeper

The Full Monographs Behind ZemBright MoodPlus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Sceletium

Interacts with 248 drugs

Sceletium (often sold as 'kanna') is a South African plant traditionally used to ease stress and lift mood. Early human studies are small and short, so its benefits are not well proven. Talk...

Read the full Sceletium monograph →
Sources

Sources & How We Checked

ZemBright MoodPlus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 97 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
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Ashwagandha 32 references
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Sceletium 3 references
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