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Ipratropium

Ipratropium is an anticholinergic medicine used to treat bronchospasm (airway tightening) in COPD and to relieve a runny nose caused by the common cold or seasonal allergic rhinitis.

Brand names AtroventIpratropium BromideAtrovent HFAIpratropium Bromide Inhalation
Drug classes Anticholinergic
Rx Forms 3
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 20 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 8, 2026
Other forms & routes:
Nasal Oral inhalation
Ipratropium at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Ipratropium is an anticholinergic (it blocks acetylcholine, the nerve signal that tightens airways and drives mucus glands), inhaled to keep airways open in COPD or sprayed in the nose to dry up a drip from colds or hay fever; it is a familiar older standby, on the market since about 1991 and available generically. Little reaches the bloodstream, so it is usually well tolerated; dry mouth, a bitter taste and, with the spray, nose irritation are what people notice most. The inhaled forms are for daily maintenance, not sudden attacks, so keep a rescue inhaler handy, and stop and call your doctor if breathing worsens right after a dose.

Clinical pearls

  • Limit the nasal spray to four days for a cold or three weeks for hay fever; it won’t clear stuffiness.
  • Keep sprays out of your eyes; if any gets in, rinse and report eye pain, halos or blurring promptly.
  • Tell every prescriber about narrow-angle glaucoma, an enlarged prostate, or other anticholinergics, including many bladder medicines, since side effects stack up.
  • The nebulizer solution can share a cup with albuterol only if used within one hour; don’t mix in other drugs.
How we write & review this content — our editorial policy →
How you get itPrescription only
Comes asNasal spray, Inhalation solution (nebulizer), Inhaler
Earliest FDA record1986
Companies listing it with the FDA24
FDA label last updatedMay 1, 2019
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Ipratropium, written from its FDA label.

What Ipratropium is used for

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Ipratropium is available in inhaled and nasal forms, each approved for specific conditions. Here is the full set of supported uses:

  • COPD maintenance (inhaled aerosol — Atrovent HFA): Atrovent HFA is approved as a bronchodilator for ongoing management of bronchospasm associated with COPD, including chronic bronchitis and emphysema.
  • COPD maintenance (inhaled aerosol — Ipratropium Bromide Inhalation aerosol): Ipratropium Bromide Inhalation aerosol is approved for maintenance treatment of bronchospasm associated with COPD, including chronic bronchitis and emphysema.
  • COPD maintenance (nebulizer solution — Ipratropium Bromide): Ipratropium Bromide inhalation solution (nebulizer) is approved for maintenance treatment of bronchospasm associated with COPD, including chronic bronchitis and emphysema — used alone or with other bronchodilators, especially beta-adrenergic medicines.
  • Runny nose from the common cold (nasal spray — Ipratropium Bromide): Ipratropium Bromide nasal spray 0.06% is approved for symptomatic relief of rhinorrhea (runny nose) from the common cold in adults and children aged 5 and older; approved for up to 4 days.
  • Runny nose from seasonal allergic rhinitis (nasal spray — Ipratropium Bromide): Ipratropium Bromide nasal spray 0.06% is approved for symptomatic relief of rhinorrhea from seasonal allergic rhinitis in adults and children aged 5 and older; approved for up to 3 weeks.

How Ipratropium works

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Ipratropium is an anticholinergic medicine, meaning it blocks the action of acetylcholine — a chemical your nervous system uses to signal muscles and glands. In the lungs, blocking this signal prevents the airways from tightening, which makes it easier to breathe. In the nose, it reduces activity in the mucus-producing glands lining the nasal passages, which cuts down on a runny nose. Because ipratropium is a quaternary amine — a chemical structure that doesn't cross easily into the bloodstream or the brain — most of its action stays local, at the site where it's applied, and whole-body (systemic) anticholinergic side effects are much less common than with older medicines in this class.

Ipratropium dosage

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How often and how you take ipratropium depends entirely on the specific product. The inhaled aerosol forms (Atrovent HFA and Ipratropium Bromide Inhalation aerosol) are taken multiple times a day by inhaling through the mouth; the nebulizer solution is also used multiple times daily, with doses spaced through the day. The nasal spray is sprayed into each nostril several times a day, for a short course only. None of these products are taken with food — they go directly into the lungs or nose.

  • Do not exceed the maximum daily dose listed on your product label or prescribed by your doctor.
  • The inhaled forms are for maintenance use only — not for sudden breathing emergencies.
  • The nasal spray is short-term: no more than 4 days for a cold, or 3 weeks for seasonal allergies.
  • If you miss a dose, take it as soon as you remember, but do not double up — just follow your regular schedule and ask your pharmacist if unsure.

Dosing details from the FDA-approved label

From the Ipratropium prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Nasal spray 0.06%: symptomatic relief of rhinorrhea associated with the common cold, adults and children age 12 years and older
    • Two sprays (84 mcg) per nostril three or four times daily (total dose 504 to 672 mcg/day)
    • Optimum dosage varies with response of the individual patient
    • Safety and effectiveness beyond four days in patients with the common cold have not been established
  • Nasal spray 0.06%: symptomatic relief of rhinorrhea associated with the common cold, children age 5-11 years
    • Two sprays (84 mcg) per nostril three times daily (total dose of 504 mcg/day)
    • Safety and effectiveness beyond four days in patients with the common cold have not been established
  • Nasal spray 0.06%: symptomatic relief of rhinorrhea associated with seasonal allergic rhinitis, adults and children age 5 years and older
    • Two sprays (84 mcg) per nostril four times daily (total dose 672 mcg/day)
    • Safety and effectiveness beyond three weeks in patients with seasonal allergic rhinitis have not been established
  • HFA inhalation aerosol (ipratropium bromide HFA / Atrovent HFA): usual starting dose
    • Two inhalations four times a day
    • Patients may take additional inhalations as required
    • Maximum: total number of inhalations should not exceed 12 in 24 hours
  • Inhalation solution (unit-dose vial, 500 mcg in 2.5 mL normal saline)
    • 500 mcg (1 Unit-Dose Vial) administered three to four times a day by oral nebulization, with doses 6 to 8 hours apart
    • Can be mixed in the nebulizer with albuterol or metaproterenol if used within one hour
Read the label’s full dosing text

DOSAGE AND ADMINISTRATION: For Symptomatic Relief of Rhinorrhea Associated with the Common Cold: The recommended dose of Ipratropium Bromide Nasal Solution 0.06% (Nasal Spray) is two sprays (84 mcg) per nostril three or four times daily (total dose 504 to 672 mcg/day) in adults and children age 12 years and older. Optimum dosage varies with response of the individual patient. The recommended dose of Ipratropium Bromide Nasal Solution 0.06% (Nasal Spray) for children age 5-11 years is two sprays (84 mcg) per nostril three times daily (total dose of 504 mcg/day). The safety and effectiveness of the use of Ipratropium Bromide Nasal Solution 0.06% (Nasal Spray) beyond four days in patients with the common cold have not been established. For Symptomatic Relief of Rhinorrhea Associated with Seasonal Allergic Rhinitis: The recommended dose of Ipratropium Bromide Nasal Solution 0.06% (Nasal Spray) is two sprays (84 mcg) per nostril four times daily (total dose 672 mcg/day) in adults and children age 5 years and older. The safety and effectiveness of the use of Ipratropium Bromide Nasal Solution 0.06% (Nasal Spray) beyond three weeks in patients with seasonal allergic rhinitis have not been established. Initial pump priming requires seven sprays of the pump. If used regularly as recommended, no further priming is required. If not used for more than 24 hours, the pump will require two sprays, or if not used for more than seven days, the pump will require seven sprays to reprime. Avoid spraying into eyes.

Read the full Dosage and Administration section on DailyMed →

Ipratropium side effects

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The most common side effects reported across ipratropium products include:

Common side effects

  • Dry mouth
  • Headache
  • Bronchitis or worsening COPD symptoms
  • Shortness of breath (dyspnea)
  • Nausea
  • Dizziness
  • Bitter taste in the mouth
  • Sinus irritation or congestion
  • Bronchitis or COPD flares
  • Upset stomach (dyspepsia)

When to get medical help

  • Call your doctor right away if you have sudden worsening of breathing or wheezing after using the inhaler — this could be paradoxical bronchospasm, a rare but serious reaction
  • Seek emergency help if you have signs of a severe allergic reaction: hives, swelling of the face, lips, tongue or throat, or trouble swallowing
  • Contact your doctor if you notice eye pain, blurred vision, halos around lights, or redness in the eyes — these may be signs of increased pressure in the eye (narrow-angle glaucoma)
  • Tell your doctor if you have trouble urinating or feel like your bladder doesn't empty fully
  • Seek care if you experience rapid or irregular heartbeat

Ipratropium warnings and precautions

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  • Not for acute attacks: The inhaled forms are maintenance medicines — they are not rescue inhalers for sudden breathing emergencies. Always have a fast-acting rescue medicine available if your doctor has prescribed one.
  • Paradoxical bronchospasm: Rarely, ipratropium can cause airways to tighten instead of opening — a potentially life-threatening reaction. Stop the medicine immediately and seek care if this happens.
  • Eye pressure risk: Ipratropium can raise pressure inside the eye and worsen narrow-angle glaucoma. Do not get the spray or aerosol in your eyes. Seek care immediately if you notice eye pain, blurred vision, or halos around lights.
  • Urinary retention: Men with an enlarged prostate and anyone with a bladder obstruction should use ipratropium cautiously — it can make urination difficult. Tell your doctor if this becomes a problem.
  • Severe allergic reactions: Anaphylaxis (a life-threatening allergic response) has been reported. Stop the medicine and get emergency help if you develop swelling of the face, lips, tongue, or throat, or have trouble breathing.

Ipratropium interactions

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Ipratropium has a key interaction to know about:

  • Other anticholinergic medicines: Taking ipratropium together with other anticholinergic drugs can add up their effects — increasing the risk of dry mouth, difficulty urinating, and eye pressure problems. Avoid combining them unless your doctor specifically approves it.
  • Nebulizer combinations (inhalation solution only): Ipratropium Bromide inhalation solution can be mixed with albuterol or metaproterenol in the nebulizer if used within one hour. Mixing with other drugs in the nebulizer has not been established as safe and should be avoided.

Interactions listed in the FDA-approved label

From the Ipratropium prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Anticholinergic-containing drugs: There is potential for an additive interaction with concomitantly used anticholinergic medications, which may lead to an increase in anticholinergic adverse effects. Avoid coadministration of ipratropium bromide HFA inhalation aerosol with other anticholinergic-containing drugs.
  • Albuterol: The label states that albuterol is the exception to the lack of formal studies evaluating interaction effects of ipratropium bromide HFA inhalation aerosol on safety and effectiveness.
  • Sympathomimetic bronchodilators, methylxanthines, oral and inhaled steroids: Ipratropium bromide HFA inhalation aerosol has been used concomitantly with these drugs commonly used in COPD, but there are no formal studies fully evaluating the interaction effects on safety and effectiveness.
Read the label’s full interactions text

Drug Interactions: No controlled clinical trials were conducted to investigate potential drug-drug interactions. There is potential for an additive interaction with other concomitantly administered medications with anticholinergic properties, including Ipratropium Bromide Nasal Solution 0.06% (Nasal Spray) for oral inhalation.

Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

Check Ipratropium against a supplement or herb →

Before taking Ipratropium

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  • Allergy to ipratropium or atropine: Do not use ipratropium if you are allergic to it, atropine, or any of its derivatives — this is a contraindication.
  • Narrow-angle glaucoma: Use with caution; ipratropium can raise eye pressure and worsen this condition.
  • Enlarged prostate or bladder obstruction: Use with caution; ipratropium can cause or worsen difficulty urinating.
  • Pregnancy: Inhaled ipratropium is negligibly absorbed into the bloodstream, so fetal exposure is expected to be very low. Published studies have not identified a drug-related risk of major birth defects. Still, discuss with your doctor.
  • Breastfeeding: Ipratropium levels in breast milk are expected to be low given how little is absorbed after inhalation. Discuss the benefits and risks with your doctor.
  • Children: The inhaled aerosol forms have not been established as safe and effective in children. The nasal spray is approved for children aged 5 and older.
  • Older adults (65+): Studies show similar effectiveness and safety in older adults compared to younger patients — no dose adjustment is specifically noted, but discuss your full health picture with your prescriber.
  • Liver or kidney disease: The pharmacokinetics of ipratropium have not been studied in people with liver or kidney problems; let your doctor know if you have these conditions.

Ipratropium overdose

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An overdose from the nasal spray is unlikely because ipratropium is poorly absorbed through the nasal lining and the gut. In studies, even large oral doses did not significantly change heart rate or blood pressure. If someone accidentally swallows a large amount or uses far more than prescribed, contact Poison Control or seek medical care right away as a precaution.

What Ipratropium does in the body

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In clinical studies, ipratropium at usual doses did not significantly affect heart rate, blood pressure, or pupil size, confirming that its action stays mostly local rather than spreading through the body. For the nasal spray, studies showed that it reduces nasal secretions within 15 minutes of use. In controlled trials, it did not affect normal nasal functions such as sense of smell, the ability of the nose to humidify air, or the movement of mucus through the nasal passages.

How your body processes Ipratropium

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Ipratropium is poorly absorbed — less than 20% enters the bloodstream after nasal use, and only 2–3% is absorbed after swallowing, which is why systemic side effects are uncommon. Once in the body, it is minimally bound to proteins in the blood and does not cross into the brain. It is partially broken down by the body into inactive products, and about half of an intravenous dose is excreted unchanged in the urine within 24 hours. The half-life (the time for half the drug to clear the body) is approximately 1.6 hours after intravenous dosing.

How to store Ipratropium

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Store tightly closed at 20° to 25°C (68° to 77°F) . Avoid freezing. Keep out of reach of children.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

Ipratropium: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Ipratropium — the kind of thing our pharmacy team would talk through with you at the counter.

My doctor gave me an ipratropium inhaler — can I use it when I have a sudden asthma attack?

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No, the ipratropium inhaler (like Atrovent HFA) is a maintenance medicine — it's meant to be used regularly every day to keep your airways open, not as a rescue inhaler during a sudden attack. If you're having a sudden flare-up, you need a fast-acting rescue inhaler like albuterol. Make sure you have one available, and let your doctor know if you don't.

The nasal spray helps my runny nose, but can I keep using it past a week?

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It depends on why you're using it. For a common cold, safety and effectiveness have only been established for up to 4 days. For seasonal allergies (hay fever), it's been studied for up to 3 weeks. Using it longer than that isn't recommended unless your doctor specifically tells you to. If your symptoms are lasting longer, check back in with your prescriber.

I got some of the inhaler spray in my eye by accident — is that a big deal?

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It can be. Getting ipratropium in your eye can cause eye pain, blurred vision, redness, and in people with a certain type of glaucoma (narrow-angle glaucoma), it can raise the pressure inside the eye. If you accidentally spray it in your eye, rinse well right away. If you notice pain, vision changes, or halos around lights afterward, call your doctor promptly. Always try to aim the inhaler or nasal spray away from your eyes.

I take another medication for my bladder — is that okay to combine with ipratropium?

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It depends on what your bladder medication is. If it's also an anticholinergic drug, combining it with ipratropium can increase side effects like difficulty urinating, dry mouth, and eye pressure problems. Please share a full list of your medications with your pharmacist or doctor before starting ipratropium so they can check for any overlap.

Will the ipratropium nasal spray help with my stuffy nose and sneezing too?

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Unfortunately, no. The nasal spray is specifically approved to reduce a runny nose — it works by cutting down mucus production. It does not relieve nasal congestion (stuffiness) or sneezing, whether those are from a cold or from seasonal allergies. You may need a separate medicine for those symptoms, so talk to your pharmacist or doctor about what would work best for your full set of symptoms.

I'm pregnant — is it safe for me to use the ipratropium inhaler?

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Inhaled ipratropium is very poorly absorbed into the bloodstream, so very little of it reaches the baby. Published studies over many years have not found a drug-related risk of major birth defects. That said, you should always let your doctor know you're pregnant so they can weigh the benefits and risks for your specific situation and make sure you're on the best treatment plan.

Is Ipratropium available over the counter?

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No. Ipratropium is a prescription medicine: every Ipratropium product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Ipratropium first available?

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The earliest FDA record we hold for Ipratropium is from 1986: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Ipratropium was first used.

Who makes Ipratropium?

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24 companies currently list Ipratropium products in the FDA's NDC Directory, including A-S Medication Solutions, Advagen Pharma Ltd, Amneal Pharmaceuticals NY LLC. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Ipratropium on HelloPharmacist

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Detailed data & references for Ipratropium Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Ipratropium forms and strengths (how it comes)

Ipratropium is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Ipratropium inactive ingredients by manufacturer.

Nasal spray

In the nose
Brands Ipratropium Bromide
How this form is used
What it may be used for
  • Ipratropium Bromide nasal spray 0.06% is used to relieve a runny nose (rhinorrhea) caused by the common cold in adults and children aged 5 and older
  • Ipratropium Bromide nasal spray 0.06% is used to relieve a runny nose (rhinorrhea) caused by seasonal allergic rhinitis in adults and children aged 5 and older
  • Ipratropium Bromide nasal spray does not relieve nasal congestion or sneezing
Important instructions
  • Ipratropium Bromide nasal spray requires initial priming with 7 sprays before first use; reprime with 2 sprays if unused for more than 24 hours, or 7 sprays if unused for more than 7 days
  • Avoid spraying Ipratropium Bromide nasal spray into your eyes
  • For colds, use Ipratropium Bromide nasal spray for no more than 4 days; for seasonal allergic rhinitis, use for no more than 3 weeks
  • Follow your prescriber's or label instructions for the number of sprays per nostril and how many times per day
Available strengths 2 strengths
21 mcg 42 mcg
41 FDA-listed product records ⓘ

Inhalation solution (nebulizer)

Inhaled
Brands Ipratropium Bromide
How this form is used
What it may be used for
  • Ipratropium Bromide inhalation solution is used as a maintenance bronchodilator for bronchospasm associated with COPD, including chronic bronchitis and emphysema
  • Ipratropium Bromide inhalation solution can be used alone or alongside other bronchodilators, especially beta-adrenergic medicines
Important instructions
  • Ipratropium Bromide inhalation solution is taken by nebulizer, inhaled through the mouth, typically three to four times a day with doses spaced 6 to 8 hours apart
  • Ipratropium Bromide inhalation solution may be mixed in the nebulizer with albuterol or metaproterenol only if used within one hour of mixing
  • Do not mix Ipratropium Bromide inhalation solution with other drugs in the nebulizer, as safety of other combinations has not been established
  • Follow your prescriber's instructions for dosing; do not change the frequency without guidance
Available strengths 1 strength
0.5 mg/2.5 mL
23 FDA-listed product records ⓘ

Inhaler

Inhaled
Brands Atrovent Ipratropium Bromide Inhalation
How this form is used
What it may be used for
  • Atrovent HFA is used as a maintenance bronchodilator for bronchospasm associated with COPD, including chronic bronchitis and emphysema
  • Ipratropium Bromide Inhalation aerosol is used as a maintenance bronchodilator for bronchospasm associated with COPD, including chronic bronchitis and emphysema
Important instructions
  • Atrovent HFA and Ipratropium Bromide Inhalation aerosol are for oral inhalation only — inhaled through the mouth, not the nose
  • Atrovent HFA and Ipratropium Bromide Inhalation aerosol are solution aerosols that do not require shaking, but coordination between pressing the canister and inhaling is important
  • Prime Atrovent HFA or Ipratropium Bromide Inhalation aerosol before first use by releasing 2 test sprays into the air; reprime with 2 sprays if the inhaler has not been used for more than 3 days
  • Avoid spraying Atrovent HFA or Ipratropium Bromide Inhalation aerosol into your eyes; discard the inhaler after the labeled number of actuations
Available strengths 1 strength
17 mcg
4 FDA-listed product records ⓘ

Ipratropium on the U.S. market: products, makers and brands

How Ipratropium appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

24 companies list 35 Ipratropium product records with the FDA, mostly as nasal spray, inhalation solution (nebulizer), inhaler; the earliest marketing or approval year on record is 1986. Brand names on the directory include Atrovent, Ipratropium Bromide, Atrovent HFA and 1 more; the rest are generics.

3
Dose forms ⓘ
24
Labelers (makers, repackagers, distributors)
4
Brand names
35
FDA-listed product records ⓘ
1986
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (11) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

A-S Medication Solutions9%
Advagen Pharma Ltd6%
Amneal Pharmaceuticals NY LLC6%
Apotex Corp.6%
Bausch & Lomb Incorporated6%
Bryant Ranch Prepack6%
Other makers63%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Ipratropium is used (Medicaid data)

A general measure of how commonly Ipratropium is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Ipratropium is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

583,555
Medicaid prescriptions filled (Q1–Q4 2025)
$41.5M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Ipratropium prescribed? Of the 1,601 medications we measure, Ipratropium ranks #245 by Medicaid prescriptions — more than 85% of them.

Where Ipratropium ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #245 of 1,601
#240 Drospirenone / Ethinyl... 601,035 Rx #241 Ciprofloxacin and Dexa... 600,153 Rx #242 Olopatadine 588,951 Rx #243 Ethinyl Estradiol / No... 587,481 Rx #244 Clozapine 587,393 Rx #245 Ipratropium 583,555 Rx #246 Benzoyl Peroxide Topic... 583,362 Rx #247 Benzoyl Peroxide 583,362 Rx #248 Iohexol 580,886 Rx #249 Estradiol Transdermal... 575,018 Rx #250 Olopatadine Ophthalmic 567,428 Rx

Utilization by Ipratropium product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 0.2 mg/mL inhalation solution is the most-dispensed Ipratropium product — about 35% of these Medicaid prescriptions.

ipratropium bromide 0.2 MG/ML Inhalation Solution Most dispensed

204,274 Medicaid prescriptions (Q1–Q4 2025) 35% of Ipratropium prescriptions shown $4M gross reimbursement (before rebates) ≈ $19 per prescription (gross)

Summed across the 20 of 48 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 836358

ipratropium bromide 0.042 MG/ACTUAT Metered Dose Nasal Spray

162,187 Medicaid prescriptions (Q1–Q4 2025) 28% of Ipratropium prescriptions shown $4.1M gross reimbursement (before rebates) ≈ $25 per prescription (gross)

Summed across the 7 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1797844

ipratropium bromide 0.021 MG/ACTUAT Metered Dose Nasal Spray

123,336 Medicaid prescriptions (Q1–Q4 2025) 21% of Ipratropium prescriptions shown $3.2M gross reimbursement (before rebates) ≈ $26 per prescription (gross)

Summed across the 7 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1797833

200 ACTUAT ipratropium bromide 0.017 MG/ACTUAT Metered Dose Inhaler

93,758 Medicaid prescriptions (Q1–Q4 2025) 16% of Ipratropium prescriptions shown $30.3M gross reimbursement (before rebates) ≈ $323 per prescription (gross)

Summed across the 1 of 4 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 836343

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Ipratropium, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 35 of 72 listed Ipratropium NDCs with Medicaid activity.

Compare Ipratropium products

A representative set of FDA-listed product records for Ipratropium — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 35 of 35 products — FDA National Drug Code Directory. See every product, package size and price: browse all 35 Ipratropium NDCs →

Ipratropium recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list one Ipratropium recall since July 2021. It is no longer listed as ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Class II Apr 13, 2022 · Terminated · Mckesson Medical-Surgical Inc. Corporate Office
cGMP deviations: Temperature abuse
  • Ipratropium Bromide Inhalation Solution, 0.02%, 0.5 mg/2.5 mL, packaged in 25-count box (25 x 2.5 mL sterile unit-dose vials), Rx only, MFG: Nephron Pharma, NDC 0487-9801-25 Lots: McKesson Medical-Surgical (MMS) is not able to identify the particular lot number received by a particular consignee for the recalled prescription products. Each letter includes the date it was distributed to customers and the dates that i… FDA record D-1040-2022 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Oct 8, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Ipratropium RxCUI 7213 3 dose forms · 4 strengths
  1. Dose form (SCDF) Inhalation Solution RxCUI 2108449 In current FDA listings
    Clinical drug / strength (SCD) bromide 0.2 MG/ML RxCUI 836358

Look up RxCUI 7213 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

💵 What Ipratropium costs pharmacies (NADAC benchmark)

The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

FormStrengthPharmacy acquisition benchmark
Spray, Metered · Nasal 42 mcg $0.778 per mL NDC details & price history
Spray, Metered · Nasal 21 mcg $0.368 per mL NDC details & price history
Solution · Respiratory (inhalation) 0.5 mg/2.5 mL $0.104–$0.112 per mL NDC details & price history
Spray · Nasal 42 mcg $0.778 per mL NDC details & price history
Spray · Nasal 21 mcg $0.368 per mL NDC details & price history
Aerosol, Metered · Respiratory (inhalation) 17 mcg $22.76 per gram NDC details & price history
Aerosol · Respiratory (inhalation) 17 mcg $22.11 per gram NDC details & price history
Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

Ipratropium brand names

Ipratropium is sold under 4 brand names in the FDA directory — Atrovent, Ipratropium Bromide, Atrovent HFA, Ipratropium Bromide Inhalation. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Atrovent Ipratropium Bromide Atrovent HFA Ipratropium Bromide Inhalation

Who makes Ipratropium: manufacturers and labelers

24 companies list Ipratropium products with the FDA. By number of product records, the largest are A-S Medication Solutions, Advagen Pharma Ltd, Amneal Pharmaceuticals NY LLC. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

A-S Medication Solutions 3 Advagen Pharma Ltd 2 Amneal Pharmaceuticals NY LLC 2 Apotex Corp. 2 Bausch & Lomb Incorporated 2 Bryant Ranch Prepack 2 Cardinal Health 107, LLC 2 Hikma Pharmaceuticals USA Inc. 2 Lupin Pharmaceuticals, Inc. 2 Northstar Rx Llc 2 American Health Packaging 1 Armstrong Pharmaceuticals, Inc. 1 Aurobindo Pharma Limited 1 Boehringer Ingelheim Pharmaceuticals, Inc. 1 Chartwell RX, LLC 1 Mylan Pharmaceuticals Inc. 1 Nephron Pharmaceuticals Corporation 1 NuCare Pharmaceuticals, Inc. 1 Oceanside Pharmaceuticals 1 Redpharm Drug 1 Rising Pharma Holdings, Inc. 1 Ritedose Pharmaceuticals, LLC 1 Sportpharm LLC 1 Sun Pharmaceutical Industries, Inc. 1

Ipratropium drug class (RxNorm)

Ipratropium belongs to the Anticholinergic class.

Pharmacologic class Anticholinergic
Drug family (ATC) Other nasal preparations, Anticholinergics
How it works Cholinergic Antagonists

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Ipratropium page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective May 1, 2019
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Ipratropium.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Ipratropium after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
20
Finished products in the current FDA directory
35
Companies listing them (makers, repackagers, distributors)
24
FDA labeler codes behind them ⓘ
24
Linked representative label ⓘ
Bausch & Lomb Incorporated
Linked label effective
May 1, 2019
Composite sections available
19
Linked SPL Set ID
3fd850a2-af0f-4291-af5d-52c8d6094e64
Linked SPL Document ID
24982952-0064-4ed9-8276-210e482c8358
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 1

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Bausch & Lomb Incorporated is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →