Inactive ingredients by manufacturer

Methotrexate inactive ingredients by manufacturer

Wondering whether your Methotrexate has lactose, gluten, soy, a dye or gelatin in it? The medicine is the same, but the fillers, coatings and colors differ from one company to the next. This page shows what each Methotrexate product's FDA label lists, so you can find a version that leaves out what you avoid and ask your pharmacist for it by its NDC.

We have read the FDA labels of 75 of the 75 current Methotrexate products on the market today, from 33 companies listing it with the FDA, and lined them up side by side.

Dr. Brian Staiger, PharmD, BCPS
Curated and coded by Dr. Brian Staiger, PharmD, BCPS, clinical pharmacist. The ingredient groups this page checks for (what counts as a gluten source, a synthetic dye, soy and so on) are his classification; the lists themselves are the manufacturers' own FDA labels. Updated October 6, 2026. Rebuilt daily from the FDA directory; labels re-read when the FDA publishes a new version.

Ask about your bottle

Is there something in your Methotrexate? Ask in plain words.

Name the company, strength or the NDC on your bottle and the ingredient you avoid. The answer comes only from the FDA labels on this page.

Answers are drawn from the FDA label data on this page and checked against it. They are not medical advice: confirm with your pharmacist before relying on them.

The short answer

Which Methotrexate products list lactose, a gluten source, soy, dyes or gelatin?

  1. LactoseDiffers by manufacturer

    33 of 75 checked products list lactose; 42 do not. See which products do not list it

  2. Wheat or gluten sourceNo checked product

    No checked Methotrexate product lists a wheat or gluten source.

  3. SoyNo checked product

    No checked Methotrexate product lists soy.

  4. Synthetic dyesDiffers by manufacturer

    9 of 75 checked products list synthetic dyes; 66 do not. See which products do not list it

  5. GelatinNo checked product

    No checked Methotrexate product lists gelatin.

Also listed by some products: Corn 31 of 75 Titanium dioxide 4 of 75 Benzyl alcohol 4 of 75 Propylene glycol 4 of 75 PEG or polysorbate 9 of 75

Find a version without it

Every current Methotrexate product and what its label lists

Hide products that list:

Methotrexate 7.5 mg/0.15 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
MedexusNDC 59137-0505-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
Methotrexate 10 mg/0.2 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
MedexusNDC 59137-0510-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
Methotrexate 10 mg/0.4 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
AntaresNDC 54436-0010-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, WATER
Methotrexate 12.5 mg/0.4 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
AntaresNDC 54436-0012-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, WATER
Methotrexate 12.5 mg/0.25 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
MedexusNDC 59137-0515-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
Methotrexate 15 mg/0.3 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
MedexusNDC 59137-0520-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
Methotrexate 15 mg/0.4 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
AntaresNDC 54436-0015-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, WATER
Methotrexate 17.5 mg/0.4 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
AntaresNDC 54436-0017-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, WATER
Methotrexate 17.5 mg/0.35 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
MedexusNDC 59137-0525-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
Methotrexate 20 mg/0.4 mL injection 2 companies none of the tracked ingredients
CompanyListsInactive ingredients on the label
AntaresNDC 54436-0020-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, WATER
MedexusNDC 59137-0530-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
Methotrexate 22.5 mg/0.4 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
AntaresNDC 54436-0022-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, WATER
Methotrexate 22.5 mg/0.45 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
MedexusNDC 59137-0535-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
Methotrexate 25 mg/0.4 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
AntaresNDC 54436-0025-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, WATER
Methotrexate 25 mg/0.5 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
MedexusNDC 59137-0540-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
Methotrexate 25 mg/mL injection 17 companies Benzyl alcohol 4
CompanyListsInactive ingredients on the label
Accord Healthcare, Inc.NDC 16729-0277-03 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
Alembic Pharmaceuticals Inc.NDC 62332-0711-05 Benzyl alcohol
Show 5 ingredients

BENZYL ALCOHOL, HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
Alembic Pharmaceuticals Inc.NDC 62332-0712-01 None of these listed
Show 4 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
Alembic Pharmaceuticals LimitedNDC 46708-0711-05 Benzyl alcohol
Show 5 ingredients

BENZYL ALCOHOL, HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
Alembic Pharmaceuticals LimitedNDC 46708-0712-01 None of these listed
Show 4 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
Fresenius KabiNDC 63323-0123-10 Benzyl alcohol
Show 4 ingredients

BENZYL ALCOHOL, HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
HikmaNDC 00143-9516-01 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
HikmaNDC 00143-9517-01 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
HikmaNDC 00143-9518-01 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
HikmaNDC 00143-9519-10 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
HospiraNDC 61703-0124-40 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
HospiraNDC 61703-0161-05 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
HospiraNDC 61703-0350-10 Benzyl alcohol
Show 5 ingredients

BENZYL ALCOHOL, HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
HospiraNDC 61703-0408-25 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
Teva Parenteral MedicinesNDC 00703-3671-01 None of these listed
Show 4 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
Teva Parenteral MedicinesNDC 00703-3675-01 None of these listed
Show 4 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
Teva Parenteral MedicinesNDC 00703-3678-01 None of these listed
Show 4 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
Methotrexate 30 mg/0.6 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
MedexusNDC 59137-0550-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
Methotrexate 50 mg/2 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
EugiaNDC 55150-0510-01 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
Methotrexate 100 mg/4 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
EugiaNDC 55150-0511-01 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
Methotrexate 200 mg/8 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
EugiaNDC 55150-0512-01 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
Methotrexate 250 mg/10 mL injection 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
EugiaNDC 55150-0513-01 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
Methotrexate 1 g injection 3 companies none of the tracked ingredients
CompanyListsInactive ingredients on the label
Fresenius KabiNDC 63323-0122-50 None of these listed
Show 2 ingredients

HYDROCHLORIC ACID, SODIUM HYDROXIDE
HikmaNDC 00143-9367-01 None of these listed
Show 2 ingredients

HYDROCHLORIC ACID, SODIUM HYDROXIDE
HikmaNDC 00143-9830-01 None of these listed
Show 2 ingredients

HYDROCHLORIC ACID, SODIUM HYDROXIDE
Methotrexate 2.5 mg tablet 29 companies Lactose 29 Corn-derived 27 Propylene glycol 4 Polyethylene glycol or polysorbate 4 Synthetic dyes 5
CompanyListsInactive ingredients on the label
A-S Medication SolutionsNDC 50090-5457-02 Lactose Corn-derived Propylene glycol Polyethylene glycol or polysorbate
Show 9 ingredients

ANHYDROUS LACTOSE, HYPROMELLOSE, UNSPECIFIED, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL, UNSPECIFIED, PROPYLENE GLYCOL, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC
Accord Healthcare Inc.NDC 16729-0486-01 Lactose Corn-derived
Show 3 ingredients

ANHYDROUS LACTOSE, MAGNESIUM STEARATE, STARCH, CORN
Alembic Pharmaceuticals Inc.NDC 62332-0730-31 Lactose Corn-derived
Show 4 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, STARCH, CORN
Alembic Pharmaceuticals LimitedNDC 46708-0730-31 Lactose Corn-derived
Show 4 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, STARCH, CORN
AurobindoNDC 59651-0182-01 Lactose Corn-derived
Show 3 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, STARCH, CORN
AvKARENDC 42291-0594-01 Lactose Corn-derived Propylene glycol Polyethylene glycol or polysorbate
Show 9 ingredients

ANHYDROUS LACTOSE, CELLULOSE, MICROCRYSTALLINE, HYPROMELLOSES, MAGNESIUM STEARATE, POLYETHYLENE GLYCOL, UNSPECIFIED, PROPYLENE GLYCOL, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC
AvPAKNDC 50268-0554-15 Lactose Corn-derived
Show 5 ingredients

ANHYDROUS LACTOSE, CELLULOSE, MICROCRYSTALLINE, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, STARCH, CORN
Bryant Ranch PrepackNDC 71335-0782-01 Lactose Corn-derived Propylene glycol Polyethylene glycol or polysorbate
Show 9 ingredients

ANHYDROUS LACTOSE, HYPROMELLOSE, UNSPECIFIED, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL, UNSPECIFIED, PROPYLENE GLYCOL, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC
Bryant Ranch PrepackNDC 71335-1118-01 Lactose Corn-derived Synthetic dyes
Show 9 ingredients

FD&C RED NO. 40, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, SILICON DIOXIDE, SODIUM CARBONATE MONOHYDRATE, SODIUM LAURYL SULFATE, SODIUM STARCH GLYCOLATE TYPE A POTATO, STARCH, CORN
Bryant Ranch PrepackNDC 71335-1772-01 Lactose Corn-derived
Show 3 ingredients

ANHYDROUS LACTOSE, MAGNESIUM STEARATE, STARCH, CORN
Bryant Ranch PrepackNDC 71335-2221-01 Lactose Corn-derived
Show 3 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, STARCH, CORN
Bryant Ranch PrepackNDC 72162-2174-01 Lactose
Show 3 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE
Bryant Ranch PrepackNDC 72162-2647-01 Lactose Corn-derived
Show 4 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, STARCH, CORN
Chartwell RXNDC 62135-0772-35 Lactose Corn-derived
Show 3 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, STARCH, CORN
CouplerNDC 67046-1524-03 Lactose Corn-derived
Show 3 ingredients

ANHYDROUS LACTOSE, MAGNESIUM STEARATE, STARCH, CORN
EliteNDC 64850-0330-01 Lactose Corn-derived
Show 3 ingredients

Lactose Monohydrate, MAGNESIUM STEARATE, STARCH, CORN
Golden State Medical SupplyNDC 51407-0121-01 Lactose Corn-derived Synthetic dyes
Show 9 ingredients

FD&C RED NO. 40, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, SILICON DIOXIDE, SODIUM CARBONATE MONOHYDRATE, SODIUM LAURYL SULFATE, SODIUM STARCH GLYCOLATE TYPE A POTATO, STARCH, CORN
HikmaNDC 00054-4550-15 Lactose Corn-derived
Show 5 ingredients

ANHYDROUS LACTOSE, MAGNESIUM STEARATE, SODIUM HYDROXIDE, SODIUM STARCH GLYCOLATE TYPE A POTATO, STARCH, CORN
MajorNDC 00904-7141-10 Lactose Corn-derived
Show 5 ingredients

ANHYDROUS LACTOSE, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, STARCH, CORN
MylanNDC 00378-0014-01 Lactose Corn-derived Synthetic dyes
Show 9 ingredients

FD&C RED NO. 40, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, SILICON DIOXIDE, SODIUM CARBONATE MONOHYDRATE, SODIUM LAURYL SULFATE, SODIUM STARCH GLYCOLATE TYPE A POTATO, STARCH, CORN
Mylan InstitutionalNDC 51079-0670-05 Lactose Corn-derived Synthetic dyes
Show 9 ingredients

FD&C RED NO. 40, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, SILICON DIOXIDE, SODIUM CARBONATE MONOHYDRATE, SODIUM LAURYL SULFATE, SODIUM STARCH GLYCOLATE TYPE A POTATO, STARCH, CORN
NuCareNDC 68071-3765-06 Lactose Corn-derived
Show 3 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, STARCH, CORN
NuCareNDC 68071-3991-09 Lactose Corn-derived
Show 3 ingredients

ANHYDROUS LACTOSE, MAGNESIUM STEARATE, STARCH, CORN
Proficient RxNDC 82804-0136-30 Lactose Corn-derived
Show 3 ingredients

ANHYDROUS LACTOSE, MAGNESIUM STEARATE, STARCH, CORN
Safecor HealthNDC 48433-0065-05 Lactose Corn-derived Synthetic dyes
Show 9 ingredients

FD&C RED NO. 40, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, SILICON DIOXIDE, SODIUM CARBONATE MONOHYDRATE, SODIUM LAURYL SULFATE, SODIUM STARCH GLYCOLATE TYPE A POTATO, STARCH, CORN
SunNDC 47335-0235-83 Lactose
Show 3 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE
TevaNDC 00555-0572-02 Lactose Corn-derived Propylene glycol Polyethylene glycol or polysorbate
Show 9 ingredients

ANHYDROUS LACTOSE, HYPROMELLOSES, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL, UNSPECIFIED, PROPYLENE GLYCOL, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC
ZydusNDC 68382-0775-01 Lactose Corn-derived
Show 5 ingredients

ANHYDROUS LACTOSE, CELLULOSE, MICROCRYSTALLINE, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, STARCH, CORN
Zydus LifesciencesNDC 70771-1058-00 Lactose Corn-derived
Show 5 ingredients

ANHYDROUS LACTOSE, CELLULOSE, MICROCRYSTALLINE, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, STARCH, CORN
Methotrexate 5 mg tablet 1 company Lactose 1 Corn-derived 1 Synthetic dyes 1 Titanium dioxide 1 Polyethylene glycol or polysorbate 1
CompanyListsInactive ingredients on the label
Teva Women's HealthNDC 51285-0366-01 Lactose Corn-derived Synthetic dyes Titanium dioxide Polyethylene glycol or polysorbate
Show 15 ingredients

ANHYDROUS LACTOSE, CROSPOVIDONE (15 MPA.S AT 5%), D&C YELLOW NO. 10 ALUMINUM LAKE, FD&C BLUE NO. 1 ALUMINUM LAKE, FD&C YELLOW NO. 6, HYPROMELLOSE 2910 (3 MPA.S), HYPROMELLOSE 2910 (6 MPA.S), MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL 400, POLYSORBATE 80, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC, TITANIUM DIOXIDE
Methotrexate 7.5 mg tablet 1 company Lactose 1 Corn-derived 1 Synthetic dyes 1 Titanium dioxide 1 Polyethylene glycol or polysorbate 1
CompanyListsInactive ingredients on the label
Teva Women's HealthNDC 51285-0367-01 Lactose Corn-derived Synthetic dyes Titanium dioxide Polyethylene glycol or polysorbate
Show 13 ingredients

ANHYDROUS LACTOSE, CROSPOVIDONE (15 MPA.S AT 5%), FD&C BLUE NO. 1 ALUMINUM LAKE, HYPROMELLOSE 2910 (3 MPA.S), HYPROMELLOSE 2910 (6 MPA.S), MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL 400, POLYSORBATE 80, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC, TITANIUM DIOXIDE
Methotrexate 10 mg tablet 1 company Lactose 1 Corn-derived 1 Synthetic dyes 1 Titanium dioxide 1 Polyethylene glycol or polysorbate 1
CompanyListsInactive ingredients on the label
Teva Women's HealthNDC 51285-0368-01 Lactose Corn-derived Synthetic dyes Titanium dioxide Polyethylene glycol or polysorbate
Show 13 ingredients

ANHYDROUS LACTOSE, CROSPOVIDONE (15 MPA.S AT 5%), FD&C RED NO. 40, HYPROMELLOSE 2910 (3 MPA.S), HYPROMELLOSE 2910 (6 MPA.S), MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL 400, POLYSORBATE 80, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC, TITANIUM DIOXIDE
Methotrexate 15 mg tablet 1 company Lactose 1 Corn-derived 1 Synthetic dyes 1 Titanium dioxide 1 Polyethylene glycol or polysorbate 1
CompanyListsInactive ingredients on the label
Teva Women's HealthNDC 51285-0369-01 Lactose Corn-derived Synthetic dyes Titanium dioxide Polyethylene glycol or polysorbate
Show 14 ingredients

ANHYDROUS LACTOSE, CROSPOVIDONE (15 MPA.S AT 5%), FD&C BLUE NO. 2--ALUMINUM LAKE, FD&C RED NO. 40, HYPROMELLOSE 2910 (3 MPA.S), HYPROMELLOSE 2910 (6 MPA.S), MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL 400, POLYSORBATE 80, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC, TITANIUM DIOXIDE
Methotrexate 2 mg/mL oral solution 1 company Polyethylene glycol or polysorbate 1
CompanyListsInactive ingredients on the label
Shorla OncologyNDC 81927-0204-01 Polyethylene glycol or polysorbate
Show 8 ingredients

CITRIC ACID MONOHYDRATE, ETHYLPARABEN, GLYCERIN, METHYLPARABEN SODIUM, POLYETHYLENE GLYCOL, SODIUM CITRATE, SUCRALOSE, WATER
Methotrexate 2.5 mg/mL oral solution 1 company none of the tracked ingredients
CompanyListsInactive ingredients on the label
AzurityNDC 52652-2001-01 None of these listed
Show 8 ingredients

CITRIC ACID MONOHYDRATE, HYDROCHLORIC ACID, METHYLPARABEN SODIUM, PROPYLPARABEN SODIUM, SODIUM CITRATE, UNSPECIFIED FORM, SODIUM HYDROXIDE, SUCRALOSE, WATER

A product with none of these listed is not certified to be without them: the label says what the manufacturer declared, and the source of a starch or a flavor is often not stated. The companies are the FDA's labelers, which include repackagers and distributors selling another company's product under their own label. The NDC opens the product's own page, with the full label and its inactive-ingredient notes.

Methotrexate without lactose

Lactose: milk sugar; a concern with lactose intolerance or a milk allergy. 33 of 75 checked products list lactose; 42 do not.

Show which Methotrexate products list lactose and which do not, by product and company

Does not list lactose

Lists lactose

  • 2.5 mg tablet: A-S Medication Solutions, Accord Healthcare Inc., Alembic Pharmaceuticals Inc., Alembic Pharmaceuticals Limited, Aurobindo, AvKARE, AvPAK, Bryant Ranch Prepack, Bryant Ranch Prepack, Bryant Ranch Prepack, Bryant Ranch Prepack, Bryant Ranch Prepack, Bryant Ranch Prepack, Chartwell RX, Coupler, Elite, Golden State Medical Supply, Hikma, Major, Mylan, Mylan Institutional, NuCare, NuCare, Proficient Rx, Safecor Health, Sun, Teva, Zydus, Zydus Lifesciences
  • 5 mg tablet: Teva Women's Health
  • 7.5 mg tablet: Teva Women's Health
  • 10 mg tablet: Teva Women's Health
  • 15 mg tablet: Teva Women's Health

Methotrexate without synthetic dyes

Synthetic dyes: FD&C or D&C colorants and their aluminum lakes. 9 of 75 checked products list synthetic dyes; 66 do not.

Show which Methotrexate products list synthetic dyes and which do not, by product and company

Does not list synthetic dyes

Lists synthetic dyes

Methotrexate without corn-derived ingredients

Corn-derived: corn starch, maize or corn syrup; a concern with corn allergy. 31 of 75 checked products list corn-derived ingredients; 44 do not.

Show which Methotrexate products list corn-derived ingredients and which do not, by product and company

Does not list corn-derived ingredients

Lists corn-derived ingredients

  • 2.5 mg tablet: A-S Medication Solutions, Accord Healthcare Inc., Alembic Pharmaceuticals Inc., Alembic Pharmaceuticals Limited, Aurobindo, AvKARE, AvPAK, Bryant Ranch Prepack, Bryant Ranch Prepack, Bryant Ranch Prepack, Bryant Ranch Prepack, Bryant Ranch Prepack, Chartwell RX, Coupler, Elite, Golden State Medical Supply, Hikma, Major, Mylan, Mylan Institutional, NuCare, NuCare, Proficient Rx, Safecor Health, Teva, Zydus, Zydus Lifesciences
  • 5 mg tablet: Teva Women's Health
  • 7.5 mg tablet: Teva Women's Health
  • 10 mg tablet: Teva Women's Health
  • 15 mg tablet: Teva Women's Health

Methotrexate without titanium dioxide

Titanium dioxide: A white colorant some people choose to avoid. 4 of 75 checked products list titanium dioxide; 71 do not.

Show which Methotrexate products list titanium dioxide and which do not, by product and company

Does not list titanium dioxide

Lists titanium dioxide

Methotrexate without benzyl alcohol

Benzyl alcohol: A preservative, mostly in injections and liquids; not for newborns. 4 of 75 checked products list benzyl alcohol; 71 do not.

Show which Methotrexate products list benzyl alcohol and which do not, by product and company

Does not list benzyl alcohol

Lists benzyl alcohol

  • 25 mg/mL injection: Alembic Pharmaceuticals Inc., Alembic Pharmaceuticals Limited, Fresenius Kabi, Hospira

Methotrexate without propylene glycol

Propylene glycol: A solvent in liquids and capsules; a concern in kidney disease, for infants, and at high doses. 4 of 75 checked products list propylene glycol; 71 do not.

Show which Methotrexate products list propylene glycol and which do not, by product and company

Does not list propylene glycol

Lists propylene glycol

  • 2.5 mg tablet: A-S Medication Solutions, AvKARE, Bryant Ranch Prepack, Teva

Methotrexate without polyethylene glycol or polysorbate

Polyethylene glycol or polysorbate: PEG, macrogol or polysorbate; a rare cause of allergic reactions. 9 of 75 checked products list polyethylene glycol or polysorbate; 66 do not.

Show which Methotrexate products list polyethylene glycol or polysorbate and which do not, by product and company

Does not list polyethylene glycol or polysorbate

Lists polyethylene glycol or polysorbate

At the pharmacy counter

How to use this at the pharmacy counter

  1. Pick the company whose list suits you and copy the NDC from the table. Many pharmacies order from wholesalers that carry several companies' versions and can request a particular one if you ask before the prescription is filled; some buy from one contracted source only, and a few insurance plans cover only certain NDCs, so ask the pharmacist to check.
  2. Treat "does not list" as exactly that. The label is what the manufacturer declared; a flavor or a starch may have an unstated source, and lines change. For celiac disease or a serious allergy, ask the manufacturer's medical information line for a written statement about the lot you have.
  3. Check the bottle each refill. A different company usually means a different shape, color and inactive-ingredient list; the pharmacist can tell you who made it, and the two-NDC comparison shows the difference line by line.
  4. If you need one company's version kept constant, ask your prescriber to write that company or the NDC on the prescription and tell the pharmacy you need it held. Rules vary by state and plan, so confirm with the pharmacist.
Ask Dr. Staiger which Methotrexate product suits you →

Common questions about Methotrexate inactive ingredients

Is Methotrexate gluten-free?
This page cannot certify any Methotrexate product gluten-free; it reports what each label declares. Of the 75 products checked, none lists a wheat, barley, rye or gluten ingredient, and none lists a starch without a stated source. If you have celiac disease, ask the manufacturer's medical information line for a written gluten statement for the lot you have.
Does Methotrexate contain lactose?
33 of 75 checked Methotrexate products list lactose; 42 do not: Accord Healthcare, Inc. (25 mg/mL injection), Alembic Pharmaceuticals Inc. (25 mg/mL injection), Alembic Pharmaceuticals Limited (25 mg/mL injection) and Antares (10 mg/0.4 mL injection, 12.5 mg/0.4 mL injection and 15 mg/0.4 mL injection and 4 more) and 8 other companies. The lactose in a tablet or capsule is a small amount, but people with a milk allergy or a strong intolerance often prefer a version that does not list it.
Does Methotrexate contain soy?
No checked Methotrexate product lists a soy ingredient (soybean oil or soy lecithin) on its label. Soy lecithin is the usual form and the amount is small, but people with a soy allergy often prefer a version that does not list it.
Is there a dye-free Methotrexate?
9 of 75 checked Methotrexate products list a synthetic dye (an FD&C or D&C colorant); 66 do not: A-S Medication Solutions (2.5 mg tablet), Accord Healthcare, Inc. (25 mg/mL injection), Accord Healthcare Inc. (2.5 mg tablet) and Alembic Pharmaceuticals Inc. (25 mg/mL injection and 2.5 mg tablet) and 24 other companies. Colorants often differ by strength within one company's line, so compare the lists above strength by strength.
Does Methotrexate contain gelatin?
No checked Methotrexate product lists gelatin on its label. Gelatin is usually bovine or porcine and the label rarely says which; for kosher, halal or vegetarian needs, ask the manufacturer.
Why do the inactive ingredients differ between manufacturers?
A generic must match the brand's active ingredient, strength, dose form and how it is absorbed; its fillers, binders, coatings and colorants are the manufacturer's own choice. That is why one Methotrexate product can list lactose and a dye while another from a different company lists neither.
Can my pharmacy give me a specific manufacturer's version?
Often, if you ask before the prescription is filled: many pharmacies order from wholesalers that carry several companies' versions and can request a particular one. Some pharmacies buy a generic from one contracted source only, and a few insurance plans cover only certain NDCs, so ask the pharmacist to check. Give them the NDC from this page; the company name alone is often enough.
How current is this list?
The products are the ones in the FDA's current NDC directory as of October 6, 2026. The list is rebuilt every day, the FDA directory is re-imported every week, and each inactive-ingredient list is the manufacturer's FDA label as our label sync last read it, re-read when the FDA publishes a new version. Formulations change, so check the label on your own bottle and ask your pharmacist if a refill looks different.

Sources: the products are the finished Methotrexate products in the FDA's current NDC directory (openFDA), as of October 6, 2026; each inactive-ingredient list is the manufacturer's FDA Structured Product Label via DailyMed, as our label sync last read it. The concern groups are HelloPharmacist's classification of the names the label declares. Educational information only, not medical advice; confirm with your pharmacist before relying on a list. ← Back to the Methotrexate guide