Inactive ingredients by manufacturer

Methotrexate inactive ingredients by manufacturer

Wondering whether your Methotrexate has lactose, gluten, soy, a dye or gelatin in it? The medicine is the same, but the fillers, coatings and colors differ from one company to the next. This page shows what each Methotrexate product's FDA label lists, so you can find a version that leaves out what you avoid and ask your pharmacist for it by its NDC.

We have read the FDA labels of 70 of the 75 current Methotrexate products on the market today, from 33 companies listing it with the FDA, and lined them up side by side. 5 are still being read and will appear on a later visit.

Ask about your bottle

Is there something in your Methotrexate? Ask in plain words.

Name the company, strength or the NDC on your bottle and the ingredient you avoid. The answer comes only from the FDA labels on this page.

Answers are drawn from the FDA label data on this page and checked against it. They are not medical advice: confirm with your pharmacist before relying on them.

The short answer

Which Methotrexate products list lactose, a gluten source, soy, dyes or gelatin?

  1. LactoseDiffers by manufacturer

    30 of 70 checked products list lactose; 40 do not. See the products

    Does not list it Accord Healthcare, Inc. Alembic Pharmaceuticals Inc. Alembic Pharmaceuticals Limited Antares Azurity Eugia Fresenius Kabi Hikma Hospira Medexus Shorla Oncology Teva Parenteral Medicines
    Lists it A-S Medication Solutions Accord Healthcare Inc. Alembic Pharmaceuticals Inc. Alembic Pharmaceuticals Limited AvKARE AvPAK Bryant Ranch Prepack Chartwell RX Coupler Elite Golden State Medical Supply Hikma Major Mylan Mylan Institutional NuCare Proficient Rx Safecor Health Teva Teva Women's Health Zydus Zydus Lifesciences
  2. Wheat or gluten sourceNo checked product

    No checked Methotrexate product lists a wheat or gluten source.

  3. SoyNo checked product

    No checked Methotrexate product lists soy.

  4. Synthetic dyesDiffers by manufacturer

    9 of 70 checked products list synthetic dyes; 61 do not. See the products

    Does not list it A-S Medication Solutions Accord Healthcare, Inc. Accord Healthcare Inc. Alembic Pharmaceuticals Inc. Alembic Pharmaceuticals Limited Antares AvKARE AvPAK Azurity Bryant Ranch Prepack Chartwell RX Coupler Elite Eugia Fresenius Kabi Hikma Hospira Major Medexus NuCare Proficient Rx Shorla Oncology Teva Teva Parenteral Medicines Zydus Zydus Lifesciences
    Lists it Bryant Ranch Prepack Golden State Medical Supply Mylan Mylan Institutional Safecor Health Teva Women's Health
  5. GelatinNo checked product

    No checked Methotrexate product lists gelatin.

Also listed by some products: Corn 29 of 70 Titanium dioxide 4 of 70 Benzyl alcohol 3 of 70 Propylene glycol 3 of 70 PEG or polysorbate 8 of 70

Find a version without it

Every current Methotrexate product and what its label lists

Hide products that list:

ProductListsInactive ingredients on the label
A-S Medication Solutions 1 product
2.5 mg tabletNDC 50090-5457-02 Lactose Corn-derived Propylene glycol Polyethylene glycol or polysorbate
Show 9 ingredients

ANHYDROUS LACTOSE, HYPROMELLOSE, UNSPECIFIED, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL, UNSPECIFIED, PROPYLENE GLYCOL, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC
Accord Healthcare, Inc. 1 product
25 mg/mL injectionNDC 16729-0277-03 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
Accord Healthcare Inc. 1 product
2.5 mg tabletNDC 16729-0486-01 Lactose Corn-derived
Show 3 ingredients

ANHYDROUS LACTOSE, MAGNESIUM STEARATE, STARCH, CORN
Alembic Pharmaceuticals Inc. 3 products
25 mg/mL injectionNDC 62332-0712-01 None of these listed
Show 4 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
25 mg/mL injectionNDC 62332-0711-05 Benzyl alcohol
Show 5 ingredients

BENZYL ALCOHOL, HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
2.5 mg tabletNDC 62332-0730-31 Lactose Corn-derived
Show 4 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, STARCH, CORN
Alembic Pharmaceuticals Limited 3 products
25 mg/mL injectionNDC 46708-0711-05 Still being read Not read yet
25 mg/mL injectionNDC 46708-0712-01 None of these listed
Show 4 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
2.5 mg tabletNDC 46708-0730-31 Lactose Corn-derived
Show 4 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, STARCH, CORN
Antares Pharma, Inc. 7 products
10 mg/0.4 mL injectionNDC 54436-0010-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, WATER
12.5 mg/0.4 mL injectionNDC 54436-0012-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, WATER
15 mg/0.4 mL injectionNDC 54436-0015-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, WATER
17.5 mg/0.4 mL injectionNDC 54436-0017-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, WATER
20 mg/0.4 mL injectionNDC 54436-0020-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, WATER
22.5 mg/0.4 mL injectionNDC 54436-0022-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, WATER
25 mg/0.4 mL injectionNDC 54436-0025-01 None of these listed
Show 2 ingredients

SODIUM CHLORIDE, WATER
Aurobindo Pharma Limited 1 product
2.5 mg tabletNDC 59651-0182-01 Still being read Not read yet
AvKARE 1 product
2.5 mg tabletNDC 42291-0594-01 Lactose Corn-derived Propylene glycol Polyethylene glycol or polysorbate
Show 9 ingredients

ANHYDROUS LACTOSE, CELLULOSE, MICROCRYSTALLINE, HYPROMELLOSES, MAGNESIUM STEARATE, POLYETHYLENE GLYCOL, UNSPECIFIED, PROPYLENE GLYCOL, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC
AvPAK 1 product
2.5 mg tabletNDC 50268-0554-15 Lactose Corn-derived
Show 5 ingredients

ANHYDROUS LACTOSE, CELLULOSE, MICROCRYSTALLINE, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, STARCH, CORN
Azurity Pharmaceuticals, Inc. 1 product
2.5 mg/mL oral solutionNDC 52652-2001-01 None of these listed
Show 8 ingredients

CITRIC ACID MONOHYDRATE, HYDROCHLORIC ACID, METHYLPARABEN SODIUM, PROPYLPARABEN SODIUM, SODIUM CITRATE, UNSPECIFIED FORM, SODIUM HYDROXIDE, SUCRALOSE, WATER
Bryant Ranch Prepack 6 products
2.5 mg tabletNDC 72162-2647-01 Lactose Corn-derived
Show 4 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, STARCH, CORN
2.5 mg tabletNDC 72162-2174-01 Lactose
Show 3 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE
2.5 mg tabletNDC 71335-2221-01 Lactose Corn-derived
Show 3 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, STARCH, CORN
2.5 mg tabletNDC 71335-1772-01 Lactose Corn-derived
Show 3 ingredients

ANHYDROUS LACTOSE, MAGNESIUM STEARATE, STARCH, CORN
2.5 mg tabletNDC 71335-1118-01 Lactose Corn-derived Synthetic dyes
Show 9 ingredients

FD&C RED NO. 40, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, SILICON DIOXIDE, SODIUM CARBONATE MONOHYDRATE, SODIUM LAURYL SULFATE, SODIUM STARCH GLYCOLATE TYPE A POTATO, STARCH, CORN
2.5 mg tabletNDC 71335-0782-01 Still being read Not read yet
Chartwell RX, LLC 1 product
2.5 mg tabletNDC 62135-0772-35 Lactose Corn-derived
Show 3 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, STARCH, CORN
Coupler LLC 1 product
2.5 mg tabletNDC 67046-1524-03 Lactose Corn-derived
Show 3 ingredients

ANHYDROUS LACTOSE, MAGNESIUM STEARATE, STARCH, CORN
Elite Laboratories, Inc. 1 product
2.5 mg tabletNDC 64850-0330-01 Lactose Corn-derived
Show 3 ingredients

Lactose Monohydrate, MAGNESIUM STEARATE, STARCH, CORN
Eugia US LLC 4 products
50 mg/2 mL injectionNDC 55150-0510-01 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
100 mg/4 mL injectionNDC 55150-0511-01 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
200 mg/8 mL injectionNDC 55150-0512-01 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
250 mg/10 mL injectionNDC 55150-0513-01 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
Fresenius Kabi USA, LLC 2 products
1 g injectionNDC 63323-0122-50 None of these listed
Show 2 ingredients

HYDROCHLORIC ACID, SODIUM HYDROXIDE
25 mg/mL injectionNDC 63323-0123-10 Benzyl alcohol
Show 4 ingredients

BENZYL ALCOHOL, HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
Golden State Medical Supply, Inc. 1 product
2.5 mg tabletNDC 51407-0121-01 Lactose Corn-derived Synthetic dyes
Show 9 ingredients

FD&C RED NO. 40, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, SILICON DIOXIDE, SODIUM CARBONATE MONOHYDRATE, SODIUM LAURYL SULFATE, SODIUM STARCH GLYCOLATE TYPE A POTATO, STARCH, CORN
Hikma Pharmaceuticals USA Inc. 7 products
1 g injectionNDC 00143-9367-01 None of these listed
Show 2 ingredients

HYDROCHLORIC ACID, SODIUM HYDROXIDE
1 g injectionNDC 00143-9830-01 None of these listed
Show 2 ingredients

HYDROCHLORIC ACID, SODIUM HYDROXIDE
25 mg/mL injectionNDC 00143-9516-01 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
25 mg/mL injectionNDC 00143-9517-01 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
25 mg/mL injectionNDC 00143-9518-01 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
25 mg/mL injectionNDC 00143-9519-10 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
2.5 mg tabletNDC 00054-4550-15 Lactose Corn-derived
Show 5 ingredients

ANHYDROUS LACTOSE, MAGNESIUM STEARATE, SODIUM HYDROXIDE, SODIUM STARCH GLYCOLATE TYPE A POTATO, STARCH, CORN
Hospira, Inc. 4 products
25 mg/mL injectionNDC 61703-0408-25 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
25 mg/mL injectionNDC 61703-0124-40 Still being read Not read yet
25 mg/mL injectionNDC 61703-0161-05 None of these listed
Show 3 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE
25 mg/mL injectionNDC 61703-0350-10 Benzyl alcohol
Show 5 ingredients

BENZYL ALCOHOL, HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
Major Pharmaceuticals 1 product
2.5 mg tabletNDC 00904-7141-10 Lactose Corn-derived
Show 5 ingredients

ANHYDROUS LACTOSE, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, STARCH, CORN
Medexus Pharma Inc. 9 products
7.5 mg/0.15 mL injectionNDC 59137-0505-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
10 mg/0.2 mL injectionNDC 59137-0510-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
12.5 mg/0.25 mL injectionNDC 59137-0515-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
15 mg/0.3 mL injectionNDC 59137-0520-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
17.5 mg/0.35 mL injectionNDC 59137-0525-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
20 mg/0.4 mL injectionNDC 59137-0530-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
22.5 mg/0.45 mL injectionNDC 59137-0535-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
25 mg/0.5 mL injectionNDC 59137-0540-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
30 mg/0.6 mL injectionNDC 59137-0550-01 None of these listed
Show 4 ingredients

hydrochloric acid, sodium chloride, sodium hydroxide, water
Mylan Pharmaceuticals Inc. 1 product
2.5 mg tabletNDC 00378-0014-01 Lactose Corn-derived Synthetic dyes
Show 9 ingredients

FD&C RED NO. 40, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, SILICON DIOXIDE, SODIUM CARBONATE MONOHYDRATE, SODIUM LAURYL SULFATE, SODIUM STARCH GLYCOLATE TYPE A POTATO, STARCH, CORN
Mylan Institutional Inc. 1 product
2.5 mg tabletNDC 51079-0670-05 Lactose Corn-derived Synthetic dyes
Show 9 ingredients

FD&C RED NO. 40, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, SILICON DIOXIDE, SODIUM CARBONATE MONOHYDRATE, SODIUM LAURYL SULFATE, SODIUM STARCH GLYCOLATE TYPE A POTATO, STARCH, CORN
NuCare Pharmaceuticals, Inc. 2 products
2.5 mg tabletNDC 68071-3991-09 Lactose Corn-derived
Show 3 ingredients

ANHYDROUS LACTOSE, MAGNESIUM STEARATE, STARCH, CORN
2.5 mg tabletNDC 68071-3765-06 Lactose Corn-derived
Show 3 ingredients

LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, STARCH, CORN
Proficient Rx LP 1 product
2.5 mg tabletNDC 82804-0136-30 Lactose Corn-derived
Show 3 ingredients

ANHYDROUS LACTOSE, MAGNESIUM STEARATE, STARCH, CORN
Safecor Health LLC 1 product
2.5 mg tabletNDC 48433-0065-05 Lactose Corn-derived Synthetic dyes
Show 9 ingredients

FD&C RED NO. 40, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE 101, SILICON DIOXIDE, SODIUM CARBONATE MONOHYDRATE, SODIUM LAURYL SULFATE, SODIUM STARCH GLYCOLATE TYPE A POTATO, STARCH, CORN
Shorla Oncology Inc. 1 product
2 mg/mL oral solutionNDC 81927-0204-01 Polyethylene glycol or polysorbate
Show 8 ingredients

CITRIC ACID MONOHYDRATE, ETHYLPARABEN, GLYCERIN, METHYLPARABEN SODIUM, POLYETHYLENE GLYCOL, SODIUM CITRATE, SUCRALOSE, WATER
Sun Pharmaceutical Industries, Inc. 1 product
2.5 mg tabletNDC 47335-0235-83 Still being read Not read yet
Teva Pharmaceuticals USA, Inc. 1 product
2.5 mg tabletNDC 00555-0572-02 Lactose Corn-derived Propylene glycol Polyethylene glycol or polysorbate
Show 9 ingredients

ANHYDROUS LACTOSE, HYPROMELLOSES, MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL, UNSPECIFIED, PROPYLENE GLYCOL, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC
Teva Parenteral Medicines, Inc. 3 products
25 mg/mL injectionNDC 00703-3671-01 None of these listed
Show 4 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
25 mg/mL injectionNDC 00703-3675-01 None of these listed
Show 4 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
25 mg/mL injectionNDC 00703-3678-01 None of these listed
Show 4 ingredients

HYDROCHLORIC ACID, SODIUM CHLORIDE, SODIUM HYDROXIDE, WATER
Teva Women's Health LLC 4 products
5 mg tabletNDC 51285-0366-01 Lactose Corn-derived Synthetic dyes Titanium dioxide Polyethylene glycol or polysorbate
Show 15 ingredients

ANHYDROUS LACTOSE, CROSPOVIDONE (15 MPA.S AT 5%), D&C YELLOW NO. 10 ALUMINUM LAKE, FD&C BLUE NO. 1 ALUMINUM LAKE, FD&C YELLOW NO. 6, HYPROMELLOSE 2910 (3 MPA.S), HYPROMELLOSE 2910 (6 MPA.S), MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL 400, POLYSORBATE 80, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC, TITANIUM DIOXIDE
7.5 mg tabletNDC 51285-0367-01 Lactose Corn-derived Synthetic dyes Titanium dioxide Polyethylene glycol or polysorbate
Show 13 ingredients

ANHYDROUS LACTOSE, CROSPOVIDONE (15 MPA.S AT 5%), FD&C BLUE NO. 1 ALUMINUM LAKE, HYPROMELLOSE 2910 (3 MPA.S), HYPROMELLOSE 2910 (6 MPA.S), MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL 400, POLYSORBATE 80, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC, TITANIUM DIOXIDE
10 mg tabletNDC 51285-0368-01 Lactose Corn-derived Synthetic dyes Titanium dioxide Polyethylene glycol or polysorbate
Show 13 ingredients

ANHYDROUS LACTOSE, CROSPOVIDONE (15 MPA.S AT 5%), FD&C RED NO. 40, HYPROMELLOSE 2910 (3 MPA.S), HYPROMELLOSE 2910 (6 MPA.S), MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL 400, POLYSORBATE 80, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC, TITANIUM DIOXIDE
15 mg tabletNDC 51285-0369-01 Lactose Corn-derived Synthetic dyes Titanium dioxide Polyethylene glycol or polysorbate
Show 14 ingredients

ANHYDROUS LACTOSE, CROSPOVIDONE (15 MPA.S AT 5%), FD&C BLUE NO. 2--ALUMINUM LAKE, FD&C RED NO. 40, HYPROMELLOSE 2910 (3 MPA.S), HYPROMELLOSE 2910 (6 MPA.S), MAGNESIUM STEARATE, MICROCRYSTALLINE CELLULOSE, POLYETHYLENE GLYCOL 400, POLYSORBATE 80, SODIUM CARBONATE MONOHYDRATE, STARCH, CORN, TALC, TITANIUM DIOXIDE
Zydus Pharmaceuticals USA Inc. 1 product
2.5 mg tabletNDC 68382-0775-01 Lactose Corn-derived
Show 5 ingredients

ANHYDROUS LACTOSE, CELLULOSE, MICROCRYSTALLINE, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, STARCH, CORN
Zydus Lifesciences Limited 1 product
2.5 mg tabletNDC 70771-1058-00 Lactose Corn-derived
Show 5 ingredients

ANHYDROUS LACTOSE, CELLULOSE, MICROCRYSTALLINE, LACTOSE MONOHYDRATE, MAGNESIUM STEARATE, STARCH, CORN

A product with none of these listed is not certified to be without them: the label says what the manufacturer declared, and the source of a starch or a flavor is often not stated. The companies are the FDA's labelers, which include repackagers and distributors selling another company's product under their own label. The NDC opens the product's own page, with the full label and its inactive-ingredient notes.

Methotrexate without lactose

Lactose: milk sugar; a concern with lactose intolerance or a milk allergy. 30 of 70 checked products list lactose; 40 do not.

Does not list lactose

Lists lactose

Methotrexate without synthetic dyes

Synthetic dyes: FD&C or D&C colorants and their aluminum lakes. 9 of 70 checked products list synthetic dyes; 61 do not.

Does not list synthetic dyes

Lists synthetic dyes

Methotrexate without corn-derived ingredients

Corn-derived: corn starch, maize or corn syrup; a concern with corn allergy. 29 of 70 checked products list corn-derived ingredients; 41 do not.

Does not list corn-derived ingredients

Lists corn-derived ingredients

Methotrexate without titanium dioxide

Titanium dioxide: A white colorant some people choose to avoid. 4 of 70 checked products list titanium dioxide; 66 do not.

Does not list titanium dioxide

Lists titanium dioxide

Methotrexate without benzyl alcohol

Benzyl alcohol: A preservative, mostly in injections and liquids; not for newborns. 3 of 70 checked products list benzyl alcohol; 67 do not.

Does not list benzyl alcohol

Lists benzyl alcohol

Methotrexate without propylene glycol

Propylene glycol: A solvent in liquids and capsules; a concern in kidney disease, for infants, and at high doses. 3 of 70 checked products list propylene glycol; 67 do not.

Does not list propylene glycol

Lists propylene glycol

Methotrexate without polyethylene glycol or polysorbate

Polyethylene glycol or polysorbate: PEG, macrogol or polysorbate; a rare cause of allergic reactions. 8 of 70 checked products list polyethylene glycol or polysorbate; 62 do not.

Does not list polyethylene glycol or polysorbate

Lists polyethylene glycol or polysorbate

At the pharmacy counter

How to use this at the pharmacy counter

  1. Pick the company whose list suits you and copy the NDC from the table. Many pharmacies order from wholesalers that carry several companies' versions and can request a particular one if you ask before the prescription is filled; some buy from one contracted source only, and a few insurance plans cover only certain NDCs, so ask the pharmacist to check.
  2. Treat "does not list" as exactly that. The label is what the manufacturer declared; a flavor or a starch may have an unstated source, and lines change. For celiac disease or a serious allergy, ask the manufacturer's medical information line for a written statement about the lot you have.
  3. Check the bottle each refill. A different company usually means a different shape, color and inactive-ingredient list; the pharmacist can tell you who made it, and the two-NDC comparison shows the difference line by line.
  4. If you need one company's version kept constant, ask your prescriber to write that company or the NDC on the prescription and tell the pharmacy you need it held. Rules vary by state and plan, so confirm with the pharmacist.
Ask Dr. Staiger which Methotrexate product suits you →

Common questions about Methotrexate inactive ingredients

Is Methotrexate gluten-free?
This page cannot certify any Methotrexate product gluten-free; it reports what each label declares. Of the 70 products checked, none lists a wheat, barley, rye or gluten ingredient, and none lists a starch without a stated source. If you have celiac disease, ask the manufacturer's medical information line for a written gluten statement for the lot you have.
Does Methotrexate contain lactose?
30 of 70 checked Methotrexate products list lactose; 40 do not: Accord Healthcare, Inc. (25 mg/mL injection), Alembic Pharmaceuticals Inc. (25 mg/mL injection), Alembic Pharmaceuticals Limited (25 mg/mL injection) and Antares (10 mg/0.4 mL injection, 12.5 mg/0.4 mL injection and 15 mg/0.4 mL injection and 4 more) and 8 other companies. The lactose in a tablet or capsule is a small amount, but people with a milk allergy or a strong intolerance often prefer a version that does not list it.
Does Methotrexate contain soy?
No checked Methotrexate product lists a soy ingredient (soybean oil or soy lecithin) on its label. Soy lecithin is the usual form and the amount is small, but people with a soy allergy often prefer a version that does not list it.
Is there a dye-free Methotrexate?
9 of 70 checked Methotrexate products list a synthetic dye (an FD&C or D&C colorant); 61 do not: A-S Medication Solutions (2.5 mg tablet), Accord Healthcare, Inc. (25 mg/mL injection), Accord Healthcare Inc. (2.5 mg tablet) and Alembic Pharmaceuticals Inc. (25 mg/mL injection and 2.5 mg tablet) and 22 other companies. Colorants often differ by strength within one company's line, so compare the lists above strength by strength.
Does Methotrexate contain gelatin?
No checked Methotrexate product lists gelatin on its label. Gelatin is usually bovine or porcine and the label rarely says which; for kosher, halal or vegetarian needs, ask the manufacturer.
Why do the inactive ingredients differ between manufacturers?
A generic must match the brand's active ingredient, strength, dose form and how it is absorbed; its fillers, binders, coatings and colorants are the manufacturer's own choice. That is why one Methotrexate product can list lactose and a dye while another from a different company lists neither.
Can my pharmacy give me a specific manufacturer's version?
Often, if you ask before the prescription is filled: many pharmacies order from wholesalers that carry several companies' versions and can request a particular one. Some pharmacies buy a generic from one contracted source only, and a few insurance plans cover only certain NDCs, so ask the pharmacist to check. Give them the NDC from this page; the company name alone is often enough.
How current is this list?
The products are the ones in the FDA's current NDC directory as of October 5, 2026, and each inactive-ingredient list is the manufacturer's FDA label as our label sync last read it. Formulations change, so check the label on your own bottle and ask your pharmacist if a refill looks different.

Sources: the products are the finished Methotrexate products in the FDA's current NDC directory (openFDA), as of October 5, 2026; each inactive-ingredient list is the manufacturer's FDA Structured Product Label via DailyMed, as our label sync last read it. The concern groups are HelloPharmacist's classification of the names the label declares. Educational information only, not medical advice; confirm with your pharmacist before relying on a list. ← Back to the Methotrexate guide