Systane COMPLETE propylene glycol .06 mg/mL Emulsion — NDC 0065-0481-55 (Billing 00065-0481-55)
This is a package of Systane COMPLETE propylene glycol .06 mg/mL Emulsion from Alcon Laboratories, Inc., marketed since Jan 2018 and currently FDA-listed; retail pharmacies pay about $1.36 per mL (NADAC).
NDC database record
One package, one record: these facts belong to NDC 0065-0481-55 alone.
- Record
- FDA NDC Directory package listing · Human OTC drug
- Code segments
- 0065 labeler · 0481 product · 55 package
- Package marketed since
- Jan 18, 2018
- Sample package
- No — commercial package
- Listing certified through
- Dec 31, 2026
- Barcode (UPC-A, from the NDC)
- 3 0065048155 7
- Medicaid fills, this package
- 4,422 prescriptions in the last four reported quarters
- FDA record last changed
- Jul 24, 2026
Other active recalls for Propylene Glycol (different manufacturers) — 1 · tap to view
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification
- GSN (GCN sequence number): 066795
- GCN: 29189
- GPI-14 (Medi-Span): 86200060002015
- HICL (First Databank): 003808
- AHFS class code: 52:92.00.00
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 6, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
Clinical
Systane COMPLETE is an over-the-counter eye emulsion containing propylene glycol. Applied directly to the eye surface, propylene glycol functions as a lubricant and moisturizer, and is commonly used in eyedrops to help relieve dryness and irritation. This product is marketed under FDA's OTC monograph rules for eye lubricants rather than through individual product approval.
Patient education
Supplement & herbal interactions
Where does this data come from?
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 6, 2026
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per mL | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $1.362 | $6.81 / 5 ml |
| Medicaid paysCMS SDUD · 12 mo | $2.35 | $11.77 / 5 ml |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
- CMS NADAC weekly file · file of Sep 30, 2026
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · through Q1 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Per unit | Per pack | Marketing start | Marketing end | Status |
|---|---|---|---|---|---|---|
| 00065-0481-01 0065-0481-01 | 1 BOTTLE, DROPPER in 1 CARTON / 1.5 mL in 1 BOTTLE, DROPPER | — | — | 2018-01-18 | — | Active |
| 00065-0481-10 0065-0481-10 Main listing | 1 BOTTLE, DROPPER in 1 CARTON / 10 mL in 1 BOTTLE, DROPPER | $1.17 / mL | $11.68 | 2018-01-18 | — | Active |
| 00065-0481-11 0065-0481-11 | 2 BOTTLE, DROPPER in 1 CARTON / 10 mL in 1 BOTTLE, DROPPER | $1.00 / mL | $20.03 | 2018-01-18 | — | Active |
| 00065-0481-55 You're viewing this | 1 BOTTLE, DROPPER in 1 CARTON / 5 mL in 1 BOTTLE, DROPPER | $1.36 / mL | $6.81 | 2018-01-18 | — | Active |
| 00065-0481-72 0065-0481-72 | 3 BOTTLE, DROPPER in 1 CARTON / 10 mL in 1 BOTTLE, DROPPER | — | — | 2018-01-18 | — | Active |
Per mL, this pack runs about 36% above the cheapest pack (NDC 00065-0481-11, $1.00 vs $1.36 NADAC).
This pack accounts for about 4.6% of this product's recent Medicaid fills; most go to a different pack size. See all packs ↓
Pack size FAQ
What quantity is in this package?
What NDC number is used to bill for this package of Systane COMPLETE propylene glycol .06 mg/mL Emulsion?
Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Leader Restorative Formula Lubricant Eye Drops .6 g/100mL 70000-0013-01 | Cardinal | 1 bottle | $0.214 | — | Availability likely | save 84% |
| Systane Balance .06 mg/mL 00065-1433-02 | Alcon | 1 bottle | $1.168 | — | Availability likely | save 14% |
| Systane COMPLETE PF .06 mg/mL 00065-1509-28 | Alcon | 1 bottle | $1.347 | — | Availability likely | save 1% |
| Systane COMPLETE .06 mg/mLthis 00065-0481-55 | Alcon | 1 bottle | $1.361 | — | Availability likely | — |
| Systane COMPLETE PF .06 mg/mL 00065-1530-01 | Alcon | 5 vials | — | — | FDA listed | — |
| OneDrop .6 g/100mL 57619-0306-01 | LABORATORIOS | 1 bottle | — | — | FDA listed | — |
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Oct 3, 2026
- CMS NADAC weekly file · file of Sep 30, 2026
Availability & generic status
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
- FDA Orange Book · refreshed Oct 3, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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UNII R57ZHV85D4
Boric acid is a weak acid derived from boron. In medicines, it typically serves as a buffer to help maintain the product's pH level and may act as a preservative in certain formulations.
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UNII BI71WT9P3R
A synthetic phospholipid (fat-like molecule) used as a surfactant and emulsifier in medicines. It helps stabilize and mix oil and water-based ingredients, and is commonly used in inhalation products and injectable formulations.
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UNII 7FLD91C86K
Edetate disodium is a chemical compound that binds and removes certain metal ions. In medicines, it acts as a preservative and stabilizer by preventing metals like calcium from interfering with the product's shelf life and consistency.
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UNII E89I1637KE
Guar gum is a natural thickener made from guar bean seeds. It's used in medicines as a binder and thickening agent to hold ingredients together and create the right texture and consistency.
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UNII QTT17582CB
A strong acid used to adjust and maintain the proper pH level in liquid medicines, ensuring stability and preventing breakdown of active ingredients.
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UNII T5L8T28FGP
Mineral oil is a clear, odorless liquid derived from crude oil. It acts as a lubricant and emollient in medications, helping pills slide smoothly during manufacturing and aiding moisture retention in topical products.
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UNII 6716Z5YR3G
A synthetic polymer compound used as an antimicrobial preservative and stabilizer in pharmaceutical formulations. It helps prevent microbial growth and maintain product stability during storage.
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UNII 13A4J4NH9I
A synthetic emulsifier derived from stearic acid and polyethylene glycol. It helps mix oil and water-based ingredients together in liquid medicines and creams to create a smooth, uniform product.
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UNII 55X04QC32I
A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
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UNII 6LUM696811
A waxy substance derived from sorbitol and stearic acid. It acts as an emulsifier and stabilizer to help mix oil and water components evenly throughout the medicine and prevent separation.
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UNII 506T60A25R
Sorbitol is a natural sugar alcohol derived from glucose. It serves as a sweetener, humectant, and bulking agent in medications to improve taste and help maintain moisture in the product.
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UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
12 inactive ingredients listed in the exact product block matched to this NDC.
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.- FDA label on DailyMed · label index refreshed Oct 6, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
Manufacturer & labeler
More NDCs from Alcon Laboratories, Inc. labeler code 00065
- BION TEARS Dextran, Hypromellose 70 1 mg/mL; 2910 (4000 MPA.S) 3 mg/mL Solution/ Drops NDC 0065-0419-18
- GenTeal Tears (Moderate) Dextran 70, Glycerin, Hypromellose 70 1 mg/mL; 2 mg/mL; 3 mg/mL Solution/ Drops NDC 0065-0426-36
- Systane Lubricant polyethylene glycol 400 and Propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops NDC 0065-0429-15
- Systane polyethylene glycol and propylene 400 4 mg/mL; 3 mg/mL Solution/ Drops NDC 0065-0431-33
- Systane polyethylene glycol 400 and propylene 400 4 mg/mL; 3 mg/mL Gel NDC 0065-0454-07
- Systane hypromellose 2910 (4000 MPA.S) 3 mg/g Gel NDC 0065-0474-01
- Systane Nighttime mineral oil and white petrolatum 30 mg/g; 940 mg/g Ointment NDC 0065-0509-35
- GenTeal Tears NIGHT-TIME mineral oil, white petrolatum .03 g/g; .94 g/g Ointment NDC 0065-0518-01
- Tetracaine Hydrochloride 5 mg/mL Solution NDC 0065-0741-14
- BSS balanced salt solution 6.4 mg/mL; .75 mg/mL; .48 mg/mL; .3 mg/mL; 3.9 mg/mL; 1.7 mg/mL Solution NDC 0065-0795-15
- BSS PLUS balanced salt solution enriched with bicarbonate, dextrose, and glutathione Kit NDC 0065-0800-50
- PATADAY ONCE DAILY RELIEF OLOPATADINE HYDROCHLORIDE 7 mg/mL Solution NDC 0065-0816-01
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
FDA label — Drug Facts FDA SPL
🎯 Indications and Usage ▾
Uses for the temporary relief of burning and irritation due to dryness of the eye for the temporary relief of discomfort due to minor irritations of the eye or to exposure to wind or sun for use as a protectant against further irritation or to relieve dryness of the eye for use as a lubricant to prevent further irritation or to relieve dryness of the eye
⏱️ Dosage and Administration ▾
Directions shake well before using put 1 or 2 drops in the affected eye(s) as needed
⚠️ Warnings ▾
Warnings For external use only Do not use if this product changes color if you are sensitive to any ingredient in this product When using this product do not touch tip of container to any surface to avoid contamination replace cap after each use Stop use and ask a doctor if you experience any of the following: eye pain changes in vision continued redness or irritation of the eye condition worsens or persists for more than 72 hours Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
🧪 Active Ingredient ▾
Active Ingredients Purpose Propylene Glycol 0.6% Lubricant
🧪 Inactive Ingredients ▾
Inactive Ingredients boric acid, dimyristoyl phosphatidylglycerol, edetate disodium, hydroxypropyl guar, mineral oil, polyoxyl 40 stearate, POLYQUAD ® (polyquaternium-1) 0.001% preservative, sorbitan tristearate, sorbitol and purified water. May contain hydrochloric acid and/or sodium hydroxide to adjust pH.
📄 Do Not Use ▾
Do not use if this product changes color if you are sensitive to any ingredient in this product
📄 When Using This Product ▾
When using this product do not touch tip of container to any surface to avoid contamination replace cap after each use
📄 Stop Use and Ask a Doctor If ▾
Stop use and ask a doctor if you experience any of the following: eye pain changes in vision continued redness or irritation of the eye condition worsens or persists for more than 72 hours
📄 Keep Out of Reach of Children ▾
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
📄 Questions or Comments ▾
Questions? In the U.S. call 1-800-757-9195 [email protected] www.systane.com
📄 Package Label / Principal Display Panel ▾
PRINCIPAL DISPLAY PANEL Systane ® LUBRICANT EYE DROPS COMPLETE OPTIMAL DRY EYE RELIEF Fast-acting hydration Tear evaporation protection Nano-droplets for better coverage* #1 DOCTOR RECOMMENDED BRAND 1 nano droplet Alcon STERILE 10mL (1/3 FL OZ) LOT: EXP.: SIDE PANEL TAMPER EVIDENT: For your protection, this bottle has an imprinted seal around the neck. Do not use if seal is damaged or missing at time of purchase. SYSTANE ® COMPLETE Our most advanced formula ever!
SYSTANE ® COMPLETE Lubricant Eye Drops hydrates fast, protects against tear evaporation, and helps support all layers of the tear film. Nano droplet technology:* ● a better delivery of the active ingredient ● better eye coverage ACTUAL SIZE Alcon Alcon Laboratories, Inc. Fort Worth, TX 76143 USA * vs SYSTANE ® BALANCE 1 Based on a survey of eye care professionals.
Data on file. www.alconpatents.com Made in USA from domestic and imported materials 300048645-0621 Systane ® LUBRICANT EYE DROPS COMPLETE MULTI-SYMPTOM DRY EYE RELIEF All-in-One Formula Tear Evaporation Protection #1 DOCTOR RECOMMENDED BRANDS 1 Alcon STERILE 10mL (1/3 fl oz) LOT: EXP.: SIDE PANEL TAMPER EVIDENT: For your protection, this bottle has an imprinted seal around the neck. Do not use if seal is damaged or missing at time of purchase. SYSTANE ® COMPLETE SYSTANE ® COMPLETE Lubricant Eye Drops hydrates fast, protects against tear evaporation, and helps support all layers of the tear film.
ACTUAL SIZE Alcon Alcon Laboratories, Inc. Fort Worth, TX 76143 USA 1 Based on a survey of eye care professionals. Data on file. www.alconpatents.com Country of Origin: Singapore 300072080-0525