Cold and Flu Day, Night Acetaminophen, Dextromethorphan HBr, Doxylamine succinate, Phenylephrine HCl Kit
🆔 Identity & classification
Where does this data come from?
🏷️ RxNorm drug class
This medicine belongs to the Anilides class.
Where does this data come from?
🏭 Manufacturer & labeler
Where does this data come from?
🩺 Clinical
Acetaminophen is used to relieve mild to moderate pain and to reduce fever. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.
Read the full MedlinePlus article ↗This is an over-the-counter combination kit containing separate day and night formulas to treat multiple cold and flu symptoms. The day formula contains acetaminophen (a pain reliever and fever reducer), dextromethorphan (a cough suppressant), and phenylephrine (a nasal decongestant). The night formula adds doxylamine succinate, which is a sleep aid. Together, these ingredients are commonly used to help manage daytime and nighttime cold and flu symptoms like aches, fever, cough, and nasal congestion.
Patient education
Supplement & herbal interactions
Where does this data come from?
Ask a licensed pharmacist directly — free, answered by our team.
💊 What it looks like
Where does this data come from?
🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
Where does this data come from?
IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per each | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| foster and thrive daytime cold and flu relief nighttime cold and flu relief 70677-1028-01 | Strategic | 2 capsules | $0.151 | — | FDA listed | — |
| Goodnow cold flu day relief cold flu night relief 82501-1211-01 | Gobrands, | 2 capsules | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 41163-0901-48 | United | 1 capsule | — | — | FDA listed | — |
| NiteTime DayTime Cold and Flu 41250-0597-02 | Meijer | 1 kit | — | — | FDA listed | — |
| Daytime Nighttime Cold and Flu Relief Multi-Symptom 67091-0336-48 | WinCo | 16 capsules | — | — | FDA listed | — |
| Cold and Flu Day, Nightthis 00363-1213-99 | Walgreen | 1 kit | — | — | FDA listed | — |
| daytime nighttime cold and flu 00363-1733-02 | Walgreen | 1 kit | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 72476-0850-48 | Care | 16 capsules | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 11822-0851-04 | Rite | 8 capsules | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 21130-0058-48 | Safeway, | 16 capsules | — | — | FDA listed | — |
| equaline daytime and nighttime cold and flu relief 41163-0567-02 | United | 1 kit | — | — | FDA listed | — |
| equate daytime cold and flu nighttime cold and flu 49035-0718-02 | Wal-Mart | 1 kit | — | — | FDA listed | — |
| Cold and Flu Daytime, Nighttime, Multi-Symptom 00363-9012-48 | Walgreens | 8 capsules | — | — | FDA listed | — |
| Vicks DayQuil NyQuil ULTRA CONCENTRATED COLD and FLU 69423-0802-96 | The | 1 kit | — | — | FDA listed | — |
| Topcare Nite Time Day Time Cold and Flu 36800-0580-72 | Topco | 2 capsules | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 68016-0799-48 | Chain | 1 capsule | — | — | Discontinued | — |
| Cold And Flu Daytime-Nighttime 11673-0984-24 | TARGET | 8 capsules | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 49035-0192-48 | EQUATE | 16 capsules | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 69256-0901-48 | Harris | 1 capsule | — | — | FDA listed | — |
| basic care daytime nighttime cold and flu 72288-0733-02 | Amazon.com | 1 kit | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 72476-0901-48 | Care | 32 capsules | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 55319-0566-24 | Family | 1 capsule | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 67091-0393-48 | WinCo | 1 capsule | — | — | FDA listed | — |
| Severe Cold and Flu 00363-1597-02 | Walgreen | 1 kit | — | — | FDA listed | — |
| Cold and Flu Daytime, Nighttime, Multi-Symptom 00363-9011-24 | Walgreens | 8 capsules | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 69842-0852-24 | CVS | 1 capsule | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 81522-0901-48 | FSA | 1 capsule | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 21130-0901-48 | Safeway, | 16 capsules | — | — | FDA listed | — |
| TopCare Day Time Nite Time Cold and Flu Relief 36800-0301-02 | Topco | 1 kit | — | — | FDA listed | — |
| Daytime Nighttime Cold and Flu Relief Multi-Symptom 59726-0901-24 | P | 8 capsules | — | — | FDA listed | — |
| daytime nighttime cold and flu 00363-0567-02 | Walgreen | 1 kit | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 69842-0896-24 | CVS | 1 capsule | — | — | FDA listed | — |
| basic care daytime cold and flu nighttime cold and flu 72288-0580-72 | Amazon.com | 2 capsules | — | — | FDA listed | — |
| Cold and Flu Daytime Nighttime 51316-0123-02 | CVS | 1 kit | — | — | FDA listed | — |
| Topcare Day Time Nite Time Cold and Flu 36800-0597-02 | Topco | 1 kit | — | — | FDA listed | — |
| Daytime Nighttime Cold Flu Relief 41163-0850-48 | United | 16 capsules | — | — | FDA listed | — |
| Daytime-Nighttime Severe Cold And Flu 41226-0627-24 | KROGER | 4 capsules | — | — | FDA listed | — |
| daytime nitetime cold and flu 41250-0733-02 | Meijer | 1 kit | — | — | FDA listed | — |
| dg health cold and flu relief 55910-0811-72 | Dolgencorp | 2 capsules | — | — | FDA listed | — |
| Severe Nighttime Severe Daytime 59779-0597-02 | CVS | 1 kit | — | — | FDA listed | — |
| Severe Cold and Flu Nighttime Daytime 42507-0597-02 | HyVee | 1 kit | — | — | FDA listed | — |
| Daytime Nighttime Cold And Flu 72288-0791-02 | Amazon.com | 1 kit | — | — | FDA listed | — |
Where does this data come from?
⏳ Availability & generic status
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
🔬 Reported adverse events (FAERS)
Top reported reactions
Age at onset
Reporter sex
Serious outcomes
Where does this data come from?
📦 Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Status |
|---|---|---|---|
| 00363-1213-02 | 1 KIT in 1 PACKAGE (0363-1213-02) * 355 mL in 1 BOTTLE, PLASTIC (0363-9912-02) * 355 mL in 1 BOTTLE, PLASTIC (0363-9913-02) | 2022-11-14 | Active |
| 00363-1213-99 You're viewing this | 1 KIT in 1 CARTON (0363-1213-99) * 355 mL in 1 BOTTLE, PLASTIC (0363-9912-02) * 355 mL in 1 BOTTLE, PLASTIC (0363-9913-02) | 2022-11-14 | Active |
Pack size FAQ
What quantity is in NDC 00363-1213-99?
What NDC number is used to bill for this package of Cold and Flu Day, Night Acetaminophen, Dextromethorphan HBr, Doxylamine succinate, Phenylephrine HCl Kit?
🧭 About this NDC listing & data coverage
Kit / multi-component package
This NDC identifies a kit — a package containing more than one component. Structured data (pricing, ingredients, equivalents) is often reported per component rather than for the kit NDC itself, which can make this page look thinner than the components' own pages.
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | — Not published for this NDC No photo available yet for this listing. |
| Inactive ingredients (structured) | — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available. |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |
Questions about this listing
Is this NDC FDA-approved?
Why is there no price listed?
Is the NDC printed on the package the same as the 11-digit billing NDC?
What do the three segments of this NDC mean?
Is this package still being marketed?
Does this product come in other package sizes?
Who lists this product with the FDA?
Do I need a prescription for this product?
Where does this data come from?
📄 FDA label — Drug Facts FDA SPL
🎯 Indications and Usage ▾
Uses temporarily relieves common cold and flu symptoms: sore throat nasal congestion minor aches and pains cough due to minor throat and bronchial irritation headache temporarily reduces fever
Uses temporarily relieves common cold and flu symptoms: headache minor aches and pains sore throat runny nose and sneezing cough due to minor throat and bronchial irritation temporarily reduces fever
⏱️ Dosage and Administration ▾
Directions do not take more than directed do not exceed 4 doses per 24 hours mL = milliliter only use the dose cup provided adults and children 12 years and over 30 mL every 4 hours children 6 to under 12 years 15 mL every 4 hours children under 6 years do not use
Directions do not take more than directed do not exceed 4 doses per 24 hours mL = milliliter only use the dose cup provided adults and children 12 years and over: 30 mL every 6 hours children under 12 years: do not use
⚠️ Warnings ▾
Warnings Liver warning: This product contains acetaminophen. Severe liver damage may occur if adult takes more than 4,000 mg of acetaminophen in 24 hours child takes more than 5 doses in 24 hours taken with other drugs containing acetaminophen adult has 3 or more alcoholic drinks every day while using this product Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If a skin reaction occurs, stop use and seek medical help right away.
Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug.
If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. if you have ever had an allergic reaction to this product or any of its ingredients Ask a doctor before use if the user has high blood pressure difficulty in urination due to enlargement of the prostate gland cough that occurs with too much phlegm (mucus) liver disease persistent or chronic cough such as occurs with smoking, asthma, or emphysema heart disease diabetes thyroid disease Ask a doctor or pharmacist before use if the user is taking the blood thinning drug warfarin.
When using this product do not exceed recommended dosage. Stop use and ask a doctor if nervousness, dizziness, or sleeplessness occur fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur pain, nasal congestion, or cough gets worse or lasts more than 5 days (children) or 7 days (adults) cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.
If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.
Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Warnings Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take more than 4,000 mg of acetaminophen in 24 hours with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If a skin reaction occurs, stop use and seek medical help right away.
Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug.
If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. if you have ever had an allergic reaction to this product or any of its ingredients Ask a doctor before use if you have liver disease glaucoma difficulty in urination due to enlargement of the prostate gland cough that occurs with too much phlegm (mucus) a breathing problem or chronic cough that lasts or as occurs with smoking, asthma, chronic bronchitis, or emphysema Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin taking sed…
📦 Storage and Handling ▾
Other information each 15 mL contains: sodium 13 mg store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F) use by expiration date on package
Other information each 30 mL contains: sodium 13 mg store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F) use by expiration date on package
🧪 Active Ingredient ▾
Active ingredients (in each 15 mL) (Day) Acetaminophen 325 mg Dextromethorphan HBr 10 mg Phenylephrine HCl 5 mg
Active ingredients (in each 30 mL) (Night) Acetaminophen 650 mg Dextromethorphan HBr 30 mg Doxylamine succinate 12.5 mg
🧪 Inactive Ingredients ▾
Inactive ingredients anhydrous citric acid, FD&C yellow #6, flavors, glycerin, polyethylene glycol, propylene glycol, purified water, sodium benzoate, sodium citrate dihydrate, sodium metabisulfite, sodium saccharin, sorbitol, sucralose
Inactive ingredients anhydrous citric acid, FD&C blue #1, FD&C red #40, flavor, glycerin, high fructose corn syrup, polyethylene glycol 400, propylene glycol, purified water, sodium benzoate, sodium chloride, sodium citrate dihydrate, sodium saccharin, sucralose
🎯 Purpose ▾
Purpose Pain reliever/fever reducer Cough suppressant Nasal decongestant
Purpose Pain reliever/fever reducer Cough suppressant Antihistamine