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Advil Multi-Symptom Cold and Flu chlorpheniramine maleate, ibuprofen, phenylephrine HCl 4 mg; 200 mg; 10 mg Tablet, Coated, 10-count — NDC 00573-0190-10 package photo

Advil Multi-Symptom Cold and Flu chlorpheniramine maleate, ibuprofen, phenylephrine HCl 4 mg; 200 mg; 10 mg Tablet, Coated, 10-count

by Haleon US Holdings LLC · 1 BLISTER PACK in 1 CARTON (0573-0190-10) / 10 TABLET, COATED in 1 BLISTER PACK
NDC 00573-0190-10
🏷️ FDA NDC (as labeled) 0573-0190-10 billing pads the labeler segment with a zero
This package
Contains10-count Pack sizes6 compare ↓
Also comes in: 1 tablet 00573-0190-01 1 tablet 00573-0190-02 1 tablet 00573-0190-03 10 tablets 00573-0190-20 10 tablets 00573-0190-30
OTC Brand On market Non-controlled
🗂️ Data synced Sep 17, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 0573-0190-10
Product NDC 0573-0190
11-digit billing NDC 00573019010
NCPDP billing unit EA — each (per item)
RxCUI 1310503
UNII V1Q0O9OJ9Z, WK2XYI10QM, 04JA59TNSJ
Application # NDA022113
SPL Set ID 7671d104-3c5c-4f63-b6b1-6c91c22592f8
Established class (EPC) Nonsteroidal Anti-inflammatory Drug
Mechanism of action Cyclooxygenase Inhibitors
Chemical class Anti-Inflammatory Agents, Non-Steroidal
DEA schedule Non-controlled
Marketing category NDA
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2018-06-25
Route ORAL
Dosage form TABLET, COATED
Substance CHLORPHENIRAMINE MALEATE; IBUPROFEN; PHENYLEPHRINE HYDROCHLORIDE
GPI-14 43994003110320
GPI class Advil Multi-Symptom Cold & Flu
GCN Seq No 070323
GCN 33836
HICL code 039826
Ingredient (HICL) Chlorphen/Phenyleph/Ibuprofen
HIC1 code B
Therapeutic class — broad (HIC1) Respiratory System
HIC2 code B5
Therapeutic class — intermediate (HIC2) Drugs Affecting The Trachea And Bronchi (Contin.2)
HIC3 code B5H
Therapeutic class — specific (HIC3) 1St Gen Antihist-Decon-Nsaid,Cox Nonspec
AHFS code 04:04.20.00
AHFS class Propylamine Derivatives
FDB label name ADVIL MULTI-SYMP COLD-FLU TAB
FDB brand name Advil Multi-Symptom Cold-Flu
Legend status O — Over-the-counter (OTC) drug or device
Why two NDCs? The FDA registers this code as 0573-0190-10 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00573-0190-10. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Histamine-1 Receptor Antagonist class.

Pharmacologic class Histamine-1 Receptor Antagonist
Drug family (ATC) Substituted alkylamines
How it works Histamine H1 Receptor Antagonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerHaleon US Holdings LLC
Application holderHALEON US HOLDINGS LLC
FDA applicationNDA022113 (NDA)
Labeler code00573
First marketedJun 2018
Product typeHuman Otc Drug
Portfolio404 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name ADVIL MULTI-SYMP COLD-FLU TAB Ingredient Chlorphen/Phenyleph/Ibuprofen
📗 Our plain-language guide HelloPharmacist
  • The main difference is what they're labeled to treat. Advil Allergy and Congestion Relief (and Advil Allergy Congestion Relief) are meant for allergy symptoms like itchy, watery ey...
  • What's the difference between Advil Allergy and Congestion Relief and Advil Multi-Symptom Cold and Flu?
  • No — these products are not for children under 12. The label is clear that the dose in each tablet is too high for younger children. If your child needs relief from cold or allergy...
  • That's a fair concern — ibuprofen can cause serious stomach bleeding in some people. Watch for signs like feeling faint, vomiting blood, stools that are black or look like coffee g...
📖 Read our full Chlorpheniramine / Ibuprofen / Phenylephrine guide →

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

💊 What it looks like

Color gray
ShapeOval
ImprintAdvil;CF
Size17 mm
ScoringNot scored
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 1 tablet 1 tablet 1 tablet 10 tablets 10 tablets
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Advil Multi-Symptom Cold and Flu 4 mg/1; 200 mg/1; 10 mgthis 00573-0190-10 Haleon 10 tablets — — FDA listed —
Advil Allergy and Congestion Relief 4 mg/1; 200 mg/1; 10 mg 00573-0196-01 Haleon 1 tablet — — FDA listed —
Advil Allergy and Congestion Relief 4 mg/1; 200 mg/1; 10 mg 00573-2161-03 Haleon 10 tablets — — FDA listed —
Advil Allergy and Congestion Relief 4 mg/1; 200 mg/1; 10 mg 67751-0149-01 Navajo 1 tablet — — FDA listed —
About this product: this is the brand-name version. We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2018
On the market since
Jun 2018
📍
2026
Currently FDA-listed
8 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
00573-0190-01 50 POUCH in 1 TRAY (0573-0190-01) / 1 TABLET, COATED in 1 POUCH 2018-06-25 Active
00573-0190-02 2 POUCH in 1 CARTON (0573-0190-02) / 1 TABLET, COATED in 1 POUCH 2019-11-01 Active
00573-0190-03 3000 POUCH in 1 CASE (0573-0190-03) / 1 TABLET, COATED in 1 POUCH 2018-06-25 Active
00573-0190-10 You're viewing this 1 BLISTER PACK in 1 CARTON (0573-0190-10) / 10 TABLET, COATED in 1 BLISTER PACK 2018-06-25 Active
00573-0190-20 2 BLISTER PACK in 1 CARTON (0573-0190-20) / 10 TABLET, COATED in 1 BLISTER PACK 2018-06-25 Active
00573-0190-30 3 BLISTER PACK in 1 CARTON (0573-0190-30) / 10 TABLET, COATED in 1 BLISTER PACK 2018-06-25 Active

Pack size FAQ

What quantity is in NDC 00573-0190-10?
NDC 00573-0190-10 is a 10-count package — 1 blister pack in 1 carton / 10 tablet, coated in 1 blister pack.
What NDC number is used to bill for this package of Advil Multi-Symptom Cold and Flu chlorpheniramine maleate, ibuprofen, phenylephrine HCl 4 mg; 200 mg; 10 mg Tablet, Coated?
Bill NDC 00573-0190-10 — the 11-digit billing format is 00573019010. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 0573-0190-10, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 00573-0190-10, written without dashes as 00573019010. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 00573-0190-10, the first segment (00573) is the labeler code FDA assigned to Haleon US Holdings LLC; the middle segment (0190) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (10) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Haleon US Holdings LLC. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 5 other package presentations of this same product, including 1 tablet (00573-0190-01), 1 tablet (00573-0190-02), 1 tablet (00573-0190-03). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Haleon US Holdings LLC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 39 words ▾

Uses temporarily relieves these symptoms associated with the common cold or flu: headache fever minor body aches and pains nasal congestion runny nose sinus pressure sneezing reduces swelling of the nasal passages temporarily restores freer breathing through the nose

⏱️ Dosage and Administration 50 words ▾

Directions do not take more than directed adults and children 12 years of age and over: take 1 tablet every 4 hours while symptoms persist do not take more than 6 tablets in any 24-hour period, unless directed by a doctor children under 12 years of age: do not use

⚠️ Warnings ~3 min read ▾

Warnings Allergy alert: Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include: hives facial swelling asthma (wheezing) shock skin reddening rash blisters If an allergic reaction occurs, stop use and seek medical help right away. Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding.

The chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others] have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directed Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.

Do not use in children under 12 years of age if you have ever had an allergic reaction to any other pain reliever/fever reducer right before or after heart surgery if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. Ask a doctor before use if you have a breathing problem such as emphysema or chronic bronchitis stomach bleeding warning applies to you you have problems or serious side effects from taking pain relievers or fever reducers you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, thyroid disease, diabetes, glaucoma, have trouble urinating due to an enlarged prostate gland, or had a stroke you are taking a diuretic Ask a doctor or pharmacist before use if you are under a doctor's care for any serious condition taking sedatives or tranquilizers taking any other product that contains phenylephrine, chlorpheniramine or any other nasal decongestant or antihistamine taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin taking any other drug When using this product take with food or milk if stomach upset occurs avoid alcoholic drinks be careful when driving a motor vehicle or operating machinery drowsiness may occur alcohol, sedatives, and tranquilizers may increase drowsiness may cause excitability especially in children Stop use and ask a doctor if you experience any of the following signs of stomach bleeding: feel faint vomit blood have bloody or black stools have stomach pain that does not get better you have symptoms of heart problems or stroke: chest pain trouble breathing weakness in one part or side of body slurred speech leg swelling pain gets worse or lasts more than 7 days fever gets worse or lasts more than 3 days nasal congestion lasts for more than 7 days redness or swelling is present in the painful area you get nervous, dizzy, or sleepless symptoms continue or get worse any new symptoms appear If pregnant or breast-feeding, ask a health professional before use.

It is especially important not to use ibuprofen at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

📦 Storage and Handling 21 words ▾

Other information read all warnings and directions before use. Keep carton. store at 20-25°C (68-77°F) avoid excessive heat above 40°C (104°F)

🧪 Active Ingredient 20 words ▾

Active ingredients (in each tablet) Chlorpheniramine maleate 4 mg Ibuprofen 200 mg (NSAID)* Phenylephrine HCl 10 mg *nonsteroidal anti-inflammatory drug

🧪 Inactive Ingredients 48 words ▾

Inactive ingredients acesulfame potassium, artificial flavors, carnauba wax, colloidal silicon dioxide, corn starch, croscarmellose sodium, glycerin, glyceryl dibehenate, hypromellose, lactic acid, lecithin, maltodextrin, medium-chain triglycerides, microcrystalline cellulose, pharmaceutical ink, polydextrose, polyvinyl alcohol, pregelatinized starch, propyl gallate, silicon dioxide, sucralose, synthetic iron oxide, talc, titanium dioxide, triacetin, xanthan gum

🎯 Purpose 7 words ▾

Purposes Antihistamine Pain reliever/Fever reducer Nasal decongestant

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 00573-0188-10 · Haleon 00573-0191-20 · Haleon →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.