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SPOTLESS 30-Day Regimen Benzoyl Peroxide Kit — NDC 14222-1602-01 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

SPOTLESS 30-Day Regimen Benzoyl Peroxide Kit — NDC 14222-1602-1 (Billing 14222-1602-01)

by Rodan & Fields · 1 KIT in 1 CARTON * 65 mL in 1 TUBE * 20 mL in 1 BOTTLE, PUMP

This is a package of SPOTLESS 30-Day Regimen Benzoyl Peroxide Kit from Rodan & Fields, marketed since Jan 2025 and currently FDA-listed. It is this product's only package size.

NDC 14222-1602-01
🏷️ FDA NDC (as labeled) 14222-1602-1 billing pads the package segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 14222-1602-1 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
14222 labeler · 1602 product · 1 package
Package marketed since
Jan 24, 2025
Sample package
No — commercial package
Listing certified through
Dec 31, 2027
Barcode (UPC-A, from the NDC)
3 1422216021 4
FDA record last changed
Jul 24, 2026
⚠️
Other active recalls for Benzoyl Peroxide (different manufacturers) — 1 · tap to view
These affect other manufacturers’ products for the same ingredient — not necessarily the exact NDC on this page.
Class II · Feb 24, 2025 — Chemical Contamination: Presence of benzene. (Denison Pharmaceuticals, LLC) · FDA recall D-0273-2025
Each entry is an official FDA enforcement report — look up any recall number in the FDA recall database ↗

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 14222-1602-1
Product NDC 14222-1602
11-digit billing NDC 14222160201
RxCUI 200009, 308696
Application # M006
SPL Set ID 8b2c187d-4b66-4872-8243-4365ea2e8b59
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2025-01-24
Route TOPICAL
Dosage form KIT
Quick answers
  • RxCUI (RxNorm): 200009
Why two NDCs? The FDA registers this code as 14222-1602-1 — a 5-4-1 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the package segment → 14222-1602-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Peroxides class.

Drug family (ATC) Peroxides
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

📗 Our plain-language guide HelloPharmacist
  • Most products are for acne. They dry up pimples and help prevent new ones. Epsolay is a prescription cream for rosacea bumps in adults. The Folliculitis Treatment Cream products ar...
  • For many acne products, start with once a day. You can move up to two or three times daily if your skin tolerates it. If you get dryness or peeling, cut back to once daily or every...
  • Redness, dryness, peeling, itching, and stinging or burning are the usual ones. Using less often can help. Using another acne product at the same time makes irritation more likely.
  • Stop if irritation gets severe. Stop right away and get help if you have hives, swelling or trouble breathing. Those can be signs of a serious allergic reaction.
📖 Read our full Benzoyl Peroxide guide →

Supplement & herbal interactions

Some supplements/herbs that may interact with Benzoyl Peroxide — tap one for details:

Dimethylsulfoxide (dmso)Moderate Turpentine OilModerate AlchemillaMinor
🌿 Every supplement checked against Benzoyl Peroxide (3 interactions) — ranked by severity →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
14222-1602-01 You're viewing this Main listing 1 KIT in 1 CARTON * 65 mL in 1 TUBE * 20 mL in 1 BOTTLE, PUMP 2025-01-24 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Rugby Benzoyl Peroxide Wash Acne Medication 50 mg/mL 00536-1259-19 Rugby 236 ml $0.028 — Availability likely —
Rugby Benzoyl Peroxide Wash Acne Medication 100 mg/g 00536-1474-42 Rugby 237 g $0.047 — Availability likely —
Rugby Benzoyl Peroxide Wash Acne Medication 100 mg/g 00536-1351-42 Rugby 237 g $0.047 — Discontinued —
Rugby Benzoyl Peroxide Wash Acne Medication 100 mg/mL 00536-1261-63 Rugby 148 ml $0.047 — Availability likely —
Rugby Benzoyl Peroxide Acne Medication 50 mg/mL 00536-1057-75 Rugby 1 tube $0.067 — Discontinued —
Rugby Benzoyl Peroxide Acne Medication 100 mg/mL 00536-1058-75 Rugby 1 tube $0.074 — Discontinued —
benzoyl peroxide 5 g/100g 45802-0216-01 Padagis 1 tube $0.178 — Availability likely —
benzoyl peroxide 10 g/100g 45802-0308-01 Padagis 1 tube $0.181 — Availability likely —
benzoyl peroxide 2.5 g/100g 45802-0101-96 Padagis 1 tube $0.201 — Availability likely —
Rugby Benzoyl Peroxide Acne Medication 25 mg/g 00536-1466-25 Rugby 1 tube $0.201 — Availability likely —
Rugby Benzoyl Peroxide Acne Medication 50 mg/g 00536-1467-25 Rugby 1 tube $0.218 — Availability likely —
Rugby Benzoyl Peroxide Acne Medication 50 mg/mL 00536-1055-25 Rugby 1 tube $0.218 — Availability likely —
Rugby Benzoyl Peroxide Acne Medication 100 mg/mL 00536-1056-25 Rugby 1 tube $0.231 — Discontinued —
Rugby Benzoyl Peroxide Acne Medication 100 mg/g 00536-1459-25 Rugby 1 tube $0.231 — Availability likely —
Skin Pharmacy Advanced Acne Therapy Targeted Treatment Wipes 25 mg/mL 68634-0068-01 AMCOL 2 packets — — FDA listed —
SkinPharmacy Advanced Acne Therapy Targeted Treatment Wipes 25 mg/mL 69842-0081-01 CVS 2 packets — — FDA listed —
Cetaphil Gentle Clear BPO Acne Cleanser 2.6 g/100mL 00299-4125-00 Galderma 124 ml — — FDA listed —
La Roche Posay Laboratoire Dermatologique Effaclar Duo Acne Treatment 55 mg/mL 49967-0076-01 L'OREAL 1 tube — — FDA listed —
CeraVe Acne Foaming Cleanser 40 mg/mL 49967-0238-01 L'Oreal 1 tube — — FDA listed —
CeraVe Acne Foaming CreamWash 100 mg/mL 49967-0604-01 L'Oreal 1 tube — — Discontinued —
Replenix Acne 50 mg/g 51326-0411-57 Topiderm, 57 g — — FDA listed —
Replenix Acne 100 mg/g 51326-0412-57 Topiderm, 57 g — — FDA listed —
ACNE FORTE Acne Treatment Cream 50 mg/mL 52063-0709-00 GSCM 1 jar — — FDA listed —
SERIOUS SKINCARE Continuously Clear Clearz It 50 mg/mL 53755-0392-00 Flageoli 59 ml — — FDA listed —
Modesa Acne Treatment 10 g/100g 55621-0017-01 Zhejiang 1 tube — — FDA listed —
Spot Acne Treatment 0.75Oz 2.5 g/100g 57337-0149-01 Rejoice 1 tube — — FDA listed —
Spot Acne Treatment 0.75Oz 2.5 g/100g 58503-0168-01 China 1 tube — — FDA listed —
Clearogen 3 2.5 g/100g 62742-4238-01 Allure 55 g — — FDA listed —
Acne Treatment 50 mg/mL 67226-2050-03 Vivier 1 tube — — FDA listed —
Acne Face and Body 25 mg/mL 70707-0101-06 Face 180 ml — — FDA listed —
Acne Med 2.5% 25 mg/mL 70707-0200-15 Face 1 bottle — — FDA listed —
Acne Med 5% 50 mg/mL 70707-0211-15 Face 1 bottle — — FDA listed —
Acne Med 10% 100 mg/mL 70707-0212-15 Face 1 bottle — — FDA listed —
Acne Face and Body Wash 25 mg/mL 70707-0711-06 Face 180 ml — — FDA listed —
Acne Therapy 30 mg/g 71397-0822-55 menScience 45 g — — FDA listed —
MD-Acne Body Acne Treatment 50 mg/mL 71804-0230-06 MD 180 ml — — FDA listed —
111 Medco Benzoyl Peroxide 100 mg/g 72811-0137-11 111 113 g — — FDA listed —
HUMANE Acne Spot Treatment 50 mg/mL 73010-0127-00 Apprendista, 1 tube — — FDA listed —
Nighttime Control 50 mg/mL 76458-0333-02 Circadia 1 bottle — — FDA listed —
5 Percent Benzoyl Peroxide Cleanser 50 mg/mL 81136-0023-01 Brand 1 tube — — FDA listed —
Acne Control Serum 5 g/100g 72957-0001-01 Private 32 g — — FDA listed —
Touch Acne Treatment Benzoyl Peroxide 25 mg/g 73246-0001-01 Diractions 227 g — — FDA listed —
Meijer Acne Foaming Cleanser Acne Treatment 40 mg/mL 79481-0023-01 Meijer 1 tube — — FDA listed —
OXY 10 Acne Cleanser 100 mg/mL 10742-1397-01 The 148 ml — — FDA listed —
Proactiv Emergency Blemish Relief 5 g/100g 11410-0012-09 Alchemee, 1 tube — — FDA listed —
SPOTLESS Acne Clearing Treatment .025 g/mL 14222-1620-01 Rodan 1 bottle — — FDA listed —
Clearasil Rapid Rescue Spot Treatment 10 g/100g 63824-0433-01 Reckitt 1 tube — — FDA listed —
Epsolay 50 mg/g 00299-5890-00 Galderma 3 g — — Discontinued —
PanOxyl Acne Clearing Spot Treatment 100 mg/g 00316-0298-01 Crown 1 tube — — FDA listed —
Clean and Clear Persa-Gel 10 100 mg/g 69968-0212-01 Kenvue 1 tube — — FDA listed —
Neutrogena Evenly Clear Acne Cleansing Mask 35 mg/mL 69968-0943-04 Kenvue 1 tube — — FDA listed —
2.5 Acne Med 25 mg/mL 70707-0152-15 Face 1 tube — — FDA listed —
Clear Med 5% 5 g/100mL 70764-0106-51 CONTROL 1 tube — — FDA listed —
MEDPURA Benzoyl Peroxide Aqueous Base, Acne Treatment Gel 50 mg/mL 71399-9478-05 Akron 1 tube — — FDA listed —
MDacne Customized Acne Treatment Benzoyl Peroxide 25 mg/mL 71804-0531-00 MDAlgorithms 1 tube — — FDA listed —
Rugby Benzoyl Peroxide Acne Medication 50 mg/g 75376-0467-25 Guangzhou 1 tube — — FDA listed —
Rugby Benzoyl Peroxide Wash Acne Medication 100 mg/g 75376-0474-42 Guangzhou 237 g — — FDA listed —
Terminator 10 100 mg/mL 80861-0002-01 AcneFree, 1 tube — — FDA listed —
OXY Advanced Care Soothing Cream Acne Cleanser 100 mg/g 10742-1206-01 The 3 g — — FDA listed —
Acne Treatment 100 mg/g 30142-0877-10 The 1 tube — — FDA listed —
Acne Cleanser 100 mg/g 41250-0264-56 Meijer, 141 g — — FDA listed —
Acne Treatment 100 mg/g 49035-0229-10 Walmart 1 tube — — FDA listed —
Rugby Benzoyl Peroxide Acne Medication 50 mg/mL 50090-1720-00 A-S 1 tube — — FDA listed —
Rugby Benzoyl Peroxide Acne Medication 100 mg/mL 50090-1792-00 A-S 1 tube — — FDA listed —
Sofie Pavitt Face Reset Benzoyl Peroxide Acne Treatment Mask .05 kg/kg 52261-7300-01 Cosco 1 tube — — FDA listed —
Vivant BP10% Gel Medication 10 g/mL 63750-0005-30 Vivant 30 ml — — FDA listed —
Walgreens Acne Control Cleanser Acne Medication 100 mg/g 00363-3602-01 Walgreen 142 g — — FDA listed —
Walgreens Daily Acne Cleanser- Sensitive Skin Formula 50 mg/mL 00363-5602-01 Walgreen 1 tube — — FDA listed —
MDacne Customized Acne Treatment Benzoyl Peroxide 50 mg/mL 71804-0536-00 MDAlgorithms 1 tube — — FDA listed —
Daily Acne Control Cleanser 100 mg/g 72288-0264-56 Amazon.com 141 g — — FDA listed —
La Roche Posay Laboratoire Dermatologique Benzoyl Peroxide Effaclar Bpo 55 mg/mL 82046-0884-01 LOreal 1 tube — — FDA listed —
Phisoderm Clear Confidence Spot Treatment 25 mg/g 10742-8293-01 The 1 tube — — FDA listed —
Oxy 5 Vanishing 50 mg/g 10742-8355-01 The 1 bottle — — FDA listed —
Proactiv Renewing Cleanser 2.5 g/100mL 11410-0005-00 Alchemee, 1 bottle — — FDA listed —
Epsolay 30 mg/g 51862-0772-30 Mayne 1 bottle — — FDA listed —
Sofie Pavitt Face Reset Benzoyl Peroxide Acne Treatment Mask .05 kg/kg 52261-7301-01 Cosco 1 tube — — FDA listed —
Clarity Clear Skin Solutions Acne Spot Treatment 1.5 g/15mL 54473-0402-01 Melaleuca, 15 ml — — FDA listed —
Age Intervention Duality Md 10 g/100g 65113-2373-02 G.S. 28 g — — FDA listed —
Rugby Benzoyl Peroxide Acne Medication 100 mg/mL 68071-4393-01 NuCare 42.5 ml — — FDA listed —
Zapzyt Acne Treatment Gel 10 g/100g 71687-0011-01 Focus 1 tube — — FDA listed —
MDacne Body Acne Treatment Benzoyl Peroxide 50 mg/mL 71804-0532-00 MDAlgorithms 90 ml — — FDA listed —
amazon basics acne foaming cleanser Acne Treatment 40 mg/mL 72288-0852-01 AMAZON.COM 1 tube — — FDA listed —
Acne Treatment 100 mg/g 76162-0229-10 Topco 1 tube — — FDA listed —
BenzoAzeline 5 500 mg/mL 78863-1300-01 Noon 1 tube — — FDA listed —
Oxy 5 Tinted 50 mg/g 10742-8356-01 The 1 bottle — — FDA listed —
Age Intervention Duality 10 g/100g 65113-2372-02 G.S. 28 g — — FDA listed —
Dermisa Acne Treatment 5 g/100g 68343-0123-01 Montani 28 g — — FDA listed —
Walgreens Creamy Acne Face Wash Acne Medication 40 mg/g 00363-2492-01 Walgreen 170 g — — FDA listed —
Neutrogena On-the-Spot Acne Treatment Vanishing Formula 25 mg/g 69968-0164-01 Kenvue 1 tube — — FDA listed —
amazon basics step 3 treatment Acne medication 25 mg/mL 72288-0618-01 AMAZON.COM 60 ml — — FDA listed —
Rugby Benzoyl Peroxide Acne Medication 100 mg/g 75376-0459-25 Guangzhou 1 tube — — FDA listed —
Monat Acne Treatment 5 g/100mL 78518-0295-01 Monat 15 ml — — FDA listed —
Oxy Advanced Care Rapid Spot Treatment 100 mg/g 10742-1201-01 The 1 tube — — FDA listed —
OXY Sensitive Face Wash Maximum Soothing 50 mg/mL 10742-1313-01 The 148 ml — — FDA listed —
Proactiv Repairing Treatment 2.5 mg/100mL 11410-0040-00 Alchemee, 30 ml — — FDA listed —
Clenziderm Therapeutic 50 mg/mL 62032-0611-01 Obagi 47 ml — — FDA listed —
PCA SKIN BPO Cleanser 5 g/100mL 68726-0168-04 CP 1 bottle — — FDA listed —
Neutrogena Clear Pore Cleanser Mask 35 mg/mL 69968-0026-04 Kenvue 125 ml — — FDA listed —
Neutrogena Stubborn Acne AM Treatment 25 mg/g 69968-0653-01 Kenvue 12 tubes — — FDA listed —
Face Reality Advanced Acne Med 25 mg/mL 70707-0156-01 Face 1 tube — — FDA listed —
Face Reality 5% Advanced Acne Med 50 mg/mL 70707-0157-01 Face 1 tube — — FDA listed —
Acne Treatment 100 mg/g 72288-0229-10 Amazon.com 1 tube — — FDA listed —
Daily Acne Control Cleanser 100 mg/g 76162-0264-28 Topco 141 g — — FDA listed —
OXY Advanced Care Sensitive Skin Acne Cleanser 50 mg/mL 10742-1203-01 The 148 ml — — FDA listed —
Target Up and Up Acne Spot Treatment 25 mg/g 11673-0149-51 TARGET 1 tube — — FDA listed —
Spotless Regimen For Acne, Blemishes And Breakouts 14222-1600-01 Rodan 1 kit — — FDA listed —
SPOTLESS 30-Day Regimenthis 14222-1602-01 Rodan 1 kit — — FDA listed —
Signature Care Acne Medication 100 mg/g 21130-0730-17 SAFEWAY, 1 tube — — FDA listed —
ZO Skin Health Acne Control Benzoyl Peroxide 100 mg/mL 42851-0087-60 ZO 1 tube — — FDA listed —
Acne Cleanser 100 mg/g 49035-0264-56 Walmart, 141 g — — FDA listed —
Clear Proof Acne Treatment Acne Medication 5 g/100g 51531-9071-00 Mary 3 g — — FDA listed —
PanOxyl 100 mg/g 00316-0228-01 Crown 1 tube — — Discontinued —
Walgreens Acne Foaming Wash Acne Medication 100 mg/g 00363-1522-01 Walgreen 156 g — — FDA listed —
CVS Health Acne Control Cleanser Acne Medication 100 mg/g 69842-0571-02 CVS 141 g — — FDA listed —
10 Acne Med 100 mg/mL 70707-0151-15 Face 1 tube — — FDA listed —
5 Acne Med 50 mg/mL 70707-0155-15 Face 1 tube — — Discontinued —
Face Reality 10% Advanced Acne Med 100 mg/mL 70707-0158-01 Face 1 tube — — FDA listed —
MEDPURA Benzoyl Peroxide Aqueous Base, Acne Treatment Gel 100 mg/mL 71399-9474-05 Akron 1 tube — — FDA listed —
Dermaharmony 5% Benzoyl Peroxide Cleansing Bar 5 g/100g 71819-0013-04 D3 113 g — — FDA listed —
amazon basics step 1 cleanser Acne treatment 25 mg/mL 72288-0120-01 AMAZON.COM 120 ml — — FDA listed —
Meijer Maximum Strength Foaming Acne Face Wash Acne Medication 100 mg/g 79481-0022-01 Meijer 1 tube — — FDA listed —
Equate Acne Wash Acne medication 100 mg/g 79903-0061-01 Wal-Mart 1 tube — — FDA listed —
Caring mill Acne Treatment 100 mg/g 81522-0951-01 FSA 28 g — — FDA listed —
Biba Acne 2.5 g/100mL 83834-0001-01 Esthetic 30 ml — — Discontinued —
Proactivplus Skin Smoothing Exfoliator 2.5 mg/100mL 11410-0011-68 Alchemee, 1 tube — — FDA listed —
Target Up And Up Acne Medication 100 mg/g 11673-0088-17 TARGET 1 tube — — FDA listed —
Acne Treatment 100 mg/g 11822-7701-03 Rite 1 tube — — FDA listed —
Breakout Control Bioelements 5 g/100mL 56152-4009-02 Cosmetic 1 bottle — — FDA listed —
Neutrogena Rapid Clear Stubborn Acne Spot 100 mg/g 69968-0043-01 Kenvue 1 tube — — FDA listed —
Clear Med 10% 10 g/100mL 70764-0107-51 CONTROL 1 tube — — FDA listed —
Naturium Benzoyl Peroxide Cleanser 5% 50 mg/mL 76354-0123-01 e.l.f. 1 tube — — FDA listed —
24 Hour Acne Serum 5 g/100g 83286-0007-01 Drmtlgy, 32 g — — FDA listed —
Oxy Advanced Care Rapid Spot Treatment 100 mg/g 10742-1205-01 The 2 g — — FDA listed —
Proactiv plus Pore Targeting Treatment 2.5 g/100mL 11410-0046-00 Alchemee, 1 bottle — — FDA listed —
Acne Solutions All-Over Clearing Treatment 25 mg/mL 49527-0117-01 CLINIQUE 1 tube — — Discontinued —
CVS Health Concealing Acne Treatment Maximum Strength Adult Acne Treatment 100 mg/g 51316-0047-16 CVS 1 tube — — FDA listed —
PanOxyl 58.7 mg/g 00316-0227-06 Crown 1 tube — — FDA listed —
PanOxyl 12.6 g/113g 00316-0264-04 Crown 113 g — — FDA listed —
Walgreens Maximum Strength Tinted Acne Spot Treatment Cream 100 mg/g 00363-0256-51 WALGREEN 1 tube — — FDA listed —
Walgreens Maximum Strength Acne Gel 100 mg/g 00363-0266-51 WALGREEN 1 tube — — FDA listed —
Benzoyl Peroxide Acne Medication 50 mg/mL 68071-2307-05 NuCare 42.5 ml — — FDA listed —
Acne Treatment 1 mg/g 69842-0646-10 CVS 1 tube — — FDA listed —
Clean and Clear persa-gel 10 Maximum Strength 100 mg/g 69968-0720-01 Kenvue 1 tube — — FDA listed —
Benzoazeline Forte .2 g/50g 78863-1180-02 Noon 1 tube — — FDA listed —
BLAIR and JACK Anti-Bump Acne Treatment 50 mg/mL 84377-0489-00 Blair 1 jar — — FDA listed —
OXY Advanced Care Soothing Cream Acne Cleanser 100 mg/mL 10742-1202-01 The 148 ml — — FDA listed —
OXY Rapid Spot Treatment Maximum Action 100 mg/g 10742-1301-01 The 1 tube — — FDA listed —
SPOTLESS Daily Acne Wash .05 g/mL 14222-1610-01 Rodan 1 tube — — FDA listed —
Replenix BP Acne 100 mg/g 51326-0841-20 Topiderm, 57 g — — FDA listed —
Anti Bac Acne Clearing 5 g/100mL 56152-4012-01 Cosmetic 50 ml — — FDA listed —
Dermaclear Spot Treatment 100 mg/g 62742-4075-04 Allure 1 bottle — — FDA listed —
Clearasil Stubborn Acne Control 5in1 Spot Treatment 10 g/100g 63824-0438-01 Reckitt 1 tube — — FDA listed —
Acne Treatment 1 mg/g 00363-0229-10 Walgreen 1 tube — — FDA listed —
Walgreens Acne Foaming Cleanser Acne Treatment 40 mg/mL 00363-0467-01 Walgreen 1 tube — — FDA listed —
Dermaharmony 10% Benzoyl Peroxide Cleansing Bar 10 g/100g 71819-0011-04 D3 113 g — — FDA listed —
Rugby Benzoyl Peroxide Acne Medication 25 mg/g 75376-0466-25 Guangzhou 1 tube — — FDA listed —
BenzoAzeline 10 1000 mg/mL 78863-1310-01 Noon 1 tube — — FDA listed —
Benzoyl Peroxide Deep Cleansing Foaming Wash .1 g/g 80861-0112-01 AcneFree, 1 g — — FDA listed —
Oxy Total Care Clarifying Moisturizer 25 mg/mL 10742-1314-01 The 1 tube — — FDA listed —
Oxy 10 Vanishing 100 mg/g 10742-8353-01 The 1 bottle — — FDA listed —
Oxy 10 Tinted 100 mg/g 10742-8354-01 The 1 bottle — — FDA listed —
UNBLEMISH Dual Intensive Acne Treatment .025 g/mL 14222-2120-01 Rodan 1 bottle — — FDA listed —
Meijer Acne Treatment Acne medication 100 mg/g 41250-0347-01 Meijer 1 tube — — FDA listed —
Meijer Invisible Acne Acne medication 100 mg/g 41250-0348-01 Meijer 1 tube — — FDA listed —
Clear Cell Clarifying Acne 50 mg/g 62742-4208-01 Allure 7 g — — FDA listed —
Daily Leave on Acne Treatment Mask 25 mg/g 62742-4212-02 Allure 1 tube — — FDA listed —
Walgreens Acne Spot Treatment 25 mg/g 00363-0116-51 WALGREEN 1 tube — — FDA listed —
Zitfree Acne Treatment 100 mg/g 67234-0035-01 Natureplex, 1 tube — — FDA listed —
Walgreens Maximum Strength Acne Treatment Acne medication 100 mg/g 00363-8798-01 Walgreen 1 tube — — FDA listed —
Walgreens Maximum Strength Acne Treatment 100 mg/g 00363-1363-17 WALGREEN 1 tube — — FDA listed —
Zmztuhua Folliculitis Treatment Cream 5 g/100g 87298-0051-01 Guangzhou 100 g — — FDA listed —
Benzoyl Peroxide 25 mg/1000mg 77924-0002-02 Malezia 50000 mg — — FDA listed —
Acne Treatment Cream 1 mg/100g 51316-0654-01 CVS 1 tube — — FDA listed —
Proactiv 10% BPO Wash 10 g/100mL 11410-0220-01 Alchemee, 1 bottle — — FDA listed —
Walgreens Acne Foaming Cleanser 40 mg/mL 00363-1364-23 WALGREEN 150 ml — — FDA listed —
Folliculitis Treatment Cream 5 g/100g 87298-0060-01 Guangzhou 100 g — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2025
On the market since
Jan 2025
📍
2026
Currently FDA-listed
1 year listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

From the label’s inactive-ingredient sectionwater, polyacrylamide, C13-14 isoalkane, jojoba esters, carbomer, diethylhexyl sodium sulfosuccinate, cocamidopropyl betaine, laureth-7, sodium chloride, sodium citrate, sodium hydroxide, propanediol, ethylhexylglycerin, phenoxyethanol, sodium benzoate water/aqua/eau, glycereth-18 ethylhexanoate, glycereth-18, disiloxane, glycerin, butylene glycol, propanediol, acrylamide/sodium acryloyldimethyltaurate copolymer, allantoin, ascorbyl palmitate, bisabolol, myristyl alcohol, PCA, phytosteryl/octyldodecyl lauroyl glutamate, polygonum cuspidatum root extract, sodium hyaluronate, zingiber officinale (ginger) root extract, fragrance/parfum, carbomer, methyl methacrylate crosspolymer, cetyl hydroxyethylcellulose, hydroxyphenyl propamidobenzoic acid, polyglyceryl-2 isostearate, polysorbate 80, sorbitan oleate, xanthan gum, diethylhexyl sodium sulfosuccinate, isohexadecane, dimethyl isosorbide, tocopherol, citric acid, sodium citrate, sodium hydroxide, caprylyl glycol, decylene glycol, hexylene glycol, pentylene glycol, 1,2-hexanediol, ethylhexylglycerin, hydroxyacetophenone, phenoxyethanol, citral, citronellol, limonene, linalool, carvone, citrus aurantium peel oil, mentha viridis (spearmint) leaf oil, pinene, mica, tin oxide, titanium dioxide (CI 77891), blue 1 (CI 42090), ext. violet 2 (CI 60730), red 33 (CI 17200)

This is label-wide narrative text, not a normalized exact-product ingredient list. A label can cover multiple strengths or packages.

Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerRodan & Fields
FDA applicationM006 (OTC MONOGRAPH DRUG)
Labeler code14222
First marketedJan 2025
Product typeHuman Otc Drug
Portfolio29 products on file

More NDCs from Rodan & Fields labeler code 14222

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Other Information 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 38 words ▾

Uses for the treatment of acne helps keep skin clear of new acne blemishes, acne pimples, blackheads and whiteheads

Uses for the treatment of acne helps keep skin clear of new acne blemishes, acne pimples, blackheads and whiteheads

⏱️ Dosage and Administration ~1 min read ▾

Directions wet skin with lukewarm water using fingertips, apply a thin, even layer and massage over entire face for 90 seconds, avoiding all contact with eyes rinse thoroughly and pat dry use once daily and increase to twice daily as tolerated wash hands after application to help avoid staining fabrics because excessive drying of the skin may occur, start with one application daily, then gradually increase to two or three times daily if needed or as directed by a doctor if bothersome dryness or peeling occurs, reduce application to once a day or every other day if going outside, apply sunscreen after using this product.

If irritation or sensitivity develops, stop use of both products and ask a doctor.

Directions clean the skin thoroughly before applying this product dispense 1-2 pumps and cover the entire affected area with a thin, even layer one to three times daily do not rinse product off face wash hands after application to help avoid staining fabrics because excessive drying of the skin may occur, start with one application daily, then gradually increase to two or three times daily if needed or as directed by a doctor if bothersome dryness or peeling occurs, reduce application to once a day or every other day if going outside, apply sunscreen after using this product.

If irritation or sensitivity develops, stop use of both products and ask a doctor.

⚠️ Warnings ~1 min read ▾

Warnings For external use only Do not use if you have very sensitive skin are sensitive to benzoyl peroxide When using this product skin irritation may occur, characterized by redness, burning, itching, peeling or possibly swelling. Irritation may be reduced by using the product less frequently or in a lower concentration. skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. avoid unnecessary sun exposure and use a sunscreen avoid contact with the eyes, lips and mouth avoid contact with hair and dyed fabrics, which may be bleached by this product Stop use and ask a doctor if irritation becomes severe Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

Warnings For external use only Do not use if you have very sensitive skin are sensitive to benzoyl peroxide When using this product skin irritation may occur, characterized by redness, burning, itching, peeling or possibly swelling. Irritation may be reduced by using the product less frequently or in a lower concentration. skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. avoid unnecessary sun exposure and use a sunscreen avoid contact with the eyes, lips and mouth avoid contact with hair and dyed fabrics, which may be bleached by this product Stop use and ask a doctor if irritation becomes severe Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

🧪 Active Ingredient 10 words ▾

Active ingredient Benzoyl peroxide 5%

Active ingredient Benzoyl peroxide 2.5%

🧪 Inactive Ingredients 139 words ▾

Inactive ingredients water, polyacrylamide, C13-14 isoalkane, jojoba esters, carbomer, diethylhexyl sodium sulfosuccinate, cocamidopropyl betaine, laureth-7, sodium chloride, sodium citrate, sodium hydroxide, propanediol, ethylhexylglycerin, phenoxyethanol, sodium benzoate

Inactive ingredients water/aqua/eau, glycereth-18 ethylhexanoate, glycereth-18, disiloxane, glycerin, butylene glycol, propanediol, acrylamide/sodium acryloyldimethyltaurate copolymer, allantoin, ascorbyl palmitate, bisabolol, myristyl alcohol, PCA, phytosteryl/octyldodecyl lauroyl glutamate, polygonum cuspidatum root extract, sodium hyaluronate, zingiber officinale (ginger) root extract, fragrance/parfum, carbomer, methyl methacrylate crosspolymer, cetyl hydroxyethylcellulose, hydroxyphenyl propamidobenzoic acid, polyglyceryl-2 isostearate, polysorbate 80, sorbitan oleate, xanthan gum, diethylhexyl sodium sulfosuccinate, isohexadecane, dimethyl isosorbide, tocopherol, citric acid, sodium citrate, sodium hydroxide, caprylyl glycol, decylene glycol, hexylene glycol, pentylene glycol, 1,2-hexanediol, ethylhexylglycerin, hydroxyacetophenone, phenoxyethanol, citral, citronellol, limonene, linalool, carvone, citrus aurantium peel oil, mentha viridis (spearmint) leaf oil, pinene, mica, tin oxide, titanium dioxide (CI 77891), blue 1 (CI 42090), ext. violet 2 (CI 60730), red 33 (CI 17200)

🎯 Purpose 6 words ▾

Purpose Acne treatment

Purpose Acne treatment

📄 Do Not Use 28 words ▾

Do not use if you have very sensitive skin are sensitive to benzoyl peroxide

Do not use if you have very sensitive skin are sensitive to benzoyl peroxide

📄 When Using This Product 188 words ▾

When using this product skin irritation may occur, characterized by redness, burning, itching, peeling or possibly swelling. Irritation may be reduced by using the product less frequently or in a lower concentration. skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. avoid unnecessary sun exposure and use a sunscreen avoid contact with the eyes, lips and mouth avoid contact with hair and dyed fabrics, which may be bleached by this product

When using this product skin irritation may occur, characterized by redness, burning, itching, peeling or possibly swelling. Irritation may be reduced by using the product less frequently or in a lower concentration. skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. avoid unnecessary sun exposure and use a sunscreen avoid contact with the eyes, lips and mouth avoid contact with hair and dyed fabrics, which may be bleached by this product

📄 Stop Use and Ask a Doctor If 20 words ▾

Stop use and ask a doctor if irritation becomes severe

Stop use and ask a doctor if irritation becomes severe

📄 Keep Out of Reach of Children 38 words ▾

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

📄 Other Information 12 words ▾

Other information store between 15-30°C (59-86°F)

Other information store between 15-30°C (59-86°F)

📄 Questions or Comments 4 words ▾

Questions? 1-888-995-5656

Questions? 1-888-995-5656

📄 Package Label / Principal Display Panel 196 words ▾

Principal Display Panel - Kit Label RODAN+FIELDS SPOTLESS REGIMEN FOR ACNE, BLEMISHES AND BREAKOUTS DESIGNED FOR TEENS AND YOUNG ADULTS Eliminates acne-causing bacteria Helps clear blackheads, whiteheads and pimples Helps prevent new blemishes from forming Reduces shine DEVELOPED BY STANFORD-TRAINED DERMATOLOGISTS DR.KATIE RODAN AND DR.KATHY FIELDS Daily Acne Wash Benzoyl Peroxide Cream 125 mL/4.2 Fl. Oz. U.S.

Acne Clearing Treatment Benzoyl Peroxide Lotion* 50 mL/1.7 Fl. Oz. U.S.

Figure

Principal Display Panel - Daily Acne Wash Tube Label RODAN+FIELDS SPOTLESS DAILY ACNE WASH 1 Figure

Principal Display Panel - Acne Clearing Treatment Tube Label RODAN+FIELDS SPOTLESS ACNE CLEARING TREATMENT 2 Figure

Principal Display Panel - 30-DAY KIT Carton Label RODAN+FIELDS SPOTLESS 30-DAY REGIMEN FOR TEEN ACNE FEMALE FOUNDED + DERMATOLOGIST DEVELOPED 95% HAD LESS ACNE IN 5 DAYS** DAILY ACNE WASH BENZOYL PEROXIDE CREAM WASH 65 ML /

2.2FL. OZ. ACNE CLEARING TREATMENT BENZOYL PEROXIDE CREAM LOTION*** 2 x 10 ML / 2 x

0.33FL. OZ. Figure

Principal Display Panel - 65 mL Tube Label RODAN+FIELDS SPOTLESS DAILY ACNE WASH 1 Benzoyl Peroxide Cream Wash Figure

Principal Display Panel - 20 mL Tube Label RODAN+FIELDS SPOTLESS ACNE CLEARING TREATMENT 2 Benzoyl Peroxide Lotion Figure

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Medicare Part D spend CMS · PART D · 2026 (Q1)

Medicare Part D (outpatient prescription) spending for Epsolay (matched by generic name) — the program that covers self-administered drugs. 1 manufacturer.
⚠️ Drug-level data: CMS publishes Part D spending by drug, not by NDC — these figures combine every manufacturer, strength and package size sold under the name Epsolay. That’s a different level of aggregation than the Medicaid card above, which is specific to this exact 11-digit NDC (pack size included), so the two aren’t directly comparable.
Period
Total Part D spend
$60.9K
Claims incl. refills
82
Beneficiaries
63
Spend / beneficiary
$967.04
Spend / claim
$742.97
Trend by period
💵 About the dollar figures: spending is what Part D plans paid before confidential manufacturer rebates, so the program’s real net cost is lower. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part D Spending by Drug (data.cms.gov), updated quarterly.

Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for SPOTLESS 30-Day Regimen (this brand).

Top reported reactions

Rash92
Erythema70
Pruritus69
Pain65
Fatigue63
Nausea62
Anxiety60

Age at onset

Neonate1
Child2
Adolescent29
Adult146
Elderly22

Reporter sex

1,318 reports
Male · 40%
Female · 59%
Unknown · 1%

Serious outcomes

Hospitalization274
Death47
Reports over time (by year) — tap or hover for the count & year
2019 2021 2023 2026 162 62
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

About this NDC listing & data coverage

Over-the-counter (OTC) product Kit / multi-component package

Kit / multi-component package

This NDC identifies a kit — a package containing more than one component. Structured data (pricing, ingredients, equivalents) is often reported per component rather than for the kit NDC itself, which can make this page look thinner than the components' own pages.

What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Rodan & Fields. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
Rodan & Fields is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 14222-1600-01 · Rodan 14222-1610-01 · Rodan →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.