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Pain Reliever PM Acetaminophen, Diphenhydramine HCL 500 mg; 25 mg Tablet, Coated, 500-count — NDC 51316-0863-50 package photo

Pain Reliever PM Acetaminophen, Diphenhydramine HCL 500 mg; 25 mg Tablet, Coated, 500-count

by CVS PHARMACY, INC · 500 TABLET, COATED in 1 BOTTLE, PLASTIC (51316-863-50)
NDC 51316-0863-50
🏷️ FDA NDC (as labeled) 51316-863-50 billing pads the product segment with a zero
OTC On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 51316-863-50
Product NDC 51316-863
11-digit billing NDC 51316086350
RxCUI 1092189
UNII 362O9ITL9D, TC2D6JAD40
UPC 0050428164556
Application # M012
SPL Set ID 17922df7-7867-4300-bd99-55aee7b60606
Established class (EPC) Histamine-1 Receptor Antagonist
Mechanism of action Histamine H1 Receptor Antagonists
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2024-09-15
Route ORAL
Dosage form TABLET, COATED
Substance ACETAMINOPHEN; DIPHENHYDRAMINE HYDROCHLORIDE
GCN Seq No 003699
GCN 70221
HICL code 001861
Ingredient (HICL) Acetaminophen/Diphenhydramine
HIC1 code B
Therapeutic class — broad (HIC1) Respiratory System
HIC2 code B5
Therapeutic class — intermediate (HIC2) Drugs Affecting The Trachea And Bronchi (Contin.2)
HIC3 code B5S
Therapeutic class — specific (HIC3) Analgesic, Non-Sal.- 1St Generation Antihistamine
AHFS code 04:04.00.00
AHFS class First Generation Antihistamines
FDB label name CVS ACETAMINOPHEN PM CAPLET
FDB brand name Acetaminophen Pm
Legend status O — Over-the-counter (OTC) drug or device
Why two NDCs? The FDA registers this code as 51316-863-50 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 51316-0863-50. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Anilides class.

Drug family (ATC) Anilides
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerCVS PHARMACY, INC
FDA applicationM012 (OTC MONOGRAPH DRUG)
Labeler code51316
First marketedSep 2024
Product typeHuman Otc Drug
Portfolio102 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name CVS ACETAMINOPHEN PM CAPLET Ingredient Acetaminophen/Diphenhydramine
📖 About the active ingredient: Acetaminophen; Diphenhydramine Hydrochloride MedlinePlus · NLM
General information about the ingredient itself — the description of this specific product follows below.

Acetaminophen is used to relieve mild to moderate pain and to reduce fever. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.

Read the full MedlinePlus article ↗
🧪 What is this product?

This is an over-the-counter coated tablet designed to be taken by mouth. It contains acetaminophen, a pain reliever and fever reducer, combined with diphenhydramine hydrochloride, an antihistamine that causes drowsiness. Products with this combination are typically used to relieve minor aches, pains, and fever while the antihistamine component is intended to help with nighttime use by promoting sleep. This is an OTC monograph drug, meaning it is marketed under FDA's established rules for this category of product.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
1
Nutrient depletion considerations

Acetaminophen, Diphenhydramine may be associated with lower levels of 1 nutrient — worth a chat with your pharmacist, not a cause for alarm.

🧪 Full Acetaminophen, Diphenhydramine nutrient depletion report →
An association is not a deficiency. Educational only — don't start or stop anything without professional guidance.
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

💊 What it looks like

Color blue
ShapeCapsule
ImprintP525
Size18 mm
ScoringNot scored
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII OP1R32D61U
    Microcrystalline cellulose is a purified form of cellulose, a natural fiber from plant sources. It acts as a binder and filler in tablets and capsules, helping hold ingredients together and give the medicine its shape and size.
  • UNII M28OL1HH48
    Croscarmellose sodium is a plant-based substance derived from cellulose. It acts as a disintegrant, helping tablets and capsules break down quickly in the digestive system so the medicine can be absorbed.
  • UNII H3R47K3TBD
    FD&C Blue No. 1 is a synthetic blue dye approved for use in foods and medicines. It serves as a colorant to give the medication its distinctive appearance and help with product identification.
  • UNII L06K8R7DQK
    A synthetic blue dye approved by the FDA for use in medications and foods. It serves as a colorant to make pills and liquids visually distinct and easier to identify.
  • UNII 3NXW29V3WO
    Hypromellose is a plant-based thickener made from cellulose. It's used in medicines as a binder to hold ingredients together, a coating for tablets, and a thickener for liquids.
  • UNII 70097M6I30
    Magnesium stearate is a salt made from magnesium and stearic acid, a fatty substance. It's used in tablets and capsules as a lubricant and glidant to help ingredients flow smoothly during manufacturing and prevent sticking.
  • UNII 3WJQ0SDW1A
    Polyethylene glycol is a synthetic liquid or solid polymer used in medicines as a solvent, lubricant, and humectant. It helps dissolve active ingredients, reduces friction during manufacturing, and retains moisture in the final product.
  • UNII 532B59J990
    Polyvinyl alcohol is a synthetic polymer made from plant-derived materials. It's used as a binder to hold ingredients together, a film-former in coatings, and a thickener in liquid formulations.
  • UNII U725QWY32X
    Povidone K30 is a synthetic polymer made from petroleum. It acts as a binder to hold tablet ingredients together and as a disintegrant to help the tablet break apart in the stomach so the medicine can be absorbed.
  • UNII ETJ7Z6XBU4
    Silicon dioxide is a naturally occurring mineral used as a glidant and anti-caking agent. It helps powder ingredients flow smoothly and prevents clumping during manufacturing and storage.
  • UNII AG9B65PV6B
    A starch derivative made from corn that helps tablets and capsules break apart quickly when swallowed. It acts as a disintegrant, allowing the medicine to dissolve and be absorbed in your stomach and intestines.
  • UNII O8232NY3SJ
    A plant-based carbohydrate derived from corn kernels. It acts as a filler to add bulk, a binder to hold ingredients together, and a disintegrant to help the tablet break apart in your stomach for absorption.
  • UNII 7SEV7J4R1U
    A powder made from a naturally occurring mineral. In medicines, talc works as a glidant and anti-caking agent, helping tablets and capsules flow smoothly during manufacturing and preventing clumping.
  • UNII 15FIX9V2JP
    Titanium dioxide is a bright white mineral powder commonly used as a colorant and opacifying agent. It makes pills and tablets white or lighter in color and helps make coatings non-transparent.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

15 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statescroscarmellose sodium, FD&C blue #1 aluminum lake, FD&C blue #2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone K30, pregelatanized starch, purified water, silicon dioxide, sodium starch glycolate, talc, titanium dioxide

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
good sense pain relief pm extra strength 500 mg/1; 25 mg 00113-0437-71 L. 50 tablets $0.044 — Availability likely —
Acetaminophen PM 25 mg/1; 500 mg 00904-6731-51 Major 50 tablets $0.044 — Availability likely —
Extra Strength PM Pain Medicine 500 mg/1; 25 mg 46122-0799-69 Amerisource 50 tablets $0.044 — Availability likely —
Acetaminophen, Diphenhydramine Hydrochloride 500 mg/1; 25 mg 70000-0411-01 LEADER/ 24 tablets $0.044 — Availability likely —
Pain Reliever PM 500 mg/1; 25 mg 70677-1149-01 Strategic 50 tablets $0.044 — Availability likely —
Acetaminophen PM 500 mg/1; 25 mg 83324-0070-20 Chain 20 tablets $0.044 — Availability likely —
Pain Relief PM Extra Strength 500 mg/1; 25 mg 83324-0085-01 CHAIN 100 tablets $0.044 — Availability likely —
Pain Reliever PM 500 mg/1; 25 mg 83324-0166-50 QUALITY 50 tablets $0.044 — Availability likely —
Pain Reliever PM Extra Strength 500 mg/1; 25 mg 62011-0420-01 Strategic 50 tablets $0.046 — FDA listed —
Pain Relief PM Extra Strength 500 mg/1; 25 mg 63868-0325-50 Chain 50 tablets $0.046 — FDA listed —
Pain Relief PM 500 mg/1; 25 mg 70677-0081-01 Strategic 100 tablets $0.046 — FDA listed —
Pain Reliever PM Extra Strength 500 mg/1; 25 mg 62011-0256-01 Strategic 50 tablets $0.047 — FDA listed —
Panadol Pm 500 mg/1; 25 mg 00135-0608-01 Haleon 24 tablets — — FDA listed —
Panadol Pm 500 mg/1; 25 mg 00135-7021-01 Haleon 2 tablets — — FDA listed —
Pain Reliever PM Extra Strength 500 mg/1; 25 mg 00363-0556-09 Walgreen 20 tablets — — FDA listed —
Extra Strength NiteTime Pain Relief 25 mg/1; 500 mg 00363-0714-42 WALGREENS 24 tablets — — FDA listed —
Extra Strength Nite-Time Pain Relief 500 mg/1; 25 mg 00363-0715-01 WALGREENS 100 tablets — — FDA listed —
Pain Reliever PM Extra Strength 500 mg/1; 25 mg 00363-0760-10 Walgreens 100 tablets — — FDA listed —
Pain Reliever PM Extra strength 500 mg/1; 25 mg 00363-0863-10 Walgreens 100 tablets — — FDA listed —
Pain Reliever PM 500 mg/1; 25 mg 00363-2035-08 Walgreen 24 tablets — — FDA listed —
Extra Strength Pain Reliever Pm 500 mg/1; 25 mg 00363-9085-15 WALGREENS 15 tablets — — FDA listed —
Acetaminophen Diphenhydramine HCL 500 mg/1; 25 mg 00363-9661-15 Walgreens 150 tablets — — FDA listed —
Acetaminophen Diphenhydramine HCL 500 mg/1; 25 mg 00363-9664-60 WALGREENS 125 tablets — — FDA listed —
Acetaminophen Diphenhydramine HCL 500 mg/1; 25 mg 00363-9799-75 WALGREEN 75 tablets — — FDA listed —
Pain Reliever PM 500 mg/1; 25 mg 11673-0754-10 TARGET 100 tablets — — FDA listed —
Pain Relief Acetaminophen PM 500 mg/1; 25 mg 11822-0556-01 Rite 80 tablets — — FDA listed —
Pain Relief Acetaminophen PM Extra Strength 500 mg/1; 25 mg 11822-2350-02 Rite 100 tablets — — FDA listed —
Acetaminophen Pm 500 mg/1; 25 mg 17714-0133-50 Advance 50 tablets — — FDA listed —
Pain Relief PM 500 mg/1; 25 mg 21130-0095-01 Safeway 24 tablets — — FDA listed —
Acetaminophen and Diphenhydramine hydrochloride 500 mg/1; 25 mg 21130-0224-18 Better 80 tablets — — FDA listed —
Acetaminophen Diphenhydramine HCl 500 mg/1; 25 mg 21130-0354-02 BETTER 20 tablets — — FDA listed —
Acetaminophen and Diphenhydramine HCL 500 mg/1; 25 mg 21130-0661-10 SAFEWAY 100 tablets — — FDA listed —
Acetaminophen and Diphenhydramine hydrochloride 500 mg/1; 25 mg 30142-0193-14 KROGER 50 tablets — — FDA listed —
Extra Strength Acetaminophen PM 500 mg/1; 25 mg 30142-0755-01 KROGER 100 tablets — — FDA listed —
Pain Relief PM Extra Strength 500 mg/1; 25 mg 36800-0095-03 TopCo 100 tablets — — FDA listed —
Pain Reliever PM Extra Strength 500 mg/1; 25 mg 36800-0466-10 TOP 100 tablets — — FDA listed —
Pain Relief PM 500 mg/1; 25 mg 36800-0556-09 Topco 20 tablets — — FDA listed —
Vicks ZzzQuil Night Pain 25 mg/1; 500 mg 37000-0974-60 The 60 tablets — — FDA listed —
Pain Relief PM Extra Strength 500 mg/1; 25 mg 37808-0556-09 H 20 tablets — — FDA listed —
Pain Relief PM Extra Strength 500 mg/1; 25 mg 37808-0795-03 HEB 100 tablets — — FDA listed —
Acetaminophen and Diphenhydramine Hydrochloride 500 mg/1; 25 mg 37835-0537-01 Bi-Mart 100 tablets — — FDA listed —
Acetaminophen PM Extra Strength 500 mg/1; 25 mg 41163-0228-50 United 50 tablets — — FDA listed —
acetaminophen pm extra strength 500 mg/1; 25 mg 41163-0515-01 United 24 tablets — — FDA listed —
Acetaminophen PM Extra Strength 500 mg/1; 25 mg 41163-0956-09 United 20 tablets — — FDA listed —
pain relief PM 500 mg/1; 25 mg 41250-0195-02 Meijer 50 tablets — — FDA listed —
Acetaminophen and Diphenhydramine HCL 25 mg/1; 500 mg 41415-0661-05 PUBLIX 50 tablets — — FDA listed —
CareOne Acetaminophen PM 500 mg/1; 25 mg 41520-0514-47 American 150 tablets — — Discontinued —
Acetaminophen PM Extra Strength 500 mg/1; 25 mg 41520-0956-09 FOODHOLD 20 tablets — — FDA listed —
Pain Relief PM 500 mg/1; 25 mg 42507-0095-03 HYVEE 100 tablets — — FDA listed —
Pain Reliever PM Extra Strength 500 mg/1; 25 mg 49035-0363-10 EQUATE 100 tablets — — FDA listed —
Extra strength Acetaminophen PM 25 mg/1; 500 mg 49483-0430-40 TIME 400 tablets — — FDA listed —
Tylenol PM 500 mg/1; 25 mg 50269-0552-01 JC 2 tablets — — FDA listed —
Tylenol PM 500 mg/1; 25 mg 50269-0608-06 JC 25 tablets — — FDA listed —
Tylenol PM Extra Strength 500 mg/1; 25 mg 50580-0608-01 Kenvue 24 tablets — — FDA listed —
Pain Reliever PM Extra Strength 500 mg/1; 25 mg 50594-0863-10 Big 100 tablets — — Discontinued —
Pain Relief PM Extra Strength 500 mg/1; 25 mg 50804-0825-02 GoodSense 20 tablets — — FDA listed —
Pain Reliever PM Extra Strength 500 mg/1; 25 mg 50844-0235-15 L.N.K. 50 tablets — — FDA listed —
Pain Reliever PM 500 mg/1; 25 mg 50844-0256-08 L.N.K. 24 tablets — — FDA listed —
Pain Reliever PM Extra Strength 500 mg/1; 25 mg 50844-0556-10 L.N.K. 40 tablets — — FDA listed —
Pain Reliever PM 500 mg/1; 25 mgthis 51316-0863-50 CVS 500 tablets — — FDA listed —
CAREALL Non-Aspirin PM Extra Strength 500 mg/1; 25 mg 51824-0069-50 New 50 tablets — — FDA listed —
CAREALL Pain Relief PM Extra Strength 500 mg/1; 25 mg 51824-0107-50 New 50 tablets — — FDA listed —
CAREALL Pain Relief PM Extra Strength 500 mg/1; 25 mg 51824-0108-50 New 50 tablets — — FDA listed —
Tylenol PM Extra Strength 500 mg/1; 25 mg 53209-1002-02 Morning 2 tablets — — FDA listed —
Pain Reliever PM 500 mg/1; 25 mg 54257-0278-02 Magno-Humphries, 100 tablets — — FDA listed —
CounterAct PM 25 mg/1; 500 mg 54473-0304-01 Melaleuca, 50 tablets — — FDA listed —
Acetaminophen PM Extra Strength 500 mg/1; 25 mg 55301-0235-06 ARMY 200 tablets — — Discontinued —
Pain Reliever PM 500 mg/1; 25 mg 55319-0562-10 Family 100 tablets — — FDA listed —
dg health pain relief pm extra strength 500 mg/1; 25 mg 55910-0437-71 Dolgencorp 50 tablets — — FDA listed —
Pain Relief PM Extra Strength 500 mg/1; 25 mg 55910-0655-10 DOLGENCORP, 40 tablets — — FDA listed —
Pain Relief PM 500 mg/1; 25 mg 55910-0834-01 DOLGENCORP, 100 tablets — — FDA listed —
pain relief pm extra strength 500 mg/1; 25 mg 56062-0437-71 Publix 50 tablets — — FDA listed —
Pain Reliever PM Extra Strength 500 mg/1; 25 mg 57243-0235-15 Salado 50 tablets — — FDA listed —
Acetaminophen PM 500 mg/1; 25 mg 57344-0095-01 AAA 24 tablets — — FDA listed —
Extra Strength Night Time Pain Medicine 500 mg/1; 25 mg 57896-0224-01 Geri-Care 100 tablets — — FDA listed —
Kroger EXTRA STRENGTH Acetaminophen PM Caplet 500 mg/1; 25 mg 59450-0174-01 The 100 tablets — — FDA listed —
Pain Reliever PM extra strength 500 mg/1; 25 mg 59726-0868-10 P 100 tablets — — FDA listed —
Pain Relief PM 500 mg/1; 25 mg 61504-0095-03 AMERIFOODS 100 tablets — — FDA listed —
Extra Strength Pain Reliever PM 500 mg/1; 25 mg 62936-0224-01 INGLES 50 tablets — — FDA listed —
good sense pain relief pm extra strength 500 mg/1; 25 mg 63629-5880-01 Bryant 14 tablets — — FDA listed —
Pain Relief PM Extra Strength 500 mg/1; 25 mg 63868-0119-50 QUALITY 50 tablets — — FDA listed —
Acetaminophen PM Extra Strength 500 mg/1; 25 mg 63868-0210-20 CHAIN 20 tablets — — FDA listed —
Extra Strength Pain Relief PM 500 mg/1; 25 mg 63941-0095-02 VALU 50 tablets — — FDA listed —
Acetaminophen PM 500 mg/1; 25 mg 63981-0056-54 COSTCO 375 tablets — — FDA listed —
Pain Reliever PM, Extra Strength, 24-7 Life by 7-Eleven 25 mg/1; 500 mg 66715-5640-04 Lil' 24 tablets — — FDA listed —
Tylenol PM Extra Strength, CVP HEALTH 25 mg/1; 500 mg 66715-6417-02 Lil' 2 tablets — — FDA listed —
Tylenol PM Extra Strength, CVP HEALTH 500 mg/1; 25 mg 66715-6517-02 Lil' 2 tablets — — FDA listed —
Pain Reliever PM, Extra Strength, 24-7 Life by 7-Eleven 25 mg/1; 500 mg 66715-8158-03 Lil' 6 tablets — — FDA listed —
Lil Drug Store Tylenol PM Extra Strength 25 mg/1; 500 mg 66715-9817-02 Lil' 2 tablets — — FDA listed —
Acetaminophen PM Extra Strength 500 mg/1; 25 mg 67091-0137-50 WinCo 50 tablets — — FDA listed —
Tylenol PM Extra Strength 500 mg/1; 25 mg 67414-0608-00 Jones 2 tablets — — FDA listed —
Tylenol PM Extra Strength 500 mg/1; 25 mg 67751-0241-01 Navajo 2 tablets — — FDA listed —
Acetaminophen Diphenhydramine HCl 500 mg/1; 25 mg 68016-0654-05 Chain 50 tablets — — FDA listed —
acetaminophen pm extra strength 500 mg/1; 25 mg 68196-0556-54 Sam's 375 tablets — — FDA listed —
Extra Strength Acetaminophen PM 500 mg/1; 25 mg 68391-0430-50 BJWC 500 tablets — — FDA listed —
Pain Reliever PM Extra Strength 500 mg/1; 25 mg 68391-0863-05 BJWC 500 tablets — — FDA listed —
Pain Relief PM Extra Strength 500 mg/1; 25 mg 68998-0071-03 MARC 80 tablets — — FDA listed —
Pain Relief PM Extra Strength 500 mg/1; 25 mg 68998-0195-02 MARC 50 tablets — — FDA listed —
Pain Relief PM Extra Strength 500 mg/1; 25 mg 69168-0003-50 Allegiant 50 tablets — — FDA listed —
Pain Relief PM Extra Strength 500 mg/1; 25 mg 69168-0393-02 Allegiant 150 tablets — — FDA listed —
Pain Reliever PM 500 mg/1; 25 mg 69607-8630-01 WR 24 tablets — — FDA listed —
Genexa Acetaminophen PM Extra Strength 500 mg/1; 25 mg 69676-0063-02 Genexa 100 tablets — — FDA listed —
Cystex PM 500 mg/1; 25 mg 69693-0417-10 Clarion 10 tablets — — FDA listed —
Acetaminophen, Diphenhydramine Hcl 25 mg/1; 500 mg 69842-0572-08 CVS 24 tablets — — FDA listed —
Acetaminophen PM Extra Strength 500 mg/1; 25 mg 69842-0956-09 CVS 20 tablets — — Discontinued —
Acetaminophen Diphenhydramine HCl 25 mg/1; 500 mg 69848-0014-02 Granules 20 tablets — — FDA listed —
Tylenol Pm Extra Strength 500 mg/1; 25 mg 70264-0028-01 R 2 tablets — — FDA listed —
RIGHT REMEDIES EXTRA STRENGTH PM Pain Relief 500 mg/1; 25 mg 70692-0149-03 Strive 30 tablets — — FDA listed —
RIGHT REMEDIES EXTRA STRENGTH Pain Relief PM Caplet 500 mg/1; 25 mg 70692-0471-31 Strive 300 tablets — — FDA listed —
GOOD REMEDIES Extra Strength Pain Relief PM Caplet 500 mg/1; 25 mg 70692-0741-03 Strive 30 tablets — — FDA listed —
pain relief PM 500 mg/1; 25 mg 72036-0095-02 HARRIS 50 tablets — — FDA listed —
Acetaminophen PM 500 mg/1; 25 mg 72036-0171-02 Harris 40 tablets — — FDA listed —
Pain Relief PM 25 mg/1; 500 mg 72090-0006-25 Pioneer 375 tablets — — FDA listed —
Pain Relief PM 25 mg/1; 500 mg 72090-0032-01 Pioneer 375 tablets — — FDA listed —
basic care acetaminophen pm 500 mg/1; 25 mg 72288-0437-78 Amazon.com 100 tablets — — FDA listed —
Acetaminophen Pm 500 mg/1; 25 mg 72476-0171-01 RETAIL 20 tablets — — FDA listed —
Acetaminophen Pm 500 mg/1; 25 mg 73057-0352-03 Ulai 24 tablets — — FDA listed —
Tylenol PM 500 mg/1; 25 mg 73097-0013-02 Savings 2 tablets — — FDA listed —
Pain Relief PM 500 mg/1; 25 mg 76168-0119-25 Velocity 50 tablets — — FDA listed —
meijer EXTRA STRENGTH Pain Relief PM Caplet 500 mg/1; 25 mg 79481-0149-01 Meijer, 100 tablets — — FDA listed —
meijer EXTRA STRENGTH Pain Relief PM CAPLET 500 mg/1; 25 mg 79481-0174-01 Meijer, 100 tablets — — FDA listed —
Pain Reliever PM 500 mg/1; 25 mg 79903-0050-09 WALMART 20 tablets — — FDA listed —
Extra Strength Pain Reliever Pm 500 mg/1; 25 mg 79903-0053-10 WALMART 100 tablets — — FDA listed —
Acetaminophen and Diphenhydramine hydrochloride 500 mg/1; 25 mg 79903-0267-80 WALMART 80 tablets — — FDA listed —
Pain Reliever PM 500 mg/1; 25 mg 79903-0298-10 Walmart 100 tablets — — FDA listed —
Pain Reliever PM 500 mg/1; 25 mg 79903-0307-10 WALMART 100 tablets — — FDA listed —
Acetaminophen PM 500 mg/1; 25 mg 81522-0095-03 FSA 100 tablets — — FDA listed —
NOTTS - Pain Relief PM 500 mg/1; 25 mg 82706-0009-01 VIVUNT 24 tablets — — FDA listed —
ValuMeds Pain Relief PM Pain Reliever and Nighttime Sleep Aid Acetaminophen, Extra Strength 500 mg/1; 25 mg 82725-1024-01 Cabinet 375 tablets — — FDA listed —
Goodmeds Extra Strength Pain Relief PM 500 mg/1; 25 mg 82725-4124-01 Cabinet 375 tablets — — FDA listed —
Pain Relief PM 25 mg/1; 500 mg 84324-0005-01 NUVICARE 100 tablets — — FDA listed —
Dr Simi Pain Reliever PM 500 mg/1; 25 mg 85786-0101-90 Farmacias 100 tablets — — FDA listed —
Dr. Simi Pain Reliever PM 25 mg/1; 500 mg 85786-0108-24 Farmacias 24 tablets — — FDA listed —
Acetaminophen PM 500 mg/1; 25 mg 85828-0095-03 Grocery 100 tablets — — FDA listed —
Pain Relief PM 500 mg/1; 25 mg 42507-0437-71 HyVee 50 tablets — — FDA listed —
Acetaminophen Pm 500 mg/1; 25 mg 72288-0090-78 Amazon.com 100 tablets — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2024
On the market since
Sep 2024
📍
2026
Currently FDA-listed
2 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
51316-0863-50 You're viewing this 500 TABLET, COATED in 1 BOTTLE, PLASTIC (51316-863-50) 2024-09-15 Active

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 51316-863-50, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 51316-0863-50, written without dashes as 51316086350. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 51316-0863-50, the first segment (51316) is the labeler code FDA assigned to CVS PHARMACY, INC; the middle segment (0863) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (50) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by CVS PHARMACY, INC. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
CVS PHARMACY, INC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 14 words ▾

Uses temporary relief of occasional headaches and minor aches and pains with accompanying sleeplessness.

⏱️ Dosage and Administration 44 words ▾

Directions do not take more than directed (see overdose warning) adults and children 12 years of age and over: take 2 caplets at bedtime. Do not take more than 2 caplets of this product in 24 hours. children under 12 years: do not use

⚠️ Warnings ~1 min read ▾

Warnings Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take: more than 4,000 mg of acetaminophen in 24 hours with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product Allergy alert : Acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If a skin reaction occurs, stop use and seek medical help right away.

Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. with any other products containing diphenhydramine, even one used on skin in children under 12 years of age if you have ever had an allergic reaction to this product or any of its ingredients Ask a doctor before use if you have liver disease a breathing problems such as emphysema or chronic bronchitis trouble urinating due to an enlarged prostate gland glaucoma Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin taking sedatives or tranquilizers When using this product drowsiness will occur avoid alcoholic drinks do not drive a motor vehicle or operate machinery Stop use and ask a doctor if sleeplessness persists continuously for more than 2 weeks.

Insomnia may be a symptom of a serious underlying medical illness. pain gets worse or last more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children.

Overdose warning: In case of overdose, get medical help or contact a Poison Control Center (1-800=222-1222) right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

🧪 Active Ingredient 12 words ▾

Active ingredients (in each caplet) Acetaminophen 500 mg Diphenhydramine HCl 25 mg

🧪 Inactive Ingredients 37 words ▾

Inactive ingredients croscarmellose sodium, FD&C blue #1 aluminum lake, FD&C blue #2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone K30, pregelatanized starch, purified water, silicon dioxide, sodium starch glycolate, talc, titanium dioxide

🎯 Purpose 5 words ▾

Purpose Pain reliever Nighttime sleep-aid

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 51316-0860-01 · CVS 51316-0875-83 · CVS →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.