Pain Relief PM Extra Strength Acetaminophen and Diphenhydramine Hydrochloride 500 mg; 25 mg Tablet, Coated, 50-count
by Chain Drug Marketing Association · 1 BOTTLE, PLASTIC in 1 CARTON (63868-325-50) / 50 TABLET, COATED in 1 BOTTLE, PLASTIC
NDC 63868-0325-50
🏷️ FDA NDC (as labeled)
63868-325-50
billing pads the product segment with a zero
This package
Also comes in:
100 tablets 63868-0325-01
OTC
On market
Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
🆔 Identity & classification
FDA NDC (as labeled)
63868-325-50
Product NDC
63868-325
11-digit billing NDC
63868032550
NCPDP billing unit
EA — each (per item)
RxCUI
1092189
UNII
362O9ITL9D, TC2D6JAD40
UPC
0635515995970
Application #
M013
SPL Set ID
475becec-1a56-4cfa-a0c5-562f8772adfb
Established class (EPC)
Histamine-1 Receptor Antagonist
Mechanism of action
Histamine H1 Receptor Antagonists
DEA schedule
Non-controlled
Marketing category
OTC MONOGRAPH DRUG
Marketing status
On market
FDA listing status
Listed (active directory)
Marketing start
2007-11-08
Marketing end
2026-11-30
Route
ORAL
Dosage form
TABLET, COATED
Substance
ACETAMINOPHEN; DIPHENHYDRAMINE HYDROCHLORIDE
GPI-14
60309902200310
GPI class
Pain Reliever PM Ex St
GCN Seq No
003699
GCN
70221
HICL code
001861
Ingredient (HICL)
Acetaminophen/Diphenhydramine
HIC1 code
B
Therapeutic class — broad (HIC1)
Respiratory System
HIC2 code
B5
Therapeutic class — intermediate (HIC2)
Drugs Affecting The Trachea And Bronchi (Contin.2)
HIC3 code
B5S
Therapeutic class — specific (HIC3)
Analgesic, Non-Sal.- 1St Generation Antihistamine
AHFS code
04:04.00.00
AHFS class
First Generation Antihistamines
FDB label name
QC NON-ASPIRIN PM CAPLET
FDB brand name
Non-Aspirin Pm
Legend status
O — Over-the-counter (OTC) drug or device
Why two NDCs?
The FDA registers this code as 63868-325-50 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 63868-0325-50. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.
🏷️ RxNorm drug class
This medicine belongs to the Anilides class.
Drug family (ATC)
Anilides
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.
🏭 Manufacturer & labeler
LabelerChain Drug Marketing Association
FDA applicationM013 (OTC MONOGRAPH DRUG)
Labeler code63868
First marketedNov 2007
Product typeHuman Otc Drug
Portfolio128 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.
🩺 Clinical
Label name QC NON-ASPIRIN PM CAPLET Ingredient Acetaminophen/Diphenhydramine
📖 About the active ingredient: Acetaminophen; Diphenhydramine Hydrochloride MedlinePlus · NLM
General information about the ingredient itself — the description of this specific product follows below.
Acetaminophen is used to relieve mild to moderate pain and to reduce fever. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body.
Read the full MedlinePlus article ↗🧪 What is this product?
This is an over-the-counter coated tablet taken by mouth that combines acetaminophen and diphenhydramine hydrochloride. Acetaminophen is commonly used to relieve mild to moderate pain and reduce fever. Diphenhydramine hydrochloride is an antihistamine typically included in nighttime pain products because it may cause drowsiness, which some people find helpful when discomfort interferes with sleep. This product is marketed under the FDA's over-the-counter monograph rules for its category.
Patient education
Supplement & herbal interactions
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.
💬 Questions about Acetaminophen and Diphenhydramine Hydrochloride?
Ask a pharmacist →
Ask a licensed pharmacist directly — free, answered by our team.
💊 What it looks like
Color
blue
ShapeOval
ImprintAAA;1031
Size17 mm
ScoringNot scored
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.
🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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UNII OP1R32D61U
Microcrystalline cellulose is a purified form of cellulose, a natural fiber from plant sources. It acts as a binder and filler in tablets and capsules, helping hold ingredients together and give the medicine its shape and size.
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UNII D9C330MD8B
Copovidone is a synthetic polymer made by combining two types of plastic-like molecules. It acts as a binder and film-former to help hold tablet ingredients together and improve how the medicine dissolves in your body.
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UNII M28OL1HH48
Croscarmellose sodium is a plant-based substance derived from cellulose. It acts as a disintegrant, helping tablets and capsules break down quickly in the digestive system so the medicine can be absorbed.
-
UNII H3R47K3TBD
FD&C Blue No. 1 is a synthetic blue dye approved for use in foods and medicines. It serves as a colorant to give the medication its distinctive appearance and help with product identification.
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UNII 3NXW29V3WO
Hypromellose is a plant-based thickener made from cellulose. It's used in medicines as a binder to hold ingredients together, a coating for tablets, and a thickener for liquids.
-
UNII J2B2A4N98G
Lactose is a natural sugar derived from milk. In medications, it serves as a filler and binder to add bulk and help hold tablet or capsule ingredients together during manufacturing.
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UNII 70097M6I30
Magnesium stearate is a salt made from magnesium and stearic acid, a fatty substance. It's used in tablets and capsules as a lubricant and glidant to help ingredients flow smoothly during manufacturing and prevent sticking.
-
UNII 3WJQ0SDW1A
Polyethylene glycol is a synthetic liquid or solid polymer used in medicines as a solvent, lubricant, and humectant. It helps dissolve active ingredients, reduces friction during manufacturing, and retains moisture in the final product.
-
UNII FZ989GH94E
Povidone is a synthetic polymer made from a plastic-like material. It acts as a binder to hold tablet ingredients together and as a disintegrant to help the tablet break apart in your stomach so the medicine can be absorbed.
-
UNII ETJ7Z6XBU4
Silicon dioxide is a naturally occurring mineral used as a glidant and anti-caking agent. It helps powder ingredients flow smoothly and prevents clumping during manufacturing and storage.
-
UNII AG9B65PV6B
A starch derivative made from corn that helps tablets and capsules break apart quickly when swallowed. It acts as a disintegrant, allowing the medicine to dissolve and be absorbed in your stomach and intestines.
-
UNII O8232NY3SJ
A plant-based carbohydrate derived from corn kernels. It acts as a filler to add bulk, a binder to hold ingredients together, and a disintegrant to help the tablet break apart in your stomach for absorption.
-
UNII 4ELV7Z65AP
Stearic acid is a fatty acid derived from plant or animal sources. It acts as a binder and lubricant in tablets and capsules, helping them hold together and flow smoothly during manufacturing.
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UNII 15FIX9V2JP
Titanium dioxide is a bright white mineral powder commonly used as a colorant and opacifying agent. It makes pills and tablets white or lighter in color and helps make coatings non-transparent.
14 inactive ingredients listed in the exact product block matched to this NDC.
The official label also statescolloidal silicon dioxide, copovidone, croscarmellose sodium, FD&C blue #1, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, pregelatinized starch, sodium starch glycolate, stearic acid, titanium dioxide
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed —
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per ea | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $0.046 | $2.30 / 50 tablets |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
NADAC price history (per ea) — tap or hover for the price & month
▲ Up 6% over the last 12 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| good sense pain relief pm extra strength 500 mg/1; 25 mg 00113-0437-71 | L. | 50 tablets | $0.044 | — | Availability likely | save 3% |
| Acetaminophen PM 25 mg/1; 500 mg 00904-6731-51 | Major | 50 tablets | $0.044 | — | Availability likely | save 3% |
| Extra Strength PM Pain Medicine 500 mg/1; 25 mg 46122-0799-69 | Amerisource | 50 tablets | $0.044 | — | Availability likely | save 3% |
| Acetaminophen, Diphenhydramine Hydrochloride 500 mg/1; 25 mg 70000-0411-01 | LEADER/ | 24 tablets | $0.044 | — | Availability likely | save 3% |
| Pain Reliever PM 500 mg/1; 25 mg 70677-1149-01 | Strategic | 50 tablets | $0.044 | — | Availability likely | save 3% |
| Acetaminophen PM 500 mg/1; 25 mg 83324-0070-20 | Chain | 20 tablets | $0.044 | — | Availability likely | save 3% |
| Pain Relief PM Extra Strength 500 mg/1; 25 mg 83324-0085-01 | CHAIN | 100 tablets | $0.044 | — | Availability likely | save 3% |
| Pain Reliever PM 500 mg/1; 25 mg 83324-0166-50 | QUALITY | 50 tablets | $0.044 | — | Availability likely | save 3% |
| Pain Reliever PM Extra Strength 500 mg/1; 25 mg 62011-0420-01 | Strategic | 50 tablets | $0.046 | — | FDA listed | — |
| Pain Relief PM Extra Strength 500 mg/1; 25 mgthis 63868-0325-50 | Chain | 50 tablets | $0.046 | — | FDA listed | — |
| Pain Relief PM 500 mg/1; 25 mg 70677-0081-01 | Strategic | 100 tablets | $0.046 | — | FDA listed | — |
| Pain Reliever PM Extra Strength 500 mg/1; 25 mg 62011-0256-01 | Strategic | 50 tablets | $0.047 | — | FDA listed | +3% |
| Panadol Pm 500 mg/1; 25 mg 00135-0608-01 | Haleon | 24 tablets | — | — | FDA listed | — |
| Panadol Pm 500 mg/1; 25 mg 00135-7021-01 | Haleon | 2 tablets | — | — | FDA listed | — |
| Pain Reliever PM Extra Strength 500 mg/1; 25 mg 00363-0556-09 | Walgreen | 20 tablets | — | — | FDA listed | — |
| Extra Strength NiteTime Pain Relief 25 mg/1; 500 mg 00363-0714-42 | WALGREENS | 24 tablets | — | — | FDA listed | — |
| Extra Strength Nite-Time Pain Relief 500 mg/1; 25 mg 00363-0715-01 | WALGREENS | 100 tablets | — | — | FDA listed | — |
| Pain Reliever PM Extra Strength 500 mg/1; 25 mg 00363-0760-10 | Walgreens | 100 tablets | — | — | FDA listed | — |
| Pain Reliever PM Extra strength 500 mg/1; 25 mg 00363-0863-10 | Walgreens | 100 tablets | — | — | FDA listed | — |
| Pain Reliever PM 500 mg/1; 25 mg 00363-2035-08 | Walgreen | 24 tablets | — | — | FDA listed | — |
| Extra Strength Pain Reliever Pm 500 mg/1; 25 mg 00363-9085-15 | WALGREENS | 15 tablets | — | — | FDA listed | — |
| Acetaminophen Diphenhydramine HCL 500 mg/1; 25 mg 00363-9661-15 | Walgreens | 150 tablets | — | — | FDA listed | — |
| Acetaminophen Diphenhydramine HCL 500 mg/1; 25 mg 00363-9664-60 | WALGREENS | 125 tablets | — | — | FDA listed | — |
| Acetaminophen Diphenhydramine HCL 500 mg/1; 25 mg 00363-9799-75 | WALGREEN | 75 tablets | — | — | FDA listed | — |
| Pain Reliever PM 500 mg/1; 25 mg 11673-0754-10 | TARGET | 100 tablets | — | — | FDA listed | — |
| Pain Relief Acetaminophen PM 500 mg/1; 25 mg 11822-0556-01 | Rite | 80 tablets | — | — | FDA listed | — |
| Pain Relief Acetaminophen PM Extra Strength 500 mg/1; 25 mg 11822-2350-02 | Rite | 100 tablets | — | — | FDA listed | — |
| Acetaminophen Pm 500 mg/1; 25 mg 17714-0133-50 | Advance | 50 tablets | — | — | FDA listed | — |
| Pain Relief PM 500 mg/1; 25 mg 21130-0095-01 | Safeway | 24 tablets | — | — | FDA listed | — |
| Acetaminophen and Diphenhydramine hydrochloride 500 mg/1; 25 mg 21130-0224-18 | Better | 80 tablets | — | — | FDA listed | — |
| Acetaminophen Diphenhydramine HCl 500 mg/1; 25 mg 21130-0354-02 | BETTER | 20 tablets | — | — | FDA listed | — |
| Acetaminophen and Diphenhydramine HCL 500 mg/1; 25 mg 21130-0661-10 | SAFEWAY | 100 tablets | — | — | FDA listed | — |
| Acetaminophen and Diphenhydramine hydrochloride 500 mg/1; 25 mg 30142-0193-14 | KROGER | 50 tablets | — | — | FDA listed | — |
| Extra Strength Acetaminophen PM 500 mg/1; 25 mg 30142-0755-01 | KROGER | 100 tablets | — | — | FDA listed | — |
| Pain Relief PM Extra Strength 500 mg/1; 25 mg 36800-0095-03 | TopCo | 100 tablets | — | — | FDA listed | — |
| Pain Reliever PM Extra Strength 500 mg/1; 25 mg 36800-0466-10 | TOP | 100 tablets | — | — | FDA listed | — |
| Pain Relief PM 500 mg/1; 25 mg 36800-0556-09 | Topco | 20 tablets | — | — | FDA listed | — |
| Vicks ZzzQuil Night Pain 25 mg/1; 500 mg 37000-0974-60 | The | 60 tablets | — | — | FDA listed | — |
| Pain Relief PM Extra Strength 500 mg/1; 25 mg 37808-0556-09 | H | 20 tablets | — | — | FDA listed | — |
| Pain Relief PM Extra Strength 500 mg/1; 25 mg 37808-0795-03 | HEB | 100 tablets | — | — | FDA listed | — |
| Acetaminophen and Diphenhydramine Hydrochloride 500 mg/1; 25 mg 37835-0537-01 | Bi-Mart | 100 tablets | — | — | FDA listed | — |
| Acetaminophen PM Extra Strength 500 mg/1; 25 mg 41163-0228-50 | United | 50 tablets | — | — | FDA listed | — |
| acetaminophen pm extra strength 500 mg/1; 25 mg 41163-0515-01 | United | 24 tablets | — | — | FDA listed | — |
| Acetaminophen PM Extra Strength 500 mg/1; 25 mg 41163-0956-09 | United | 20 tablets | — | — | FDA listed | — |
| pain relief PM 500 mg/1; 25 mg 41250-0195-02 | Meijer | 50 tablets | — | — | FDA listed | — |
| Acetaminophen and Diphenhydramine HCL 25 mg/1; 500 mg 41415-0661-05 | PUBLIX | 50 tablets | — | — | FDA listed | — |
| CareOne Acetaminophen PM 500 mg/1; 25 mg 41520-0514-47 | American | 150 tablets | — | — | Discontinued | — |
| Acetaminophen PM Extra Strength 500 mg/1; 25 mg 41520-0956-09 | FOODHOLD | 20 tablets | — | — | FDA listed | — |
| Pain Relief PM 500 mg/1; 25 mg 42507-0095-03 | HYVEE | 100 tablets | — | — | FDA listed | — |
| Pain Reliever PM Extra Strength 500 mg/1; 25 mg 49035-0363-10 | EQUATE | 100 tablets | — | — | FDA listed | — |
| Extra strength Acetaminophen PM 25 mg/1; 500 mg 49483-0430-40 | TIME | 400 tablets | — | — | FDA listed | — |
| Tylenol PM 500 mg/1; 25 mg 50269-0552-01 | JC | 2 tablets | — | — | FDA listed | — |
| Tylenol PM 500 mg/1; 25 mg 50269-0608-06 | JC | 25 tablets | — | — | FDA listed | — |
| Tylenol PM Extra Strength 500 mg/1; 25 mg 50580-0608-01 | Kenvue | 24 tablets | — | — | FDA listed | — |
| Pain Reliever PM Extra Strength 500 mg/1; 25 mg 50594-0863-10 | Big | 100 tablets | — | — | Discontinued | — |
| Pain Relief PM Extra Strength 500 mg/1; 25 mg 50804-0825-02 | GoodSense | 20 tablets | — | — | FDA listed | — |
| Pain Reliever PM Extra Strength 500 mg/1; 25 mg 50844-0235-15 | L.N.K. | 50 tablets | — | — | FDA listed | — |
| Pain Reliever PM 500 mg/1; 25 mg 50844-0256-08 | L.N.K. | 24 tablets | — | — | FDA listed | — |
| Pain Reliever PM Extra Strength 500 mg/1; 25 mg 50844-0556-10 | L.N.K. | 40 tablets | — | — | FDA listed | — |
| Pain Reliever PM 500 mg/1; 25 mg 51316-0863-50 | CVS | 500 tablets | — | — | FDA listed | — |
| CAREALL Non-Aspirin PM Extra Strength 500 mg/1; 25 mg 51824-0069-50 | New | 50 tablets | — | — | FDA listed | — |
| CAREALL Pain Relief PM Extra Strength 500 mg/1; 25 mg 51824-0107-50 | New | 50 tablets | — | — | FDA listed | — |
| CAREALL Pain Relief PM Extra Strength 500 mg/1; 25 mg 51824-0108-50 | New | 50 tablets | — | — | FDA listed | — |
| Tylenol PM Extra Strength 500 mg/1; 25 mg 53209-1002-02 | Morning | 2 tablets | — | — | FDA listed | — |
| Pain Reliever PM 500 mg/1; 25 mg 54257-0278-02 | Magno-Humphries, | 100 tablets | — | — | FDA listed | — |
| CounterAct PM 25 mg/1; 500 mg 54473-0304-01 | Melaleuca, | 50 tablets | — | — | FDA listed | — |
| Acetaminophen PM Extra Strength 500 mg/1; 25 mg 55301-0235-06 | ARMY | 200 tablets | — | — | Discontinued | — |
| Pain Reliever PM 500 mg/1; 25 mg 55319-0562-10 | Family | 100 tablets | — | — | FDA listed | — |
| dg health pain relief pm extra strength 500 mg/1; 25 mg 55910-0437-71 | Dolgencorp | 50 tablets | — | — | FDA listed | — |
| Pain Relief PM Extra Strength 500 mg/1; 25 mg 55910-0655-10 | DOLGENCORP, | 40 tablets | — | — | FDA listed | — |
| Pain Relief PM 500 mg/1; 25 mg 55910-0834-01 | DOLGENCORP, | 100 tablets | — | — | FDA listed | — |
| pain relief pm extra strength 500 mg/1; 25 mg 56062-0437-71 | Publix | 50 tablets | — | — | FDA listed | — |
| Pain Reliever PM Extra Strength 500 mg/1; 25 mg 57243-0235-15 | Salado | 50 tablets | — | — | FDA listed | — |
| Acetaminophen PM 500 mg/1; 25 mg 57344-0095-01 | AAA | 24 tablets | — | — | FDA listed | — |
| Extra Strength Night Time Pain Medicine 500 mg/1; 25 mg 57896-0224-01 | Geri-Care | 100 tablets | — | — | FDA listed | — |
| Kroger EXTRA STRENGTH Acetaminophen PM Caplet 500 mg/1; 25 mg 59450-0174-01 | The | 100 tablets | — | — | FDA listed | — |
| Pain Reliever PM extra strength 500 mg/1; 25 mg 59726-0868-10 | P | 100 tablets | — | — | FDA listed | — |
| Pain Relief PM 500 mg/1; 25 mg 61504-0095-03 | AMERIFOODS | 100 tablets | — | — | FDA listed | — |
| Extra Strength Pain Reliever PM 500 mg/1; 25 mg 62936-0224-01 | INGLES | 50 tablets | — | — | FDA listed | — |
| good sense pain relief pm extra strength 500 mg/1; 25 mg 63629-5880-01 | Bryant | 14 tablets | — | — | FDA listed | — |
| Pain Relief PM Extra Strength 500 mg/1; 25 mg 63868-0119-50 | QUALITY | 50 tablets | — | — | FDA listed | — |
| Acetaminophen PM Extra Strength 500 mg/1; 25 mg 63868-0210-20 | CHAIN | 20 tablets | — | — | FDA listed | — |
| Extra Strength Pain Relief PM 500 mg/1; 25 mg 63941-0095-02 | VALU | 50 tablets | — | — | FDA listed | — |
| Acetaminophen PM 500 mg/1; 25 mg 63981-0056-54 | COSTCO | 375 tablets | — | — | FDA listed | — |
| Pain Reliever PM, Extra Strength, 24-7 Life by 7-Eleven 25 mg/1; 500 mg 66715-5640-04 | Lil' | 24 tablets | — | — | FDA listed | — |
| Tylenol PM Extra Strength, CVP HEALTH 25 mg/1; 500 mg 66715-6417-02 | Lil' | 2 tablets | — | — | FDA listed | — |
| Tylenol PM Extra Strength, CVP HEALTH 500 mg/1; 25 mg 66715-6517-02 | Lil' | 2 tablets | — | — | FDA listed | — |
| Pain Reliever PM, Extra Strength, 24-7 Life by 7-Eleven 25 mg/1; 500 mg 66715-8158-03 | Lil' | 6 tablets | — | — | FDA listed | — |
| Lil Drug Store Tylenol PM Extra Strength 25 mg/1; 500 mg 66715-9817-02 | Lil' | 2 tablets | — | — | FDA listed | — |
| Acetaminophen PM Extra Strength 500 mg/1; 25 mg 67091-0137-50 | WinCo | 50 tablets | — | — | FDA listed | — |
| Tylenol PM Extra Strength 500 mg/1; 25 mg 67414-0608-00 | Jones | 2 tablets | — | — | FDA listed | — |
| Tylenol PM Extra Strength 500 mg/1; 25 mg 67751-0241-01 | Navajo | 2 tablets | — | — | FDA listed | — |
| Acetaminophen Diphenhydramine HCl 500 mg/1; 25 mg 68016-0654-05 | Chain | 50 tablets | — | — | FDA listed | — |
| acetaminophen pm extra strength 500 mg/1; 25 mg 68196-0556-54 | Sam's | 375 tablets | — | — | FDA listed | — |
| Extra Strength Acetaminophen PM 500 mg/1; 25 mg 68391-0430-50 | BJWC | 500 tablets | — | — | FDA listed | — |
| Pain Reliever PM Extra Strength 500 mg/1; 25 mg 68391-0863-05 | BJWC | 500 tablets | — | — | FDA listed | — |
| Pain Relief PM Extra Strength 500 mg/1; 25 mg 68998-0071-03 | MARC | 80 tablets | — | — | FDA listed | — |
| Pain Relief PM Extra Strength 500 mg/1; 25 mg 68998-0195-02 | MARC | 50 tablets | — | — | FDA listed | — |
| Pain Relief PM Extra Strength 500 mg/1; 25 mg 69168-0003-50 | Allegiant | 50 tablets | — | — | FDA listed | — |
| Pain Relief PM Extra Strength 500 mg/1; 25 mg 69168-0393-02 | Allegiant | 150 tablets | — | — | FDA listed | — |
| Pain Reliever PM 500 mg/1; 25 mg 69607-8630-01 | WR | 24 tablets | — | — | FDA listed | — |
| Genexa Acetaminophen PM Extra Strength 500 mg/1; 25 mg 69676-0063-02 | Genexa | 100 tablets | — | — | FDA listed | — |
| Cystex PM 500 mg/1; 25 mg 69693-0417-10 | Clarion | 10 tablets | — | — | FDA listed | — |
| Acetaminophen, Diphenhydramine Hcl 25 mg/1; 500 mg 69842-0572-08 | CVS | 24 tablets | — | — | FDA listed | — |
| Acetaminophen PM Extra Strength 500 mg/1; 25 mg 69842-0956-09 | CVS | 20 tablets | — | — | Discontinued | — |
| Acetaminophen Diphenhydramine HCl 25 mg/1; 500 mg 69848-0014-02 | Granules | 20 tablets | — | — | FDA listed | — |
| Tylenol Pm Extra Strength 500 mg/1; 25 mg 70264-0028-01 | R | 2 tablets | — | — | FDA listed | — |
| RIGHT REMEDIES EXTRA STRENGTH PM Pain Relief 500 mg/1; 25 mg 70692-0149-03 | Strive | 30 tablets | — | — | FDA listed | — |
| RIGHT REMEDIES EXTRA STRENGTH Pain Relief PM Caplet 500 mg/1; 25 mg 70692-0471-31 | Strive | 300 tablets | — | — | FDA listed | — |
| GOOD REMEDIES Extra Strength Pain Relief PM Caplet 500 mg/1; 25 mg 70692-0741-03 | Strive | 30 tablets | — | — | FDA listed | — |
| pain relief PM 500 mg/1; 25 mg 72036-0095-02 | HARRIS | 50 tablets | — | — | FDA listed | — |
| Acetaminophen PM 500 mg/1; 25 mg 72036-0171-02 | Harris | 40 tablets | — | — | FDA listed | — |
| Pain Relief PM 25 mg/1; 500 mg 72090-0006-25 | Pioneer | 375 tablets | — | — | FDA listed | — |
| Pain Relief PM 25 mg/1; 500 mg 72090-0032-01 | Pioneer | 375 tablets | — | — | FDA listed | — |
| basic care acetaminophen pm 500 mg/1; 25 mg 72288-0437-78 | Amazon.com | 100 tablets | — | — | FDA listed | — |
| Acetaminophen Pm 500 mg/1; 25 mg 72476-0171-01 | RETAIL | 20 tablets | — | — | FDA listed | — |
| Acetaminophen Pm 500 mg/1; 25 mg 73057-0352-03 | Ulai | 24 tablets | — | — | FDA listed | — |
| Tylenol PM 500 mg/1; 25 mg 73097-0013-02 | Savings | 2 tablets | — | — | FDA listed | — |
| Pain Relief PM 500 mg/1; 25 mg 76168-0119-25 | Velocity | 50 tablets | — | — | FDA listed | — |
| meijer EXTRA STRENGTH Pain Relief PM Caplet 500 mg/1; 25 mg 79481-0149-01 | Meijer, | 100 tablets | — | — | FDA listed | — |
| meijer EXTRA STRENGTH Pain Relief PM CAPLET 500 mg/1; 25 mg 79481-0174-01 | Meijer, | 100 tablets | — | — | FDA listed | — |
| Pain Reliever PM 500 mg/1; 25 mg 79903-0050-09 | WALMART | 20 tablets | — | — | FDA listed | — |
| Extra Strength Pain Reliever Pm 500 mg/1; 25 mg 79903-0053-10 | WALMART | 100 tablets | — | — | FDA listed | — |
| Acetaminophen and Diphenhydramine hydrochloride 500 mg/1; 25 mg 79903-0267-80 | WALMART | 80 tablets | — | — | FDA listed | — |
| Pain Reliever PM 500 mg/1; 25 mg 79903-0298-10 | Walmart | 100 tablets | — | — | FDA listed | — |
| Pain Reliever PM 500 mg/1; 25 mg 79903-0307-10 | WALMART | 100 tablets | — | — | FDA listed | — |
| Acetaminophen PM 500 mg/1; 25 mg 81522-0095-03 | FSA | 100 tablets | — | — | FDA listed | — |
| NOTTS - Pain Relief PM 500 mg/1; 25 mg 82706-0009-01 | VIVUNT | 24 tablets | — | — | FDA listed | — |
| ValuMeds Pain Relief PM Pain Reliever and Nighttime Sleep Aid Acetaminophen, Extra Strength 500 mg/1; 25 mg 82725-1024-01 | Cabinet | 375 tablets | — | — | FDA listed | — |
| Goodmeds Extra Strength Pain Relief PM 500 mg/1; 25 mg 82725-4124-01 | Cabinet | 375 tablets | — | — | FDA listed | — |
| Pain Relief PM 25 mg/1; 500 mg 84324-0005-01 | NUVICARE | 100 tablets | — | — | FDA listed | — |
| Dr Simi Pain Reliever PM 500 mg/1; 25 mg 85786-0101-90 | Farmacias | 100 tablets | — | — | FDA listed | — |
| Dr. Simi Pain Reliever PM 25 mg/1; 500 mg 85786-0108-24 | Farmacias | 24 tablets | — | — | FDA listed | — |
| Acetaminophen PM 500 mg/1; 25 mg 85828-0095-03 | Grocery | 100 tablets | — | — | FDA listed | — |
| Acetaminophen and Diphenhydramine hydrochloride 500 mg/1; 25 mg 58602-0760-14 | Aurohealth | 50 tablets | — | — | FDA listed | — |
| Tylenol PM Extra Strength 500 mg/1; 25 mg 85237-2945-01 | Select | 2 tablets | — | — | FDA listed | — |
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.
⏳ Availability & generic status
🏛️
2007
On the market since
Nov 2007
📍
2026
Currently FDA-listed
19 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.
🔬 Reported adverse events (FAERS)
Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Pain Relief PM Extra Strength (this brand).
Top reported reactions
Age at onset
Reporter sex
Male · 40%
Female · 60%
Serious outcomes
Reports over time (by year) — tap or hover for the count & year
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.
📦 Packaging — all sizes for this product
| Package NDC | Description | Per unit | Per pack | Marketing start | Status |
|---|---|---|---|---|---|
| 63868-0325-50 You're viewing this | 1 BOTTLE, PLASTIC in 1 CARTON (63868-325-50) / 50 TABLET, COATED in 1 BOTTLE, PLASTIC | $0.0459 / ea | $2.29 | 2007-11-08 | Active |
| 63868-0325-01 | 100 TABLET, COATED in 1 BOTTLE, PLASTIC (63868-325-01) | $0.0459 / ea | $4.59 | 2007-11-08 | Active |
This pack has the lowest per-ea cost of the 2 priced pack sizes ($0.0459 NADAC).
Pack size FAQ
What quantity is in NDC 63868-0325-50?
NDC 63868-0325-50 is a 50-count package — 1 bottle, plastic in 1 carton / 50 tablet, coated in 1 bottle, plastic.
What is the difference between NDC 63868-0325-50 and NDC 63868-0325-01?
Both are Pain Relief PM Extra Strength Acetaminophen and Diphenhydramine Hydrochloride 500 mg; 25 mg Tablet, Coated — the drug itself is identical. NDC 63868-0325-50 is the 50-count package, while NDC 63868-0325-01 is the 100 tablets package.
What NDC number is used to bill for this package of Pain Relief PM Extra Strength Acetaminophen and Diphenhydramine Hydrochloride 500 mg; 25 mg Tablet, Coated?
Bill NDC 63868-0325-50 — the 11-digit billing format is 63868032550. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.
Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.
📄 FDA label — Drug Facts FDA SPL
The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage
⏱️ Dosage and Administration
⚠️ Warnings
📦 Storage and Handling
🧪 Active Ingredient
🧪 Inactive Ingredients
🎯 Purpose
🎯 Indications and Usage ▾
Uses temporary relief of occasional headaches and minor aches and pains with accompanying sleeplessness
⏱️ Dosage and Administration ▾
Directions do not take more than directed (see overdose warning ) adults and children 12 years and over take 2 caplets at bedtime do not take more than 2 caplets of this product in 24 hours children under 12 years do not use this adult product in children under 12 years of age; this will provide more than the recommended dose (overdose) and may cause liver damage
⚠️ Warnings ▾
Warnings Liver warning This product contains acetaminophen. Severe liver damage may occur if you take more than 4,000 mg of acetaminophen in 24 hours with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. with any other product containing diphenhydramine, even one used on skin in children under 12 years of age if you have ever had an allergic reaction to this product or any of its ingredients Ask a doctor before use if you have liver disease a breathing problem such as emphysema or chronic bronchitis trouble urinating due to an enlarged prostate gland glaucoma Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin taking sedatives or tranquilizers When using this product drowsiness will occur avoid alcoholic drinks do not drive a motor vehicle or operate machinery Stop use and ask a doctor if sleeplessness persists continuously for more than 2 weeks.
Insomnia may be a symptom of serious underlying medical illness. pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children.
Overdose warning In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
📦 Storage and Handling ▾
Other information store between 20-25°C (68-77°F) in a dry place retain carton for complete product information
🧪 Active Ingredient ▾
Active ingredients (in each caplet) Purpose Acetaminophen 500 mg Pain reliever Diphenhydramine HCl 25 mg Nighttime sleep aid
🧪 Inactive Ingredients ▾
Inactive ingredients colloidal silicon dioxide, copovidone, croscarmellose sodium, FD&C blue #1, hypromellose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, pregelatinized starch, sodium starch glycolate, stearic acid, titanium dioxide
🎯 Purpose ▾
Active ingredients (in each caplet) Purpose Acetaminophen 500 mg Pain reliever Diphenhydramine HCl 25 mg Nighttime sleep aid
No label section mentions that — try another word, or open the full label on DailyMed below.
Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA.
Prefer the government’s original formatting? View this label on DailyMed ↗
For educational and professional reference only — not medical advice. Pricing reflects published
NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.