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Senna Syrup Natural Vegetable Laxative 8.8 mg/5mL Liquid, 237 mL — NDC 58657-0518-08 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Senna Syrup Natural Vegetable Laxative 8.8 mg/5mL Liquid, 237 mL — NDC 58657-518-08 (Billing 58657-0518-08)

by Method Pharmaceuticals · 237 mL in 1 BOTTLE

This is a package of 237 mL of Senna Syrup Natural Vegetable Laxative 8.8 mg/5mL Liquid from Method Pharmaceuticals, marketed since Sep 2021 and currently FDA-listed; retail pharmacies pay about $0.0369 per mL (NADAC). It is this product's only package size.

NDC 58657-0518-08
🏷️ FDA NDC (as labeled) 58657-518-08 billing pads the product segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 58657-518-08
Product NDC 58657-518
11-digit billing NDC 58657051808
NCPDP billing unit ML — per mL (volume)
RxCUI 702311
UNII 3FYP5M0IJX
Application # M007
SPL Set ID ce83ba78-7e0d-b37f-e053-2995a90a9383
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2021-09-28
Route ORAL
Dosage form LIQUID
Substance SENNOSIDES

Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification

GPI-14 46200060201220
GPI class Senna
GCN Seq No 002922
GCN 08660
HICL code 001289
Ingredient (HICL) Sennosides
HIC1 code D
Therapeutic class — broad (HIC1) Biliary System/Gastro-Intestinal System
HIC2 code D6
Therapeutic class — intermediate (HIC2) Drugs Acting Principally On The Colon
HIC3 code D6S
Therapeutic class — specific (HIC3) Laxatives And Cathartics
AHFS code 56:12.00.00
AHFS class Cathartics And Laxatives
FDB label name SENNA 8.8 MG/5 ML SYRUP
FDB brand name Senna
Legend status O — Over-the-counter (OTC) drug or device
Quick answers
  • GSN (GCN sequence number): 002922
  • GCN: 08660
  • GPI-14 (Medi-Span): 46200060201220
  • HICL (First Databank): 001289
  • AHFS class code: 56:12.00.00
  • RxCUI (RxNorm): 702311
Why two NDCs? The FDA registers this code as 58657-518-08 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 58657-0518-08. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Contact laxatives class.

Drug family (ATC) Contact laxatives
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

Label name SENNA 8.8 MG/5 ML SYRUP Ingredient Sennosides
📖 What it is MedlinePlus · NLM

Senna is used on a short-term basis to treat constipation. It also is used to empty the bowels before surgery and certain medical procedures. Senna is in a class of medications called stimulant laxatives. It works by increasing activity of the intestines to cause a bowel movement.

Read the full MedlinePlus article ↗
📗 Our plain-language guide HelloPharmacist
  • Senna typically produces a bowel movement within 6 to 12 hours. That's why most people take it at bedtime — so it can do its job overnight and you get results in the morning. If no...
  • How long does it take for senna to work?
  • Senna is designed for short-term, occasional use. You should not use it for more than 1 week unless your doctor specifically tells you it's okay. Using laxatives too often or for t...
  • Laxatives like senna can affect how your body absorbs other medications. To be safe, take senna at least 2 hours before or after any other drugs you use. It's always a good idea to...
📖 Read our full Senna guide →

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly $0.037 $8.75 / 237 ml
Medicaid paysCMS SDUD · 12 mo $0.0592 $14.03 / 237 ml
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per mL) — tap or hover for the price & month
Apr 2022 Dec 2023 Mar 2026 Sep 2026 $0.044 $0.035
▼ Down 13% over the last 18 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
58657-0518-08 You're viewing this Main listing 237 mL in 1 BOTTLE 2021-09-28 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Senna Liquid 8.8 mg/5mL 00536-1266-59 RUGBY 237 ml $0.037 — Availability likely —
Senna 8.8 mg/5mL 39328-0020-08 Patrin 237 ml $0.037 — Availability likely —
Senna Syrup 8.8 mg/5mL 54859-0808-08 Llorens 237 ml $0.037 — Availability likely —
Senna Syrup 8.8 mg/5mL 57237-0301-24 Rising 237 ml $0.037 — Availability likely —
Senna Syrup 8.8 mg/5mLthis 58657-0518-08 Method 237 ml $0.037 — Availability likely —
Senna 8.8 mg/5mL 82568-0024-08 AARNA 237 ml $0.037 — Availability likely —
Senna 8.8 mg/5mL 00121-4967-40 PAI 10 cups — — FDA listed —
Senna 8.8 mg/5mL 00536-1483-59 Rugby 237 ml — — FDA listed —
Senna 8.8 mg/5mL 00904-7528-94 Major 10 cups — — FDA listed —
OneLAX SENNA 417.12 mg/237mL 17856-1127-01 ATLANTIC 120 syringes — — FDA listed —
OneLAX SENNA 417.12 mg/237mL 17856-8127-02 Atlantic 50 cups — — FDA listed —
Senna UD 8.8 mg/5mL 39328-0120-50 Patrin 10 cups — — FDA listed —
Senna UD 26.4 mg/15mL 39328-0220-50 Patrin 10 cups — — FDA listed —
Senna Syrup 8.8 mg/5mL 48433-0219-40 Safecor 40 cups — — FDA listed —
Senna Syrup 8.8 mg/5mL 50268-0731-24 AVPAK 24 cups — — FDA listed —
Senna Syrup 8.8 mg/5mL 57237-0310-54 Rising 40 cups — — FDA listed —
GeriCare Senna Syrup 8.8 mg/5mL 57896-0472-08 Geri-Care 237 ml — — FDA listed —
Senna 8.8 mg/5mL 60687-0851-77 American 10 cups — — FDA listed —
Senna Syrup 8.8 mg/5mL 63629-9268-01 Bryant 237 ml — — FDA listed —
SENNA Syrup 8.8 mg/5mL 66424-0562-08 SDA 236 ml — — FDA listed —
Senna 417.12 mg/237mL 68094-0049-62 Precision 10 cups — — FDA listed —
Senna 8.8 mg/5mL 69618-0069-58 Reliable 237 ml — — FDA listed —
OneLAX SENNA 417.12 mg/237mL 71399-0027-08 Akron 237 ml — — FDA listed —
Senna Syrup 8.8 mg/5mL 72090-0022-01 Pioneer 237 ml — — FDA listed —
Senna Syrup 8.8 mg/5mL 72162-1672-02 Bryant 237 ml — — FDA listed —
Senna Syrup 8.8 mg/5mL 73564-0812-08 Aldama 1 bottle — — FDA listed —
Senna Syrup 8.8 mg/5mL 81033-0120-50 Kesin 50 cups — — FDA listed —
Senna Syrup 8.8 mg/5mL 84415-0021-01 Everpharm 100 cups — — FDA listed —
Senna Liquid 8.8 mg/5mL 84447-0120-01 Belleview 200000 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2021
On the market since
Sep 2021
📍
2026
Currently FDA-listed
5 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerMethod Pharmaceuticals
FDA applicationM007 (OTC MONOGRAPH DRUG)
Labeler code58657
First marketedSep 2021
Product typeHuman Otc Drug
Portfolio11 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Ask a Doctor Before Use If 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Other Information 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 16 words ▾

Uses • Relieves occasional constipation (irregularity) • Generally causes bowel movement in 6 to 12 hours

⏱️ Dosage and Administration 59 words ▾

Dosage Age Usual Dose Maximum Dose Adults and Children 12 years and older 2-3 teaspoons once a day 3 teaspoons twice a day 6-12 years 1 to 1 1/2 teaspoons once a day 1 1/2 teaspoons twice a day 2-6 years 1/2 to 3/4 teaspoon once a day 3/4 teaspoons twice a day under 2 years Consult a doctor

⚠️ Warnings 16 words ▾

Warning Do not use laxative products for longer than 1 week unless directed by a doctor.

🧪 Active Ingredient 5 words ▾

Active Ingredients Sennosides 8.8 mg

🧪 Inactive Ingredients 12 words ▾

Inactive Ingredients Chocolate flavor, methylparaben, propylene glycol, proylparaben, purified water and sucrose

🎯 Purpose 2 words ▾

Purpose Laxative

📄 Ask a Doctor Before Use If 31 words ▾

Ask a doctor before use if you • have stomach pain, nausea or vomiting • notice a change in bowel habits that last over 2 weeks • are pregnant or breastfeeding.

📄 When Using This Product 19 words ▾

Directions Shake well before using. Do not exceed maximum dose. Take at bedtime or as directed by a doctor.

📄 Stop Use and Ask a Doctor If 20 words ▾

Stop Use and ask a doctor if you have rectal bleeding or failure to have a bowel movement after use.

📄 Keep Out of Reach of Children 21 words ▾

Keep out of Reach of Children In case of accidental overdose, get medical help or contact a Poison Control Center immediately.

📄 Other Information 27 words ▾

Store at controlled room temperature 20-25°C(68-77°F). Excursions permitted 15-30° (59-86°F). Tamper Evident : Do not use if foil seal over bottle opening is torn, broken or missing.

📄 Package Label / Principal Display Panel 19 words ▾

Senna Syrup Manufactured for : Method Pharmaceuticals, LLC 419 Bank St Ste 100 Southlake, TX 76092 Rev 01.0721 senna-syr

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Medicaid utilization & spend

📍 This exact package only: Medicaid data is reported per full 11-digit NDC — labeler, product and pack size — so every number here is for this package alone, not the drug overall. Other pack sizes report separately.
💊 Pharmacy benefit only: These are Medicaid outpatient pharmacy claims, billed by NDC. They exclude the medical benefit — clinic- or hospital-administered drugs billed under HCPCS J-codes — so drugs used mostly that way (e.g. Avastin, Lucentis, Keytruda) can look low or missing here. That’s expected, not an error.
📅 Q1 2025 – Q1 2026 · 5 quarters of data
ⓘ The newest quarter is usually incomplete when first published; states restate recent quarters in later CMS releases, so the latest figures typically revise upward. State coverage-policy changes can also shift quarter-to-quarter totals.
Prescriptions last 4 qtrs
9.4K
Units reimbursed last 4 qtrs
2.2M
Gross reimbursed last 4 qtrs
$129.6K
Avg / prescription
$13.85
Avg / unit
$0.0592
Latest quarter Q1 2026
3.1KRx
Medicaid pays / mL
$0.0592
gross reimbursed
vs
NADAC / mL
$0.0369
acquisition cost
=
Spread
+$0.0223
+60% vs cost
What Medicaid paid per mL (before rebates; includes the pharmacy’s dispensing fee) compared with NADAC — the average price pharmacies pay to buy the drug. A positive spread means Medicaid reimbursed more than the purchase price, before manufacturer rebates.
Fee-for-service vs managed care ⓘ
31% FFS 69% MCO
Fee-for-service · 2,932 Rx Managed care · 6,427 Rx
State Medicaid map
Alaska: no data reported AK Maine: no data reported ME Washington: 60,676 units · 777 per 100k residents WA Idaho: no data reported ID Montana: no data reported MT North Dakota: no data reported ND Minnesota: 57,006 units · 994 per 100k residents MN Wisconsin: 37,343 units · 632 per 100k residents WI Michigan: 108,925 units · 1,085 per 100k residents MI New York: 202,685 units · 1,036 per 100k residents NY Vermont: no data reported VT New Hampshire: no data reported NH Oregon: 20,578 units · 486 per 100k residents OR Nevada: 3,060 units · 95.8 per 100k residents NV Wyoming: no data reported WY South Dakota: no data reported SD Iowa: no data reported IA Illinois: no data reported IL Indiana: 23,557 units · 343 per 100k residents IN Ohio: 361,965 units · 3,071 per 100k residents OH Pennsylvania: 204,312 units · 1,576 per 100k residents PA New Jersey: 40,510 units · 436 per 100k residents NJ Massachusetts: 109,026 units · 1,557 per 100k residents MA California: 97,075 units · 249 per 100k residents CA Utah: 4,593 units · 134 per 100k residents UT Colorado: no data reported CO Nebraska: 42,147 units · 2,131 per 100k residents NE Missouri: 12,027 units · 194 per 100k residents MO Kentucky: 76,645 units · 1,693 per 100k residents KY West Virginia: no data reported WV Virginia: 61,932 units · 711 per 100k residents VA Maryland: 9,900 units · 160 per 100k residents MD Connecticut: 24,639 units · 681 per 100k residents CT Rhode Island: no data reported RI Arizona: 24,228 units · 326 per 100k residents AZ New Mexico: no data reported NM Kansas: 30,418 units · 1,035 per 100k residents KS Arkansas: no data reported AR Tennessee: 73,212 units · 1,027 per 100k residents TN North Carolina: no data reported NC South Carolina: 62,838 units · 1,170 per 100k residents SC Delaware: no data reported DE Oklahoma: no data reported OK Louisiana: no data reported LA Mississippi: no data reported MS Alabama: no data reported AL Georgia: 13,194 units · 120 per 100k residents GA D.C.: no data reported DC Hawaii: no data reported HI Texas: 426,198 units · 1,397 per 100k residents TX Florida: no data reported FL
Units reimbursed · per 100k residents
95.83,071
gray = no data reported ⓘ
Colors are per 100,000 residents, so big states don’t automatically dominate. Tap or hover a state for its actual totals.
Tap or hover a state
…for its Medicaid breakdown
🏆 Top states by units · per 100k residents
1 Ohio 3,071 /100k
2 Nebraska 2,131 /100k
3 Kentucky 1,693 /100k
4 Pennsylvania 1,576 /100k
5 Massachusetts 1,557 /100k
6 Texas 1,397 /100k
7 South Carolina 1,170 /100k
8 Michigan 1,085 /100k
National units — by quarter
💵 About the dollar figures: “reimbursed” is what Medicaid paid pharmacies before confidential manufacturer rebates, so the program’s real net cost is lower than these numbers. Fee-for-service and managed-care claims are combined unless split above. Source: CMS State Drug Utilization Data; per-100k rates use 2023 Census population estimates.
← 58657-0509-16 · Method 58657-0524-04 · Method →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.