Hemorrhoidal Cream Glycerin, Phenylephrine Hydrochloride, Pramoxine Hydrochloride, White Petrolatum .28 g/28g; 4.032 g/28g; .07 g/28g; 4.2 g/28g Cream — NDC 70000-0425-01 package photo

Hemorrhoidal Cream Glycerin, Phenylephrine Hydrochloride, Pramoxine Hydrochloride, White Petrolatum .28 g/28g; 4.032 g/28g; .07 g/28g; 4.2 g/28g Cream

by Cardinal Health 110, LLC. dba Leader · 1 TUBE in 1 BOX (70000-0425-1) / 28 g in 1 TUBE
NDC 70000-0425-01
🏷️ FDA NDC (as labeled) 70000-0425-1 billing pads the package segment with a zero
OTC On market Non-controlled
🗂️ Data synced Aug 27, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

🆔 Identity & classification

FDA NDC (as labeled) 70000-0425-1
Product NDC 70000-0425
11-digit billing NDC 70000042501
NCPDP billing unit GM — per gram (weight)
RxCUI 1293649
UNII 88AYB867L5, PDC6A3C0OX, 04JA59TNSJ, 4T6H12BN9U
UPC 0096295135503
Application # M015
SPL Set ID 85a51d5c-679e-1959-e053-2a91aa0a76d5
Established class (EPC) Non-Standardized Chemical Allergen
Physiologic effect Increased Histamine Release; Cell-mediated Immunity; Increased IgG Production
Chemical class Allergens; Glycerol
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2020-12-30
Route TOPICAL
Dosage form CREAM
Substance PRAMOXINE HYDROCHLORIDE; GLYCERIN; PHENYLEPHRINE HYDROCHLORIDE; PETROLATUM
GPI-14 89992004743720
GPI class Hemorrhoidal
GCN Seq No 061414
GCN 97205
HICL code 034011
Ingredient (HICL) Phenyleph/Pramoxin/Glycr/W.pet
HIC1 code Q
Therapeutic class — broad (HIC1) Ear/Eye/Nose/Rectum/Topical/Vagina/Other
HIC2 code Q3
Therapeutic class — intermediate (HIC2) Anal-Rectal Preparations
HIC3 code Q3D
Therapeutic class — specific (HIC3) Hemorrhoidal Preparations
AHFS code 12:12.04.00
AHFS class Alpha-Adrenergic Agonists (12:12)
FDB label name HEMORRHOIDAL CREAM
FDB brand name Hemorrhoidal Cream
Legend status O — Over-the-counter (OTC) drug or device
Why two NDCs? The FDA registers this code as 70000-0425-1 — a 5-4-1 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the package segment → 70000-0425-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Local anesthetics class.

Drug family (ATC) Local anesthetics, Anesthetics for topical use
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerCardinal Health 110, LLC. dba Leader
FDA applicationM015 (OTC MONOGRAPH DRUG)
Labeler code70000
First marketedDec 2020
Product typeHuman Otc Drug
Portfolio163 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name HEMORRHOIDAL CREAM Ingredient Phenyleph/Pramoxin/Glycr/W.pet
🧪 What is this product?

This is a topical over-the-counter cream formulated under FDA monograph rules and intended for application to the rectal area. It contains phenylephrine hydrochloride, a decongestant that narrows blood vessels, and pramoxine hydrochloride, a numbing agent typically used to reduce discomfort. Glycerin and white petrolatum serve as emollients and skin protectants to soften and soothe the affected area.

Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII ZY81Z83H0X
    Aloe vera leaf is a plant extract derived from the aloe plant. It is used in medicines as a natural moisturizer and skin-soothing agent in topical formulations.
  • UNII K679OBS311
    Carboxymethylcellulose sodium is a plant-derived thickening agent made from cellulose. In medicines, it acts as a binder to hold ingredients together, a disintegrant to help the tablet break apart, or a thickener in liquids.
  • UNII 936JST6JCN
    Cetyl alcohol is a waxy, fatty substance derived from plant or animal sources. It acts as an emulsifier and thickener in medicines, helping blend oil and water components and giving products a smooth, creamy texture.
  • UNII 230OU9XXE4
    A waxy substance made from glycerin and stearic acid that acts as an emulsifier to blend oily and watery ingredients together. It also helps thicken and stabilize the medicine's texture.
  • UNII A2I8C7HI9T
    Methylparaben is a preservative derived from benzoic acid that prevents growth of bacteria, fungi, and mold in medicines. It extends the product's shelf life and maintains safety during storage.
  • UNII I9O0E3H2ZE
    Paraffin is a waxy, petroleum-derived substance used as a coating, lubricant, and hardening agent in tablets and capsules. It helps protect the medicine from moisture and gives pills a smooth finish.
  • UNII 6OZP39ZG8H
    Polysorbate 80 is a synthetic emulsifier derived from sorbitol and oleic acid. It helps mix oil and water-based ingredients together in medications and improves how the product disperses in the body.
  • UNII 6DC9Q167V3
    Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
  • UNII Z8IX2SC1OH
    Propylparaben is a chemical preservative used to prevent bacterial and fungal growth in medicines and personal care products. It helps extend shelf life and maintain product safety during storage.
  • UNII 4ELV7Z65AP
    Stearic acid is a fatty acid derived from plant or animal sources. It acts as a binder and lubricant in tablets and capsules, helping them hold together and flow smoothly during manufacturing.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
  • UNII TTV12P4NEE
    Xanthan gum is a thickening and stabilizing ingredient made from fermented corn or other sugars. It's added to medicines to improve texture, prevent separation of liquids and solids, and help the product stay consistent.

12 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesaloe barbadensis leaf extract, carboxymethylcellulose sodium, cetyl alcohol, glyceryl monostearate, methylparaben, paraffin, propylene glycol, propylparaben, stearic acid, tween 80, water, xanthan gum

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMedingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly $0.085 $2.37 / 28 g
Medicaid paysCMS SDUD · 12 mo $0.3853 $10.79 / 28 g
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per g) — tap or hover for the price & month
Jun 2021 Jan 2026 Apr 2026 Aug 2026 $0.085 $0.079
▲ Up 6% over the last 11 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Good Sense Hemorrhoidal Maximum Strength Pain Relief 14.4 g/100g; .25 g/100g; 1 g/100g; 15 g/100g 00113-0944-24 L. 1 tube $0.045 Availability likely save 46%
Hemorrhoidal Cream .28 g/28g; 4.032 g/28g; .07 g/28g; 4.2 g/28gthis 70000-0425-01 Cardinal 1 tube $0.085 Availability likely
GNP Hemorrhoidal Maximum Strength 150 mg/g; 144 mg/g; 10 mg/g; 25 mg/g 46122-0776-37 Amerisourcebergen 1 tube $0.130 Availability likely +54%
Hemorrhoidal Cream 150 mg/g; 144 mg/g; 10 mg/g; 2.5 mg/g 00363-0641-09 Walgreens 1 tube FDA listed
Hemorrhoidal Pain Relief Cream 144 mg/g; 2.5 mg/g; 10 mg/g; 150 mg/g 00363-9127-01 WALGREENS 1 tube FDA listed
PREPARATION H Maximum Strength 144 mg/g; 2.5 mg/g; 10 mg/g; 150 mg/g 00573-2868-10 Haleon 1 tube FDA listed
Hemorrhoidal 14.4 g/100g; .25 g/100g; 1 g/100g; 15 g/100g 11822-2944-00 Rite 1 tube Discontinued
Hemorrhoidal Pain Relief 10 mg/g; 2.5 mg/g; 144 mg/g; 150 mg/g 13709-0335-01 Neilmed 1 tube FDA listed
Signature Care Hemorrhoidal Cream (with applicator) 2.5 mg/g; 10 mg/g; 144 mg/g; 150 mg/g 21130-0981-02 BETTER 1 tube FDA listed
hemorrhoidal maximum strength pain relief 14.4 g/100g; .25 g/100g; 1 g/100g; 15 g/100g 30142-0944-24 Kroger 1 tube FDA listed
topcare hemorrhoidal 14.4 g/100g; .25 g/100g; 1 g/100g; 15 g/100g 36800-0944-24 Topco 1 tube FDA listed
Equaline Hemorrhoidal 14.4 g/100g; .25 g/100g; 1 g/100g; 15 g/100g 41163-0944-24 United 1 tube FDA listed
hemorrhoidal 14.4 g/100g; .25 g/100g; 1 g/100g; 15 g/100g 41250-0944-24 Meijer 1 tube FDA listed
Hemorrhoidal 14.4 g/100g; .25 g/100g; 1 g/100g; 15 g/100g 42507-0944-24 HyVee 1 tube FDA listed
equate hemorrhoidal 14.4 g/100g; .25 g/100g; 1 g/100g; 15 g/100g 49035-0944-24 Wal-Mart 1 tube FDA listed
Nikzon Hemorrhoidal 144 mg/g; 150 mg/g; 2.5 mg/g; 10 mg/g 50066-0010-09 Genomma 1 tube FDA listed
CVS Maximum OTC Strength Hemorrhoidal with Aloe 144 mg/g; 2.5 mg/g; 10 mg/g; 150 mg/g 51316-0203-01 CVS 28 g FDA listed
Family Wellness HEMORRHOID 144 mg/g; 2.5 mg/g; 10 mg/g; 150 mg/g 55319-0981-25 FAMILY 1 tube FDA listed
Family Wellness 14.4 g/100g; .25 g/100g; 1 g/100g; 15 g/100g 55621-0012-01 Zhejiang 1 tube FDA listed
hemorrhoidal 14.4 g/100g; .25 g/100g; 1 g/100g; 15 g/100g 56062-0944-24 Publix 1 tube FDA listed
Hemorrhoidal 14.4 g/100g; .25 g/100g; 1 g/100g; 15 g/100g 59779-0944-24 CVS 1 tube FDA listed
Hemorrhoidal Cream 1 g/100g; 15 g/100g; 14.4 g/100g; .25 g/100g 69396-0033-18 Trifecta 1 tube FDA listed
Hemorrhoidal Cream 1 g/100g; 15 g/100g; 14.4 g/100g; .25 g/100g 69396-0171-18 Trifecta 1 tube FDA listed
Family Wellness 14.4 g/100g; .25 g/100g; 1 g/100g; 15 g/100g 69571-0004-02 FRONT 1 tube FDA listed
CVS Health Hemorrhoidal Cream 14.4 g/100g; .25 g/100g; 1 g/100g; 15 g/100g 69571-0010-28 FRONT 1 tube FDA listed
Thera Plus Hemorrhoidal 144 mg/g; 150 mg/g; 2.5 mg/g; 10 mg/g 80684-0141-00 FOURSTAR 26 g FDA listed
Thera Plus Hemorrhoidal 144 mg/g; 2.5 mg/g; 10 mg/g; 150 mg/g 80684-0210-01 Fourstar 26 g FDA listed
Up and Up Hemorrhoid MAX STRENGTH 144 mg/g; 2.5 mg/g; 10 mg/g; 150 mg/g 82442-0025-51 Target 1 tube FDA listed
Hemorrhoidal Cream with Aloe 15 g/100g; .25 g/100g; 1 g/100g; 14.4 g/100g 83324-0044-09 Chain 1 tube FDA listed
Maximum Strength Hemorrhoidal Cream with Aloe 15 g/100g; .25 g/100g; 1 g/100g; 14.4 g/100g 83324-0330-01 Chain 1 tube FDA listed
Bloop Hemorrhoid Relief Topical 14.4 g/100g; 1 g/100g; 15 g/100g; .25 g/100g 83838-0155-01 Three 1 tube FDA listed
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2020
On the market since
Dec 2020
📍
2026
Currently FDA-listed
6 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

🗺️ Medicaid utilization & spend

📍 This exact package only: Medicaid data is reported per full 11-digit NDC — labeler, product and pack size — so every number here is for 70000-0425-01, not the drug overall. Other pack sizes report separately.
💊 Pharmacy benefit only: These are Medicaid outpatient pharmacy claims, billed by NDC. They exclude the medical benefit — clinic- or hospital-administered drugs billed under HCPCS J-codes — so drugs used mostly that way (e.g. Avastin, Lucentis, Keytruda) can look low or missing here. That’s expected, not an error.
📅 Q1 2025 – Q1 2026 · 5 quarters of data
ⓘ The newest quarter is usually incomplete when first published; states restate recent quarters in later CMS releases, so the latest figures typically revise upward. State coverage-policy changes can also shift quarter-to-quarter totals.
Prescriptions last 4 qtrs
157
Units reimbursed last 4 qtrs
4.9K
Gross reimbursed last 4 qtrs
$1.9K
Avg / prescription
$12.00
Avg / unit
$0.3853
Latest quarter Q1 2026
60Rx
Medicaid pays / g
$0.3853
gross reimbursed
vs
NADAC / g
$0.0845
acquisition cost
=
Spread
+$0.3008
+356% vs cost
What Medicaid paid per g (before rebates; includes the pharmacy’s dispensing fee) compared with NADAC — the average price pharmacies pay to buy the drug. A positive spread means Medicaid reimbursed more than the purchase price, before manufacturer rebates.
Fee-for-service vs managed care
14% FFS 86% MCO
Fee-for-service · 22 Rx Managed care · 135 Rx
State Medicaid map
Alaska: no data reported AK Maine: no data reported ME Washington: no data reported WA Idaho: no data reported ID Montana: no data reported MT North Dakota: no data reported ND Minnesota: 474 units · 8.3 per 100k residents MN Wisconsin: no data reported WI Michigan: no data reported MI New York: no data reported NY Vermont: no data reported VT New Hampshire: no data reported NH Oregon: no data reported OR Nevada: no data reported NV Wyoming: no data reported WY South Dakota: no data reported SD Iowa: no data reported IA Illinois: no data reported IL Indiana: no data reported IN Ohio: 1,792 units · 15.2 per 100k residents OH Pennsylvania: no data reported PA New Jersey: 890 units · 9.6 per 100k residents NJ Massachusetts: no data reported MA California: no data reported CA Utah: no data reported UT Colorado: no data reported CO Nebraska: 1,734 units · 87.7 per 100k residents NE Missouri: no data reported MO Kentucky: no data reported KY West Virginia: no data reported WV Virginia: no data reported VA Maryland: no data reported MD Connecticut: no data reported CT Rhode Island: no data reported RI Arizona: no data reported AZ New Mexico: no data reported NM Kansas: no data reported KS Arkansas: no data reported AR Tennessee: no data reported TN North Carolina: no data reported NC South Carolina: no data reported SC Delaware: no data reported DE Oklahoma: no data reported OK Louisiana: no data reported LA Mississippi: no data reported MS Alabama: no data reported AL Georgia: no data reported GA D.C.: no data reported DC Hawaii: no data reported HI Texas: no data reported TX Florida: no data reported FL
Units reimbursed · per 100k residents
8.387.7
gray = no data reported
Colors are per 100,000 residents, so big states don’t automatically dominate. Tap or hover a state for its actual totals.
Tap or hover a state
…for its Medicaid breakdown
🏆 Top states by units · per 100k residents
1 Nebraska 87.7 /100k
2 Ohio 15.2 /100k
3 New Jersey 9.6 /100k
4 Minnesota 8.3 /100k
National units — by quarter
💵 About the dollar figures: “reimbursed” is what Medicaid paid pharmacies before confidential manufacturer rebates, so the program’s real net cost is lower than these numbers. Fee-for-service and managed-care claims are combined unless split above. Source: CMS State Drug Utilization Data; per-100k rates use 2023 Census population estimates.

🔬 Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Hemorrhoidal Cream (this brand).

Top reported reactions

Anaemia1
Anorectal Discomfort1
Burning Sensation1
Chills1
Depression1
Diarrhoea1
Dyschezia1

Reporter sex

0 reports

Serious outcomes

Hospitalization1
Life-threatening1
Disabling1
Death1
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
70000-0425-01 You're viewing this 1 TUBE in 1 BOX (70000-0425-1) / 28 g in 1 TUBE 2020-12-30 Active

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage 46 words

Uses for temporary relief of pain, soreness and burning helps relieve the local itching and discomfort associated with hemorrhoids temporarily provides a coating for relief of anorectal discomforts temporarily protects the inflamed irritated anorectal surface to help make bowel movements less painful temporarily shrinks hemorrhoidal tissue

⏱️ Dosage and Administration 109 words

Directions Adults: Children under 12 years of age: consult a doctor. when practical, cleanse the affected area with mild soap and warm water and rinse thoroughly. Gently dry by patting or blotting with toilet tissue or a soft cloth before application of this product. apply externally to the affected area up to 4 times daily, especially at night or in the morning or after each bowel movement. apply externally or in the lower portion of the anal canal only. for application in the lower anal canal: remove cover from dispensing cap.

Attach dispensing cap to tube. Lubricate dispensing cap well, then gently insert dispensing cap partway into the anus.

⚠️ Warnings 160 words

Warnings For external use only. When using this product do not put this product into the rectum by using fingers or any mechanical device or applicator do not exceed recommended daily dosage unless directed by a doctor Ask a doctor before use if you have heart disease high blood pressure thyroid disease diabetes difficulty urinating due to an enlarged prostate gland Ask a doctor or pharmacist before use if you are presently taking a prescription drug for high blood pressure or depression. Stop use and ask a doctor if bleeding occurs condition worsens or does not improve within 7 days the symptoms being treated do not subside or if redness, irritation, swelling, pain or other symptoms develop or increase.

Some people can develop allergic reactions to ingredients in this product. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center (1-800-222-1222) right away.

📦 Storage and Handling 14 words

Other Information store at room temperature 68° - 77° F (20° - 25° C).

🧪 Active Ingredient 13 words

Active ingredients Glycerin 14.4% Phenylephrine HCl 0.25% Pramoxine HCl 1% White petrolatum 15%

🧪 Inactive Ingredients 24 words

Inactive ingredients aloe barbadensis leaf extract, carboxymethylcellulose sodium, cetyl alcohol, glyceryl monostearate, methylparaben, paraffin, propylene glycol, propylparaben, stearic acid, tween 80, water, xanthan gum

🎯 Purpose 6 words

Purpose Protectant Vasoconstrictor Local anesthetic Protectant

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.