HomeNDC LookupIngredientsOlopatadine Hydrochloride › 70069-0491-01
OLOPATADINE HYDROCHLORIDE 2 mg/mL Solution/ Drops, 1 bottle — NDC 70069-0491-01 package photo

OLOPATADINE HYDROCHLORIDE 2 mg/mL Solution/ Drops, 1 bottle

by Somerset Therapeutics, LLC · 1 BOTTLE, PLASTIC in 1 CARTON (70069-491-01) / 2.5 mL in 1 BOTTLE, PLASTIC
NDC 70069-0491-01
🏷️ FDA NDC (as labeled) 70069-491-01 billing pads the product segment with a zero
OTC Generic On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

🆔 Identity & classification

FDA NDC (as labeled) 70069-491-01
Product NDC 70069-491
11-digit billing NDC 70069049101
NCPDP billing unit ML — per mL (volume)
RxCUI 1111343
UNII 2XG66W44KF
Application # ANDA215006
SPL Set ID 6ee9f8f5-973c-4c71-8069-e76cd87b07dc
Established class (EPC) Histamine-1 Receptor Antagonist; Histamine-1 Receptor Inhibitor; Mast Cell Stabilizer
Mechanism of action Histamine H1 Receptor Antagonists
Physiologic effect Decreased Histamine Release
DEA schedule Non-controlled
Marketing category ANDA
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2024-12-20
Route OPHTHALMIC
Dosage form SOLUTION/ DROPS
Substance OLOPATADINE HYDROCHLORIDE
GPI-14 86802065102030
GCN Seq No 062065
GCN 97848
HICL code 012815
Ingredient (HICL) Olopatadine Hcl
HIC1 code Q
Therapeutic class — broad (HIC1) Ear/Eye/Nose/Rectum/Topical/Vagina/Other
HIC2 code Q6
Therapeutic class — intermediate (HIC2) Ophthalmic Preparations
HIC3 code Q6R
Therapeutic class — specific (HIC3) Eye Antihistamines
AHFS code 52:02.00.00
AHFS class Antiallergic Agents
FDB label name OLOPATADINE HCL 0.2% EYE DROP
FDB brand name Olopatadine Hcl
Legend status O — Over-the-counter (OTC) drug or device
Why two NDCs? The FDA registers this code as 70069-491-01 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 70069-0491-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Histamine-1 Receptor Inhibitor class.

Pharmacologic class Histamine-1 Receptor Inhibitor, Histamine-1 Receptor Antagonist, Mast Cell Stabilizer
Drug family (ATC) Antiallergic agents, excl. corticosteroids, Other antiallergics
How it works Histamine H1 Receptor Antagonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerSomerset Therapeutics, LLC
Application holderSOMERSET THERAPEUTICS LLC
FDA applicationANDA215006 (ANDA)
Labeler code70069
First marketedDec 2024
Product typeHuman Otc Drug
Portfolio182 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name OLOPATADINE HCL 0.2% EYE DROP Ingredient Olopatadine Hcl
📖 What it is MedlinePlus · NLM

Prescription ophthalmic olopatadine (Pazeo) and nonprescription ophthalmic olopatadine (Pataday) are used to relieve itchy eyes caused by allergic reactions to pollen, ragweed, grass, animal hair, or pet dander. Olopatadine is in a class of medications called mast cell stabilizers. It works by preventing the release of substances that cause eye itching.

Read the full MedlinePlus article ↗
📗 Our plain-language guide HelloPharmacist
  • It does both, but with different products. The eye drops are for allergy-related itchy and red eyes. The nasal spray — brands like Patanase — is for seasonal allergic rhinitis, mea...
  • What exactly does olopatadine treat — is it just for eyes, or can it help my runny nose too?
  • You need to take your contacts out before you put the drops in. Wait at least 10 minutes after using the drops before you put them back in. Also, don't wear contacts at all if your...
  • Can I wear my contact lenses while using olopatadine eye drops?
📖 Read our full Olopatadine guide →

Supplement & herbal interactions

Some supplements/herbs that may interact with Olopatadine Hydrochloride — tap one for details:

Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII F5UM2KM3W7
    Benzalkonium chloride is a chemical compound that works as a preservative and antimicrobial agent in medications. It prevents bacterial and fungal growth in liquid formulations to keep the product safe during storage and use.
  • UNII 7FLD91C86K
    Edetate disodium is a chemical compound that binds and removes certain metal ions. In medicines, it acts as a preservative and stabilizer by preventing metals like calcium from interfering with the product's shelf life and consistency.
  • UNII QTT17582CB
    A strong acid used to adjust and maintain the proper pH level in liquid medicines, ensuring stability and preventing breakdown of active ingredients.
  • UNII FZ989GH94E
    Povidone is a synthetic polymer made from a plastic-like material. It acts as a binder to hold tablet ingredients together and as a disintegrant to help the tablet break apart in your stomach so the medicine can be absorbed.
  • UNII 451W47IQ8X
    Sodium chloride is common table salt. It's used in medicines as a buffer to maintain proper pH, as a filler to add bulk, or to adjust the osmotic balance in liquid formulations.
  • UNII 55X04QC32I
    A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
  • UNII GR686LBA74
    Sodium phosphate, dibasic is a salt derived from phosphoric acid. It acts as a buffer to help maintain the medicine's pH balance and may serve as a binder or filler in tablets and capsules.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

8 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesInactive ingredients benzalkonium chloride 0.01%, dibasic sodium phosphate, edetate disodium, hydrochloric acid/sodium hydroxide (adjust pH), povidone, sodium chloride and water for injection

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMedingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly $2.997 $7.49 / 2.5 ml
Medicaid paysCMS SDUD · 12 mo $6.02 $15.06 / 2.5 ml
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per mL) — tap or hover for the price & month
Dec 2025 Feb 2026 May 2026 Aug 2026 $3.397 $2.995
▼ Down 12% over the last 9 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Olopatadine Hydrochloride 2 mg/mL 24208-0617-01 Bausch 1 bottle $2.005 Availability likely save 33%
Leader Olopatadine Hydrochloride 2 mg/mL 70000-0716-01 CARDINAL 1 bottle $2.005 Availability likely save 33%
Olopatadine Hydrochloride 2 mg/mL 00536-1307-23 Rugby 1 bottle $2.997 Availability likely
olopatadine hydrochloride 2 mg/mL 16571-0861-25 Rising 2.5 ml $2.997 Availability likely
Olopatadine Hydrochloride Ophthalmic Solution 2 mg/mL 43598-0764-02 Dr. 1 bottle $2.997 Availability likely
Olopatadine Hydrochloride 2 mg/mL 46122-0671-27 Amerisource 1 bottle $2.997 Availability likely
Olopatadine Hydrochloride 2 mg/mL 68001-0530-69 BluePoint 1 bottle $2.997 Availability likely
Olopatadine Hydrochloride 2 mg/mL 68001-0674-92 BluePoint 1 bottle $2.997 Availability likely
Olopatadine Hydrochloride 2 mg/mLthis 70069-0491-01 Somerset 1 bottle $2.997 Availability likely
Eye Allergy Itch Relief Once Daily Relief 2 mg/mL 70677-1155-01 Strategic 1 bottle $2.997 Availability likely
Olopatadine Hydrochloride Ophthalmic Solution 2 mg/mL 83324-0120-25 Chain 1 bottle $2.997 Availability likely
Eye Allergy Itch Relief 2 mg/mL 70000-0053-01 CARDINAL 1 bottle $3.096 Availability likely +3%
Pataday Once Daily Relief 2 mg/mL 00065-8150-01 Alcon 1 bottle $5.893 Availability likely +97%
Olopatadine Hydrochloride 2 mg/mL 00363-0869-01 WALGREEN 1 bottle FDA listed
Olopatadine Hydrochloride Ophthalmic Solution 2 mg/mL 00363-7131-25 Walgreens 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 00363-8022-39 WALGREEN 1 bottle FDA listed
Olopatadine Hydrochloride Ophthalmic Solution 2 mg/mL 11673-0688-25 Target 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 11822-0063-02 RITE 1 bottle FDA listed
Olopatadine Hydrochloride Ophthalmic Solution 2 mg/mL 11822-9975-02 Rite 1 bottle FDA listed
Olopatadine Hydrochloride Ophthalmic Solution 2 mg/mL 21130-0105-02 Albertsons 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 24208-0967-01 Bausch 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 30142-0026-27 Kroger 1 bottle FDA listed
Once Daily Relief 2 mg/mL 37808-0045-25 H 1 bottle FDA listed
Eye Allergy Itch Relief Once Daily Relief 2 mg/mL 43598-0827-02 Dr. 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 46122-0824-29 AmerisourceBergen 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 46708-0710-03 Alembic 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 50090-5613-00 A-S 1 bottle FDA listed
Allergy Relief Eye Drops 2 mg/mL 51316-0675-25 CVS 1 bottle FDA listed
Retaine Allergy 5 mg/2.5mL 54799-0920-25 OCuSOFT 2.5 ml FDA listed
Olopatadine Hydrochloride Ophthalmic Solution Once Daily 2 mg/mL 55910-0137-25 DOLGENCORP, 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 58602-0007-39 Aurohealth 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 58602-0010-39 Aurohealth 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 58602-0013-39 Aurohealth 1 bottle FDA listed
Olopatadine hydrochloride 2 mg/mL 60505-6222-02 Apotex 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 62332-0502-03 Alembic 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 62332-0710-03 Alembic 1 bottle FDA listed
Olopatadine Hydrochloride Ophthalmic Solution 2 mg/mL 63868-0821-25 Chain 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 63941-0024-39 Best 1 bottle FDA listed
Olopatadine Hydrochloride Ophthalmic 2 mg/mL 68083-0231-01 Gland 1 bottle FDA listed
Eye Allergy Itch Relief 2 mg/mL 69168-0495-77 Allegiant 2 bottles FDA listed
CVS Eye Allergy Itch Relief Once Daily 2 mg/mL 69842-0269-25 CVS 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 72036-0009-39 Harris 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 72476-0851-21 Retail 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 72657-0194-11 GLENMARK 2 bottles FDA listed
Olopatadine Hydrochloride 2 mg/mL 73581-0709-02 YYBA 2 bottles FDA listed
Olopatadine Hydrochloride 2 mg/mL 76162-0044-39 TOPCO 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 79481-1001-02 Meijer 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 79903-0001-39 Wal-Mart 1 bottle FDA listed
Equate Olopatadine Hydrochloride 2 mg/mL 79903-0318-01 WAL-MART 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 80539-0001-39 Allwell 1 bottle FDA listed
Olopatadine Hydrochloride Ophthalmic Solution 2 mg/mL 82442-0967-02 TARGET 1 bottle FDA listed
Olopatadine Hydrochloride 2 mg/mL 73581-0712-02 YYBA 2 bottles FDA listed
Olopatadine Hydrochloride 2 mg/mL 73581-0713-02 YYBA 2 bottles FDA listed
About this product: this is a generic version of the medicine. FDA equivalence ratings are shown when available, and other versions are listed above, least expensive first.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2024
On the market since
Dec 2024
📍
2026
Currently FDA-listed
2 years listed
🔓
·
Generic on the market
this product is a generic
This is a generic drug

This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

🗺️ Medicaid utilization & spend

📍 This exact package only: Medicaid data is reported per full 11-digit NDC — labeler, product and pack size — so every number here is for 70069-0491-01, not the drug overall. Other pack sizes report separately.
💊 Pharmacy benefit only: These are Medicaid outpatient pharmacy claims, billed by NDC. They exclude the medical benefit — clinic- or hospital-administered drugs billed under HCPCS J-codes — so drugs used mostly that way (e.g. Avastin, Lucentis, Keytruda) can look low or missing here. That’s expected, not an error.
📅 Q1 2025 – Q4 2025 · 4 quarters of data
ⓘ The newest quarter is usually incomplete when first published; states restate recent quarters in later CMS releases, so the latest figures typically revise upward. State coverage-policy changes can also shift quarter-to-quarter totals.
Prescriptions last 4 qtrs
15K
Units reimbursed last 4 qtrs
43.4K
Gross reimbursed last 4 qtrs
$261.1K
Avg / prescription
$17.40
Avg / unit
$6.0222
Latest quarter Q4 2025
9.7KRx
Medicaid pays / mL
$6.0222
gross reimbursed
vs
NADAC / mL
$2.9968
acquisition cost
=
Spread
+$3.0254
+101% vs cost
What Medicaid paid per mL (before rebates; includes the pharmacy’s dispensing fee) compared with NADAC — the average price pharmacies pay to buy the drug. A positive spread means Medicaid reimbursed more than the purchase price, before manufacturer rebates.
Fee-for-service vs managed care
63% FFS 37% MCO
Fee-for-service · 9,438 Rx Managed care · 5,572 Rx
State Medicaid map
Alaska: 40 units · 5.5 per 100k residents AK Maine: 128 units · 9.2 per 100k residents ME Washington: no data reported WA Idaho: 240 units · 12.2 per 100k residents ID Montana: 193 units · 17.0 per 100k residents MT North Dakota: no data reported ND Minnesota: 1,950 units · 34.0 per 100k residents MN Wisconsin: 1,898 units · 32.1 per 100k residents WI Michigan: 1,500 units · 14.9 per 100k residents MI New York: 6,622 units · 33.8 per 100k residents NY Vermont: 208 units · 32.1 per 100k residents VT New Hampshire: 28 units · 2.0 per 100k residents NH Oregon: 215 units · 5.1 per 100k residents OR Nevada: 323 units · 10.1 per 100k residents NV Wyoming: no data reported WY South Dakota: no data reported SD Iowa: no data reported IA Illinois: no data reported IL Indiana: 1,008 units · 14.7 per 100k residents IN Ohio: 4,233 units · 35.9 per 100k residents OH Pennsylvania: 1,713 units · 13.2 per 100k residents PA New Jersey: 230 units · 2.5 per 100k residents NJ Massachusetts: no data reported MA California: 13,314 units · 34.2 per 100k residents CA Utah: no data reported UT Colorado: 1,288 units · 21.9 per 100k residents CO Nebraska: 360 units · 18.2 per 100k residents NE Missouri: 983 units · 15.9 per 100k residents MO Kentucky: no data reported KY West Virginia: no data reported WV Virginia: 818 units · 9.4 per 100k residents VA Maryland: 278 units · 4.5 per 100k residents MD Connecticut: 488 units · 13.5 per 100k residents CT Rhode Island: no data reported RI Arizona: 633 units · 8.5 per 100k residents AZ New Mexico: no data reported NM Kansas: 198 units · 6.7 per 100k residents KS Arkansas: no data reported AR Tennessee: 888 units · 12.5 per 100k residents TN North Carolina: 1,138 units · 10.5 per 100k residents NC South Carolina: 93 units · 1.7 per 100k residents SC Delaware: 73 units · 7.1 per 100k residents DE Oklahoma: no data reported OK Louisiana: no data reported LA Mississippi: no data reported MS Alabama: no data reported AL Georgia: 103 units · 0.9 per 100k residents GA D.C.: no data reported DC Hawaii: 318 units · 22.2 per 100k residents HI Texas: 1,868 units · 6.1 per 100k residents TX Florida: no data reported FL
Units reimbursed · per 100k residents
0.935.9
gray = no data reported
Colors are per 100,000 residents, so big states don’t automatically dominate. Tap or hover a state for its actual totals.
Tap or hover a state
…for its Medicaid breakdown
🏆 Top states by units · per 100k residents
1 Ohio 35.9 /100k
2 California 34.2 /100k
3 Minnesota 34.0 /100k
4 New York 33.8 /100k
5 Vermont 32.1 /100k
6 Wisconsin 32.1 /100k
7 Hawaii 22.2 /100k
8 Colorado 21.9 /100k
National units — by quarter
💵 About the dollar figures: “reimbursed” is what Medicaid paid pharmacies before confidential manufacturer rebates, so the program’s real net cost is lower than these numbers. Fee-for-service and managed-care claims are combined unless split above. Source: CMS State Drug Utilization Data; per-100k rates use 2023 Census population estimates.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
70069-0491-01 You're viewing this 1 BOTTLE, PLASTIC in 1 CARTON (70069-491-01) / 2.5 mL in 1 BOTTLE, PLASTIC 2024-12-20 Active

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage 14 words

Use temporarily relieves itchy eyes due to pollen, ragweed, grass, animal hair and dander

⏱️ Dosage and Administration 56 words

Directions adults and children 2 years of age and older: put 1 drop in the affected eye(s) once daily, no more than once per day if using other ophthalmic products while using this product, wait at least 5 minutes between each product replace cap after each use children under 2 years of age: consult a doctor

⚠️ Warnings 102 words

Warnings For external use only Do not use if solution changes color or becomes cloudy if you are sensitive to any ingredient in this product to treat contact lens related irritation When using this product do not touch tip of container to any surface to avoid contamination remove contact lenses before use wait at least 10 minutes before reinserting contact lenses after use do not wear a contact lens if your eye is red Stop use and ask a doctor if you experience: eye pain changes in vision increased redness of the eye itching worsens or lasts for more than 72 hours

📦 Storage and Handling 12 words

Other information only for use in the eye store between 2°-25°C (36°-77°F)

🧪 Inactive Ingredients 22 words

Inactive ingredients benzalkonium chloride 0.01%, dibasic sodium phosphate, edetate disodium, hydrochloric acid/sodium hydroxide (adjust pH), povidone, sodium chloride and water for injection

🎯 Purpose 13 words

Drug Facts Active Ingredients Purpose Olopatadine 0.2% (equivalent to olopatadine hydrochloride 0.222%) Antihistamine

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.