J7503
J7503 – Tacrolimus, extended release, (envarsus xr), oral, 0.25 mg · NDC Crosswalk & Billing Units
HCPCS Level II J-code · Medicare Part B drug billing
J-code
● 6 NDCs crosswalked per 0.25 MG $1.863/unit ASP+6%
📋 J7503 summary
J7503 is a HCPCS Level II J-code used to bill Tacrolimus, extended release, (envarsus xr), oral, 0.25 mg, billed per 0.25 MG. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.
Brand names associated with J7503: Envarsus Xr
Code J7503
Billing unit 0.25 MG Payment limit $1.863/unit NDC-Crosswalk 6
Quarter Q3 2026
RxCUI Atlas Trace the drug concept →
⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.
🗂️ Key billing facts
HCPCS codeJ7503
DescriptorTacrolimus, extended release, (envarsus xr), oral, 0.25 mg
Billing unit0.25 MG
Payment limit / unit$1.863
Est. ASP / unit$1.758 est.
Mapped NDCs6
Data periodQ3 2026
Last updated2026-08-20
💊 About Tacrolimus DRUG GUIDE
Tacrolimus is prescribed to help prevent your body from rejecting a transplanted organ.
It is used in adults who receive a kidney, liver, or heart transplant, and in children who receive a liver transplant.
It is always used alongside other anti-rejection medicines.Because tacrolimus works by dampening your immune system, it lowers the risk of your body attacking the new organ — but it also means you need to be watched closely for infections and other side effects throughout your treatment.
Clinical overview from our editorial drug guide for Tacrolimus. For billing reference, see the sections above.
🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026
📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).
Medicare payment limit / unit
$1.863
Est. ASP / unit
$1.758 est.
Est. after 2% sequester
$1.826
HCPCS dosage
0.25 MG
The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.
Full HCPCS code details (official CMS record)
Long descriptionTacrolimus, extended release, (envarsus xr), oral, 0.25 mg
CoverageD — Special coverage instructions apply
Pricing indicator51 — Drug — priced under the ASP methodology
Type of service1 — Medical care
BETOS-2O1E
ASC payment group—
Action codeN — No maintenance this year
Effective date2019-01-01
Date added2016-01-01
Source: CMS HCPCS Level II code file (imported via admin).
🧮 Dosing & billing-units calculator HCPCS UNITS
One billing unit of J7503 = 0.25 mg. Enter a regimen to convert dose → billing units and project a full course.
Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.
🔁 NDCs that bill under J7503 LEAST EXPENSIVE FIRST
6 NDCs map to J7503. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($1.863/unit) × that package's bill units.
| NDC (11-digit) | Drug | Labeler | Package | Strength | Bill units | Est. pay / pkg | NADAC / unit | Status | Source |
|---|---|---|---|---|---|---|---|---|---|
| 68992-3010-01 | Envarsus XR Tacrolimus 1 mg/1 TABLET, EXTENDED RELEASE | Veloxis | 1 POUCH in 1 CARTON (68992-3010-1) / 1 BO... | 1 mg/1 | 400 | $745.20 | $5.981 | ● Active | CMS + PDAC |
| 68992-3010-03 | Envarsus XR Tacrolimus 1 mg/1 TABLET, EXTENDED RELEASE | Veloxis | 1 POUCH in 1 CARTON (68992-3010-3) / 1 BO... | 1 mg/1 | 120 | $223.56 | $5.981 | ● Active | CMS + PDAC |
| 68992-3040-01 | Envarsus XR Tacrolimus 4 mg/1 TABLET, EXTENDED RELEASE | Veloxis | 1 POUCH in 1 CARTON (68992-3040-1) / 1 BO... | 4 mg/1 | 1,600 | $2,980.80 | — | ● Active | CMS + PDAC |
| 68992-3040-03 | Envarsus XR Tacrolimus 4 mg/1 TABLET, EXTENDED RELEASE | Veloxis | 1 POUCH in 1 CARTON (68992-3040-3) / 1 BO... | 4 mg/1 | 480 | $894.24 | — | ● Active | CMS + PDAC |
| 68992-3075-01 | Envarsus XR Tacrolimus .75 mg/1 TABLET, EXTENDED RELEASE | Veloxis | 1 POUCH in 1 CARTON (68992-3075-1) / 1 BO... | .75 mg/1 | 300 | $558.90 | — | ● Active | CMS + PDAC |
| 68992-3075-03 | Envarsus XR Tacrolimus .75 mg/1 TABLET, EXTENDED RELEASE | Veloxis | 1 POUCH in 1 CARTON (68992-3075-3) / 1 BO... | .75 mg/1 | 90 | $167.67 | — | ● Active | CMS + PDAC |
NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.
📊 Medicare utilization & spend CMS · PART B · 2026 (Q1)
Period
Total Part B spend
$31.82M
Claims
34,358
Beneficiaries
13,290
Spend / beneficiary
$2,394.30
Spend / claim
$926.14
Trend by period
Where J7503 ranks among Part B drugs · 2026 (Q1) · neighbors ±5
Total spending — #95 of 824
#90
CYRAMZA J9308
$33.32M
#91
KADCYLA J9354
$32.97M
#92
BENLYSTA J0490
$32.83M
#93
TRUXIMA Q5115
$32.81M
#94
VYEPTI J3032
$31.97M
#95
ENVARSUS XR J7503
$31.82M
#96
ARALAST NP* J0256
$31.72M
#97
CUVITRU J1555
$31.71M
#98
NEULASTA ONPRO* J2506
$31.45M
#99
ADSTILADRIN J9029
$31.33M
#100
ZEPZELCA J9223
$31.07M
Total claims — #73 of 824
#68
FLUOROURACIL J9190
37,237
#69
ORTHOVISC J7324
37,232
#70
YUPELRI J7677
37,078
#71
ACTEMRA(J3262) J3262
36,246
#72
JUBBONTI* Q5136
34,987
#73
ENVARSUS XR J7503
34,358
#74
RECLAST* J3489
34,241
#75
RETACRIT(Q5106) Q5106
33,752
#76
LEVULAN J7308
31,923
#77
FERAHEME(Q0138)* Q0138
31,621
#78
EPOGEN(J0885)* J0885
31,448
Top Medicare Part B drugs by the selected metric. Click any drug to open its J-code page. Source: CMS Medicare Quarterly Part B Spending by Drug.
Full breakdown by period (2)
| Period | Total spend | Beneficiaries | Claims | $/beneficiary | $/claim |
|---|---|---|---|---|---|
| 2026 (Q1) | $31.82M | 13,290 | 34,358 | $2,394.30 | $926.14 |
| 2025 (Q1-Q4) | $132.2M | 16,517 | 161,542 | $8,003.98 | $818.37 |
Provider-administered (Part B) spend, calculated for the whole HCPCS code (CMS does not publish Medicare spend per individual NDC). Self-administered use is covered under Part D instead. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part B Spending by Drug (data.cms.gov), updated quarterly.
📈 Medicare Part B claims detail CMS PSPS · 2024
Calendar-year 2024 Medicare Part B fee-for-service activity for this HCPCS code, summed across all carriers, localities and specialties (CMS Physician/Supplier Procedure Summary). A “service” is one billed line/unit — not one claim — so counts run higher than claim counts.
Allowed charges
$136.56M
Medicare paid
$106.12M
Submitted services
79,672,328
Denial rate
5.7%
Allowed / service
$1.82
Submitted charges
$183.82M
Source: CMS Physician/Supplier Procedure Summary (PSPS), CY2024 — Medicare Part B carrier + DME fee-for-service claims (excludes Medicare Advantage). Figures are for the whole HCPCS code, which may cover uses beyond this drug. ⚠ CMS hides any figure covering fewer than 11 patients (a privacy rule), so totals — especially denials and low-volume codes — run a little low.
📊 What bills under J7503
J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.
NDC products by ingredient
NDC products by labeler
🗃️ Data sources & freshness
Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.
HCPCS code & descriptor
CMS HCPCS Level II code file
Loaded
Payment limit & billing unit
CMS Medicare Part B ASP Pricing File (quarterly)
Q3 2026 · as of 2026-08-20
NDC ↔ HCPCS crosswalk
CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)
6 NDCs mapped
NADAC acquisition cost
CMS National Average Drug Acquisition Cost (weekly)
Available for mapped NDCs
Utilization & spend
CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners
Latest data year 2026
Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.
⚠️ Practical billing caveats
- A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
- Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
- Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
- Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
- The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
- Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.
❓ J7503 billing FAQ
What is HCPCS code J7503?
J7503 is a HCPCS Level II J-code used to bill Tacrolimus, extended release, (envarsus xr), oral, 0.25 mg under Medicare Part B and most medical (not pharmacy) benefits.
What is the billing unit for J7503?
One unit of J7503 represents 0.25 MG. Report the number of units equal to the dose administered divided by 0.25 MG.
How many units of J7503 should I bill?
Divide the dose administered by the code's unit size (0.25 MG) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.
How much does Medicare pay for J7503?
The Medicare Part B payment limit is $1.863 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $1.826 per unit. Payment limits are revised quarterly.
Which NDCs bill under J7503?
6 NDCs currently map to J7503 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.
Does a crosswalk mean J7503 is covered?
No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.
For professional billing reference only — verify against the current CMS files before submitting claims.