J9190
J9190 – Injection, fluorouracil, 500 mg · NDC Crosswalk & Billing Units
HCPCS Level II J-code · Medicare Part B drug billing
J-code
● 44 NDCs crosswalked per 500 MG $2.024/unit ASP+6%
📋 J9190 summary
J9190 is a HCPCS Level II J-code used to bill fluorouracil, 500 mg, billed per 500 MG. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.
Code J9190
Billing unit 500 MG Payment limit $2.024/unit NDC-Crosswalk 44
Quarter Q3 2026
RxCUI Atlas Trace the drug concept →
⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.
🗂️ Key billing facts
HCPCS codeJ9190
DescriptorInjection, fluorouracil, 500 mg
Billing unit500 MG
Payment limit / unit$2.024
Est. ASP / unit$1.909 est.
Mapped NDCs44
Data periodQ3 2026
Last updated2026-08-20
💊 About Fluorouracil DRUG GUIDE
When given intravenously, Fluorouracil (and Favlyxa) treats adenocarcinoma of the colon and rectum, breast, stomach, and pancreas — typically as part of a combination chemotherapy regimen.Topical forms treat skin conditions: Tolak Cream is approved for actinic keratosis (sun-damaged skin lesions) on the face, ears, and scalp.
Fluorouracil 5% topical cream and topical solution are used for multiple actinic or solar keratoses, and the 5% strength is also used for superficial basal cell carcinomas when other treatments are not practical.
Clinical overview from our editorial drug guide for Fluorouracil. For billing reference, see the sections above.
🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026
📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).
Medicare payment limit / unit
$2.024
Est. ASP / unit
$1.909 est.
Est. after 2% sequester
$1.984
HCPCS dosage
500 MG
The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.
Full HCPCS code details (official CMS record)
Long descriptionInjection, fluorouracil, 500 mg
CoverageD — Special coverage instructions apply
Pricing indicator51 — Drug — priced under the ASP methodology
Type of service1 — Medical care
BETOS-2O1D
ASC payment group—
Action codeN — No maintenance this year
Effective date2009-01-01
Date added1984-01-01
Source: CMS HCPCS Level II code file (imported via admin).
🧮 Dosing & billing-units calculator HCPCS UNITS
One billing unit of J9190 = 500 mg. Enter a regimen to convert dose → billing units and project a full course.
Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.
🔁 NDCs that bill under J9190 WITH EST. MEDICARE PAY
44 NDCs map to J9190. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($2.024/unit) × that package's bill units.
| NDC (11-digit) | Drug | Labeler | Package | Strength | Bill units | Est. pay / pkg | NADAC / unit | Status | Source |
|---|---|---|---|---|---|---|---|---|---|
| 16729-0276-38 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Accord | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS ASP |
| 25021-0215-98 | fluorouracil 50 mg/mL INJECTION, SOLUTION | Sagent | 1 BOTTLE in 1 CARTON (25021-215-98) / 50... | 50 mg/mL | 5 | $10.12 | — | ● Active | CMS + PDAC |
| 25021-0215-99 | fluorouracil 50 mg/mL INJECTION, SOLUTION | Sagent | 1 BOTTLE in 1 CARTON (25021-215-99) / 100... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS + PDAC |
| 55150-0498-01 | FLUOROURACIL 50 mg/mL INJECTION, SOLUTION | Eugia | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 5 | $10.12 | — | ● Active | CMS + PDAC |
| 55150-0499-01 | FLUOROURACIL 50 mg/mL INJECTION, SOLUTION | Eugia | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS + PDAC |
| 62332-0751-50 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Alembic | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 5 | $10.12 | — | ● Active | CMS + PDAC |
| 62332-0779-31 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Alembic | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS + PDAC |
| 63323-0117-10 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Fresenius | 10 VIAL, SINGLE-DOSE in 1 TRAY (63323-117-... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS + PDAC |
| 63323-0117-18 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Fresenius | 10 VIAL, SINGLE-DOSE in 1 TRAY (63323-117-... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS ASP |
| 63323-0117-19 | Fluorouracil | FreseniUS | — | — | 10 | $20.24 | — | — | CMS ASP |
| 63323-0117-20 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Fresenius | 10 VIAL, SINGLE-DOSE in 1 TRAY (63323-117-... | 50 mg/mL | 20 | $40.48 | — | ● Active | CMS + PDAC |
| 63323-0117-28 | Fluorouracil | FreseniUS | — | — | 20 | $40.48 | — | — | CMS ASP |
| 63323-0117-51 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Fresenius | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 5 | $10.12 | — | ● Active | CMS + PDAC |
| 63323-0117-58 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Fresenius | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 5 | $10.12 | — | ● Active | CMS ASP |
| 63323-0117-59 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Fresenius | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 5 | $10.12 | — | ● Active | CMS ASP |
| 63323-0117-61 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Fresenius | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS + PDAC |
| 63323-0117-68 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Fresenius | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS ASP |
| 63323-0117-69 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Fresenius | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS ASP |
| 68001-0524-30 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | BluePoint | 10 VIAL in 1 CARTON (68001-524-30) / 10 m... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS + PDAC |
| 68001-0524-31 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | BluePoint | 10 VIAL in 1 CARTON (68001-524-31) / 20 m... | 50 mg/mL | 20 | $40.48 | — | ● Active | CMS + PDAC |
| 68001-0525-27 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | BluePoint | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 5 | $10.12 | — | ● Active | CMS + PDAC |
| 68001-0525-32 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | BluePoint | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS + PDAC |
| 68001-0627-27 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | BluePoint | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 5 | $10.12 | — | ● Active | CMS + PDAC |
| 68001-0628-32 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | BluePoint | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS + PDAC |
| 70700-0186-23 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Xiromed | 10 VIAL in 1 CARTON (70700-186-23) / 10 m... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS + PDAC |
| 70700-0187-23 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Xiromed | 10 VIAL in 1 CARTON (70700-187-23) / 20 m... | 50 mg/mL | 20 | $40.48 | — | ● Active | CMS + PDAC |
| 70700-0188-22 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Xiromed | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 5 | $10.12 | — | ● Active | CMS + PDAC |
| 70700-0189-22 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Xiromed | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS + PDAC |
| 71288-0154-76 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Meitheal | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 10 | $20.24 | — | ● Active | CMS + PDAC |
| 71288-0170-75 | Fluorouracil 50 mg/mL INJECTION, SOLUTION | Meitheal | 1 VIAL, PHARMACY BULK PACKAGE in 1 CARTON... | 50 mg/mL | 5 | $10.12 | — | ● Active | CMS + PDAC |
| 62991-1486-01 | Fluorouracil 1 g/g POWDER | LETCO | 5 g in 1 JAR (62991-1486-1) | 1 g/g | 2 | $4.05 | — | ● Active | PDAC |
| 62991-1486-02 | Fluorouracil 1 g/g POWDER | LETCO | 25 g in 1 JAR (62991-1486-2) | 1 g/g | 2 | $4.05 | — | ● Active | PDAC |
| 62991-1486-03 | Fluorouracil 1 g/g POWDER | LETCO | 10 g in 1 JAR (62991-1486-3) | 1 g/g | 2 | $4.05 | — | ● Active | PDAC |
| 51927-1085-00 | FLUOROURACIL 1 kg/kg POWDER | Professional | 1 kg in 1 CONTAINER (51927-1085-0) | 1 kg/kg | 2 | $4.05 | — | ● Active | PDAC |
| 51552-0733-05 | FLUOROURACIL (1X100GM,USP) | Unknown | — | — | 2 | $4.05 | — | — | PDAC |
| 51552-0733-04 | FLUOROURACIL (1X25GM,USP) | Unknown | — | — | 2 | $4.05 | — | — | PDAC |
| 51552-0733-02 | FLUOROURACIL (1X5GM,USP) | Unknown | — | — | 2 | $4.05 | — | — | PDAC |
| 51552-0733-01 | FLUOROURACIL (1X1GM,USP) | Unknown | — | — | 2 | $4.05 | — | — | PDAC |
| 38779-0025-05 | Fluorouracil 1 g/g POWDER | Medisca | 100 g in 1 JAR (38779-0025-5) | 1 g/g | 2 | $4.05 | — | ● Active | PDAC |
| 38779-0025-04 | Fluorouracil 1 g/g POWDER | Medisca | 25 g in 1 BOTTLE, GLASS (38779-0025-4) | 1 g/g | 2 | $4.05 | — | ● Active | PDAC |
| 38779-0025-01 | Fluorouracil 1 g/g POWDER | Medisca | 10 g in 1 BOTTLE, GLASS (38779-0025-1) | 1 g/g | 2 | $4.05 | — | ● Active | PDAC |
| 00703-3015-13 | ADRUCIL (S.D.V.) 50 MG/ML | Unknown | — | — | 0.1 | $0.20 | — | — | PDAC |
| 00703-3019-12 | ADRUCIL (PHARMACY BULK PACKAGE) 50 MG/ML | Unknown | — | — | 0.1 | $0.20 | — | — | PDAC |
| 00703-3018-12 | ADRUCIL (PHARMACY BULK PACKAGE) 50 MG/ML | Unknown | — | — | 0.1 | $0.20 | — | — | PDAC |
NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.
📊 Medicare utilization & spend CMS · PART B · 2026 (Q1)
Period
Total Part B spend
$492.3K
Claims
37,237
Beneficiaries
13,913
Spend / beneficiary
$35.39
Spend / claim
$13.22
Trend by period
Where J9190 ranks among Part B drugs · 2026 (Q1) · neighbors ±5
Total spending — #443 of 824
#438
AMNICORE PRO+, PER S... Q4299
$516.2K
#439
SIMULECT J0480
$512.7K
#440
IXEMPRA J9207
$507.9K
#441
SIGNIFOR LAR J2502
$497.3K
#442
REEVA, PER SQ CM** Q4314
$496.6K
#443
FLUOROURACIL J9190
$492.3K
#444
BIO-CONNEKT PER SQUA... Q4161
$490.4K
#445
ALPHANATE J7186
$474.9K
#446
EPICORD 1 SQ CM** Q4187
$473.8K
#447
GEMCITABINE HCL(J920... J9201
$466.6K
#448
BERINERT J0597
$461.9K
Total claims — #68 of 824
#63
LEQVIO J1306
38,806
#64
ARFORMOTEROL TARTRAT... J7605
38,654
#65
SIMPONI ARIA J1602
38,495
#66
IHEEZO J2403
37,882
#67
OPDIVO J9299
37,629
#68
FLUOROURACIL J9190
37,237
#69
ORTHOVISC J7324
37,232
#70
YUPELRI J7677
37,078
#71
ACTEMRA(J3262) J3262
36,246
#72
JUBBONTI* Q5136
34,987
#73
ENVARSUS XR J7503
34,358
Top Medicare Part B drugs by the selected metric. Click any drug to open its J-code page. Source: CMS Medicare Quarterly Part B Spending by Drug.
Full breakdown by period (2)
| Period | Total spend | Beneficiaries | Claims | $/beneficiary | $/claim |
|---|---|---|---|---|---|
| 2026 (Q1) | $492.3K | 13,913 | 37,237 | $35.39 | $13.22 |
| 2025 (Q1-Q4) | $2.24M | 34,129 | 158,707 | $65.53 | $14.09 |
Provider-administered (Part B) spend, calculated for the whole HCPCS code (CMS does not publish Medicare spend per individual NDC). Self-administered use is covered under Part D instead. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part B Spending by Drug (data.cms.gov), updated quarterly.
📈 Medicare Part B claims detail CMS PSPS · 2024
Calendar-year 2024 Medicare Part B fee-for-service activity for this HCPCS code, summed across all carriers, localities and specialties (CMS Physician/Supplier Procedure Summary). A “service” is one billed line/unit — not one claim — so counts run higher than claim counts.
Allowed charges
$2.27M
Medicare paid
$1.75M
Submitted services
1,352,298
Denial rate
17.0%
Allowed / service
$2.03
Submitted charges
$19.94M
Source: CMS Physician/Supplier Procedure Summary (PSPS), CY2024 — Medicare Part B carrier + DME fee-for-service claims (excludes Medicare Advantage). Figures are for the whole HCPCS code, which may cover uses beyond this drug. ⚠ CMS hides any figure covering fewer than 11 patients (a privacy rule), so totals — especially denials and low-volume codes — run a little low.
🗺️ Where J9190 is utilized CMS · BY PROVIDER · 2024
Medicare Part B services for this code by the rendering provider's state — 600,547 services across 49 states & territories in 2024 (CMS reports include DC and U.S. territories). Switch to per 100k to compare states fairly regardless of population. Hover or tap a state for its top ZIP codes.
Hover or tap a state to see its numbers + top ZIP codes.
Per-capita = services ÷ 2023 state population × 100,000 (so high-population states aren't automatically "hotter"). Counts reflect the provider's location, not the patient's. Providers with fewer than 11 patients are hidden by CMS for privacy, so totals run low and per-100k can be noisy in small states — read this as relative geography, not exact counts. Source: CMS Medicare Physician & Other Practitioners — by Provider and Service, 2024.
📊 What bills under J9190
J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.
NDC products by ingredient
NDC products by labeler
🗃️ Data sources & freshness
Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.
HCPCS code & descriptor
CMS HCPCS Level II code file
Loaded
Payment limit & billing unit
CMS Medicare Part B ASP Pricing File (quarterly)
Q3 2026 · as of 2026-08-20
NDC ↔ HCPCS crosswalk
CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)
44 NDCs mapped
NADAC acquisition cost
CMS National Average Drug Acquisition Cost (weekly)
Not available for mapped NDCs
Utilization & spend
CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners
Latest data year 2026
Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.
⚠️ Practical billing caveats
- A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
- Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
- Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
- Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
- The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
- Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.
❓ J9190 billing FAQ
What is HCPCS code J9190?
J9190 is a HCPCS Level II J-code used to bill Injection, fluorouracil, 500 mg under Medicare Part B and most medical (not pharmacy) benefits.
What is the billing unit for J9190?
One unit of J9190 represents 500 MG. Report the number of units equal to the dose administered divided by 500 MG.
How many units of J9190 should I bill?
Divide the dose administered by the code's unit size (500 MG) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.
How much does Medicare pay for J9190?
The Medicare Part B payment limit is $2.024 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $1.984 per unit. Payment limits are revised quarterly.
Which NDCs bill under J9190?
44 NDCs currently map to J9190 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.
Does a crosswalk mean J9190 is covered?
No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.
For professional billing reference only — verify against the current CMS files before submitting claims.