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Diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Spray — RxCUI 1053138

RxNorm drug concept · Semantic clinical drug
RxCUI 1053138 Semantic clinical drug · SCD ● Current RxNorm concept 23 FDA products 24 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1053138
Official nameDiphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Spray
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asdiphenhydramine hydrochloride 2 % / zinc acetate 0.1 % Topical Spray; diphenhydrAMINE HCl 2 % / zinc acetate 0.1 % Topical Spray
FDA products mapped23
Package NDCs mapped24
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Diphenhydramine Topical: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • You can use it for temporary relief of pain and itching from everyday skin problems — things like insect bites, minor burns, minor cuts and scrapes, and general skin irritations. I...
  • What can I actually use this cream or spray for?
  • You can apply it up to 3 to 4 times a day, but no more than that. More frequent use isn't going to help more — and the label is clear that you shouldn't exceed that limit. For kids...
  • This is really important — do not use this topical product at the same time as any other product that contains diphenhydramine, even a pill or capsule. That includes allergy medici...
📖 Read our full Diphenhydramine Topical guide →

🕸️ Concept Web — How Diphenhydramine hydrochloride 20 MG/ML / zinc ac... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Diphenhydramine hydrochloride 20 MG/ML / zinc acetate 1 MG/ML Topical Spray RxCUI 1053138

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 4

    The active substance itself — no strength, form, or brand attached yet.

    • Diphenhydramine 3498
    • Zinc acetate 58295
    • Diphenhydramine / zinc acetate 466522
    • Diphenhydramine hydrochloride 1362
  2. Brand names 2

    The same medicine's trade names. A brand name alone says nothing about strength or form.

    • Benadryl Itch Stopping 607032
    • Wal-Dryl 1053139
  3. Dose forms 12

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Diphenhydramine / zinc acetate Topical Spray 377321
    • Diphenhydramine hydrochloride / zinc acetate Topical Spray 2646549
    • Diphenhydramine / zinc acetate Topical Product 1158436
    • Diphenhydramine hydrochloride / zinc acetate Topical Product 2659163
    • Diphenhydramine / zinc acetate Topical Spray [Benadryl Itch Stopping] 702464
    • Diphenhydramine / zinc acetate Topical Spray [Wal-Dryl] 1053141
    • Diphenhydramine hydrochloride / zinc acetate Topical Spray [Benadryl Itch Stopping] 2654957
    • Diphenhydramine hydrochloride / zinc acetate Topical Spray [Wal-Dryl] 2655738
    • +4 more in this family
  4. Clinical & branded drugs 6

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

Showing up to 8 concepts per family — 20 of 24 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

  • Diphenhydramine hydrochloride 20 MG/ML SCDC · 1049097
  • Zinc acetate 1 MG/ML SCDC · 340184
  • Diphenhydramine / zinc acetate Topical Spray SCDF · 377321
  • Diphenhydramine hydrochloride / zinc acetate Topical Spray SCDFP · 2646549
  • Diphenhydramine / zinc acetate Topical Product SCDG · 1158436
  • Diphenhydramine hydrochloride / zinc acetate Topical Product SCDGP · 2659163

Brand-Name Concepts

📦 FDA Products & Package NDCs

23 products · 24 package NDCs
24 package NDCs map to RxCUI 1053138 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00363-0215-76 76 g in 1 CAN (0363-0215-76) Diphenhydramine HCl and Zinc Acetate Walgreen Company 2012-01-12
00363-2177-00 88 mL in 1 BOTTLE, SPRAY (0363-2177-00) EXTRA STRENGTH WAL-DRYL ITCH RELIEF WALGREEN CO 2011-01-03
11822-0647-02 59 g in 1 BOTTLE, PUMP (11822-0647-2) Rite Aid Itch Relief Rite Aid 2021-03-31
11822-0647-03 85 g in 1 CAN (11822-0647-3) Rite Aid Itch Relief Rite Aid 2021-03-31
36800-0126-76 76 g in 1 CANISTER (36800-126-76) Diphenhydramine HCl and Zinc Acetate Topco Associates LLC 2019-03-05
37808-0526-27 76 g in 1 CAN (37808-526-27) Diphenhydramine HCl and Zinc Acetate HEB 2017-12-22
41250-0058-30 76 g in 1 CAN (41250-058-30) Diphenhydramine HCl and Zinc Acetate Meijer Distribution Inc 2015-09-15
41250-0295-20 59 mL in 1 BOTTLE, SPRAY (41250-295-20) Itch Relief Meijer, Inc. 2018-11-01
42507-0986-76 76 g in 1 CANISTER (42507-986-76) Itch Relief HY-VEE, INC 2026-01-12
46122-0572-46 59 mL in 1 BOTTLE, SPRAY (46122-572-46) Good neighbor Pharmacy Itch Relief AMERISOURCEBERGEN DRUG CORPORATION 2014-04-14
49035-0015-03 88 mL in 1 CANISTER (49035-015-03) Diphenhydramine HCl and Zinc Acetate Wal-Mart Stores, Inc. 2013-03-03
50804-0064-02 59 mL in 1 TUBE (50804-064-02) GoodSense Anti-Itch Geiss, Destin & Dunn, Inc 2025-05-01
55910-0295-20 59 mL in 1 BOTTLE, SPRAY (55910-295-20) Itch Relief Old East Main Co. 2010-07-14
59450-0295-20 59 mL in 1 BOTTLE, SPRAY (59450-295-20) Itch Relief The Kroger Co. 2024-02-02
63868-0952-02 59 mL in 1 BOTTLE, SPRAY (63868-952-02) Quality Choice Itch Relief Chain Drug Marketing Association 2014-04-14
63941-0259-02 59 mL in 1 BOTTLE, SPRAY (63941-259-02) Best Choice Itch Relief Valu Merchandisers 2014-04-14
69842-0235-27 76 g in 1 CANISTER (69842-235-27) Itch Relief CVS Pharmacy 2019-02-01
69842-0952-02 59 mL in 1 BOTTLE, SPRAY (69842-952-02) CVS Itch Relief CVS 2014-04-14
69968-0270-02 59 mL in 1 BOTTLE, SPRAY (69968-0270-2) Benadryl Extra Strength Itch Cooling Kenvue Brands LLC 2019-04-01
70000-0023-01 59 mL in 1 BOTTLE, SPRAY (70000-0023-1) Itch Relief Cardinal Health, 110 dba Leader 2011-08-02
72839-0647-02 59 mL in 1 BOTTLE (72839-647-02) Warrior First Aid Anti Itch Derma Care Research Labs, LLC 2022-07-25
79481-0598-01 76 g in 1 CAN (79481-0598-1) Extra Strength Itch Relief Meijer Distribution Inc 2023-08-15
82895-0715-60 59 mL in 1 BOTTLE, SPRAY (82895-715-60) Westlake Itch Relief Westlake HB Pharma LLC 2023-10-01
83324-0302-27 76 g in 1 CAN (83324-302-27) Extra Strength Itch Relief Chain Drug Marketing Association Inc 2024-06-06
Observed labelers: Meijer Distribution Inc (2) · Rite Aid (2) · AMERISOURCEBERGEN DRUG CORPORATION (1) · Cardinal Health, 110 dba Leader (1) · Chain Drug Marketing Association (1) · Chain Drug Marketing Association Inc (1) · +16 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.