🆔 Identity & classification

FDA NDC (as labeled) 46122-572-46

Product NDC 46122-572

11-digit billing NDC 46122057246

NCPDP billing unit ML — per mL (volume)

RxCUI 1053138

UNII FM5526K07A, TC2D6JAD40

UPC 0087701431708

Application # M017

SPL Set ID 87395273-380c-7cef-e053-2991aa0a54c6

Established class (EPC) Copper Absorption Inhibitor; Histamine-1 Receptor Antagonist

Mechanism of action Histamine H1 Receptor Antagonists

Physiologic effect Decreased Copper Ion Absorption

DEA schedule Non-controlled

Marketing category OTC MONOGRAPH DRUG

Marketing status On market

FDA listing status Listed (active directory)

Marketing start 2014-04-14

Route TOPICAL

Dosage form SPRAY

Substance ZINC ACETATE; DIPHENHYDRAMINE HYDROCHLORIDE

GPI-14 90209902080920

GPI class GNP Itch Relief Spray

GCN Seq No 060991

GCN 27146

HICL code 009759

Ingredient (HICL) Diphenhydramine Hcl/Zinc Acet

HIC1 code L

Therapeutic class — broad (HIC1) Skin/Subcutaneous Tissue

HIC2 code L3

Therapeutic class — intermediate (HIC2) Protectives

HIC3 code L3P

Therapeutic class — specific (HIC3) Antipruritics,Topical

AHFS code 84:08.00.00

AHFS class Antipruritics And Local Anesthetics

FDB label name GNP ITCH RELIEF 2%-0.1% SPRAY

FDB brand name Itch Relief

Legend status O — Over-the-counter (OTC) drug or device

Why two NDCs? The FDA registers this code as 46122-572-46 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 46122-0572-46. Same drug, same package — only the format differs.

Where does this data come from?

Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Histamine-1 Receptor Antagonist class.

Pharmacologic class Histamine-1 Receptor Antagonist

Drug family (ATC) Propionic acid derivatives, Antihistamines for topical use, Aminoalkyl ethers

How it works Histamine H1 Receptor Antagonists

Where does this data come from?

Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerAMERISOURCEBERGEN DRUG CORPORATION

FDA applicationM017 (OTC MONOGRAPH DRUG)

Labeler code46122

First marketedApr 2014

Product typeHuman Otc Drug

Portfolio37 products on file

🔎 All NDCs from AMERISOURCEBERGEN DRUG CORPORATION

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).

Where does this data come from?

Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name GNP ITCH RELIEF 2%-0.1% SPRAY Ingredient Diphenhydramine Hcl/Zinc Acet

🧪 What is this product?

Good Neighbor Pharmacy Itch Relief is a topical spray containing diphenhydramine hydrochloride and zinc acetate. Diphenhydramine is an antihistamine commonly included in over-the-counter itch-relief products to reduce itching sensations, while zinc acetate is an astringent often used to soothe and dry irritated skin. This is an OTC monograph drug, meaning it is marketed under established FDA guidelines for its product category rather than through individual drug approval.

Patient education

📘 MedlinePlus patient leaflet ↗

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →

Where does this data come from?

Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.

Where does this data come from?

Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?

No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.

Why might an inactive ingredient be missing?

Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.

Can inactive ingredients matter?

Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price system	Per mL	Per package
Retail pharmacies payNADAC · weekly	$0.047	$2.78 / 59 ml
Medicaid paysCMS SDUD · 12 mo	No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly	No Part D plan price is available for this NDC in our data.

NADAC price history (per mL) — tap or hover for the price & month

▲ Up 4% over the last 11 months.

Where does this data come from?

NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

Product	Labeler	Pack	NADAC/unit	TE	Status	Price vs. this
Good neighbor Pharmacy Itch Relief .1 g/100mL; 2 g/100mLthis 46122-0572-46	AMERISOURCEBERGEN	59 ml	$0.047	—	Availability likely	—
Itch Relief 20 mg/mL; 1 mg/mL 70000-0023-01	Cardinal	59 ml	$0.047	—	Availability likely	—
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 00363-0215-76	Walgreen	76 g	—	—	FDA listed	—
Extra Strength Wal-Dryl Itch Relief 20 mg/mL; 1 mg/mL 00363-2177-00	WALGREEN	88 ml	—	—	FDA listed	—
Rite Aid Itch Relief 2 g/100g; .1 g/100g 11822-0647-02	Rite	59 g	—	—	FDA listed	—
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 30142-0134-27	Kroger	76 g	—	—	Discontinued	—
Diphenhydramine HCl and Zinc Acetate 1.5 g/76g; .075 g/76g 36800-0126-76	Topco	76 g	—	—	FDA listed	—
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 37808-0526-27	HEB	76 g	—	—	FDA listed	—
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 41250-0058-30	Meijer	76 g	—	—	FDA listed	—
Itch Relief 20 mg/mL; 1 mg/mL 41250-0295-20	Meijer,	59 ml	—	—	FDA listed	—
Itch Relief 1 mg/g; 20 mg/g 42507-0986-76	HY-VEE,	76 g	—	—	FDA listed	—
Diphenhydramine HCl and Zinc Acetate 1.5 g/88mL; .075 g/88mL 49035-0015-03	Wal-Mart	88 ml	—	—	FDA listed	—
GoodSense Anti-Itch 2 g/100mL; .1 g/100mL 50804-0064-02	Geiss,	59 ml	—	—	FDA listed	—
Itch Relief 20 mg/mL; 1 mg/mL 55910-0295-20	Old	59 ml	—	—	FDA listed	—
Itch Relief 1 mg/mL; 20 mg/mL 59450-0295-20	The	59 ml	—	—	FDA listed	—
Quality Choice Itch Relief .1 g/100mL; 2 g/100mL 63868-0952-02	Chain	59 ml	—	—	FDA listed	—
Best Choice Itch Relief .1 g/100mL; 2 g/100mL 63941-0259-02	Valu	59 ml	—	—	FDA listed	—
Itch Relief 1.5 g/76g; .076 g/76g 69842-0235-27	CVS	76 g	—	—	FDA listed	—
CVS Itch Relief .1 g/100mL; 2 g/100mL 69842-0952-02	CVS	59 ml	—	—	FDA listed	—
Benadryl Extra Strength Itch Cooling 20 mg/mL; 1 mg/mL 69968-0270-02	Kenvue	59 ml	—	—	FDA listed	—
Itch Relief 20 mg/mL; 1 mg/mL 72476-0295-20	Retail	059 l	—	—	Discontinued	—
Warrior First Aid Anti Itch 2 g/100mL; .1 g/100mL 72839-0647-02	Derma	59 ml	—	—	FDA listed	—
Extra Strength Itch Relief 20 mg/g; 1 mg/g 79481-0598-01	Meijer	76 g	—	—	FDA listed	—
Westlake Itch Relief .1 g/100mL; 2 g/100mL 82895-0715-60	Westlake	59 ml	—	—	FDA listed	—
Extra Strength Itch Relief 20 mg/g; 1 mg/g 83324-0302-27	Chain	76 g	—	—	FDA listed	—

About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.

Where does this data come from?

Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️

2014

On the market since

Apr 2014

📍

2026

Currently FDA-listed

12 years listed

🔒

·

No generic listed yet

brand only

ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?

Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

🔬 Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Diphenhydramine HCl, Zinc Acetate — the ingredient across all brands.

Top reported reactions

Headache4

Diarrhoea3

Dizziness3

Fatigue3

Pruritus3

Rash3

Skin Haemorrhage3

Age at onset

Adult3

Elderly4

Reporter sex

Male · 27%

Female · 73%

Serious outcomes

Hospitalization3

Reports over time (by year) — tap or hover for the count & year

Most recent year is provisional (FAERS lags ~3 months).

Where does this data come from?

Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

📦 Packaging — all sizes for this product

Package NDC	Description	Marketing start	Status
46122-0572-46 You're viewing this	59 mL in 1 BOTTLE, SPRAY (46122-572-46)	2014-04-14	Active

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.

🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings and Cautions ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose

🎯 Indications and Usage 39 words ▾

for temporary relieves pain and itching due to: insect bites minor burns sunburn minor skin irritations minor cuts scrapes rashes due to poison ivy, poison oak, and poison sumac dries the oozing and weeping of poison: ivy oak sumac

⏱️ Dosage and Administration 33 words ▾

do not use more often than directed adults and children 2 years and older: apply to affected area not more than 3 to 4 times daily children under 2 years: ask a doctor

⚠️ Warnings and Cautions 66 words ▾

For external use only on large areas of the body with any other product containing diphenhydramine, even one taken by mouth on chicken pox on measles do not get into eyes condition worsens symptoms last more than 7 days or clear up and occur again within a few days If swallowed, get medical help or contact a Poison Control Center right away. for external use only

⚠️ Warnings 4 words ▾

for external use only

🧪 Active Ingredient 10 words ▾

Diphenhydramine hydrochloride 2% Topical analgesic Zinc acetate 0.1% Skin protectant

🧪 Inactive Ingredients 9 words ▾

Purified Water, Glycerin, SD Alcohol, Povidone, Povidonee (K-30), Trolamine

🎯 Purpose 10 words ▾

Diphenhydramine hydrochloride 2% Topical analgesic Zinc acetate 0.1% Skin protectant

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

🔗 Related NDC lookups

🧪 All Diphenhydramine Hcl, Zinc Acetate NDCsSame ingredient 🏭 All AMERISOURCEBERGEN labeler NDCsLabeler code 46122 📚 All Copper Absorption Inhibitor NDCsDrug class

💊 Related drugs in this class

Other drugs that share this product’s specific therapeutic class — Antipruritics,Topical.

Doxepin Hcl 00093-9609-95 Pramoxine Hcl/Calamine 00187-5465-06 Pramoxine Hcl/Zinc Acetate 00187-5466-06 Pramoxine Hcl/Benzyl Alcohol 00225-0495-33 Pramoxine Hcl/Menthol 00316-0234-12 Pramoxine Hcl/Camph/Zinc Acet 00395-0400-96 Pramoxine Hcl/Diphenhydramine 11383-0192-01 Diphenhydramine Hcl 37205-0338-16 Pramoxine/Zinc Oxide/Calamine 54859-0120-04

Where does this data come from?

Other drugs sharing this product’s First Databank therapeutic class (HIC3). Each links to that NDC’s page in our directory.

Good neighbor Pharmacy Itch Relief Diphenhydramine HCl, Zinc Acetate .1 g/100mL; 2 g/100mL Spray, 59 mL

🆔 Identity & classification

🏷️ RxNorm drug class

🏭 Manufacturer & labeler

🩺 Clinical

Patient education

Supplement & herbal interactions

🧪 Inactive Ingredients / Excipients

Inactive ingredient FAQ

💲 Pricing

🔁 Therapeutic equivalents

⏳ Availability & generic status

🔬 Reported adverse events (FAERS)

Top reported reactions

Age at onset

Reporter sex

Serious outcomes

📦 Packaging — all sizes for this product

📄 FDA label — Drug Facts FDA SPL

🔗 Related NDC lookups

💊 Related drugs in this class