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Diphenhydramine HCl and Zinc Acetate Anti-Itch Continuous Spray 1.5 g/88mL; .075 g/88mL Aerosol, Spray, 88 mL — NDC 49035-0015-03 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Diphenhydramine HCl and Zinc Acetate Anti-Itch Continuous Spray 1.5 g/88mL; .075 g/88mL Aerosol, Spray, 88 mL — NDC 49035-015-03 (Billing 49035-0015-03)

by Wal-Mart Stores, Inc. · 88 mL in 1 CANISTER

This is a package of 88 mL of Diphenhydramine HCl and Zinc Acetate Anti-Itch Continuous Spray 1.5 g/88mL; .075 g/88mL Aerosol, Spray from Wal-Mart Stores, Inc., marketed since Mar 2013 and currently FDA-listed, this package's marketing is listed to end Oct 2026. It is this product's only package size.

NDC 49035-0015-03
🏷️ FDA NDC (as labeled) 49035-015-03 billing pads the product segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 49035-015-03 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
49035 labeler · 015 product · 03 package
Package marketed since
Mar 3, 2013
Package marketing ended
Oct 31, 2026
Sample package
No — commercial package
Barcode (UPC-A, from the NDC)
3 4903501503 1
FDA record last changed
Jul 24, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 49035-015-03
Product NDC 49035-015
11-digit billing NDC 49035001503
RxCUI 1053138
UNII TC2D6JAD40, FM5526K07A
Application # M017
SPL Set ID 709c3bb8-5b36-4823-941a-45ddb3e431c4
Established class (EPC) Copper Absorption Inhibitor; Histamine-1 Receptor Antagonist
Mechanism of action Histamine H1 Receptor Antagonists
Physiologic effect Decreased Copper Ion Absorption
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2013-03-03
Marketing end 2026-10-31
Route TOPICAL
Dosage form AEROSOL, SPRAY
Substance DIPHENHYDRAMINE HYDROCHLORIDE; ZINC ACETATE
Quick answers
  • RxCUI (RxNorm): 1053138
Why two NDCs? The FDA registers this code as 49035-015-03 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 49035-0015-03. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Histamine-1 Receptor Antagonist class.

Pharmacologic class Histamine-1 Receptor Antagonist
Drug family (ATC) Propionic acid derivatives, Antihistamines for topical use, Aminoalkyl ethers
How it works Histamine H1 Receptor Antagonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

📖 About the active ingredient: Diphenhydramine Hydrochloride; Zinc Acetate MedlinePlus · NLM
General information about the ingredient itself — the description of this specific product follows below.

Diphenhydramine is used to treat allergy and cold symptoms: sneezing runny nose red, itchy, watery eyes itching of the nose or throat Diphenhydramine is also used to treat insomnia (difficulty falling asleep or staying asleep) in adults, but should not be used to make a child sleepy. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Diphenhydramine is also available in combination with other medications. This monograph only includes information about the use of diphenh...

Read the full MedlinePlus article ↗
🧪 What is this product?

This is a topical spray product marketed as an over-the-counter anti-itch remedy under FDA's monograph rules for its category. It contains diphenhydramine hydrochloride, an antihistamine commonly used to relieve itching and minor skin irritation, and zinc acetate, a mineral agent typically included in skin care products for its astringent and soothing properties. The spray form allows direct application to affected areas of the skin.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
49035-0015-03 You're viewing this Main listing 88 mL in 1 CANISTER 2013-03-03 Oct 31, 2026 Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Good neighbor Pharmacy Itch Relief .1 g/100mL; 2 g/100mL 46122-0572-46 AMERISOURCEBERGEN 59 ml $0.047 — Availability likely —
Itch Relief 20 mg/mL; 1 mg/mL 70000-0023-01 Cardinal 59 ml $0.047 — Availability likely —
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 00363-0215-76 Walgreen 76 g — — FDA listed —
Extra Strength Wal-Dryl Itch Relief 20 mg/mL; 1 mg/mL 00363-2177-00 WALGREEN 88 ml — — FDA listed —
Rite Aid Itch Relief 2 g/100g; .1 g/100g 11822-0647-02 Rite 59 g — — FDA listed —
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 30142-0134-27 Kroger 76 g — — Discontinued —
Diphenhydramine HCl and Zinc Acetate 1.5 g/76g; .075 g/76g 36800-0126-76 Topco 76 g — — FDA listed —
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 37808-0526-27 HEB 76 g — — FDA listed —
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 41250-0058-30 Meijer 76 g — — FDA listed —
Itch Relief 20 mg/mL; 1 mg/mL 41250-0295-20 Meijer, 59 ml — — FDA listed —
Itch Relief 1 mg/g; 20 mg/g 42507-0986-76 HY-VEE, 76 g — — FDA listed —
Diphenhydramine HCl and Zinc Acetate 1.5 g/88mL; .075 g/88mLthis 49035-0015-03 Wal-Mart 88 ml — — FDA listed —
GoodSense Anti-Itch 2 g/100mL; .1 g/100mL 50804-0064-02 Geiss, 59 ml — — FDA listed —
Itch Relief 20 mg/mL; 1 mg/mL 55910-0295-20 Old 59 ml — — FDA listed —
Itch Relief 1 mg/mL; 20 mg/mL 59450-0295-20 The 59 ml — — FDA listed —
Quality Choice Itch Relief .1 g/100mL; 2 g/100mL 63868-0952-02 Chain 59 ml — — FDA listed —
Best Choice Itch Relief .1 g/100mL; 2 g/100mL 63941-0259-02 Valu 59 ml — — FDA listed —
Itch Relief 1.5 g/76g; .076 g/76g 69842-0235-27 CVS 76 g — — FDA listed —
CVS Itch Relief .1 g/100mL; 2 g/100mL 69842-0952-02 CVS 59 ml — — FDA listed —
Benadryl Extra Strength Itch Cooling 20 mg/mL; 1 mg/mL 69968-0270-02 Kenvue 59 ml — — FDA listed —
Itch Relief 20 mg/mL; 1 mg/mL 72476-0295-20 Retail 059 l — — Discontinued —
Warrior First Aid Anti Itch 2 g/100mL; .1 g/100mL 72839-0647-02 Derma 59 ml — — FDA listed —
Extra Strength Itch Relief 20 mg/g; 1 mg/g 79481-0598-01 Meijer 76 g — — FDA listed —
Westlake Itch Relief .1 g/100mL; 2 g/100mL 82895-0715-60 Westlake 59 ml — — FDA listed —
Extra Strength Itch Relief 20 mg/g; 1 mg/g 83324-0302-27 Chain 76 g — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2013
On the market since
Mar 2013
📍
2026
Currently FDA-listed
13 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerWal-Mart Stores, Inc.
FDA applicationM017 (OTC MONOGRAPH DRUG)
Labeler code49035
First marketedMar 2013
Product typeHuman Otc Drug
Portfolio83 products on file

More NDCs from Wal-Mart Stores, Inc. labeler code 49035

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Other Information 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 45 words ▾

​Uses for the temporary relief of pain and itching associated with: minor burns sunburns minor cuts scrapes insect bites minor skin irritations rashes due to poison ivy, poison oak and poison sumac dries the oozing and weeping of poison ivy, poison oak and poison sumac

⏱️ Dosage and Administration 31 words ▾

​Directions adults and children 2 years of age and older: apply to affected area not more than 3 to 4 times daily children under 2 years of age: ask a doctor

⚠️ Warnings 102 words ▾

Warnings For external use only. Flammable: Keep away from fire or flame. Do not puncture or incinerate.

Contents under pressure. Do not store at temperatures above 120°F ​Do not use on large areas of the body with any other product containing diphenhydramine, even one taken by mouth ​Stop use and ask doctor if conditions worsens symptoms last more than 7 days or clear up and occur again within a few days ​When using this product avoid contact with eyes use only as directed ​Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

🧪 Active Ingredient 8 words ▾

Active ingredients Diphenhydramine HCl 2%, Zinc Acetate 0.1%

🧪 Inactive Ingredients 14 words ▾

​ ​Inactive ingredients aloe barbadensis leaf juice, glycerin, purified water, sd alcohol 40-B, tromethamine

🎯 Purpose 5 words ▾

​Purpose External analgesic Skin protectant

📄 Do Not Use 20 words ▾

​Do not use on large areas of the body with any other product containing diphenhydramine, even one taken by mouth

📄 When Using This Product 12 words ▾

​When using this product avoid contact with eyes use only as directed

📄 Stop Use and Ask a Doctor If 24 words ▾

​Stop use and ask doctor if conditions worsens symptoms last more than 7 days or clear up and occur again within a few days

📄 Keep Out of Reach of Children 19 words ▾

​Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

📄 Other Information 10 words ▾

​Other information store between 20° to 25°C (68° to 77°F)

📄 Questions or Comments 2 words ▾

​Questions? 1-888-287-1915

📄 Package Label / Principal Display Panel 50 words ▾

​Principal Display Panel Equate Extra Strength Anti-Itch Continuous Spray Diphenhydramine HCl 2%, Zinc Acetate 0.1% External Analgesic, Skin Protectant Relieves pain and itching from: Insect bites Rashes due to poison ivy, oak & sumac Minor burns, cuts and skin irritations

2.7 OZ (76 g) Equate Anti Itch Continuous Spray 46-AICWM-02

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Extra Strength Itch Relief — the ingredient across all brands.

Top reported reactions

Fatigue2
Headache2
Nausea2
Pruritus2
Anaemia1
Arthralgia1
Arthritis Bacterial1

Reporter sex

6 reports
Male · 67%
Female · 33%

Serious outcomes

Hospitalization1
Reports over time (by year) — tap or hover for the count & year
2024 2025 2026 2 2
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page it is currently marketed — but Wal-Mart Stores, Inc. has reported a marketing end date of 2026-10-31, after which this package is expected to stop being marketed. The directory data on this page refreshes weekly.
Who lists this product with the FDA?
Wal-Mart Stores, Inc. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 49035-0012-30 · Walmart 49035-0016-02 · Wal-Mart →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.