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Itch Relief Diphenhydramine HCl, Zinc Acetate 20 mg/mL; 1 mg/mL Spray, 059 l — NDC 72476-295-20 (Billing 72476-0295-20)

by Retail Business Services, LLC · .059 L in 1 BOTTLE, SPRAY

This is a package of 059 l of Itch Relief Diphenhydramine HCl, Zinc Acetate 20 mg/mL; 1 mg/mL Spray from Retail Business Services, LLC, no longer marketed (first marketed Oct 2011), no longer in the FDA NDC Directory. It is this product's only package size.

NDC 72476-0295-20
🏷️ FDA NDC (as labeled) 72476-295-20 billing pads the product segment with a zero
OTC Discontinued Non-controlled ⚠ Discontinued by firm ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 2, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 72476-295-20 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
72476 labeler · 295 product · 20 package
Package marketed since
Oct 6, 2011
Sample package
No — commercial package
Listing certified through
Dec 31, 2027
Barcode (UPC-A, from the NDC)
3 7247629520 5
FDA record last changed
Jul 2, 2026
⚠️
Excluded from the active FDA NDC Directory. The labeler reported this product as discontinued, so it is excluded from the active NDC Directory. The listing was last certified through Jul 2026. A label may still appear on DailyMed, but the NDC is no longer in the current FDA NDC Directory. Search the FDA NDC Directory ↗

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 72476-295-20
Product NDC 72476-295
11-digit billing NDC 72476029520
RxCUI 1053138
UNII TC2D6JAD40, FM5526K07A
Application # M017
SPL Set ID 50153065-8511-404f-be47-55a14f2502f5
Established class (EPC) Copper Absorption Inhibitor; Histamine-1 Receptor Antagonist
Mechanism of action Histamine H1 Receptor Antagonists
Physiologic effect Decreased Copper Ion Absorption
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status Discontinued
FDA listing status Discontinued by firm (certified through Jul 2026)
Marketing start 2011-10-06
Route TOPICAL
Dosage form SPRAY
Substance DIPHENHYDRAMINE HYDROCHLORIDE; ZINC ACETATE
Quick answers
  • RxCUI (RxNorm): 1053138
Why two NDCs? The FDA registers this code as 72476-295-20 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 72476-0295-20. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Histamine-1 Receptor Antagonist class.

Pharmacologic class Histamine-1 Receptor Antagonist
Drug family (ATC) Propionic acid derivatives, Antihistamines for topical use, Aminoalkyl ethers
How it works Histamine H1 Receptor Antagonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

🧪 What is this product?

This is a topical spray product marketed as an over-the-counter monograph drug containing diphenhydramine hydrochloride and zinc acetate. Diphenhydramine is an antihistamine commonly used in itch-relief products to help reduce itching sensations on the skin. Zinc acetate is typically included in such formulations for its astringent and skin-soothing properties. The spray form allows direct application to affected skin areas.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
72476-0295-20 You're viewing this Main listing .059 L in 1 BOTTLE, SPRAY 2011-10-06 — Discontinued by firm

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Good neighbor Pharmacy Itch Relief .1 g/100mL; 2 g/100mL 46122-0572-46 AMERISOURCEBERGEN 59 ml $0.047 — Availability likely —
Itch Relief 20 mg/mL; 1 mg/mL 70000-0023-01 Cardinal 59 ml $0.047 — Availability likely —
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 00363-0215-76 Walgreen 76 g — — FDA listed —
Extra Strength Wal-Dryl Itch Relief 20 mg/mL; 1 mg/mL 00363-2177-00 WALGREEN 88 ml — — FDA listed —
Rite Aid Itch Relief 2 g/100g; .1 g/100g 11822-0647-02 Rite 59 g — — FDA listed —
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 30142-0134-27 Kroger 76 g — — Discontinued —
Diphenhydramine HCl and Zinc Acetate 1.5 g/76g; .075 g/76g 36800-0126-76 Topco 76 g — — FDA listed —
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 37808-0526-27 HEB 76 g — — FDA listed —
Diphenhydramine HCl and Zinc Acetate 1.52 g/76g; .076 g/76g 41250-0058-30 Meijer 76 g — — FDA listed —
Itch Relief 20 mg/mL; 1 mg/mL 41250-0295-20 Meijer, 59 ml — — FDA listed —
Itch Relief 1 mg/g; 20 mg/g 42507-0986-76 HY-VEE, 76 g — — FDA listed —
Diphenhydramine HCl and Zinc Acetate 1.5 g/88mL; .075 g/88mL 49035-0015-03 Wal-Mart 88 ml — — FDA listed —
GoodSense Anti-Itch 2 g/100mL; .1 g/100mL 50804-0064-02 Geiss, 59 ml — — FDA listed —
Itch Relief 20 mg/mL; 1 mg/mL 55910-0295-20 Old 59 ml — — FDA listed —
Itch Relief 1 mg/mL; 20 mg/mL 59450-0295-20 The 59 ml — — FDA listed —
Quality Choice Itch Relief .1 g/100mL; 2 g/100mL 63868-0952-02 Chain 59 ml — — FDA listed —
Best Choice Itch Relief .1 g/100mL; 2 g/100mL 63941-0259-02 Valu 59 ml — — FDA listed —
Itch Relief 1.5 g/76g; .076 g/76g 69842-0235-27 CVS 76 g — — FDA listed —
CVS Itch Relief .1 g/100mL; 2 g/100mL 69842-0952-02 CVS 59 ml — — FDA listed —
Benadryl Extra Strength Itch Cooling 20 mg/mL; 1 mg/mL 69968-0270-02 Kenvue 59 ml — — FDA listed —
Itch Relief 20 mg/mL; 1 mg/mLthis 72476-0295-20 Retail 059 l — — Discontinued —
Warrior First Aid Anti Itch 2 g/100mL; .1 g/100mL 72839-0647-02 Derma 59 ml — — FDA listed —
Extra Strength Itch Relief 20 mg/g; 1 mg/g 79481-0598-01 Meijer 76 g — — FDA listed —
Westlake Itch Relief .1 g/100mL; 2 g/100mL 82895-0715-60 Westlake 59 ml — — FDA listed —
Extra Strength Itch Relief 20 mg/g; 1 mg/g 83324-0302-27 Chain 76 g — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2011
On the market since
Oct 2011
📍
2026
Currently FDA-listed
15 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

We could not link this NDC to a current FDA Structured Product Label. An inactive-ingredient list is therefore not available from this source.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerRetail Business Services, LLC
FDA applicationM017 (OTC MONOGRAPH DRUG)
Labeler code72476
First marketedOct 2011
Product typeHuman Otc Drug
Portfolio67 products on file

More NDCs from Retail Business Services, LLC labeler code 72476

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🤒 Adverse Reactions 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 Ask a Doctor Before Use If 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 25 words ▾

Uses for the temporary relief of pain and itching associated with minor skin irratations dries the oozing and weeping of poison: ivy, oak and sumac

⏱️ Dosage and Administration 37 words ▾

Directions •do not use more than directed •adults and children 2 years of age and older: apply to affected area not more than 3 to 4 times daily •children under 2 years of age: ask a doctor

⚠️ Warnings 96 words ▾

Warnings For external use only Flammable. Keep away from fire of flame. Do not use on large areas of the body with any other product containing diphenhydramine, even one taken by mouth Ask a doctor before use on chicken pox or measles When using this product do not get into eyes Stop use and ask a doctor if condition worsens or symptoms last more than 7 days or clear up and occur again within a few days.

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

🤒 Adverse Reactions 21 words ▾

ADVERSE REACTION DIST. BY FOODHOLD U.S.A., LLC LANDOVER, MD 20785 1-877-846-9949 ©2021 Ahold Delhaize Licensing Sari Quilty guaranteed or money back.

📦 Storage and Handling 11 words ▾

Other information • store at 20⁰ to 25⁰C (68⁰ to 77⁰F)

🧪 Active Ingredient 13 words ▾

Active ingredients Diphenhydramine HCl 2% Zinc Acetate 0.1% Purpose External analgesic Skin protectant

🧪 Inactive Ingredients 10 words ▾

Inactive ingredients alcohol, glycerin, povidone, purified water, tris (hydroxymethyl) aminomethane

🎯 Purpose 5 words ▾

Purpose External analgesic Skin protectant

📄 Do Not Use 20 words ▾

Do not use on large areas of the body with any other product containing diphenhydramine, even one taken by mouth

📄 Ask a Doctor Before Use If 10 words ▾

Ask a doctor before use on chicken pox or measles

📄 When Using This Product 9 words ▾

When using this product do not get into eyes

📄 Stop Use and Ask a Doctor If 26 words ▾

Stop use and ask a doctor if condition worsens or symptoms last more than 7 days or clear up and occur again within a few days.

📄 Keep Out of Reach of Children 19 words ▾

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

📄 Package Label / Principal Display Panel 54 words ▾

principal display panel TEAR HERE CAREONE ® Itch Relief Spray TOPICAL ANALGESIC SKIN PROTECTANT Pain and Itch Reliever COMPARE TO THE ACTIVE INGREDIENTS IN BENADRYL ® SPRAY* RELIEVES ITCHING DUE TO INSECT BITES, POISON OAK OR IVY, OR OTHER MINOR SKIN IRRITATIONS OUR PHARMACISTS RECOMMEND 2 FL OZ (59 mL) image description image description

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Over-the-counter (OTC) product No longer marketed (per FDA listing data)
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos — Not published for this NDC No photo available yet for this listing.
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
What does the discontinued status mean for this NDC?
The labeler reported a marketing end date (or the listing was delisted), so this specific package is no longer actively marketed. Remaining stock may still be dispensed for a time, and the NDC stays valid for historical records and claims — but data feeds (pricing, labeling) typically stop updating for it. Other package sizes or other manufacturers' versions of the same medication may still be marketed — see the equivalents section where available.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Who lists this product with the FDA?
Retail Business Services, LLC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 72476-0281-15 · Retail 72476-0296-15 · Retail →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.