Acetaminophen; Oxycodone Hydrochloride Tablet shortage
Acetaminophen; Oxycodone Hydrochloride Tablet is currently listed in shortage by the FDA. The FDA lists 6 affected products. This page was last refreshed from FDA data on Sep 25, 2026.
Endo Pharmaceuticals is stopping production of Percocet (oxycodone/acetaminophen) tablets, and this change may be permanent. The same medicine in all affected strengths is still listed by other manufacturers, including SpecGx, Major Pharmaceuticals, KVK-Tech, and Aurolife Pharma.
Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available (see options).
Do you take this drug? See the ‘What to do’ recommendation from Dr. Brian Staiger, PharmD →What’s in shortage — at a glance
These figures count only the manufacturers that reported this shortage to the FDA — not every company that makes Acetaminophen; Oxycodone Hydrochloride Tablet. Other makers that haven’t reported a problem are shown in the green card below.
Shortage timeline
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Nov 3, 2025Currently in shortage6 of 6 products affected.
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Nov 3, 2025First reported to the FDA6 products first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
What exactly is on backorder — by manufacturer
Manufacturer: Endo Pharmaceuticals, Inc. 📞 800-828-9393 6 NDCS click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| To Be Discontinued | Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 2.5 mg (NDC 60951-701-70) | — | — | Discontinuation of the manufacture of the drug | — |
| To Be Discontinued | Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 5 mg (NDC 60951-602-85) | — | — | Discontinuation of the manufacture of the drug | — |
| To Be Discontinued | Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 10 mg (NDC 60951-712-70) | — | — | Discontinuation of the manufacture of the drug | — |
| To Be Discontinued | Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 5 mg (NDC 60951-602-70) | — | — | Discontinuation of the manufacture of the drug | — |
| To Be Discontinued | Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 7.5 mg (NDC 60951-700-70) | — | — | Discontinuation of the manufacture of the drug | — |
| To Be Discontinued | Acetaminophen; Oxycodone Hydrochloride, Tablet, 325 mg; 2.5 mg (NDC 63481-627-70) | — | — | Discontinuation of the manufacture of the drug | — |
These rows are manufacturer reports to the FDA for Acetaminophen; Oxycodone Hydrochloride Tablet — they do not necessarily cover every manufacturer that makes this drug. A company appears here only if it told the FDA it has a supply problem, so other makers may still have stock. That’s the basis for the Where else can I get Acetaminophen; Oxycodone Hydrochloride Tablet? options further down this page.
Why is Acetaminophen; Oxycodone Hydrochloride Tablet in shortage?
Endo Pharmaceuticals has reported to the FDA that they are permanently stopping the manufacture of their acetaminophen/oxycodone combination tablets. This affects all four strengths they made — the 325 mg/2.5 mg, 325 mg/5 mg, 325 mg/7.5 mg, and 325 mg/10 mg tablets. They did not share a specific public reason for why they made this decision.
It's worth knowing that this report only covers Endo Pharmaceuticals' products. Other manufacturers of this combination medication may have filed separate reports with the FDA, so this doesn't necessarily reflect the availability of every version of this drug on the market.
Based on the manufacturer-reported reason(s) and notes on file with the FDA for Acetaminophen; Oxycodone Hydrochloride Tablet, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as manufacturers report changes.
What should I do if I take Acetaminophen; Oxycodone Hydrochloride Tablet?
Acetaminophen with oxycodone (the combination tablet) is currently on the FDA shortage list. The maker that filed this report, Endo Pharmaceuticals, is discontinuing its version, so I want to walk you through what that means for the strength you take.
All four strengths on this record are affected, and none of them has an available source from this manufacturer right now: 325 mg/2.5 mg, 325 mg/5 mg, 325 mg/7.5 mg, and 325 mg/10 mg. The reported reason is discontinuation — this maker has chosen to stop producing the drug — so for this manufacturer the supply problem may be permanent. That said, this report reflects only Endo; the same medicine is still listed from several other makers.
Here is what I suggest, in order:
- Do not stop, skip, or change your dose on your own — keep taking it as prescribed while you sort out supply.
- Because this is a discontinuation, ask your pharmacist or prescriber about next steps soon.
- The same medicine (oxycodone with acetaminophen tablets) is listed from other makers such as SpecGx, Major Pharmaceuticals, KVK-Tech, and Aurolife; your pharmacy may be able to source one, though it may not be in local stock.
This is national, manufacturer-reported data and may not match your pharmacy's actual shelf. Manufacturer contact numbers are listed on this page for reference, though pharmacies usually handle those calls.
- Don’t stop or change the medication on your own — talk to your prescriber first.
- If this is part of an ongoing or essential regimen (for example HIV treatment or prevention, seizure, heart, transplant, diabetes or mental-health medicines), do not skip or ration doses — contact your pharmacist or prescriber right away to arrange continued supply before you run out.
- Ask your pharmacy to check other manufacturers, strengths, package sizes, and nearby stores.
- Ask your prescriber whether a different strength, formulation, or the brand/generic version is appropriate.
- This is a controlled substance. Transfers between pharmacies and switching strengths have extra federal/state rules — ask the pharmacy before you assume a transfer is possible.
Where else can I get Acetaminophen; Oxycodone Hydrochloride Tablet?
FDA shortages are manufacturer-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every maker of Acetaminophen; Oxycodone Hydrochloride Tablet is necessarily short. Below we pull together the other still-marketed options that are not reported in shortage: the same medicine from manufacturers that haven’t reported a problem, and alternative dosage forms. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.
Same medicine, other manufacturers (not reported short)
Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from makers that have not filed a shortage with the FDA:
| Product | Strength | Form / route | Manufacturer | NDC |
|---|---|---|---|---|
| Oxycodone And Acetaminophen | OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1 | Tablet · Oral | SpecGx LLC | 00406-0512-01 |
| Oxycodone And Acetaminophen | OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 | Tablet · Oral | SpecGx LLC | 00406-0522-01 |
| Oxycodone And Acetaminophen | OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Tablet · Oral | SpecGx LLC | 00406-0523-01 |
| Oxycodone And Acetaminophen | OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1 | Tablet · Oral | Major Pharmaceuticals | 00904-7093-61 |
| Oxycodone And Acetaminophen | OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 | Tablet · Oral | Major Pharmaceuticals | 00904-7094-61 |
| Oxycodone And Acetaminophen | OXYCODONE HYDROCHLORIDE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Tablet · Oral | Major Pharmaceuticals | 00904-7095-61 |
| Oxycodone And Acetaminophen | OXYCODONE 2.5 mg/1; ACETAMINOPHEN 325 mg/1 | Tablet · Oral | KVK-Tech, Inc. | 10702-0184-01 |
| Oxycodone And Acetaminophen | OXYCODONE 5 mg/1; ACETAMINOPHEN 325 mg/1 | Tablet · Oral | KVK-Tech, Inc. | 10702-0185-01 |
| Oxycodone And Acetaminophen | OXYCODONE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 | Tablet · Oral | KVK-Tech, Inc. | 10702-0186-01 |
| Oxycodone And Acetaminophen | OXYCODONE 10 mg/1; ACETAMINOPHEN 325 mg/1 | Tablet · Oral | KVK-Tech, Inc. | 10702-0187-01 |
| Oxycodone And Acetaminophen | OXYCODONE HYDROCHLORIDE 5 mg/1; ACETAMINOPHEN 325 mg/1 | Tablet · Oral | Aurolife Pharma, LLC | 13107-0044-01 |
| Oxycodone And Acetaminophen | OXYCODONE HYDROCHLORIDE 7.5 mg/1; ACETAMINOPHEN 325 mg/1 | Tablet · Oral | Aurolife Pharma, LLC | 13107-0045-01 |
Alternative dosage forms of Acetaminophen; Oxycodone Hydrochloride
A different form of the same drug (for example a solution when capsules are short). A form change is a clinical decision — ask your prescriber:
Therapeutic equivalents & pricing 30 productsclick to expand
Orange Book–rated equivalents of the affected strengths, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| Oxycodone and Acetaminophen 5 mg/1; 325 mg | Camber | 100 tablets | $0.086 | AA | FDA listed |
| Oxycodone and Acetaminophen 5 mg/1; 325 mg | Epic | 100 tablets | $0.088 | AA | FDA listed |
| Oxycodone And Acetaminophen 5 mg/1; 325 mg | SpecGx | 100 tablets | $0.117 | AA | Availability likely |
| Oxycodone And Acetaminophen 5 mg/1; 325 mg | Major | 100 tablets | $0.117 | AA | Availability likely |
| Oxycodone and Acetaminophen 5 mg/1; 325 mg | KVK-Tech, | 100 tablets | $0.117 | AA | Availability likely |
| Oxycodone and Acetaminophen 5 mg/1; 325 mg | Aurolife | 100 tablets | $0.117 | AA | Availability likely |
| Oxycodone And Acetaminophen 5 mg/1; 325 mg | Camber | 100 tablets | $0.117 | AA | Availability likely |
| Oxycodone and Acetaminophen 5 mg/1; 325 mg | Rhodes | 100 tablets | $0.117 | AA | Availability likely |
| Oxycodone and Acetaminophen 5 mg/1; 325 mg | Alvogen, | 100 tablets | $0.117 | AA | Availability likely |
| Oxycodone and Acetaminophen 5 mg/1; 325 mg | AvPAK | 50 tablets | $0.117 | AA | Availability likely |
| Oxycodone and Acetaminophen 5 mg/1; 325 mg | Amneal | 100 tablets | $0.117 | AA | Availability likely |
| Oxycodone and Acetaminophen 5 mg/1; 325 mg | American | 100 tablets | $0.117 | AA | Availability likely |
| Endocet 5 mg/1; 325 mg | Par | 500 tablets | $0.117 | AA | Availability likely |
| Oxycodone Hydrochloride and Acetaminophen 5 mg/1; 325 mg | Elite | 100 tablets | $0.117 | AA | Availability likely |
| Oxycodone and Acetaminophen 5 mg/1; 325 mg | Granules | 100 tablets | $0.117 | AA | Availability likely |
| Oxycodone And Acetaminophen 5 mg/1; 325 mg | Eywa | 100 tablets | $0.117 | AA | Availability likely |
| Oxycodone and Acetaminophen 10 mg/1; 325 mg | Epic | 100 tablets | $0.199 | AA | FDA listed |
| Oxycodone and Acetaminophen 10 mg/1; 325 mg | Lupin | 100 tablets | $0.201 | AA | FDA listed |
| Oxycodone And Acetaminophen 10 mg/1; 325 mg | SpecGx | 100 tablets | $0.231 | AA | Availability likely |
| Oxycodone And Acetaminophen 10 mg/1; 325 mg | Major | 100 tablets | $0.231 | AA | Availability likely |
| Oxycodone and Acetaminophen 10 mg/1; 325 mg | KVK-Tech, | 100 tablets | $0.231 | AA | Availability likely |
| Oxycodone and Acetaminophen 10 mg/1; 325 mg | Aurolife | 100 tablets | $0.231 | AA | Availability likely |
| Oxycodone and Acetaminophen 10 mg/1; 325 mg | Camber | 100 tablets | $0.231 | AA | Availability likely |
| Oxycodone And Acetaminophen 10 mg/1; 325 mg | Camber | 100 tablets | $0.231 | AA | Availability likely |
| Oxycodone and Acetaminophen 10 mg/1; 325 mg | Rhodes | 100 tablets | $0.231 | AA | Availability likely |
| Oxycodone and Acetaminophen 10 mg/1; 325 mg | Alvogen, | 100 tablets | $0.231 | AA | Availability likely |
| Oxycodone and Acetaminophen 325 mg/1; 10 mg | AvPAK | 50 tablets | $0.231 | AA | Availability likely |
| Oxycodone and Acetaminophen 10 mg/1; 325 mg | Amneal | 100 tablets | $0.231 | AA | Availability likely |
| Endocet 10 mg/1; 325 mg | Par | 100 tablets | $0.231 | AA | Availability likely |
| Oxycodone Hydrochloride and Acetaminophen 10 mg/1; 325 mg | Elite | 100 tablets | $0.231 | AA | Availability likely |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Acetaminophen; Oxycodone Hydrochloride Tablet — that fall in the same broad treatment class (opioid analgesic and non-salicylate analgesics) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Identity & classification
Where does this data come from?
Other analgesia/addiction shortages
Acetaminophen; Oxycodone Hydrochloride Tablet shortage FAQs
Is Acetaminophen; Oxycodone Hydrochloride Tablet in shortage?
Which products are affected?
When will Acetaminophen; Oxycodone Hydrochloride Tablet be available again?
Can I still get Acetaminophen; Oxycodone Hydrochloride somewhere?
What should I do if I take Acetaminophen; Oxycodone Hydrochloride Tablet?
Still have a question about the Acetaminophen; Oxycodone Hydrochloride Tablet shortage?
Ask a pharmacist about this shortage →View Acetaminophen; Oxycodone Hydrochloride T... on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (still-marketed manufacturers by ingredient & form); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.