Insulin Lispro-Aabc Injection shortage
Insulin Lispro-Aabc Injection is currently listed in shortage by the FDA. The FDA lists 2 affected products. This page was last refreshed from FDA data on Sep 17, 2026.
Eli Lilly is permanently stopping the Lyumjev (insulin lispro-aabc) Tempo Pen. Lyumjev KwikPen, which contains the same medicine, is still listed by Eli Lilly as available in both U-100 and U-200 strengths.
Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available (see options).
Do you take this drug? See the ‘What to do’ recommendation from Dr. Brian Staiger, PharmD →What’s in shortage — at a glance
These figures count only the manufacturers that reported this shortage to the FDA — not every company that makes Insulin Lispro-Aabc Injection. Other makers that haven’t reported a problem are shown in the green card below.
Shortage timeline
-
Oct 24, 2025Currently in shortage2 of 2 products affected.
-
Oct 24, 2025First reported to the FDA2 products first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
What exactly is on backorder — by manufacturer
Manufacturer: Eli Lilly and Co. 📞 800-545-5979 2 NDCS click to expand
| Status | NDC / product | Strength / size | Availability | Related information | Reason |
|---|---|---|---|---|---|
| To Be Discontinued | Lyumjev, Injection, U-100 Tempo Pen Sample (NDC 0002-8235-99) | — | — | A business decision was made to discontinue manufacture of the drug. | — |
| To Be Discontinued | Lyumjev, Injection, U-100 Tempo Pen (NDC 0002-8235-05) | — | — | A business decision was made to discontinue manufacture of the drug. | — |
These rows are manufacturer reports to the FDA for Insulin Lispro-Aabc Injection — they do not necessarily cover every manufacturer that makes this drug. A company appears here only if it told the FDA it has a supply problem, so other makers may still have stock. That’s the basis for the Where else can I get Insulin Lispro-Aabc Injection? options further down this page.
Why is Insulin Lispro-Aabc Injection in shortage?
Eli Lilly has made a business decision to permanently stop making Lyumjev (insulin lispro-aabc) in the U-100 Tempo Pen form — that includes both the regular U-100 Tempo Pen and the U-100 Tempo Pen Sample package. No specific reason beyond it being a business decision was shared publicly with the FDA.
It's worth knowing that this report covers only these two specific Tempo Pen presentations from Eli Lilly. The FDA did not provide a public explanation for why this business decision was made, so I can only share what was officially reported — that these particular packages are being permanently discontinued by the manufacturer.
Based on the manufacturer-reported reason(s) and notes on file with the FDA for Insulin Lispro-Aabc Injection, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as manufacturers report changes.
What should I do if I take Insulin Lispro-Aabc Injection?
Insulin Lispro-Aabc Injection (sold as Lyumjev) is currently on the FDA shortage list, and I want to walk you through what this means for you.
The two products affected are the U-100 Tempo Pen and the U-100 Tempo Pen Sample. Neither has an available source right now. There are no other strengths of the Tempo Pen still reported as available on this record.
The reason listed is a business decision by the manufacturer to discontinue making these products. Because this is a discontinuation rather than a temporary delay, this supply problem may be permanent, and there is no recovery date to share. That said, this affects the Tempo Pen form specifically — the same insulin is still made in other pen forms.
Here is what I suggest, in order:
- Do not stop, skip, or change your doses on your own.
- Ask your pharmacy to check whether they can still source your Tempo Pen through wholesalers.
- The same medicine, Lyumjev, is still available in the Kwikpen (100 units/mL and 200 units/mL). Your pharmacy may be able to source one of these, though it may not be in local stock.
- Since the Tempo Pen is being discontinued, talk with your prescriber or pharmacist about the right next step for you.
Manufacturer contact numbers are listed on this page for reference; your pharmacy usually handles those calls.
This is general, national information and may not match your local pharmacy's actual stock.
- Don’t stop or change the medication on your own — talk to your prescriber first.
- If this is part of an ongoing or essential regimen (for example HIV treatment or prevention, seizure, heart, transplant, diabetes or mental-health medicines), do not skip or ration doses — contact your pharmacist or prescriber right away to arrange continued supply before you run out.
- Ask your pharmacy to check other manufacturers, strengths, package sizes, and nearby stores.
- Ask your prescriber whether a different strength, formulation, or the brand/generic version is appropriate.
Uses, dosing, side effects, prices, and the complete FDA label — written in plain English and pharmacist-reviewed.
Where else can I get Insulin Lispro-Aabc Injection?
FDA shortages are manufacturer-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every maker of Insulin Lispro-Aabc Injection is necessarily short. Below we pull together the other still-marketed options that are not reported in shortage: the same medicine from manufacturers that haven’t reported a problem, and alternative dosage forms. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.
Same medicine, other manufacturers (not reported short)
Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from makers that have not filed a shortage with the FDA:
| Product | Strength | Form / route | Manufacturer | NDC |
|---|---|---|---|---|
| Lyumjev Kwikpen | INSULIN LISPRO 100 [iU]/mL | Injection, Solution · Subcutaneous | Eli Lilly and Company | 00002-8207-05 |
| Lyumjev Kwikpen | INSULIN LISPRO 200 [iU]/mL | Injection, Solution · Subcutaneous | Eli Lilly and Company | 00002-8228-27 |
Therapeutic equivalents & pricing 5 productsclick to expand
Orange Book–rated equivalents of the affected strengths / sizes, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| LYUMJEV Tempo Pen 100 [iU]/mL | Eli | 5 syringes | $10.138 | — | Availability likely |
| LYUMJEV KwikPen 100 [iU]/mL | Eli | 5 syringes | $10.157 | — | Availability likely |
| LYUMJEV Tempo Pen 100 [iU]/mL | Eli | 1 syringe | — | — | FDA listed |
| Lyumjev 100 [iU]/mL | Eli | 5 cartridges | — | — | FDA listed |
| LYUMJEV Junior KwikPen 100 [iU]/mL | Eli | 5 syringes | — | — | FDA listed |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Insulin Lispro-Aabc Injection — that fall in the same broad treatment class (insulins) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Identity & classification
Where does this data come from?
Other endocrinology/metabolism shortages
Insulin Lispro-Aabc Injection shortage FAQs
Is Insulin Lispro-Aabc Injection in shortage?
Which products are affected?
When will Insulin Lispro-Aabc Injection be available again?
Can I still get Insulin Lispro-Aabc somewhere?
What should I do if I take Insulin Lispro-Aabc Injection?
Still have a question about the Insulin Lispro-Aabc Injection shortage?
Ask a pharmacist about this shortage →View Insulin Lispro-Aabc Injection on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (still-marketed manufacturers by ingredient & form); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.