Amoxicillin With Claritin Interaction Details
In our latest question and answer, the pharmacist discusses whether or not amoxicillin and Claritin can safely be taken together.

Question
I take Claritin every day for allergies. It is okay to take with amoxicillin I was just given for an infection?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 20, 2025
Key points
- There is no known drug interaction between amoxicillin and Claritin (loratadine). They are considered safe to take together.
Answer
There is no known interaction between amoxicillin and Claritin (loratadine). They are considered safe to take together.
In fact, it may be beneficial to take both together as Claritin can help relieve some of the symptoms an infection may cause (such as a runny nose, watery eyes, sneezing, etc.).
Other Antihistamines Are Safe With Amoxicillin Too
Amoxicillin has no known interactions with any of the second-generation antihistamines available over-the-counter, which include:
- Zyrtec (cetirizine)
- Allegra (fexofenadine)
- Xyzal (levocetirizine)
You can feel safe combining amoxicillin with any of these.
Amoxicillin Information
Amoxicillin is used to treat certain infections caused by bacteria, such as pneumonia; bronchitis (infection of the airway tubes leading to the lungs); and infections of the ears, nose, throat, urinary tract, and skin. It is also used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers.
Amoxicillin is in a class of medications called penicillin-like antibiotics and works by stopping the growth of bacteria. Specifically, it inhibits bacterial cell wall synthesis by binding to specific penicillin-binding proteins (PBPs) that are located inside the cell wall.
Claritin Information
Claritin (loratadine) is used to temporarily relieve the symptoms of hay fever (allergy to pollen, dust, or other substances in the air) and other allergies. These symptoms include sneezing, runny nose, and itchy eyes, nose, or throat. Loratadine is also used to treat itching and redness caused by hives.
Claritin is in a class of medications called antihistamines and works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Final Words
Thanks so much for reaching out and please feel free to contact us anytime!
-
Dr. Brian Staiger, PharmD
- 9547 views