Levocetirizine

21 interactions 2 explained in plain English
Also sold as: Xyzal
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Diphenhydramine Injection Levodopa Oral Inhalation Esketamine Nasal Spray Asenapine Transdermal Patch Hydromorphone Rectal Hydromorphone Injection
20 Major 1 Moderate
All (21) Major (20) Moderate (1)

Major

Levocetirizine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of CNS depression Details Levocetirizine Buprenorphine Belbuca Explained Increased risk of CNS depression Details Levocetirizine Aripiprazole Injection Abilify Increased risk of CNS depression Details Levocetirizine Asenapine Transdermal Patch Secuado Increased risk of CNS depression Details Levocetirizine Butorphanol Injection Butorphic Increased risk of CNS depression Details Levocetirizine Butorphanol Nasal Spray Stadol® NS Increased risk of CNS depression Details Levocetirizine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Levocetirizine Diazepam Rectal Diastat Increased risk of CNS depression Details Levocetirizine Diphenhydramine Injection Banophen Increased risk of CNS depression Details Levocetirizine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of CNS depression Details Levocetirizine Esketamine Nasal Spray Spravato Increased risk of CNS depression Details Levocetirizine Fentanyl Transdermal Patch Duragesic® Increased risk of CNS depression Details Levocetirizine Hydromorphone Injection Dilaudid Increased risk of CNS depression Details Levocetirizine Hydromorphone Rectal available generically Increased risk of CNS depression Details Levocetirizine Lacosamide Injection Motpoly An increased risk of CNS depression Details Levocetirizine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Levocetirizine Midazolam Nasal Spray Nayzilam Increased risk of CNS depression Details Levocetirizine Midazolam Injection Nayzilam Increased risk of CNS depression Details Levocetirizine Morphine Injection Astramorph® PF Increased risk of CNS depression Details Levocetirizine Nalbuphine Injection Nubain® Increased risk of CNS depression Details

Moderate

Levocetirizine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.