Is Zyrtec Safe To Take With Amoxicillin?

In our latest question and answer, our pharmacist discusses whether or not Zyrtec can be taken with amoxicillin.

2 min read Updated Jun 2026 Read by 13,060 people
Is Zyrtec Safe To Take With Amoxicillin?
Share
Santiago asked

Hello, I take Zyrtec every day to prevent allergies but I recently came down with a cold and my doctor gave me amoxicillin. Are they okay to use together?

Sep 16, 2022
The quick answer
  • Zyrtec and amoxicillin are safe to take together with no known drug interaction between them.
  • Zyrtec may help relieve symptoms like runny nose, watery eyes, and postnasal drip while you're taking amoxicillin.
  • You can continue taking your daily Zyrtec along with your prescribed amoxicillin.
A quick summary of Dr. Brian Staiger, PharmD's full answer below, condensed by AI from that answer only (not from any outside source). The pharmacist's answer is the source of record.

Answer

Thanks for reaching out to us! Zyrtec (cetirizine) and amoxicillin are perfectly safe to take together. There is no known drug interaction between them.

Zyrtec may even help with some of the symptoms you may be experiencing. Since Zyrtec is an antihistamine, it can help alleviate a runny nose, watery eyes, and postnasal drip, even if it isn't allergies that are causing these symptoms.

Other antihistamines are safe to take with amoxicillin as well, and include:

  • Allegra (fexofenadine)
  • Claritin (loratadine)
  • Xyzal (levocetirizine)

You can feel safe continuing to take your Zyrtec daily, in addition to the amoxicillin your doctor has prescribed for you.

About Zyrtec

Zyrtec is used to temporarily relieve the symptoms of hay fever (allergy to pollen, dust, or other substances in the air) and allergy to other substances (such as dust mites, animal dander, cockroaches, and molds). These symptoms include sneezing; runny nose; itchy, red, watery eyes; and itchy nose or throat. It is also used to treat itching and redness caused by hives. However, cetirizine does not prevent hives or other allergic skin reactions.

Cetirizine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.

References & sources
  1. Amoxicillin Prescribing Information — AccessFDA
  2. Amoxicillin Monograph — PubChem
  3. Cetirizine Monograph — PubChem
Glossary — Terms in This Answer
Antihistamine
A medication that blocks histamine, a chemical in the body that causes allergy symptoms like itching, sneezing, and runny nose.
Cetirizine
The active ingredient in Zyrtec, an antihistamine used to relieve allergy symptoms.
Amoxicillin
An antibiotic medication used to treat bacterial infections.
Drug interaction
When two medications affect each other in ways that could change how they work or cause harmful effects.
Postnasal drip
A condition where mucus from the nose drains down the back of the throat.
Hay fever
An allergic reaction to pollen, dust, or other airborne substances that causes sneezing, runny nose, and itchy eyes.
Hives
Red, itchy welts or bumps that appear on the skin, often as an allergic reaction.
Histamine
A chemical in the body that is released during allergic reactions and causes symptoms like itching, sneezing, and swelling.
Did this answer your question?
Dr. Brian Staiger, PharmD
About the pharmacist

Dr. Brian Staiger, PharmD

Clinical Pharmacy

Doctor of Pharmacy, board certified clinical pharmacist (BCPS), American Herbalist Guild, Medication Therapy Management certified

Brian Staiger, PharmD, BCPS, is a licensed pharmacist with more than 13 years of experience across retail pharmacy, clinical pharmacy, medication safety, pharmacy program development, and healthcare administration. He is the founder of HelloPharmacist.com, where he helps patients...

More answers from Brian →
Ask a Pharmacist