Is Zyrtec Safe To Take With Amoxcillin?
In our latest question and answer, our pharmacist discusses whether or not Zyrtec can be taken with amoxicillin.

Question
Hello, I take Zyrtec every day to prevent allergies but I recently came down with a cold and my doctor gave me amoxicillin. Are they okay to use together?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 15, 2025
Key points
- There is no known drug interaction between Zyrtec (cetirizine) and amoxicillin. They can be taken together.
Answer
Thanks for reaching out to us! Zyrtec (cetirizine) and amoxicillin are perfectly safe to take together. There is no known drug interaction between them.
Zyrtec may even help with some of the symptoms you may be experiencing. Since Zyrtec is an antihistamine, it can help alleviate a runny nose, watery eyes, and postnasal drip, even if it isn't allergies that are causing these symptoms.
Other antihistamines are safe to take with amoxicillin as well, and include:
- Allegra (fexofenadine)
- Claritin (loratadine)
- Xyzal (levocetirizine)
You can feel safe continuing to take your Zyrtec daily, in addition to the amoxicillin your doctor has prescribed for you.
About Zyrtec
Zyrtec is used to temporarily relieve the symptoms of hay fever (allergy to pollen, dust, or other substances in the air) and allergy to other substances (such as dust mites, animal dander, cockroaches, and molds). These symptoms include sneezing; runny nose; itchy, red, watery eyes; and itchy nose or throat. Itis also used to treat itching and redness caused by hives. However, cetirizine does not prevent hives or other allergic skin reactions.
Cetirizine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
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Dr. Brian Staiger, PharmD
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