Herb & supplement monograph

Shiitake Mushroom Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Shiitake Mushroom interacts with medications. The heart of this page is the interaction list — every drug Shiitake Mushroom is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Shiitake Mushroom is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Shiitake Mushroom Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Shiitake Mushroom drug interaction appears low for most people. None of the listed interactions are rated major, and every one rests on lab research alone, with no confirmed effects in humans.

Interactions deserving the most attention

The combination that deserves the most care involves immunosuppressants, such as transplant medications, because lab studies suggest shiitake extracts can stimulate the immune system and could, in theory, work against these drugs. Since transplant medicines have little room for error, this theoretical concern is worth taking seriously even without human reports. Lab work also hints that a shiitake extract might speed up an enzyme the body uses to clear certain medications, which could lower their levels, though this has never been seen in people.

What the rest of the list means

The long list of medications here comes from just two theoretical mechanisms applied across many drugs, not from hundreds of separate problems. Both concerns are based only on laboratory findings, and neither has been shown to cause meaningful changes in people. For most everyday medications, eating shiitake mushrooms is unlikely to cause trouble.

Check your medications against Shiitake Mushroom

Based on HelloPharmacist’s Shiitake Mushroom interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Shiitake Mushroom

312 medications have a known interaction with Shiitake Mushroom, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
6-mercaptopurinePurinethol
Moderate Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.

Read the full Shiitake Mushroom + 6-mercaptopurine interaction 6-mercaptopurine drug page: uses, dosage & side effects
AbrocitinibCibinqo
Moderate Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.

Read the full Shiitake Mushroom + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effects
Acetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Butalbital, Caffeine, Codeine interaction
Acetaminophen, Butalbital, CodeineBancap w/ Codeine
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Butalbital, Codeine interaction
Acetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Butalbital, Codeine Phosphate interaction
Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction
Acetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Caffeine, Codeine interaction
Acetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Caffeine, Codeine, Salicylamide interaction
Acetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Caffeine, Dihydrocodeine interaction
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction
Acetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction
Acetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Chlorpheniramine, Dextromethorphan interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interaction
Acetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Chlorzoxazone, Codeine interaction
Acetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Codeine interaction
Acetaminophen, Codeine, DoxylamineMersyndol
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Codeine, Doxylamine interaction
Acetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Codeine, Methocarbamol interaction
Acetaminophen, DextromethorphanTylenol Cough Ex Strength
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Dextromethorphan interaction
Acetaminophen, Dextromethorphan, Doxylamine, PseudoephedrineVicks NyQuil
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Dextromethorphan, Doxylamine, Pseudoephedrine interaction
Acetaminophen, Dextromethorphan, Guaifenesin, PhenylephrineConar-A
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylephrine interaction
Acetaminophen, Dextromethorphan, Guaifenesin, PhenylpropanolamineAnatuss
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Dextromethorphan, Guaifenesin, Phenylpropanolamine interaction
Acetaminophen, Dextromethorphan, Guaifenesin, PseudoephedrineRobitussin Cold, Severe Cold, Suphedrine Cold/Cough
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Dextromethorphan, Guaifenesin, Pseudoephedrine interaction
Acetaminophen, Dextromethorphan, Phenylpropanolamine, PyrilamineTheracaps
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Dextromethorphan, Phenylpropanolamine, Pyrilamine interaction
Acetaminophen, Dextromethorphan, PseudoephedrineAlka-Seltzer PLUS Flu Liquid Gels, Non Aspirin Cold Caps, Tylenol Cold, Tylenol Flu Daytime Ex Strength, Tylenol Flu Ex Strength
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Dextromethorphan, Pseudoephedrine interaction
Acetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Hydrocodone interaction
Acetaminophen, MeperidineDemerol APAP
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Meperidine interaction
Acetaminophen, OxycodonePercocet, Roxicet, Tylox, Xartemis XR
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Oxycodone interaction
Acetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
Moderate Cytochrome P450 2d6 (cyp2d6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Read the full Shiitake Mushroom + Acetaminophen, Propoxyphene interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Shiitake Mushroom combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Shiitake Mushroom affects

Every type of medication (drug category) Shiitake Mushroom is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 2 drug categories Shiitake Mushroom interacts with
Cytochrome P450 2d6 (cyp2d6) SubstratesImmunosuppressants
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
Monograph

Shiitake Mushroom: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly alongside cancer treatment, but evidence for most supplement uses is limited. Talk with your pharmacist or doctor before using concentrated shiitake supplements.

Scientific name
Lentinula edodes
Family
Omphalotaceae
Part used
Fruiting body (mushroom cap and stem); mycelium extracts
Common forms
Whole food (fresh or dried mushrooms), capsules, tablets, powders, liquid extracts, and standardized extracts such as lentinan and AHCC
People commonly use it for
  • Immune support
  • General wellness and nutrition
  • Cholesterol and heart health
  • Adjunct in cancer care (lentinan, AHCC)
  • Antioxidant support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally safe as a food, but concentrated supplements and raw mushrooms can cause reactions in some people.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid consuming greater than food amounts.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid consuming greater than food amounts.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Shiitake is an edible mushroom that has been used for food and in traditional medicine in East Asia for centuries. It grows naturally on the wood of certain hardwood trees and is now widely cultivated around the world.

People eat shiitake fresh or dried as part of meals, and it is also sold as a dietary supplement in capsules, powders, and liquid extracts. Some specialized extracts taken from shiitake, such as lentinan and AHCC, are studied more often in medical research, usually for immune support.

How it works

Shiitake contains compounds that researchers believe may affect the body in several ways. The best known is lentinan, a type of beta-glucan (a complex sugar) thought to interact with the immune system. Shiitake also contains a compound called eritadenine that has been studied for possible effects on cholesterol.

The mushroom also provides antioxidants and other natural substances that may help protect cells. It is important to know that much of this information comes from laboratory and animal research, and these effects have not been clearly proven in people taking common supplement forms.

Effectiveness

Does Shiitake Mushroom work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 22 uses evaluated
1 Leans ineffective 21 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.
Possibly Ineffective Dental Plaque
Rating & evidence shown verbatim from Natural Medicines

A solution containing an extract of shiitake mushroom is less effective than fluoride mouthwash for reducing dental plaque.

Also studied for 21 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Aging
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral shiitake mushroom for aging, there is insufficient reliable information about the clinical effects of shiitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Atherosclerosis
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral shiitake mushroom for atherosclerosis, there is insufficient reliable information about the clinical effects of shiitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Breast cancer
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral shiitake mushroom for breast cancer, there is insufficient reliable information about the clinical effects of shiitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Cancer
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral shiitake mushroom is beneficial in patients with cancer.

Insufficient Reliable Evidence To Rate Chemotherapy-induced anemia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral shiitake mushroom is beneficial in patients with chemotherapy-induced anemia.

Insufficient Reliable Evidence To Rate Chemotherapy-induced leukopenia
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral shiitake mushroom is beneficial in patients with chemotherapy-induced leukopenia.

Insufficient Reliable Evidence To Rate Chemotherapy-induced nausea and vomiting (CINV)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral shiitake mushroom is beneficial in patients with CINV.

Insufficient Reliable Evidence To Rate Common cold
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral shiitake mushroom for the common cold, there is insufficient reliable information about the clinical effects of shiitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Coronavirus disease 2019 (COVID-19)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral shiitake mushroom for COVID-19, there is insufficient reliable information about the clinical effects of shiitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral shiitake mushroom for diabetes, there is insufficient reliable information about the clinical effects of shiitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Genital herpes
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral shiitake mushroom for genital herpes, there is insufficient reliable information about the clinical effects of shiitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Hepatitis C
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral shiitake mushroom is beneficial in patients with hepatitis C.

Insufficient Reliable Evidence To Rate HIV/AIDS
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral shiitake mushroom for HIV/AIDS, there is insufficient reliable information about the clinical effects of shiitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Human papillomavirus (HPV)
Rating & evidence shown verbatim from Natural Medicines

It is unclear if oral shiitake mushroom is beneficial in patients with HPV.

Insufficient Reliable Evidence To Rate Hypercholesterolemia
Rating & evidence shown verbatim from Natural Medicines

It is unclear whether oral shiitake mushroom is beneficial for lowering blood lipid levels.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral shiitake mushroom for hypertension, there is insufficient reliable information about the clinical effects of shiitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Impaired glucose tolerance (prediabetes)
Rating & evidence shown verbatim from Natural Medicines

Oral shiitake mushroom has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Insufficient Reliable Evidence To Rate Influenza
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral shiitake mushroom for influenza, there is insufficient reliable information about the clinical effects of shiitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Liver cancer
Rating & evidence shown verbatim from Natural Medicines

Small, low-quality clinical studies suggest that oral shiitake mushroom extract may improve overall survival in patients with liver cancer.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral shiitake mushroom for obesity, there is insufficient reliable information about the clinical effects of shiitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Prostate cancer
Rating & evidence shown verbatim from Natural Medicines

It is unclear whether shiitake mushroom has a role in preventing disease progression.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Eating shiitake as a normal food is considered safe for most people. Concentrated supplements are less studied, so use them with care and ideally under the guidance of a healthcare professional.

Raw or undercooked shiitake can cause a skin reaction in some people known as "shiitake dermatitis," an itchy rash. Cooking the mushrooms thoroughly usually prevents this. People with mushroom allergies should avoid shiitake.

Pregnancy and breastfeeding: Eating shiitake as food is likely fine, but there is not enough safety information on concentrated shiitake supplements during these times. To be safe, avoid supplement doses unless your doctor approves. If you have an autoimmune condition or are scheduled for surgery, talk to your healthcare provider before using shiitake supplements.

Side effects

When eaten as food, shiitake rarely causes problems. Some people may experience digestive upset, such as bloating or loose stools, especially with large amounts or concentrated supplements.

A well-known but uncommon reaction is shiitake dermatitis—an itchy, streaky rash that can appear after eating raw or undercooked mushrooms. Allergic reactions are possible. Stop use and seek medical care if you have trouble breathing, swelling, or a severe rash.

Shiitake Mushroom: Reported Adverse Effects

Documented safety reports on Shiitake Mushroom from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, shiitake mushroom is generally well tolerated when cooked and consumed as a food.

Most Common Adverse Effects:

Orally: Abdominal discomfort, bloating, diarrhea, nausea, and vomiting.

Serious Adverse Effects (Rare):

Orally: Consumption of raw shiitake mushroom can cause shiitake dermatitis, a skin eruption resembling whiplash marks which can be accompanied by systemic symptoms. Large pieces that have been inadequately chewed can cause intestinal blockage, occasionally requiring surgery.

Reports by condition
Allergic rhinitis (hay fever) Immunologic

Allergic contact dermatitis can occur by contact with shiitake hyphae (filaments). It appears to be more common in growers or others that handle shiitake mushrooms extensively. Contact or inhalation also results in other symptoms of allergy, such as asthma, rhinitis, conjunctivitis, and pneumonia.

  1. Ueda A, Obama K, Aoyama K, et al. Allergic contact dermatitis in shiitake (Lentinus edodes (Berk) Sing) growers. Contact Dermatitis 1992;26:228-33.
  2. Curnow, P. and Tam, M. Contact dermatitis to Shiitake mushroom. Australas.J.Dermatol. 2003;44(2):155-157.
  3. Sudy E, Urbina F. Shiitake dermatitis: clinical forms of presentation. Int J Dermatol 2023.
  4. Boels D, Landreau A, Bruneau C, et al. Shiitake dermatitis recorded by French Poison Control Centers - new case series with clinical observations. Clin Toxicol (Phila). 2014 Jul;52(6):625-8.
  5. Ricar J, Pizinger K, Cetkovska P. Shiitake dermatitis: a distinctive clinical entity. Int J Dermatol. 2013 Dec;52(12):1620-1.
  6. Kopp T, Mastan P, Mothes N, Tzaneva S, Stingl G, Tanew A. Systemic allergic contact dermatitis due to consumption of raw shiitake mushroom. Clin Exp Dermatol. 2009 Dec;34(8):e910-3.
  7. Pravettoni V, Primavesi L, Piantanida M. Shiitake mushroom (Lentinus edodes): a poorly known allergen in Western countries responsible for severe work-related asthma. Int J Occup Med Environ Health. 2014 Oct;27(5):871-4.
Asthma Pulmonary/Respiratory

In mushroom workers, hypersensitivity pneumonitis due to shiitake spore inhalation has occurred. Symptoms include difficulty breathing, chest pain, a dry cough, asthma, and rhinitis.

  1. Murakami M, Kawabe K, Hosoi Y, et al. Decreased pulmonary perfusion in hypersensitivity pneumonitis caused by Shiitake mushroom spores. J Intern Med 1997;241:85-8.
  2. Matsui S, Nakazawa T, Umegae Y, Mori M. Hypersensitivity pneumonitis induced by Shiitake mushroom spores. Intern Med 1992;31:1204-6.
  3. Fujiwara, K., Sato, T., Yonei, T., Genba, K., Nogami, N., and Yamadori, I. [A case of chronic hypersensitivity pneumonitis induced by shiitake mushroom spores]. Nihon Kokyuki.Gakkai Zasshi 2000;38(12):908-913.
  4. Sastre, J., Ibanez, M. D., Lopez, M., and Lehrer, S. B. Respiratory and immunological reactions among Shiitake (Lentinus edodes) mushroom workers. Clin.Exp.Allergy 1990;20(1):13-19.
  5. Ampere A, Delhaes L, Soots J, Bart F, Wallaert B. Hypersensitivity pneumonitis induced by Shiitake mushroom spores. Med Mycol. 2012 Aug;50(6):654-7.
  6. Boels D, Landreau A, Bruneau C, et al. Shiitake dermatitis recorded by French Poison Control Centers - new case series with clinical observations. Clin Toxicol (Phila). 2014 Jul;52(6):625-8.
  7. Pravettoni V, Primavesi L, Piantanida M. Shiitake mushroom (Lentinus edodes): a poorly known allergen in Western countries responsible for severe work-related asthma. Int J Occup Med Environ Health. 2014 Oct;27(5):871-4.
  8. Ricar J, Pizinger K, Cetkovska P. Shiitake dermatitis: a distinctive clinical entity. Int J Dermatol. 2013 Dec;52(12):1620-1.
Cluster headache Neurologic/CNS

In patients experiencing shiitake dermatitis, other symptoms may include prickling in the hands. Malaise has also been reported following oral intake or contact.

Orally, the shiitake mushroom extract AHCC has been reported to cause mild and transient headache.

  1. Nguyen AH, Gonzaga MI, Lim VM, Adler MJ, Mitkov MV, Cappel MA. Clinical features of shiitake dermatitis: a systematic review. Int J Dermatol. 2017 Jun;56(6):610-616.
  2. Matsui S, Nakazawa T, Umegae Y, Mori M. Hypersensitivity pneumonitis induced by Shiitake mushroom spores. Intern Med 1992;31:1204-6.
  3. Baran W, Batycka-Baran A, Maj J, Szepietowski JC. Shiitake dermatitis - now also in Poland. Acta Derm Venereol. 2015 Jan;95(1):102-3.
  4. Spierings, E. L., Fujii, H., Sun, B., and Walshe, T. A Phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers. J Nutr Sci Vitaminol.(Tokyo) 2007;53(6):536-539.
Dermatitis Ocular/Otic

Conjunctivitis has been reported rarely in mushroom growers and handlers, or following oral intake in patients with shiitake dermatitis.

  1. Boels D, Landreau A, Bruneau C, et al. Shiitake dermatitis recorded by French Poison Control Centers - new case series with clinical observations. Clin Toxicol (Phila). 2014 Jul;52(6):625-8.
  2. Nguyen AH, Gonzaga MI, Lim VM, Adler MJ, Mitkov MV, Cappel MA. Clinical features of shiitake dermatitis: a systematic review. Int J Dermatol. 2017 Jun;56(6):610-616.
  3. Ricar J, Pizinger K, Cetkovska P. Shiitake dermatitis: a distinctive clinical entity. Int J Dermatol. 2013 Dec;52(12):1620-1.
Dermatitis Dermatologic

Orally, shiitake mushrooms can cause shiitake dermatitis, a skin eruption that resembles whiplash marks, usually found on the trunk and limbs. This dermatitis is thought to be a toxic response to lentinan or other compounds found normally in uncooked or inadequately cooked shiitake mushroom. The rash can be made worse by scratching. Symptom onset is usually within hours to days and can persist for 3-4 weeks before resolving on its own. There is some evidence that treatment with steroids alone or with antihistamines might reduce the duration of the rash by a small amount in some people. The dermatitis may include small purple spots from broken capillaries, skin plaques, burning, blanching, and pustules. Rarely the rash may look like measles rather than whiplash. Histologically, there may be evidence of dermal and epidermal edema, lymphocyte infiltration, and skin thickening. Other symptoms associated with the dermatitis include fever, aching, malaise, eosinophilia, diarrhea, prickling in the hands, trouble swallowing, conjunctivitis, and pustules with small ulcers in the mouth. It is likely that the dermatitis and other symptoms are due to a delayed type hypersensitivity reaction. Cooking shiitake mushroom generally prevents shiitake dermatitis, although some cases have occurred in people who have consumed cooked sources. It appears that to inactivate lentinan, cooking temperatures of at least 130°C are needed.

Less common is a photosensitivity reaction associated with oral ingestion, which involves rash and pruritus after sun exposure.

Orally, the shiitake mushroom extract AHCC has been reported to cause mild itching.

  1. Hanada K, Hashimoto I. Flagellate mushroom (Shiitake) dermatitis and photosensitivity. Dermatol 1998;197:255-7.
  2. Nakamura T. Shiitake (Lentinus edodes) dermatitis. Contact Dermatitis 1992;27:65-70.
  3. Lippert, U., Martin, V., Schwertfeger, C., Junghans, V., Ellinghaus, B., and Fuchs, T. Shiitake dermatitis. Br.J Dermatol. 2003;148(1):178-179.
  4. Mak, R. K. and Wakelin, S. H. Shiitake dermatitis: the first case reported from a European country. Br J Dermatol 2006;154(4):800-801.
  5. Ade R, Sukut C, Wiser HJ, Shockman S, Buescher L. Shiitake dermatitis demonstrating Köebner phenomenon. Int J Dermatol. 2015;54(5):e179-81.
  6. Adler MJ, Larsen WG. Clinical variability of shiitake dermatitis. J Am Acad Dermatol. 2012 Oct;67(4):e140-1.
  7. Adriano AR, Acosta ML, Azulay DR, Quiroz CD, Talarico SR. Shiitake dermatitis: the first case reported in Brazil. An Bras Dermatol. 2013 May-Jun;88(3):417-9.
  8. Baran W, Batycka-Baran A, Maj J, Szepietowski JC. Shiitake dermatitis - now also in Poland. Acta Derm Venereol. 2015 Jan;95(1):102-3.
  9. Boels D, Landreau A, Bruneau C, et al. Shiitake dermatitis recorded by French Poison Control Centers - new case series with clinical observations. Clin Toxicol (Phila). 2014 Jul;52(6):625-8.
  10. Corazza M, Zauli S, Ricci M, et al. Shiitake dermatitis: toxic or allergic reaction? J Eur Acad Dermatol Venereol. 2015 Jul;29(7):1449-51.
  11. Czarnecka AB, Kreft B, Marsch WCh. Flagellate dermatitis after consumption of Shiitake mushrooms. Postepy Dermatol Alergol. 2014 Jun;31(3):187-90.
  12. Hamer SE, Kulkarni K, Cohen SN. Shiitake dermatitis with oral ulceration and pustules. Clin Exp Dermatol. 2015 Apr;40(3):332-3.
  13. Hiernickel C, Metz S, Elsner P. Shiitake dermatitis: an impressive case report. J Dtsch Dermatol Ges. 2015 May;13(5):455-6.
  14. Karanovic S, George S, Topham E. Don't miss shiitake dermatitis: a case report. Br J Gen Pract. 2014 Aug;64(625):426-7.
  15. Kopp T, Mastan P, Mothes N, Tzaneva S, Stingl G, Tanew A. Systemic allergic contact dermatitis due to consumption of raw shiitake mushroom. Clin Exp Dermatol. 2009 Dec;34(8):e910-3.
  16. Loo HV, Oon HH. Flagellate dermatitis following consumption of shiitake mushroom. Dermatol Reports. 2011 Oct 5;3(2):e21.
  17. Luber AJ, Ackerman LS. Flagellate shiitake mushroom dermatitis. Dermatol Online J. 2015 Aug 15;21(8). pii: 13030/qt7rm57553.
  18. Mendonça CN, Silva PM, Avelleira JC, Nishimori FS, Cassia Fde F. Shiitake dermatitis. An Bras Dermatol. 2015 Mar-Apr;90(2):276-8.
  19. Netchiporouk E, Pehr K, Ben-Shoshan M, Billick RC, Sasseville D, Singer M. Pustular flagellate dermatitis after consumption of shiitake mushrooms. JAAD Case Rep. 2015 May 2;1(3):117-9.
  20. Nguyen AH, Gonzaga MI, Lim VM, Adler MJ, Mitkov MV, Cappel MA. Clinical features of shiitake dermatitis: a systematic review. Int J Dermatol. 2017 Jun;56(6):610-616.
  21. Poppe LM, Anders D, Kneitz H, Bröcker EB, Benoit S. Flagellate dermatitis caused by shiitake mushrooms. An Bras Dermatol. 2012 May-Jun;87(3):463-5.
  22. Ricar J, Pizinger K, Cetkovska P. Shiitake dermatitis: a distinctive clinical entity. Int J Dermatol. 2013 Dec;52(12):1620-1.
  23. Uslu U, Linkner RV. Shiitake mushroom dermatitis. Cutis. 2015 May;95(5):E11-2.
  24. Wang AS, Barr KL, Jagdeo J. Shiitake mushroom-induced flagellate erythema: A striking case and review of the literature. Dermatol Online J. 2013 Apr 15;19(4):5.
  25. Boels D, Greillet C, Langrand J, et al. Shiitake dermatitis: experience of the Poison Control Centre Network in France from 2014 to 2019. Clin Toxicol (Phila) 2022.
  26. Ma JY, Liu JW. Shiitake flagellate dermatitis. Mayo Clin Proc 2022;97(12):2192-2193.
  27. Booms A, Rashid Z, Al-Rubaie V, Bal A. Shiitake dermatitis: a case report of a rare mushroom-induced dermatitis in the United States. Int J Dermatol 2022.
  28. Sudy E, Urbina F. Shiitake dermatitis: clinical forms of presentation. Int J Dermatol 2023.
  29. Chu EY, Anand D, Dawn A, Elenitsas R, Adler DJ. Shiitake dermatitis: a report of 3 cases and review of the literature. Cutis. 2013 Jun;91(6):287-90.
  30. Sumiyoshi, Y., Hashine, K., Kakehi, Y., Yoshimura, K., Satou, T., Kuruma, H., Namiki, S., and Shinohara, N. Dietary administration of mushroom mycelium extracts in patients with early stage prostate cancers managed expectantly: a phase II study. Jpn.J Cl
Dermatitis Hematologic

Ingestion of shiitake mushroom powder 4 grams daily for 10 weeks caused eosinophilia in 5 of 10 healthy humans. Eosinophilia, and leukocytosis or leukopenia have been reported with shiitake dermatitis.

  1. Levy AM, Kita H, Phillips SF, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol 1998;101:613-20.
  2. Mendonça CN, Silva PM, Avelleira JC, Nishimori FS, Cassia Fde F. Shiitake dermatitis. An Bras Dermatol. 2015 Mar-Apr;90(2):276-8.
  3. Nguyen AH, Gonzaga MI, Lim VM, Adler MJ, Mitkov MV, Cappel MA. Clinical features of shiitake dermatitis: a systematic review. Int J Dermatol. 2017 Jun;56(6):610-616.
  4. Poppe LM, Anders D, Kneitz H, Bröcker EB, Benoit S. Flagellate dermatitis caused by shiitake mushrooms. An Bras Dermatol. 2012 May-Jun;87(3):463-5.
Dermatitis Gastrointestinal

Orally, shiitake mushrooms can cause abdominal discomfort, including bloating, nausea, pain, vomiting, and diarrhea. Gastrointestinal symptoms, such as diarrhea, problems swallowing, or mouth ulcers have been associated with shiitake dermatitis. Consumption of large pieces of shiitake mushroom with inadequate chewing can cause abdominal obstruction that has resulted in death in one case and surgical intervention in two others. In another case, parenteral nutrition was used exclusively until the shiitake mushroom pieces were passed.

Topically, an oral rinse containing shiitake mushroom extract has been associated with teeth sensitivity, teeth staining, and burning in the mouth.

  1. Levy AM, Kita H, Phillips SF, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol 1998;101:613-20.
  2. Spierings, E. L., Fujii, H., Sun, B., and Walshe, T. A Phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers. J Nutr Sci Vitaminol.(Tokyo) 2007;53(6):536-539.
  3. Sumiyoshi, Y., Hashine, K., Kakehi, Y., Yoshimura, K., Satou, T., Kuruma, H., Namiki, S., and Shinohara, N. Dietary administration of mushroom mycelium extracts in patients with early stage prostate cancers managed expectantly: a phase II study. Jpn.J Cl
  4. Thaiudom, S., Piyaniran, W., and Chutaputthi, A. A study of the efficacy of Active Hexose Correlated Compound (AHCC) in the treatment of chronic Hepatitis C patients at Phramongkutklao Hospital. The Medical News (Thailand) 2010;325:13-16.
  5. Boels D, Landreau A, Bruneau C, et al. Shiitake dermatitis recorded by French Poison Control Centers - new case series with clinical observations. Clin Toxicol (Phila). 2014 Jul;52(6):625-8.
  6. Nguyen AH, Gonzaga MI, Lim VM, Adler MJ, Mitkov MV, Cappel MA. Clinical features of shiitake dermatitis: a systematic review. Int J Dermatol. 2017 Jun;56(6):610-616.
  7. Hitosugi M, Kitamura O, Takatsu A, Yoshino Y. Autopsy case of duodenal obstruction from impacted mushroom. J Gastroenterol 1998;33:562-5.
  8. Shozushima M, Ohata K, Nonaka K, Matsuhashi N. Shiitake mushroom-induced ileus managed using double-balloon enteroscopy. Endoscopy. 2013;45 Suppl 2 UCTN:E437.
  9. Tan J, Yuan K, Zuo J, et al. Two cases of small bowel obstruction due to a shiitake mushroom. Gastroenterol Rep (Oxf) 2019;7(4):298-300. doi: 10.1093/gastro/gox028.
  10. Miyagishima D, Inoue M, Kinjo K, et al. A case of bowel obstruction due to shiitake mushrooms: Diagnostic features on computed tomography. Intern Med 2022.
  11. Soga K, Mukai H, Kitae H. Management of shiitake mushroom-induced ileus using balloon enteroscopy. Dig Endosc 2022;34(4):e58-e59.
  12. Lingström P, Zaura E, Hassan H, et al. The anticaries effect of a food extract (shiitake) in a short-term clinical study. J Biomed Biotechnol. 2012;2012:217164.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official standardized dose for shiitake supplements, and products vary widely in strength and form. Some research used specialized extracts (like lentinan given by injection in a medical setting), which is very different from over-the-counter capsules.

If you choose a shiitake supplement, follow the directions on the product label and do not exceed the recommended amount. Because quality and concentration differ between brands, it is best to check with your pharmacist or doctor to find a reasonable, safe option for you.

Pregnancy & Breastfeeding

Shiitake Mushroom & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid consuming greater than food amounts.

Shiitake Mushroom & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid consuming greater than food amounts.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 67 references that drive our Shiitake Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hitosugi M, Kitamura O, Takatsu A, Yoshino Y. Autopsy case of duodenal obstruction from impacted mushroom. J Gastroenterol 1998;33:562-5. PubMed
  2. Hanada K, Hashimoto I. Flagellate mushroom (Shiitake) dermatitis and photosensitivity. Dermatol 1998;197:255-7. PubMed
  3. Levy AM, Kita H, Phillips SF, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol 1998;101:613-20. PubMed
  4. Murakami M, Kawabe K, Hosoi Y, et al. Decreased pulmonary perfusion in hypersensitivity pneumonitis caused by Shiitake mushroom spores. J Intern Med 1997;241:85-8. PubMed
  5. Matsui S, Nakazawa T, Umegae Y, Mori M. Hypersensitivity pneumonitis induced by Shiitake mushroom spores. Intern Med 1992;31:1204-6.
  6. Nakamura T. Shiitake (Lentinus edodes) dermatitis. Contact Dermatitis 1992;27:65-70.
  7. Ueda A, Obama K, Aoyama K, et al. Allergic contact dermatitis in shiitake (Lentinus edodes (Berk) Sing) growers. Contact Dermatitis 1992;26:228-33.
  8. Burikhanov, R. B., Wakame, K., Igarashi, Y., Wang, S., and Matsuzaki, S. Suppressive effect of active hexose correlated compound (AHCC) on thymic apoptosis induced by dexamethasone in the rat. Endocr.Regul. 2000;34(4):181-188.
  9. Gao, Y., Zhang, D., Sun, B., Fujii, H., Kosuna, K., and Yin, Z. Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses. Cancer Immunol.Immunother. 2006;55(10):1258-1266. PubMed
  10. Ritz, B. W., Nogusa, S., Ackerman, E. A., and Gardner, E. M. Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection. J Nutr. 2006;136(11):2868-2873. PubMed
  11. Aviles, H., O'Donnell, P., Sun, B., and Sonnenfeld, G. Active hexose correlated compound (AHCC) enhances resistance to infection in a mouse model of surgical wound infection. Surg.Infect.(Larchmt.) 2006;7(6):527-535. PubMed
  12. Spierings, E. L., Fujii, H., Sun, B., and Walshe, T. A Phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers. J Nutr Sci Vitaminol.(Tokyo) 2007;53(6):536-539. PubMed
  13. Aviles, H., O'Donnell, P., Orshal, J., Fujii, H., Sun, B., and Sonnenfeld, G. Active hexose correlated compound activates immune function to decrease bacterial load in a murine model of intramuscular infection. Am J Surg. 2008;195(4):537-545. PubMed
  14. Ritz, B. W. Supplementation with active hexose correlated compound increases survival following infectious challenge in mice. Nutr.Rev. 2008;66(9):526-531. PubMed
  15. Terakawa, N., Matsui, Y., Satoi, S., Yanagimoto, H., Takahashi, K., Yamamoto, T., Yamao, J., Takai, S., Kwon, A. H., and Kamiyama, Y. Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controll
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Shiitake Mushroom

391 brands in our database make a supplement containing Shiitake Mushroom.

Product directory

Supplement products with Shiitake Mushroom

1,667 products in our database contain Shiitake Mushroom. Open any to see its full ingredient list and every drug interaction we check.

20 Veggies & Mushrooms by PureMax Labs YummyVite Capsule 60 Capsule(s) View ingredients & interactions 4Life Transfer Factor Plus by 4Life Capsule 60 Capsule(s) View ingredients & interactions 4Life Transfer Factor Plus RiteStart Men by 4Life Unknown 30 Packet(s) View ingredients & interactions 5 Defenders Capsules by Real Mushrooms Capsule 90 Capsule(s) View ingredients & interactions 5 Defenders Capsules by Real Mushrooms Capsule 200 Capsule(s) View ingredients & interactions 5 Defenders Powder by Real Mushrooms Powder 45 Gram(s) · 1.59 Ounce(s) View ingredients & interactions 5 Defenders Powder by Real Mushrooms Powder 100 Gram(s) · 3.53 Ounce(s) View ingredients & interactions 7M+ by Organixx Capsule 60 Veggie Cap(s) View ingredients & interactions 8 Mushroom Complex by BioSchwartz Capsule 60 Veggie Capsule(s) View ingredients & interactions Active Energy Mango Lemonade Flavor by Sunwarrior Sport Powder 10 Ounce(s) · 285 Gram(s) View ingredients & interactions Active Energy Peachy Mango Flavor by Sunwarrior Sport Powder 10 Ounce(s) · 285 Gram(s) View ingredients & interactions Active Energy Strawberry Lemonade Flavor by Sunwarrior Sport Powder 10 Ounce(s) · 285 Gram(s) View ingredients & interactions Active Energy Watermelon Wave Flavor by Sunwarrior Sport Powder 10 Ounce(s) · 285 Gram(s) View ingredients & interactions Active Energy Watermelon Wave Flavor by Sunwarrior Sport Powder 10 Ounce(s) · 285 Gram(s) View ingredients & interactions Active Immunity by Akasha Naturals Tablet Or Pill 90 Tablet(s) View ingredients & interactions Adaptogenic by Anima Mundi Liquid 4 Ounce(s) · 113 Gram(s) View ingredients & interactions Adaptogenic Potion by SuperSmart Liquid 120 mL View ingredients & interactions Adrenasyl +BioPerine by Approved Science Capsule 60 Capsule(s) View ingredients & interactions Adult's Daily Immune Wellness by Buried Treasure Liquid Nutrients Liquid 16 fl. Oz. · 473 mL View ingredients & interactions AG1 by Athletic Greens Powder 360 Gram(s) · 12.7 Ounce(s) View ingredients & interactions AHCC by Pure Prescriptions Capsule 180 Capsule(s) View ingredients & interactions AHCC by Source Naturals Powder 1 oz. · 28.35 Gram(s) View ingredients & interactions AHCC by Source Naturals Powder 2 oz. · 56.7 Gram(s) View ingredients & interactions AHCC by AOR Advanced Orthomolecular Research Advanced Capsule 30 Vegetarian Capsule(s) View ingredients & interactions
Pharmacist Counseling Corner

Shiitake Mushroom: Common Questions

What is Shiitake Mushroom used for, and does it work?
People use Shiitake Mushroom for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Shiitake Mushroom interact with prescription medications?
Yes. We list 312 medications with a known interaction with Shiitake Mushroom. Use the checker above to see how Shiitake Mushroom interacts with a specific drug.
How are Shiitake Mushroom interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Shiitake Mushroom with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Shiitake Mushroom interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Shiitake Mushroom used for?
People use it as a nutritious food and as a supplement for immune support, heart and cholesterol health, and antioxidant effects. Evidence is strongest for it being a healthy food; most supplement claims are not well proven.
Is Shiitake Mushroom safe to eat?
Yes, for most people cooked shiitake is safe and nutritious. Eating it raw or undercooked can cause an itchy rash in some people, so cook it thoroughly.
Can I take shiitake supplements while pregnant or breastfeeding?
Eating shiitake as food is likely fine, but concentrated supplements have not been well studied during pregnancy or breastfeeding. It's safest to avoid supplement doses unless your doctor approves.
Does shiitake boost the immune system?
Some shiitake-derived extracts like lentinan have been studied for immune effects, mostly as an add-on to cancer treatment in research settings. There isn't strong proof that everyday shiitake supplements meaningfully boost immunity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Products that contain Shiitake Mushroom

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