Drug Interaction Report

Abiraterone and Aripiprazole: Interaction Details

A pharmacist-reviewed analysis of the Abiraterone and Aripiprazole interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Aripiprazole

Abilify Opipza
+

Abiraterone

Abirtega Yonsa Zytiga Zytiga®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 164 documented Abiraterone interactions, 149 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
probable
Severity
Major

What happens

Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects

Interaction Deep Dive

Abiraterone acetate is a moderate CYP2D6 inhibitor. Coadministration of abiraterone with CYP2D6 substrates increases the concentration of CYP2D6 substrates, which may increase the risk of adverse reactions related to these substrates. When abiraterone acetate (1000 mg/day) and predniSONE were administered with dextromethorphan (30 mg), the dextromethorphan Cmax and AUC were increased 2.8-fold and 2.9-fold, respectively. Avoid coadministration for which minimal changes in concentration may lead to serious toxicities. If alternative treatments cannot be used, consider a dose reduction of the concomitant CYP2D6 substrate drug1.

Why it happens (mechanism)

Inhibition of CYP2D6-substrate metabolism by abiraterone acetate

Literature reports

1 report — tap to read

a) The Cmax and AUC of dextromethorphan (CYP2D6 substrate) were increased 2.8- and 2.9-fold, respectively when dextromethorphan 30 mg was given with abiraterone acetate 1000 mg daily (plus predniSONE). The AUC for dextrorphan, the active metabolite of dextromethorphan, increased approximately 1.3-fold 1.

Common questions

Can I take Abiraterone and Aripiprazole together?

Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Always confirm with your pharmacist or prescriber before making any change.

How serious is the Abiraterone and Aripiprazole interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

From our Q&A

Real reader questions about these medications, each personally answered by our pharmacist:

Questions for your pharmacist

  • Does my dose of Abiraterone or Aripiprazole need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (1)

  1. Product Information: AKEEGA(TM) oral tablets, niraparib, abiraterone acetate oral tablets. Janssen Biotech, Inc. (per FDA), Horsham, PA, 2023. DailyMed
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Aripiprazole

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Abiraterone

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Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Aripiprazole + 1,4-butanediol Activated Charcoal American Hellebore Arsenic Beer Cesium Ephedra Gamma-hydroxybutyrate (ghb) + 242 more
Abiraterone + Activated Charcoal Beer Grapefruit Siberian Cocklebur St. John's Wort Wine Acacia Rigidula Adrafinil + 173 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.