Alfuzosin and Idelalisib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Idelalisib
Alfuzosin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased alfuzosin exposure and risk for toxicity
Interaction Deep Dive
Coadministration of alfuzosin (a CYP3A4 substrate) with potent CYP3A4 inhibitors, such as idelalisib, is contraindicated because coadministration may increase alfuzosin exposure and risk for toxicity1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated alfuzosin metabolism
Common questions
Can I take Alfuzosin and Idelalisib together?
Increased alfuzosin exposure and risk for toxicity Always confirm with your pharmacist or prescriber before making any change.
How serious is the Alfuzosin and Idelalisib interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Alfuzosin or Idelalisib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: UROXATRAL(R) oral extended release tablets, alfuzosin HCl oral extended release tablets. Covis Pharmaceuticals, Inc. (per FDA), Cary, NC, 2014. DailyMed
Keep reading about Idelalisib
Keep reading about Alfuzosin
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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