Alfuzosin

297 interactions 566 cited references
Also sold as: UroXatral Uroxatral®
About Alfuzosin

Alfuzosin is an alpha blocker used to treat urinary symptoms caused by an enlarged prostate in men. Read the full Alfuzosin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Telithromycin Telaprevir Sparfloxacin Saquinavir Ritonavir Posaconazole
34 Contraindicated 219 Major 43 Moderate 1 Minor
All (297) Contraindicated (34) Major (219) Moderate (43) Minor (1)

Contraindicated

Alfuzosin Atazanavir Reyataz Increased alfuzosin exposure and an increased risk of QT interval prolongation Details Alfuzosin Bepridil An increased risk of QT interval prolongation Details Alfuzosin Boceprevir Increased alfuzosin exposure Details Alfuzosin Cisapride Propulsid® Increased risk of QT interval prolongation Details Alfuzosin Clarithromycin Biaxin Increased alfuzosin exposure and an increased risk of QT interval prolongation Details Alfuzosin Cobicistat Tybost Increased alfuzosin exposure Details Alfuzosin Conivaptan Vaprisol Increased alfuzosin exposure Details Alfuzosin Darunavir Increased alfuzosin exposure, thereby increasing the risk for serious and/or life-threatening reactions Details Alfuzosin Dronedarone Multaq Increased risk of QT interval prolongation Details Alfuzosin Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Alfuzosin Fluconazole Diflucan Increased alfuzosin exposure and an increased risk of QT interval prolongation Details Alfuzosin Fosamprenavir Lexiva Increased alfuzosin plasma concentrations Details Alfuzosin Idelalisib Zydelig Increased alfuzosin exposure and risk for toxicity Details Alfuzosin Indinavir Increased alfuzosin plasma concentrations Details Alfuzosin Itraconazole Sporanox Increased alfuzosin exposure Details Alfuzosin Ketoconazole Extina Increased alfuzosin exposure and an increased risk of QT interval prolongation Details Alfuzosin Levoketoconazole Recorlev An increased risk of QT interval prolongation and torsades pointes, an increased CYP3A4 substrate exposure and an increased risk o... Details Alfuzosin Lopinavir Increased alfuzosin concentration and increased risk of torsade de pointes Details Alfuzosin Mesoridazine An increased risk of QT interval prolongation Details Alfuzosin Nelfinavir Viracept Increased alfuzosin exposure and an increased risk of QT interval prolongation Details Alfuzosin Nirmatrelvir Increased alfuzosin exposure; hypotension Details Alfuzosin Pimozide An increased risk of QT interval prolongation Details Alfuzosin Piperaquine An increased risk of QT interval prolongation Details Alfuzosin Posaconazole Noxafil Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Alfuzosin Ritonavir Norvir An increase in alfuzosin exposure Details Alfuzosin Saquinavir Increased alfuzosin plasma concentrations Details Alfuzosin Sparfloxacin An increased risk of QT interval prolongation Details Alfuzosin Telaprevir Increased alfuzosin concentrations Details Alfuzosin Telithromycin Increased alfuzosin plasma concentrations and an increased risk of QT interval prolongation Details Alfuzosin Terfenadine An increased risk of QT interval prolongation Details Alfuzosin Thioridazine An increased risk of QT interval prolongation Details Alfuzosin Tipranavir Aptivus Increased alfuzosin plasma concentrations Details Alfuzosin Ziprasidone Geodon An increased risk of QT interval prolongation Details Alfuzosin Ketoconazole Topical Extina® Foam Increased alfuzosin exposure and an increased risk of QT interval prolongation Details

Major

Alfuzosin Abametapir Increased exposure of CYP3A4 substrate Details Alfuzosin Amitriptyline Elavil An increased risk of QT interval prolongation Details Alfuzosin Sertraline An increased risk of QT interval prolongation Details Alfuzosin Buprenorphine Belbuca An increased risk of QT interval prolongation Details Alfuzosin Relugolix Orgovyx Increased risk of QT interval prolongation Details Alfuzosin Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details

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