Amoxapine and Linezolid Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Amoxapine
No brand names on recordLinezolid Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of serotonin syndrome
Interaction Deep Dive
Concurrent use of protriptyline and an MAOI, such as linezolid, is contraindicated. If substitution of protriptyline for an MAOI is necessary, a minimum of 14 days should be allowed to elapse after the latter is discontinued. Initiate protriptyline cautiously with gradual increase in dosage until optimum response is achieved1.
Why it happens (mechanism)
Additive serotonergic effects
Common questions
Can I take Amoxapine and Linezolid Injection together?
An increased risk of serotonin syndrome Always confirm with your pharmacist or prescriber before making any change.
How serious is the Amoxapine and Linezolid Injection interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Amoxapine or Linezolid Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: amoxapine oral tablets, amoxapine oral tablets. Chartwell RX, LLC. (per DailyMed), Congers, NY, 2024. DailyMed
Keep reading about Amoxapine
Keep reading about Linezolid Injection
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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