Amoxapine

78 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Amoxapine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Amoxapine Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Amoxapine Sertraline Explained Modest elevation in amoxapine exposure and an increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental... Details Amoxapine Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular system effects Details Amoxapine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Amoxapine Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amoxapine Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amoxapine Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Amoxapine Aspirin Acuprin® An increased risk of bleeding Details Amoxapine Aspirin Rectal Aspirin An increased risk of bleeding Details Amoxapine Azithromycin AzaSite An increased risk of QT interval prolongation Details Amoxapine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Amoxapine Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Amoxapine Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Amoxapine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Amoxapine Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amoxapine Clonidine Transdermal Patch Catapres Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Amoxapine Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Amoxapine Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Amoxapine Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Amoxapine Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Amoxapine Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amoxapine Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amoxapine Dolasetron Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Amoxapine Dolasetron Injection Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Amoxapine Etodolac Lodine An increased risk of bleeding Details Amoxapine Fenoprofen Fenopron An increased risk of bleeding Details Amoxapine Fentanyl Transdermal Patch Duragesic® Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Amoxapine Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amoxapine Flurbiprofen Ansaid An increased risk of bleeding Details Amoxapine Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Amoxapine Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amoxapine Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amoxapine Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Amoxapine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Amoxapine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Amoxapine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.