Drug Interaction Report

Cabergoline and Zuclopenthixol: Interaction Details

A pharmacist-reviewed analysis of the Cabergoline and Zuclopenthixol interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Jul 11, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Cabergoline

Dostinex®
+

Zuclopenthixol

No brand names on record
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Jul 11, 2026
Editorial policy · Data sources
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Interaction severity
Not rated
Severity is not yet rated.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Onset
<br> Pharmacokinetics Pharmacokinetics Onset and Duration A) Onset<br>
Evidence
theoretical
Severity
Not rated

What happens


a) Store in original container at controlled room temperature between 20 and 25 degrees C (68 and 77 degrees F) 1.
Trade Names No results available Regulatory Status No results available References  1. Product Information: DOSTINEX oral tablets

Interaction Deep Dive

a) Administration

Why it happens (mechanism)

Pharmacologic antagonism effect on dopamine-2 receptors
IV Compatibility (single) No results available Pregnancy & Lactation A) Teratogenicity/Effects in Pregnancy

Common questions

Can I take Cabergoline and Zuclopenthixol together?

A) Store in original container at controlled room temperature between 20 and 25 degrees C (68 and 77 degrees F) . Trade Names No results available Regulatory Status No results available References  1. Product Information: DOSTINEX oral tablets Always confirm with your pharmacist or prescriber before making any change.

How serious is the Cabergoline and Zuclopenthixol interaction?

It is rated <br> a) the pharmacokinetics of cabergoline were not altered in patients with moderate-to-severe renal impairment (n=12) as assessed by creatinine clearance [1].<br> adme absorption<br> a) bioavailability<br>. Severity is not yet rated.

How quickly could this interaction happen?

The documented onset is "<br> pharmacokinetics pharmacokinetics onset and duration a) onset<br>". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Cabergoline or Zuclopenthixol need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (21)

  1. Product Information: DOSTINEX oral tablets, cabergoline oral tablets. Pharmacia & Upjohn Company (per FDA), New York, NY, 2025. DailyMed
  2. Anon: European Multicentre Study Group for Cabergoline in Lactation Inhibition: Single dose cabergoline versus bromocriptine in inhibition of puerperal lactation: randomised, double-blind, multicentre study. BMJ 1991; 302:1367-1371.
  3. Caballero-Gordo A, Lopez-Nazareno N, Calderay M, et al: Oral cabergoline. Single-dose inhibition of puerperal lactation. J Reprod Med 1991; 36:717-721.
  4. Giorda G, de Vincentis A, Motta T, et al: Cabergoline versus bromocriptine in suppression of lactation after cesarean delivery. Gynecol Obstet Invest 1991; 31:93-96. PubMed
  5. Melis GB, Mais V, Paoletti AM, et al: Prevention of puerperal lactation by a single oral administration of the new prolactin-inhibiting drug, cabergoline. Obstet Gynecol 1988; 71:311-314.
  6. National Institute for Occupational Safety and Health (NIOSH): NIOSH list of hazardous drugs in healthcare settings, 2024. Centers for Disease Control and Prevention (CDC). Atlanta, GA. 2024. DOI
  7. National Institute for Occupational Safety and Health (NIOSH): Managing hazardous drug exposures: information for healthcare settings. Centers for Disease Control and Prevention (CDC). Atlanta, GA. 2023.
  8. Webster J, Piscitelli G, Polli A, et al: Dose-dependent suppression of serum prolactin by cabergoline in hyperprolactinaemia: a placebo controlled, double blind, multicentre study. Clin Endocrinol 1992; 37:534-541. DOI
  9. Ferrari C, Paracchi A, Mattei AM, et al: Cabergoline in the long-term therapy of hyperprolactinemic disorders. Acta Endocrinol 1992; 126:489-494. PubMed
  10. Ciccarelli E, Giusti M, Miola C, et al: Effectiveness and tolerability of long term treatment with cabergoline, a new long-lasting ergoline derivative, in hyperprolactinemic patients. J Clin Endocrinol Metab 1989; 69:725-728. DOI
  11. Mattei AM, Ferrari C, Baroldi P, et al: Prolactin-lowering effect of acute and once weekly repetitive oral administration of cabergoline at two dose levels in hyperprolactinemic patients. J Clin Endocrinol Metab 1988; 66:193-198. DOI
  12. Ferrari C, Barbieri C, Caldara R, et al: Long-lasting prolactin-lowering effect of cabergoline, a new dopamine agonist, in hyperprolactinemic patients. J Clin Endocrinol Metab 1986; 63:941-945. PubMed
  13. Product Information: DOSTINEX(R) oral tablets, cabergoline oral tablets. Pharmacia & Upjohn Company (per FDA), New York, NY, 2019. DailyMed
  14. Colao A, Abs R, Barcena DG, et al: Pregnancy outcomes following cabergoline treatment: extended results from a 12-year observational study. Clinical endocrinology 2008; 68(1):66-71. PubMed
  15. Rains CR, Bryson HM, & Fitton A: Cabergoline: A review of its pharmacological properties and therapeutic potential in the treatment of hyperprolactinaemia and inhibition of lactation. Drugs 1995; 49(2):255-279.
  16. Product Information: Dostinex(R), cabergoline. Pharmacia & Upjohn, Kalamazoo, MI, 1997. DailyMed
  17. Pontiroli AE, Cammelli L, Baroldi P, et al: Inhibition of basal and metoclopramide-induced prolactin release by cabergoline, an extremely long-acting dopaminergic drug. J Clin Endocrinol Metab 1987; 65:1057-1059. PubMed
  18. Wiseman LR & Fitton A: Cabergoline: a review of its efficacy in the treatment of Parkinson's disease. CNS Drugs 1999; 12(6):484-497.
  19. Pontiroli AE, Viberti GC, Mangili R, et al: Selective and extremely long inhibition of prolactin release in man by 1-ethyl-3-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta carbonyl)-urea-diphosphate (FCE 21336). Br J Clin Pharmacol 1987a; 23:433-438. PubMed
  20. Bevan JS, Webster J, Burke CW, et al: Dopamine agonists and pituitary tumor shrinkage. Endocrine Rev 1992; 13:220-240. DOI
  21. Ferrari C, Paracchi A, & Romano C: Long-lasting lowering of serum growth hormone and prolactin levels by single and repetitive cabergoline administration in dopamine-responsive acromegalic patients. Clin Endocrinol 1988; 29:467-476. PubMed
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