Cabotegravir and Tebipenem Pivoxil: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Cabotegravir
Tebipenem Pivoxil
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased tebipenem pivoxil exposure and an increased risk of tebipenem pivoxil-related adverse effects
Interaction Deep Dive
Concomitant use of tebipenem pivoxil (OAT1/OAT3 substrate) with OAT1/OAT3 inhibitors is generally not recommended as it may increase tebipenem pivoxil exposure. If concomitant use with tebipenem pivoxil is necessary, monitor more frequently for adverse reactions associated with tebipenem pivoxil (eg, diarrhea and headache)1.
Why it happens (mechanism)
Inhibition of OAT1-mediated efflux transport of tebipenem pivoxil; inhibition of OAT3-mediated efflux transport of tebipenem pivoxil
Literature reports
1 report — tap to read
a) In drug interaction studies, following a single oral dose of 250 mg of tebipenem pivoxil coadministered with probenecid (inhibitor of the renal transporters OAT1 and OAT3), tebipenem Cmax increased by approximately 1.5-fold and plasma AUC by approximately 2.9-fold 1.
Common questions
Can I take Cabotegravir and Tebipenem Pivoxil together?
Increased tebipenem pivoxil exposure and an increased risk of tebipenem pivoxil-related adverse effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Cabotegravir and Tebipenem Pivoxil interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Cabotegravir or Tebipenem Pivoxil need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: UTEBZI oral tablets, tebipenem pivoxil oral tablets. GlaxoSmithKline, Durham, NC, 2026.
Keep reading about Cabotegravir
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