Cholestyramine

40 interactions 1 explained in plain English

Also sold as: Prevalite Questran

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Deferasirox Dexamethasone Injection Dexamethasone Ophthalmic Digoxin Ezetimibe

5 Major 23 Moderate 12 Minor

All (40) Major (5) Moderate (23) Minor (12)

Major

Cholestyramine Deferasirox Exjade Decreased deferasirox concentrations Details Cholestyramine Dexamethasone Injection Decadron Decreased dexamethasone concentration Details Cholestyramine Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Decreased dexamethasone concentration Details Cholestyramine Digoxin Cardoxin® Reduced digoxin exposure Details Cholestyramine Ezetimibe Zetia Reduced ezetimibe exposure and reduced efficacy of ezetimibe Details

Moderate

Cholestyramine Calcifediol Rayaldee Decreased absorption of calcifediol Details Cholestyramine Cephalexin Keflet® Tablets Decreased cephalexin effectiveness Details Cholestyramine Diclofenac Ophthalmic Voltaren® Eye Drops Decreased diclofenac bioavailability Details Cholestyramine Diclofenac Topical (Actinic Keratosis) Pennsaid Decreased diclofenac bioavailability Details Cholestyramine Diclofenac Topical (Arthritis Pain) Pennsaid® Decreased diclofenac bioavailability Details Cholestyramine Diclofenac Transdermal Patch Flector Decreased diclofenac bioavailability Details Cholestyramine Entacapone Comtan Enhanced entacapone adverse effects (diarrhea, dyskinesias) Details Cholestyramine Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Cholestyramine Furosemide Injection Disal Decreased furosemide effectiveness Details Cholestyramine Levothyroxine Ermeza Reduced efficacy of levothyroxine and an increased risk of hypothyroidism Details Cholestyramine Liothyronine Cytomel Decreased effectiveness of liothyronine Details Cholestyramine Maralixibat Livmarli Reduced exposure and efficacy of maralixibat Details Cholestyramine Meloxicam Alloxate An increased clearance of meloxicam Details Cholestyramine Meloxicam Injection Alloxate An increased clearance of meloxicam Details Cholestyramine Methotrexate Jylamvo Decreased methotrexate effectiveness Details Cholestyramine Methotrexate Injection Abitrexate® Decreased methotrexate effectiveness Details Cholestyramine Metronidazole Flagyl Decreased metronidazole effectiveness Details Cholestyramine Metronidazole Injection Flagyl Decreased metronidazole effectiveness Details Cholestyramine Metronidazole Topical MetroCream® Decreased metronidazole effectiveness Details Cholestyramine Metronidazole Vaginal MetroGel® Vaginal Decreased metronidazole effectiveness Details Cholestyramine Obeticholic Acid Ocaliva Reduced exposure and efficacy of obeticholic acid Details Cholestyramine Odevixibat Bylvay Reduced exposure and efficacy of odevixibat Details Cholestyramine Paricalcitol Zemplar Decreased systemic paricalcitol concentrations Details

Minor

Cholestyramine Acetaminophen And Codeine Capital® & Codeine Explained Decreased acetaminophen effectiveness Details Cholestyramine Acetaminophen Acephen Decreased acetaminophen effectiveness Details Cholestyramine Acetaminophen Injection Acephen Decreased acetaminophen effectiveness Details Cholestyramine Acetaminophen Rectal Acephen Decreased acetaminophen effectiveness Details Cholestyramine Doxercalciferol Hectoral® Reduced doxercalciferol efficacy Details Cholestyramine Doxercalciferol Injection Hectorol Reduced doxercalciferol efficacy Details Cholestyramine Fluvastatin Lescol Decreased fluvastatin effectiveness Details Cholestyramine Glipizide Glucotrol Decreased glipiZIDE effectiveness; increased blood glucose Details Cholestyramine Hydrocortisone Ala-Cort Decreased hydrocortisone effectiveness Details Cholestyramine Hydrocortisone Injection A-Hydrocort® Decreased hydrocortisone effectiveness Details Cholestyramine Naproxen Aleve Delayed absorption of naproxen Details Cholestyramine Niacin Endur-Acin Decreased nicotinic acid exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.