Drug Interaction Report

Conivaptan and Lurasidone: Interaction Details

A pharmacist-reviewed analysis of the Conivaptan and Lurasidone interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Conivaptan

Vaprisol
+

Lurasidone

Latuda Latuda®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Contraindicated
These should generally not be used together.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 125 documented Conivaptan interactions, 7 are rated contraindicated — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Contraindicated

What happens

Increased lurasidone exposure

Interaction Deep Dive

The concomitant use of conivaptan (strong CYP3A inhibitor) with lurasidone (CYP3A substrate) is contraindicated due to the potential for increased lurasidone exposure1. Lurasidone may be initiated no sooner than 1 week after completion of conivaptan therapy 3. Ketoconazole 400 mg/day (strong CYP3A inhibitor) increased the lurasidone Cmax by 6.9-fold and the AUC by 9-fold 2. Conivaptan increased the AUC of CYP3A substrates midazolam, simvastatin, and amlodipine 3.

Why it happens (mechanism)

Inhibition of CYP3A-mediated lurasidone metabolism

Literature reports

4 reports — tap to read

a) Coadministration of a single dose of lurasidone 10 mg with ketoconazole 400 mg/day at steady state (for 5 days) resulted in an increase in lurasidone Cmax and AUC by 6.9 and 9 times the levels relative to lurasidone administration alone, respectively 2

b) The strong CYP3A inhibitor conivaptan 40 mg/day IV increased the AUC of midazolam, a CYP3A substrate, by approximately 100% with a 1-mg IV dose and by 200% with a 2-mg oral dose 3.

c) Conivaptan 30 mg/day IV tripled the AUC of simvastatin, a CYP3A substrate 3.

d) Conivaptan 40 mg orally twice daily doubled the AUC and half-life of amlodipine, a CYP3A substrate 3.

Common questions

Can I take Conivaptan and Lurasidone together?

Increased lurasidone exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Conivaptan and Lurasidone interaction?

It is rated contraindicated. These should generally not be used together.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Conivaptan or Lurasidone need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (3)

  1. Product Information: LATUDA(TM) oral tablets, lurasidone HCl oral tablets. Sunovion Pharmaceuticals, Inc. (per manufacturer), Marlborough, MA, 2013. DailyMed
  2. Product Information: LATUDA(R) oral tablets, lurasidone HCl oral tablets. Sunovion Pharmaceuticals Inc. Fort Lee, NJ, 2010. DailyMed
  3. Product Information: VAPRISOL(R) intravenous injection, conivaptan HCl intravenous injection. Cumberland Pharmaceuticals Inc (per FDA), Nashville, TN, 2016.
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Conivaptan

Keep reading about Conivaptan

All Conivaptan interactions (125)
Also serious with: Ketoconazole Topical Ivabradine Maraviroc Colchicine
Lurasidone

Keep reading about Lurasidone

All Lurasidone interactions (135) Lurasidone drug information
Also serious with: Apalutamide Metoclopramide Nasal Spray Metoclopramide Injection Atazanavir
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Lurasidone + Activated Charcoal Grapefruit Indian Snakeroot Rauvolfia Vomitoria St. John's Wort Acacia Rigidula Adrafinil African Wild Potato + 141 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.