Drug Interaction Report

Dabigatran and Darunavir: Interaction Details

A pharmacist-reviewed analysis of the Dabigatran and Darunavir interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Darunavir

No brand names on record
+

Dabigatran

Pradaxa®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
LinkedIn
Interaction severity
Moderate
Can be significant — usually manageable with monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 284 documented Dabigatran interactions, 29 are rated moderate — including this one.
Onset
unspecified
Evidence
probable
Severity
Moderate

What happens

Increased dabigatran etexilate exposure

Interaction Deep Dive

Concurrent use of darunavir and dabigatran etexilate may increase dabigatran etexilate exposure. Clinical monitoring is recommended when dabigatran etexilate is coadministered with darunavir1234.

Why it happens (mechanism)

Inhibition of P-gp-mediated efflux transport of dabigatran etexilate

Literature reports

1 report — tap to read

a) In a drug interaction study, concurrent administration of dabigatran etexilate 150 mg with darunavir/ritonavir 800/100 mg single dose resulted in increased exposure of dabigatran etexilate. The least-mean square ratio of AUC and Cmax of dabigatran etexilate with or without darunavir were 1.72 (90% CI, 1.33 to 2.23) and 1.64 (90% CI, 1.21 to 2.23) respectively. In another drug interaction study, concurrent administration of dabigatran etexilate 150 mg with darunavir/ritonavir 800/100 mg every day for 14 days resulted in the least-mean square ratio of AUC and Cmax of dabigatran etexilate with or without darunavir were 1.18 (90% CI, 0.9 to 1.53) and 1.22 (90% CI, 0.89 to 1.67) respectively 1.

Common questions

Can I take Dabigatran and Darunavir together?

Increased dabigatran etexilate exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Dabigatran and Darunavir interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "probable". Good supporting evidence, though not definitively proven.

Questions for your pharmacist

  • Does my dose of Dabigatran or Darunavir need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there anything you'd monitor while I'm on both?

References (4)

  1. Product Information: PREZISTA(R) oral suspension, oral tablets, darunavir oral suspension, oral tablets. Janssen Products, LP (per FDA), Horsham, PA, 2023. DailyMed
  2. Product Information: PREZCOBIX® PED oral tablets for suspension, darunavir cobicistat oral tablets for suspension. Janssen Products, LP (per FDA), Horsham, PA, 2026. DailyMed
  3. Product Information: PREZCOBIX® oral tablets, darunavir cobicistat oral tablets. Janssen Products, LP (per FDA), Horsham, PA, 2026. DailyMed
  4. Product Information: SYMTUZA(R) oral tablets, darunavir, cobicistat, emtricitabine, tenofovir alafenamide oral tablets. Janssen Therapeutics (per FDA), Titusville, NJ, 2022. DailyMed
Was this write-up helpful?
Darunavir

Keep reading about Darunavir

All Darunavir interactions (115)
Also serious with: Lovastatin Ivabradine Colchicine Lurasidone
Dabigatran

Keep reading about Dabigatran

All Dabigatran interactions (284) Dabigatran drug information
Also serious with: Levoketoconazole Defibrotide Zanubrutinib Enasidenib
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Darunavir + Activated Charcoal Grapefruit St. John's Wort Acacia Rigidula Adrafinil African Wild Potato American Elder Astaxanthin + 137 more
Dabigatran + Activated Charcoal Danshen Piracetam St. John's Wort Aconite Allspice Aloe Alpha-lipoic Acid + 227 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

Check another combination

Our instant two-drug interaction checker is almost here.

Coming soon

The instant two-drug checker is on its way.

In the meantime, browse the directory below to look up any drug and see its documented interactions.

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.