Dextroamphetamine and Omeprazole: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Dextroamphetamine
Omeprazole
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Here's what's going on. Your body gets rid of dextroamphetamine partly through your urine, and how fast it leaves depends on how acidic or alkaline (the opposite of acidic) your urine is. Omeprazole can make your body fluids a bit less acidic, which can slow how quickly the amphetamine clears out. That means more of it may build up and its effects may last longer, so you could notice things like a faster heartbeat, jitteriness, trouble sleeping, or a poor appetite.
The good news: this concern is based on theory more than strong studies. Please don't change either medicine on your own. Just tell your pharmacist or doctor you take both, and they can watch how you're doing and adjust things if needed.
Mechanism: Amphetamine renal excretion is pH-dependent; urinary alkalinization increases nonionized fraction, promotes tubular reabsorption, and prolongs half-life. Omeprazole (via reduced gastric acid and potential effect on urinary pH) is flagged as an alkalinizing agent, theoretically decreasing amphetamine renal elimination and increasing exposure and pharmacodynamic effect.
- Direction: increased amphetamine exposure/effect (neither drug is a prodrug requiring activation here)
- Magnitude: not quantified
- Onset: unspecified
- Evidence: theoretical
- Management: monitor for sympathomimetic excess (tachycardia, hypertension, insomnia, anxiety, anorexia); stimulant dose may need individualization; consider alternatives if clinically significant.
What happens
Increased exposure to amphetamine
Interaction Deep Dive
Do not use amphetamines together with gastrointestinal1 or urinary alkalizing agents, because doing so can lead to elevated blood concentrations and enhanced amphetamine activity 2. Amphetamine elimination depends on pH, and alkaline urine will markedly prolong the half-life 1.
Why it happens (mechanism)
Decreased renal elimination
How to manage this interaction
What your care team may do:
- Keep taking both medicines exactly as prescribed unless told otherwise.
- Watch for signs of too much stimulant effect, such as a racing heart, high blood pressure, feeling wired, trouble sleeping, or loss of appetite.
- Your stimulant dose may be adjusted and individualized, and your team may monitor you more closely.
- If problems persist, your prescriber might consider a different option.
What you should do: Let your pharmacist or doctor know you take both, and report any new or bothersome symptoms. This is a manageable situation your team can tailor to you.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Dextroamphetamine and Omeprazole together?
Omeprazole may slow how your body clears dextroamphetamine, so amphetamine effects could be stronger or last longer; keep taking both as prescribed and tell your pharmacist or doctor so they can monitor you and adjust the dose if needed. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Dextroamphetamine and Omeprazole interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Dextroamphetamine and Omeprazole interaction managed?
What your care team may do: Keep taking both medicines exactly as prescribed unless told otherwise. Watch for signs of too much stimulant effect, such as a racing heart, high blood pressure, feeling wired, trouble sleeping, or loss of appetite. Your stimulant dose may be adjusted and individualized, and your team may monitor you more closely. If problems persist, your prescriber might consider a d… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Dextroamphetamine or Omeprazole need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: Desoxyn(R) oral tablets, methamphetamine HCl oral tablets. Recordati Rare Diseases Inc (per FDA), Lebanon, NJ, 2017.
- Product Information: EVEKEO ODT(TM) orally disintegrating tablets, amphetamine sulfate orally disintegrating tablets. Arbor Pharmaceuticals LLC (per FDA), Atlanta, GA, 2019.
Keep reading about Dextroamphetamine
Keep reading about Omeprazole
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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