Digoxin

453 interactions 2 explained in plain English 980 cited references
Also sold as: Cardoxin® Digitek Digitek® Digox Lanoxicaps® Lanoxin Lanoxin®
About Digoxin

Digoxin is a cardiac glycoside used to treat heart failure and abnormal heart rhythms by strengthening the heart's contractions and slowing heart rate. Read the full Digoxin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Digoxin Pectin Halls Breezers Reduced digoxin exposure Details Digoxin Penicillamine Aagylur Reduced digoxin exposure Details Digoxin Perindopril Aceon An increased digoxin exposure Details Digoxin Pexidartinib Turalio Increased digoxin exposure Details Digoxin Pheasant's Eye Increased risk of digoxin toxicity Details Digoxin Phenylbutazone Equi-Phar Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Phenytoin Dilantin Reduced digoxin exposure Details Digoxin Piketoprofen Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Piperine Increased digoxin exposure Details Digoxin Piroxicam Feldene Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Pirtobrutinib Jaypirca Increased digoxin exposure and an increased risk of digoxin-related adverse effects Details Digoxin Polythiazide Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Digoxin Ponesimod Ponvory An increased risk of severe bradycardia and heart block Details Digoxin Posaconazole Noxafil Increased digoxin exposure Details Digoxin Potassium Phosphate K-Phos Increased risk of severe and potentially fatal hyperkalemia Details Digoxin Pranoprofen Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Proglumetacin Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Propafenone Rythmol Increased digoxin exposure Details Digoxin Propantheline Probanthine Increased exposure Details Digoxin Propyphenazone Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Proquazone Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Quercetin Altered digoxin exposure Details Digoxin Quinapril Accupril An increased digoxin exposure Details Digoxin Quinethazone Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Digoxin Quinidine Cardioquin® Increased digoxin exposure Details Digoxin Quinine Increased digoxin exposure Details Digoxin Rabeprazole Aciphex An increased digoxin exposure Details Digoxin Ramipril Altace An increased digoxin exposure Details Digoxin Ranolazine Aspruzyo Increased digoxin exposure Details Digoxin Remibrutinib Rhapsido Increased P-gp substrate exposure and an increased risk of P-gp substrates-related adverse reactions Details Digoxin Rifabutin Mycobutin Reduced digoxin exposure Details Digoxin Rifampin Rifadin Altered digoxin exposure and an increased risk of digoxin toxicity Details Digoxin Ritonavir Norvir Altered digoxin exposure and an increased risk of digoxin toxicity Details Digoxin Rofecoxib Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Rolapitant Varubi Increased digoxin exposure Details Digoxin Rucaparib Rubraca Increased digoxin exposure Details Digoxin Salicylic Acid Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Salsalate Disalcid Increased digoxin exposure and prolonged half-life of digoxin Details Digoxin Saquinavir Increased digoxin exposure and an increased risk of digoxin toxicity Details Digoxin Sarecycline Seysara Increased digoxin exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.